Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo
Abstract
The foxa gene is an integral component of the endoderm specification subcircuit of the endomesoderm gene regulatory network in the Strongylocentrotus purpuratus embryo. Its transcripts become confined to veg2, then veg1 endodermal territories, and, following gastrulation,throughout the gut. It is also expressed in the stomodeal ectoderm. gatae and otx genes provide input into the pregastrular regulatory system of foxa, and Foxa represses its own transcription,resulting in an oscillatory temporal expression profile. Here, we report three separate essential functions of the foxa gene: it represses mesodermal fate in the veg2 endomesoderm; it is required in postgastrular development for the expression of gut-specific genes; and it is necessary for stomodaeum formation. If its expression is reduced by a morpholino, more endomesoderm cells become pigment and other mesenchymal cell types, less gut is specified, and the larva has no mouth. Experiments in which blastomere transplantation is combined with foxa MASO treatment demonstrate that, in the normal endoderm, a crucial role of Foxa is to repress gcm expression in response to a Notch signal, and hence to repress mesodermal fate. Chimeric recombination experiments in which veg2, veg1 or ectoderm cells contained foxa MASO show which region of foxaexpression controls each of the three functions. These experiments show that the foxa gene is a component of three distinct embryonic gene regulatory networks.
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Gatae operates a regulatory exclusion function in the sea star, repressing mesodermal state controllers ets1/2 and gatac in the endodermal domain.
“The data in Fig. 3 show that directly or indirectly gatae operates a regulatory ''exclusion function'' (22); that is, it is responsible for regulatory repression in the endodermal domain of mesodermal state controllers, including ets1 / 2 and gatac .”
From Evolutionary plasticity of developmental gene regulatory network architecture (2007) · cites this paper as [22]
In sea urchins endoderm cells are prevented from expressing mesoderm genes by foxa repression of gcm, whereas in sea stars endoderm cells are also prevented from expressing mesoderm genes, but by gatae (possibly indirectly) blocking gatac and ets1.
“In sea urchins endoderm cells are prevented from expressing mesoderm genes by foxa repression of gcm (22, 23), whereas in sea stars endoderm cells are also prevented from expressing mesoderm genes, but not by foxa : instead it is gatae that executes the exclusion function (possibly indirectly), by blocking expression of gatac and ets1 .”
From Evolutionary plasticity of developmental gene regulatory network architecture (2007) · cites this paper as [22]
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- Authors
- Oliveri, P., Walton, K. D., Davidson, E. H., & McClay, D. R.
- Affiliations
- California Institute of Technology (US)
- Duke University (US)
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-11-01
- Volume
- 133
- Issue
- 21
- Pages
- 4173-4181
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2057195804
- Semantic Scholar
- e64e5ec68f00351a702942445a9da497f5965a32
- Cited by
- 141
- References
- 54
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 14 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 12
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (publishedVersion)
- Funders
- National Institutes of Health (5p01hd037105-20)
- National Institute of General Medical Sciences (R01GM061464, GM61464)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD14483, HD37105, R01HD014483)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- FoxA, endomesoderm specification, Strongylocentrotus purpuratus, sea urchin embryo, Otx, global climate models, Notch signaling, gene regulatory networks, morpholino knockdown, blastomere transplantation
- MeSH terms
- Animals, Embryonic Structures, Endoderm, Mesoderm, Mouth, Recombinant Proteins, Signal Transduction, Oligonucleotides, Antisense, In Situ Hybridization, Gene Expression Regulation, Developmental, Cell Lineage, Body Patterning, Strongylocentrotus purpuratus, Forkhead Transcription Factors
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