Cited by 121Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsNuclear Receptors and Signaling

The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.

Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon

Open access

Nakatani, Tomoya, Kumai, Minoru, Mizuhara, Eri, Minaki, Yasuko, Ono, Yuichi·2010·Developmental Biology

DOI 10.1016/j.ydbio.2009.12.017

Open this paper in CoChat — free account Open PDF

Abstract

Mesencephalic dopaminergic (mesDA) neurons control movement and behavior, and their loss causes severe neurological disorders, such as Parkinson's disease. Recent studies have revealed that mesDA neurons originate from mesencephalic floor plate (FP) cells, which had been thought of as non-neurogenic organizer cells regulating regional patterning and axonal projections. Otx2 and its FP-specific downstream factor Lmx1a have been shown to be sufficient to confer neurogenic activity on FP cells and determine a mesDA fate. However, the mechanism underlying how these factors control mesDA development and how FP cells and mesDA neurons are coordinately specified are still largely unknown. In the present study, we obtained evidence that Lmx1a and Lmx1b cooperate with Foxa2 to specify mesDA neuron identity by gain-of-function approaches using transgenic mice. Lmx1a/b appeared to select a mesDA fate by suppressing red nucleus fate in the context of Foxa2-positive progenitors, at least in part, through repressing the Sim1-Lhx1 and Ngn1 pathways that inhibit proper mesDA differentiation. We also found that, in the mesencephalon, FP cell fate is primarily determined by Foxa2 with a supportive action of Lmx1a/b through repressing Nkx6.1, which inhibits FP cell differentiation. Thus, FP and mesDA identities are determined by distinct specification pathways, both of which are controlled by the same combination of transcription factors, Lmx1a/b and Foxa2, and, as a consequence, mesDA neurons are generated from mesencephalic FP cells.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.ydbio.2009.12.017

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Retracted: Lmx1b -Controlled Isthmic Organizer Is Essential for Development of Midbrain Dopaminergic Neurons
Guo, C., Qiu, H., Shi, M., Huang, Y., Johnson, R. L., Rubinstein, M., Chen, S.-D., & Ding, Y. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3267-08.2008 · Cited by 11
Retracted
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE
Olanow, C. W., & Tatton, W. G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.123 · Cited by 1,409
Dopamine Neuron Agenesis in Nurr1-Deficient Mice
Zetterström, R. H., Solomin, L., Jansson, L., Hoffer, B. J., Olson, L., & Perlmann, T. (1997) · Science · doi:10.1126/science.276.5310.248 · Cited by 1,096
FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate
Ye, W., Shimamura, K., Rubenstein, J. L. R., Hynes, M., & Rosenthal, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81437-3 · Cited by 878
Identification of intrinsic determinants of midbrain dopamine neurons
Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B., Perlmann, T., & Ericson, J. (2006) · Cell · doi:10.1016/j.cell.2005.10.037 · Cited by 587
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
Mendez, I. M., Viñuela, Á., Astradsson, A., Mukhida, K., Hallett, P. J., Robertson, H. A., Tierney, T. S., Holness, R. O., Dagher, A., Trojanowski, J. Q., et al. (2008) · Nature Medicine · doi:10.1038/nm1752 · Cited by 442
Fetal nigral transplantation as a therapy for Parkinson's disease
Olanow, C. W., Kordower, J. H., & Freeman, T. B. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80038-5 · Cited by 423
Fetal Nigral Transplantation as a Therapy for Parkinson's Disease
Olanow, C. W., & Fahn, S. (2006) · Springer eBooks · doi:10.1007/0-387-32823-8_6 · Cited by 415
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
Smidt, M. P., Asbreuk, C. H. J., Cox, J. J., Chen, H., Johnson, R. L., & Burbach, J. P. H. (2000) · Nature Neuroscience · doi:10.1038/73902 · Cited by 394

Show all 37 references

Sorted by citations

Effects and mechanisms of working memory training: a review
von Bastian, C. C., & Oberauer, K. (2014) · Psychological Research · doi:10.1007/s00426-013-0524-6 · Cited by 318
How to make a midbrain dopaminergic neuron
Arenas, E., Denham, M., & Villaescusa, C. (2015) · Development · doi:10.1242/dev.097394 · Cited by 321
From nerve net to nerve ring, nerve cord and brain — evolution of the nervous system
Arendt, D., Tosches, M. A., & Marlow, H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.15 · Cited by 279
SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress
Byers, B., Cord, B. J., Nguyen, H. N., Schüle, B., Fenno, L. E., Lee, P. C., Deisseroth, K. A., Langston, J. W., Pera, R. A. R., & Palmer, T. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026159 · Cited by 305
Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches
Poulin, J.-F., Gaertner, Z., Moreno-Ramos, O. A., & Awatramani, R. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.01.004 · Cited by 238
Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells
Xi, J., Liu, Y., Liu, H., Chen, H., Emborg, M. E., & Zhang, S. (2012) · Stem Cells · doi:10.1002/stem.1152 · Cited by 209
Midbrain dopaminergic neurons: A review of the molecular circuitry that regulates their development
Hegarty, S. V., Sullivan, A. M., & O’Keeffe, G. W. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.04.014 · Cited by 190
Dopaminergic Neurons and Brain Reward Pathways
Luo, S. X., & Huang, E. J. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.023 · Cited by 170
Lmx1a and Lmx1b Function Cooperatively to Regulate Proliferation, Specification, and Differentiation of Midbrain Dopaminergic Progenitors
Yan, C. H., Levesque, M., Claxton, S., Johnson, R. L., & Ang, S.-L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1077-11.2011 · Cited by 144
Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson’s disease-linked DNAJC6 mutations
Wulansari, N., Darsono, W., Woo, H.-J., Chang, M., Kim, J., Bae, E.-J., Sun, W., Lee, J.-H., Cho, I.-J., Shin, H., et al. (2021) · Science Advances · doi:10.1126/sciadv.abb1540 · Cited by 127
Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei
Blaess, S., Bodea, G. O., Kabanova, A., Chanet, S., Mugniery, E., Derouiche, A., Stephen, D., & Joyner, A. L. (2011) · Neural Development · doi:10.1186/1749-8104-6-29 · Cited by 133
Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development
Deng, Q., Andersson, E., Hedlund, E., Alekseenko, Z., Coppola, E., Panman, L., Millonig, J. H., Brunet, J., Ericson, J., & Perlmann, T. (2011) · Development · doi:10.1242/dev.065482 · Cited by 126
Engineering of Midbrain Organoids Containing Long-Lived Dopaminergic Neurons
Tieng, V., Stoppini, L., Villy, S., Fathi, M., Dubois‐Dauphin, M., & Krause, K. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0442 · Cited by 122
Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells
Jaeger, I. S., Arber, C., Risner-Janiczek, J. R., Küchler, J., Pritzsche, D., Chen, I., Naveenan, T., Ungless, M. A., & Li, M. C. (2011) · Development · doi:10.1242/dev.066746 · Cited by 116
Dopamine and training-related working-memory improvement
Bäckman, L., & Nyberg, L. H. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.014 · Cited by 90
Stem cell potential in Parkinson's disease and molecular factors for the generation of dopamine neurons
Kim, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.08.006 · Cited by 71
Genetic control of midbrain dopaminergic neuron development
Blaess, S., & Ang, S. (2015) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.169 · Cited by 69
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects
Borgs, L., Peyre, E., Alix, P., Hanon, K., Grobarczyk, B., Godin, J. D., Purnelle, A., Krusy, N., Maquet, P., Lefebvre, P. P., et al. (2016) · Scientific Reports · doi:10.1038/srep33377 · Cited by 62
Copy number variability in Parkinson’s disease: assembling the puzzle through a systems biology approach
Cognata, V. L., Morello, G., D’Agata, V., & Cavallaro, S. (2016) · Human Genetics · doi:10.1007/s00439-016-1749-4 · Cited by 62
Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b
Doucet-Beaupré, H., Ang, S., & Lévesque, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.10.020 · Cited by 58
An Lmx1b–miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool
Anderegg, A., Lin, H.-P., Chen, J.-A., Caronia-Brown, G., Cherepanova, N., Yun, B., Joksimovic, M., Rock, J., Harfe, B. D., Johnson, R., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003973 · Cited by 57
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain
Gazea, M., Tasouri, E., Tolve, M., Bosch, V., Kabanova, A., Gojak, C., Kurtulmus, B., Novikov, O., Spatz, J. P., Pereira, G., et al. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.10.033 · Cited by 59
Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation
Yi, S., He, X., Rhee, Y., Park, C., Takizawa, T., Nakashima, K., & Lee, S. (2014) · Development · doi:10.1242/dev.095802 · Cited by 57
Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system
Bodea, G. O., Spille, J.-H., Abe, P., Sentürk, A., Acker‐Palmer, A., Stumm, R. K., Kubitscheck, U., & Blaess, S. (2014) · Development · doi:10.1242/dev.099937 · Cited by 57
Maternal Vitamin D Prevents Abnormal Dopaminergic Development and Function in a Mouse Model of Prenatal Immune Activation
Luan, W., Hammond, L. A., Vuillermot, S., Meyer, U., & Eyles, D. W. (2018) · Scientific Reports · doi:10.1038/s41598-018-28090-w · Cited by 55
An epigenetic signature of developmental potential in neural stem cells and early neurons
Burney, M. J., Johnston, C., Wong, K., Teng, S., Beglopoulos, V., Stanton, L. W., Williams, B. P., Bithell, A., & Buckley, N. J. (2013) · Stem Cells · doi:10.1002/stem.1431 · Cited by 49
Wnt1-regulated genetic networks in midbrain dopaminergic neuron development
Wurst, W., & Prakash, N. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt046 · Cited by 48
Fail-Safe Therapy by Gamma-Ray Irradiation Against Tumor Formation by Human-Induced Pluripotent Stem Cell-Derived Neural Progenitors
Katsukawa, M., Nakajima, Y., Fukumoto, A., Doi, D., & Takahashi, J. B. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0394 · Cited by 48
Development and Differentiation of Midbrain Dopaminergic Neuron: From Bench to Bedside
Wang, M., Ling, K., Tan, J. J., & Lu, C. (2020) · Cells · doi:10.3390/cells9061489 · Cited by 50
Preliminary evidence that allelic variation in the LMX1A gene influences training-related working memory improvement
Bellander, M., Brehmer, Y., Westerberg, H., Karlsson, S., Fürth, D., Bergman, O., Eriksson, E., & Bäckman, L. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.03.021 · Cited by 48
Magnetic Nanoparticles Enhance Adenovirus Transduction In Vitro and In Vivo
Sapet, C., Pellegrino, C., Laurent, N., Sicard, F., & Zelphati, O. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0629-9 · Cited by 45
BMP and TGF-β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells
Cai, J., Schleidt, S. S., Pelta‐Heller, J., Hutchings, D., Cannarsa, G. J., & Iacovitti, L. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.01.012 · Cited by 44
MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch–Nyhan disease?
Guibinga, G.-H., Hrustanovic, G., Bouic, K., Jinnah, H. A., & Friedmann, T. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr495 · Cited by 44
Vitamin C-Induced Epigenetic Modifications in Donor NSCs Establish Midbrain Marker Expressions Critical for Cell-Based Therapy in Parkinson's Disease
Wulansari, N., Kim, E.-H., Sulistio, Y. A., Rhee, Y.-H., Song, J., & Lee, S.-H. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.08.017 · Cited by 36
Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion
Tian, C., Li, Y., Huang, Y., Wang, Y., Chen, D., Liu, J., Deng, X., Sun, L., Anderson, K. M., Qi, X., et al. (2015) · Scientific Reports · doi:10.1038/srep12622 · Cited by 41
Lmx1a Encodes a Rostral Set of Mesodiencephalic Dopaminergic Neurons Marked by the Wnt/B-Catenin Signaling Activator R-spondin 2
Hoekstra, E. J., von Oerthel, L., van der Heide, L. P., Kouwenhoven, W. M., Veenvliet, J. V., Wever, I., Jin, Y.-R., Yoon, J. K., van der Linden, A. J. A., Holstege, F. C. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074049 · Cited by 41
A Parkinson’s disease model composed of 3D bioprinted dopaminergic neurons within a biomimetic peptide scaffold
Abdelrahman, S., Alsanie, W. F., Khan, Z. N., Albalawi, H. I., Felimban, R. I., Moretti, M., Steiner, N., Chaudhary, A., & Hauser, C. A. E. (2022) · Biofabrication · doi:10.1088/1758-5090/ac7eec · Cited by 41
Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice andC. elegans
Tiveron, M.-C., Béclin, C., Murgan, S., Wild, S., Angelova, A., Marc, J., Coré, N., de Chevigny, A., Herrera, E., Bosio, A., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3888-16.2017 · Cited by 39
A novel role for FOXA2 and SHH in organizing midbrain signaling centers
Bayly, R. D., Brown, C. Y., & Agarwala, S. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.06.018 · Cited by 39
Doublesex and mab-3–related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate
Gennet, N., Gale, E. A., Nan, X., Farley, E. K., Takács, K., Oberwallner, B., Chambers, D. J., & Li, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016679108 · Cited by 38
Developmental Vitamin D (DVD) Deficiency Reduces Nurr1 and TH Expression in Post-mitotic Dopamine Neurons in Rat Mesencephalon
Luan, W., Hammond, L. A., Cotter, E., Osborne, G. W., Alexander, S., Nink, V., Cui, X., & Eyles, D. W. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0497-3 · Cited by 37
A Review of Working Memory Training in the Management of Attention Deficit Hyperactivity Disorder
Al-Saad, M. S. H., Al-Jabri, B. A., & Almarzouki, A. F. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.686873 · Cited by 45
LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model
Rhee, Y., Kim, T., Jo, A. Y., Chang, M., Park, C., Kim, S.-M., Song, J., Oh, S., Yi, S., Kim, H. H., et al. (2016) · Brain · doi:10.1093/brain/aww203 · Cited by 35
A novel floor plate boundary defined by adjacentEn1andDbx1microdomains distinguishes midbrain dopamine and hypothalamic neurons
Nouri, N., & Awatramani, R. B. (2017) · Development · doi:10.1242/dev.144949 · Cited by 38
Single‐cell study of neural stem cells derived from human iPSCs reveals distinct progenitor populations with neurogenic and gliogenic potential
Lam, M., Sanosaka, T., Lundin, A., Imaizumi, K., Etal, D., Karlsson, F. H., Clausen, M., Cairns, J., Hicks, R., Kohyama, J., et al. (2019) · Genes to Cells · doi:10.1111/gtc.12731 · Cited by 32
Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors
Nouri, N., Patel, M. J., Joksimovic, M., Poulin, J.-F., Anderegg, A., Taketo, M. M., Ma, Y. C., & Awatramani, R. B. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.07.002 · Cited by 34
Development and Dynamic Regulation of Mitochondrial Network in Human Midbrain Dopaminergic Neurons Differentiated from iPSCs
Du, F., Qing, Y., Yan, S., Chen, D., & Yan, S. S. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.08.014 · Cited by 35
Crosstalk of Intercellular Signaling Pathways in the Generation of Midbrain Dopaminergic Neurons In Vivo and from Stem Cells
Brodski, C., Blaess, S., Partanen, J. M., & Prakash, N. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7010003 · Cited by 35
Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons
Ma, K., Deng, X., Xia, X., Fan, Z., Qi, X., Wang, Y., Li, Y., Ma, Y., Chen, Q., Peng, H., et al. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0132-x · Cited by 33
Clinical translation of cell transplantation in the brain
Dunnett, S. B., & Rosser, A. (2011) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32834c2356 · Cited by 32
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
Risi, M. D., Tufano, M., Alvino, F. G., Ferraro, M. G., Torromino, G., Gigante, Y., Monfregola, J., Marrocco, E., Pulcrano, S., Tunisi, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23903-5 · Cited by 34
New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems
Zieger, E., & Schubert, M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.09.001 · Cited by 32
Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration
Vallender, E. J., Goswami, D. B., Shinday, N. M., Westmoreland, S. V., Yao, W., & Rowlett, J. K. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.01.030 · Cited by 31
Cell replacement therapy for Parkinson’s disease: how close are we to the clinic?
Ganz, J., Lev, N., Melamed, E., & Offen, D. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.74 · Cited by 30
Roles of Transcription Factors in the Development and Reprogramming of the Dopaminergic Neurons
Tian, L., Al‐Nusaif, M., Chen, X., Li, S., & Le, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020845 · Cited by 29
Discovery of Novel Cell Surface Markers for Purification of Embryonic Dopamine Progenitors for Transplantation in Parkinson's Disease Animal Models
Fathi, A., Mirzaei, M., Dolatyar, B., Tabar, M. S., Bayat, M., Shahbazi, E., Lee, J., Javan, M., Zhang, S., Gupta, V., et al. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000809 · Cited by 29
Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons
Sherf, O., Zolotov, L. N., Liser, K., Tilleman, H. G., Jovanovic, V. M., Zega, K., Jukić, M. M., & Brodski, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139697 · Cited by 28
Lmx1a Allows Context-Specific Isolation of Progenitors of GABAergic or Dopaminergic Neurons During Neural Differentiation of Embryonic Stem Cells
Nefzger, C. M., Su, C. T. E., Fabb, S. A., Hartley, B. J., Beh, S. J., Zeng, W. R., Haynes, J. M., & Pouton, C. W. (2012) · Stem Cells · doi:10.1002/stem.1105 · Cited by 27
Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?
von Linstow, C. U., DeLano-Taylor, M., Kordower, J. H., & Brundin, P. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-191877 · Cited by 25
Polymorphisms of dopamine pathway genes NRG 1 and LMX 1A are associated with cognitive performance in bipolar disorder
Rolstad, S., Pålsson, E., Ekman, C. J., Eriksson, E., Sellgren, C. M., & Landén, M. (2015) · Bipolar Disorders · doi:10.1111/bdi.12347 · Cited by 27
ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience
Jiménez-Moreno, N., Kollareddy, M., Stathakos, P., Moss, J. J., Antón, Z., Shoemark, D. K., Sessions, R. B., Witzgall, R., Caldwell, M. A., & Lane, J. D. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.201910133 · Cited by 26
Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain
Trujillo-Paredes, N., Valencia, C., Guerrero-Flores, G., Arzate, D. M., Baizabal, J., Guerra‐Crespo, M., Fuentes-Hernández, A., Zea-Armenta, I., & Covarrubias, L. (2016) · Biology Open · doi:10.1242/bio.013383 · Cited by 24
Embryonic development of selectively vulnerable neurons in Parkinson’s disease
Oliveira, M. A. P., Balling, R., Smidt, M. P., & Fleming, R. M. T. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-017-0022-4 · Cited by 24
Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial md DA neurons
Hoekstra, E. J., von Oerthel, L., van der Linden, A. J. A., Schellevis, R. D., Scheppink, G., Holstege, F. C. P., Koerkamp, M. J. A. G., van der Heide, L. P., & Smidt, M. P. (2012) · European Journal of Neuroscience · doi:10.1111/ejn.12022 · Cited by 22
The signaling pathways of LMX1B and its role in glomerulosclerosis
Zhou, T., & Qin, Y. (2012) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2012.727832 · Cited by 21
Expression of Early Developmental Markers Predicts the Efficiency of Embryonic Stem Cell Differentiation into Midbrain Dopaminergic Neurons
Salti, A., Nat, R., Neto, S. C., Puschban, Z., Wenning, G. K., & Dechant, G. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0238 · Cited by 22
Wnt1 signal determines the patterning of the diencephalic dorso-ventral axis
Navarro-Garberí, M., Bueno, C., & Martı́nez, S. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1126-4 · Cited by 20
LMX1B Is Part of a Transcriptional Complex with PSPC1 and PSF
Hoekstra, E. J., Mesman, S., de Munnik, W. A., & Smidt, M. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053122 · Cited by 20
The role of developmental transcription factors in adult midbrain dopaminergic neurons
Doucet-Beaupré, H., & L�vesque, M. (2013) · OA Neurosciences · doi:10.13172/2054-7358-1-1-947 · Cited by 19
Dopaminergic-Like Neurons Derived from Oral Mucosa Stem Cells by Developmental Cues Improve Symptoms in the Hemi-Parkinsonian Rat Model
Ganz, J., Arie, I., Buch, S., Ben‐Zur, T., Barhum, Y., Pour, S., Araidy, S., Pitaru, S., & Offen, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100445 · Cited by 18
The hTH-GFP Reporter Rat Model for the Study of Parkinson's Disease
Iacovitti, L., Wei, X., Cai, J., Kostuk, E. W., Lin, R., Gorodinsky, A., Roman, P., Kusek, G., Das, S. S., Dufour, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113151 · Cited by 18
Efficient generation of dopaminergic-like neurons by overexpression of Nurr1 and Pitx3 in mouse induced Pluripotent Stem Cells
Salemi, S., Baktash, P., Rajaei, B., Noori, M., Amini, H., Shamsara, M., & Massumi, M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.05.032 · Cited by 18
Advances in stem-cell–generated transplantation therapy for Parkinson's disease
Sundberg, M., & Ole Isacson, A. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.876986 · Cited by 17
Migration of bone marrow progenitor cells in the adult brain of rats and rabbits
Dennie, D., Louboutin, J., & Strayer, D. S. (2016) · World Journal of Stem Cells · doi:10.4252/wjsc.v8.i4.136 · Cited by 17
The effects of vitamins and dietary pattern on epigenetic modification of non-communicable diseases
Khajebishak, Y., Alivand, M. R., Faghfouri, A. H., Moludi, J., & Payahoo, L. (2021) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000735 · Cited by 16
From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson’s Disease Modeling and Regenerative Therapy
Yeap, Y. J., Tng, T. J. W., Lee, M. J., Goh, M., & Lim, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032523 · Cited by 18
Discovering differential genome sequence activity with interpretable and efficient deep learning
Hammelman, J., & Gifford, D. (2021) · bioRxiv · doi:10.1371/journal.pcbi.1009282 · Cited by 19
Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-XL
Seiz, E. G., Ramos, M., Courtois, E. T., Tønnesen, J., Kokaia, M., Liste, I., & Martı́nez-Serrano, A. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.07.018 · Cited by 16
Ldb1 Is Essential for the Development of Isthmic Organizer and Midbrain Dopaminergic Neurons
Kim, S., Zhao, Y., Lee, J.-M., Kim, W. R., Gorivodsky, M., Westphal, H., & Geum, D. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0307 · Cited by 13
Cellular Programming and Reprogramming: Sculpting Cell Fate for the Production of Dopamine Neurons for Cell Therapy
Aguila, J. C., Hedlund, E., & Sánchez‐Pernaute, R. (2012) · Stem Cells International · doi:10.1155/2012/412040 · Cited by 13
Neural correlates of working memory training in HIV patients: study protocol for a randomized controlled trial
Chang, L., Løhaugen, G. C. C., Douet, V., Miller, E. N., Skranes, J. S., & Ernst, T. M. (2016) · Trials · doi:10.1186/s13063-016-1160-4 · Cited by 13
Trim46 contributes to the midbrain development via Sonic Hedgehog signaling pathway in zebrafish embryos
Jung, J., Kim, J., Huh, T., & Rhee, M. (2021) · Animal Cells and Systems · doi:10.1080/19768354.2021.1889661 · Cited by 12
Induced Pluripotent Stem Cell Technology and Direct Conversion: New Possibilities to Study and Treat Parkinson’s Disease
Roessler, R., Boddeke, E., & Copray, S. C. V. M. (2012) · Stem Cell Reviews and Reports · doi:10.1007/s12015-012-9369-4 · Cited by 12
Integration of genomic and functional approaches reveals enhancers at LMX1A and LMX1B
Burzynski, G. M., Reed, X., Maragh, S., Matsui, T., & McCallion, A. S. (2013) · Molecular Genetics and Genomics · doi:10.1007/s00438-013-0771-7 · Cited by 10
Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery
Azimi, S. M., Sheridan, S. D., Ghannad‐Rezaie, M., Eimon, P. M., & Yanik, M. F. (2018) · eLife · doi:10.7554/elife.31922 · Cited by 11
The generation of midbrain dopaminergic neurons
Blaess, S., Stott, S., & Ang, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00017-5 · Cited by 12
Retina-derived POU domain factor 1 coordinates expression of genes relevant to renal and neuronal development
Fiorino, A., Manenti, G., Gamba, B., Bucci, G., Cecco, L. D., Sardella, M., Buscemi, G., Ciceri, S., Radice, M. T., Radice, P., et al. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.013 · Cited by 10
Lmx1b Influences Correct Post-mitotic Coding of Mesodiencephalic Dopaminergic Neurons
Wever, I., Largo‐Barrientos, P., Hoekstra, E. J., & Smidt, M. P. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00062 · Cited by 10
The Generation of Midbrain Dopaminergic Neurons
Stott, S., & Ang, S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397265-1.00099-x · Cited by 10
The Basic Helix-Loop-Helix Gene Nato3 Drives Expression of Dopaminergic Neuron Transcription Factors in Neural Progenitors
Peterson, D. J., Marckini, D. N., Straight, J., King, E. M., Johnson, W., Sarah, S. S., Chowdhary, P. K., & DeLano-Taylor, M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.003 · Cited by 8
Telencephalic neural precursor cells show transient competence to interpret the dopaminergic niche of the embryonic midbrain
Baizabal, J., Valencia, C., Guerrero-Flores, G., & Covarrubias, L. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.003 · Cited by 7
Development and maturation of the spinal cord
Hawryluk, G. W. J., Ruff, C. A., & Fehlings, M. G. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52137-8.00001-2 · Cited by 7
Molecular Determinants of A9 Dopaminergic Neurons
Mishra, A. K., Dixit, S., Singh, A. L., Shukla, T., & Rizvi, S. I. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08861-1 · Cited by 6
Histamine Modulates Midbrain Dopamine Neuron Differentiation Through the Regulation of Epigenetic Marks
Vargas-Romero, F., González‐Barrios, R., Guerra-Calderas, L., Escobedo-Ávila, I., Cortés, D., López-Ornelas, A., Rocha, L., Soto‐Reyes, E., & Velasco, I. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00215 · Cited by 6
Modulation of the Generation of Dopaminergic Neurons from Human Neural Stem Cells by Bcl-XL
Martı́nez-Serrano, A., Castillo, C. G., Courtois, E. T., García-García, E., & Liste, I. (2011) · Vitamins and hormones · doi:10.1016/b978-0-12-386015-6.00029-9 · Cited by 5
TGFβ3, dibutyryl cAMP and a notch inhibitor modulate phenotype late in stem cell-derived dopaminergic neuron maturation
Sibuea, S. M., Ho, J. K., Pouton, C. W., & Haynes, J. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1111705 · Cited by 4
A review article on the development of dopaminergic neurons and establishment of dopaminergic neuron–based in vitro models by using immortal cell lines or stem cells to study and treat Parkinson's disease
Erol, A. Y. G. (2024) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10383 · Cited by 3
Midbrain Patterning
Nakamura, H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397265-1.00020-4 · Cited by 3
Forced LMX1A expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons
Rifes, P., Kajtez, J., Christiansen, J. R., Schörling, A. L., Rathore, G. S., Wolf, D. A., Heuer, A., & Kirkeby, A. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.04.010 · Cited by 2
Dopaminergic Differentiation Potential of Neural Precursor Cells Derived from Embryonic Stem Cells
Guerrero-Flores, G., & Covarrubias, L. (2011) · InTech eBooks · doi:10.5772/15392 · Cited by 2

Authors: Nakatani, T., Kumai, M., Mizuhara, E., Minaki, Y., & Ono, Y.
Affiliations: KAN Research Institute (JP)
ORCID: Minaki, Yasuko
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 2010-03
Volume: 339
Issue: 1
Pages: 101-113
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1016/j.ydbio.2009.12.017
OpenAlex: W1963783082
Cited by: 121
References: 37
Citations by year: 2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 14 · 2015: 12 · 2014: 8 · 2013: 16 · 2012: 13
FWCI: 4.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1234 d)
Locations: Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Directorate for Biological Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: Lmx1a, Lmx1b, FOXA2, midbrain dopaminergic neurons, neuronal specification, Ngn1, NKX6.1, transcriptional repression, Parkinson's disease
MeSH terms: Animals, Cell Differentiation, Dopamine, Immunohistochemistry, Mesencephalon, Mice, Transgenic, Neurons, Stem Cells, Transcription Factors, Homeodomain Proteins, Cell Lineage, Mice, Hepatocyte Nuclear Factor 3-beta, LIM-Homeodomain Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks