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Cited by 6Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesDrug-Induced Adverse Reactions

End-of-dose emergent psychopathology in ambulatory patients with epilepsy on stable-dose lamotrigine monotherapy: A case series of six patients

Frey, Lauren C., Strom, Laura A., Shrestha, Archana, Spitz, Mark C.·2009·Epilepsy & Behavior
DOI 10.1016/j.yebeh.2009.05.008
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Abstract

Objective Specific psychological withdrawal symptoms following the cessation of treatment with many drugs that affect the central nervous system, including anxiolytics and antidepressants, have been well documented. Studies have investigated withdrawal symptoms associated with some of the older antiepileptic drugs, but the potential for withdrawal symptoms associated with newer antiepileptic drugs, including lamotrigine, has not yet been investigated.Methods Using a retrospective chart review, we identified six patients with epilepsy who reported transient emergent psychological symptoms during stable, chronic lamotrigine monotherapy.Results These symptoms included anxiety, emotional lability, and irritability. In each case, the symptoms resulted in marked subjective distress and reliably occurred in the 1-2h before the patients were due to take their next dose of medication.Conclusions Lamotrigine withdrawal symptoms exist and can occur as an end-of-dose phenomenon, even in patients on stable medication doses. End-of-dose withdrawal from lamotrigine is a clinically significant adverse effect that can hamper successful treatment with this medication.

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Crossref · 10.1016/j.yebeh.2009.05.008

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  • In a 1-year multicenter prospective follow-up study of long-acting injectable risperidone adjunctive therapy for treatment-resistant schizophrenia, Kimura et al. found a prevalence of supersensitivity psychosis of 65%.

    “Kimura et al. [158] studied long-acting injectable risperidone as adjunctive therapy to treatment-resistant schizophrenia in a 1-year multicenter prospective follow-up study, the mean dose was equivalent to 1,000 mg/day chlorpromazine. They found a prevalence of SP of 65%.”

    From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [158]

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Authors
Frey, L. C., Strom, L. A., Shrestha, A., & Spitz, M. C.
Affiliations
  • University of Colorado Anschutz (US)
  • Veterans Health Administration (US)
Corresponding author
Frey, Lauren C.
ORCID
Strom, Laura A.
Venue
Epilepsy & Behavior
Publisher
Elsevier BV
Published
2009-08
Volume
15
Issue
4
Pages
521-523
ISSN
1525-5050 (ISSN-L)
DOI
10.1016/j.yebeh.2009.05.008
OpenAlex
W2027951464
Cited by
6
References
17
Citations by year
2025: 1 · 2024: 1 · 2020: 1 · 2014: 1
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Epilepsy & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
Keywords
lamotrigine, antiepileptic drug withdrawal, psychopathology, anxiety, emotional lability, irritability, epilepsy, monotherapy, adverse drug reactions, outpatients
MeSH terms
Lamotrigine, Adult, Affective Symptoms, Agoraphobia, Anticonvulsants, Mental Disorders, Bipolar Disorder, Depression, Epilepsy, Female, Humans, Irritable Mood, Male, Middle Aged, Seizures, Triazines, Young Adult

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