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Cited by 33Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesDrug-Induced Adverse Reactions

Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate.

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Duncan, J S, Shorvon, S D, Trimble, M R·1988·Journal of Neurology, Neurosurgery & Psychiatry
DOI 10.1136/jnnp.51.7.924PMC PMC1033195
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Abstract

A prospective, double-blind, placebo-controlled investigation of possible withdrawal symptoms from phenytoin, carbamazepine and sodium valproate is reported in patients with active epilepsy, on combination therapy. There was an increase in seizures on reduction and withdrawal of carbamazepine, but there was no convincing evidence of withdrawal symptoms from any of these drugs.

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Crossref · 10.1136/jnnp.51.7.924

Cites

49 of 49 references verified0 citation errors · 0 not checkable

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  • Antipsychotics that are rapidly eliminated or rapidly dissociated from D2 receptors (e.g., clozapine, quetiapine) have greater risks of rebound when medication is decreased, switched, or discontinued.

    “Antipsychotics rapidly eliminated or rapidly dissociated from the D2 receptors (i.e., clozapine, quetiapine) [161, 162] are known to have greater risks of rebound when medication is decreased, switched, or discontinued [13, 154, 156, 157, 163].”

    From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [156]

    The Abstract and Discussion examine withdrawal of phenytoin, carbamazepine, and sodium valproate in patients with epilepsy; the Discussion reports no convincing withdrawal syndrome for those drugs. Searches for clozapine, quetiapine, D2 receptors, and rapid elimination found no passage addressing rebound risk from antipsychotics. (LLM, conf=0.78)

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Research works printed but not linked: 6

  1. Gross MM, Lewis E, Hastey J. Acute alcohol withdrawal syn- drome. In: Kissin B, Begleiter H, eds. The Biology of Alco- holism Vol 3. Clinical Pathology. New York: Plenum Press, 1974:191-263.
  2. Bjorkquist SE, Isohanni M, Makela R, Malinen L. Ambulant treatment of alcohol withdrawal symptoms with carbamazepine-a double blind trial. Acta Psychiatr Scand 1976;53:333-42.
  3. Lader M. Benzodiazepine withdrawal states. In: Trimble MR, ed. Benzodiazepines Divided. Chichester: John Wiley, 1983:17-32.
  4. Petursson H, Lader MH. Benzodiazepine tolerance and with- drawal syndrome. In: Burrows GD, Werry JS, eds. Advances in Human Psychopharmacology. Greenwich, Connecticut: JAI Press, 1984:89-119.
  5. Demers-Desrosiers LA, Nestoros JN, Vaillancourt P. Acute psy- chosis precipitated by withdrawal of anticonvulsant medica- tion. Am J Psychiatry 1978;135:981-2.
  6. Masland RL. Carbamazepine. Neurotoxicity. In: Woodbury DM, Penry JK, Pippenger CE, eds. Antiepileptic Drugs. New York: Raven Press, 1982:521-31. by copyright. on July 15, 2023 by guest. Protected http://jnnp.bmj.com/ J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.51.7.924 on 1 July 1988. Downloaded from

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Authors
Duncan, J. S., Shorvon, S. D., & Trimble, M. R.
Affiliations
National Hospital for Neurology and Neurosurgery (GB)
ORCID
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
1988-07-01
Volume
51
Issue
7
Pages
924-928
ISSN
0022-3050 (ISSN-L)
DOI
10.1136/jnnp.51.7.924
PMC
PMC1033195
OpenAlex
W2143699531
Cited by
33
References
49
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2020: 1 · 2019: 2 · 2016: 1 · 2015: 1
FWCI
1.87
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
Keywords
drug withdrawal symptoms, phenytoin, carbamazepine, valproic acid, epilepsy, antiepileptic drugs, combination antiepileptic therapy, seizure recurrence, medication reduction
MeSH terms
Adolescent, Adult, Aged, Carbamazepine, Clinical Trials as Topic, Double-Blind Method, Drug Therapy, Combination, Epilepsy, Female, Humans, Male, Middle Aged, Phenytoin, Prospective Studies, Substance Withdrawal Syndrome, Valproic Acid

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