PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

Oxidants, oxidative stress and the biology of ageing

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Therapeutic Insights on Ferroptosis in Parkinson's disease

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Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes

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Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease

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The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans

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Crosstalk between Nrf2 signaling and mitochondrial function in Parkinson's disease

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Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration

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Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I

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E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination

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Ferroptosis triggers mitochondrial fragmentation via Drp1 activation

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Mitochondrial Mechanisms of Necroptosis in Liver Diseases

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NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells

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PARL: The mitochondrial rhomboid protease

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Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells

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The Pleiotropic Role of the KEAP1/NRF2 Pathway in Cancer

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Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Protein–Protein Interaction

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Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium

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Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism

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Necroptosis: Who Knew There were so Many Interesting Ways to Die?

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Type I interferon enhances necroptosis of Salmonella Typhimurium–infected macrophages by impairing antioxidative stress responses

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Involvement of the Actin Machinery in Programmed Cell Death

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Oxeiptosis—a cell death pathway to mitigate damage caused by radicals

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Microparticulate/nanoparticulate powders of a novel Nrf2 activator and an aerosol performance enhancer for pulmonary delivery targeting the lung Nrf2/Keap-1 pathway

Muralidharan, P., Hayes, D., Black, S. M., & Mansour, H. M. (2016) · Molecular Systems Design & Engineering · doi:10.1039/c5me00004a · Cited by 62

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

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Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control

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A novel PGAM5 inhibitor LFHP-1c protects blood–brain barrier integrity in ischemic stroke

Gao, C., Xu, Y., Liang, Z., Wang, Y., Shang, Q., Zhang, S., Wang, C., Ni, M., Wu, D., Huang, Z., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.01.008 · Cited by 61

The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses

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The Role of Nrf2 in the Attenuation of Cardiovascular Disease

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Nrf2‐dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis

Pantoja, I. E. M., Hu, C., Perrone‐Bizzozero, N. I., Zheng, J., & Bizzozero, O. A. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13837 · Cited by 55

Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target

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Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

Cvetko, F., Caldwell, S. T., Higgins, M., Suzuki, T., Yamamoto, M. P., Prag, H. A., Hartley, R. C., Dinkova‐Kostova, A. T., & Murphy, M. P. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.016551 · Cited by 54

The electrophile responsive proteome: Integrating proteomics and lipidomics with cellular function

Higdon, A. N., Landar, A., Barnes, S., & Darley-Usmar, V. M. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4523 · Cited by 51

PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2

Li, S., Wen, P., Zhang, D., Li, D., Gao, Q., Liu, H., & Di, Y. (2023) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2022.2162537 · Cited by 51

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy

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NADPH Oxidase 4 (NOX4) in Cancer: Linking Redox Signals to Oncogenic Metabolic Adaptation

Szántó, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052702 · Cited by 52

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

DeBlasi, J. M., Falzone, A., Caldwell, S., Prieto-Farigua, N., Prigge, J. R., Schmidt, E. E., Chio, I. I. C., Karreth, F. A., & DeNicola, G. M. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-3848 · Cited by 49

Resveratrol protects against oxidative stress by activating the Keap‑1/Nrf2 antioxidant defense system in obese‑asthmatic rats

Li, X., Ma, L., Ji, H. L., Qin, Y., Jin, S., & Xu, L. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6747 · Cited by 48

PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics

Nag, S., Szederkenyi, K., Gorbenko, O., Tyrrell, H., Yip, C. M., & McQuibban, G. A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112895 · Cited by 49

High PGAM5 expression induces chemoresistance by enhancing Bcl-xL-mediated anti-apoptotic signaling and predicts poor prognosis in hepatocellular carcinoma patients

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Functional role of PGAM5 multimeric assemblies and their polymerization into filaments

Ruiz, K., Thaker, T. M., Agnew, C., Miller-Vedam, L. E., Trenker, R., Herrera, C., Ingaramo, M., Toso, D. B., Frost, A. S., & Jura, N. (2019) · Nature Communications · doi:10.1038/s41467-019-08393-w · Cited by 47

Photoproximity Profiling of Protein–Protein Interactions in Cells

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Phosphoglycerate Mutase 5 Knockdown Alleviates Neuronal Injury After Traumatic Brain Injury Through Drp1-Mediated Mitochondrial Dysfunction

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Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly

Chaikuad, A., Filippakopoulos, P., Marcsisin, S. R., Picaud, S., Schröder, M., Sekine, S., Ichijo, H., Engen, J. R., Takeda, K., & Knapp, S. (2017) · Structure · doi:10.1016/j.str.2017.05.020 · Cited by 46

Natural Allies for Heart Health: Nrf2 Activation and Cardiovascular Disease Management

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A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation.

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Heme oxygenase-1 protects liver against ischemia/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control

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Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation

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Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease

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Protein Composition of Immunoprecipitated Synaptic Ribbons

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Ischemic Preconditioning Protects Astrocytes against Oxygen Glucose Deprivation Via the Nuclear Erythroid 2-Related Factor 2 Pathway

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Interaction Energetics and Druggability of the Protein–Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2)

Zhong, M., Lynch, A. J., Muellers, S. N., Jehle, S., Luo, L., Hall, D. R., Iwase, R., Carolan, J. P., Egbert, M. E., Wakefield, A., et al. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00943 · Cited by 40

PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release

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A Prioritized and Validated Resource of Mitochondrial Proteins in Plasmodium Identifies Unique Biology

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Mitochondrial biology in airway pathogenesis and the role of NRF2

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Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats

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Fueling the Flames: Mammalian Programmed Necrosis in Inflammatory DiseasesPreprint

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The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis

Huang, Z., Wu, M., Zeng, L., & Wang, D. (2022) · Cardiology Research and Practice · doi:10.1155/2022/4287711 · Cited by 37

Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury

Yang, C., Liu, X., Yang, F., Zhang, W., Chen, Z., Yan, D., You, Q., & Xiang, W. (2016) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-016-0105-2 · Cited by 37

Apoptosis Inducing Factor Binding Protein PGAM5 Triggers Mitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activity of X-Linked Inhibitor of Apoptosis

Lenhausen, A. M., Wilkinson, A. S., Lewis, E. M., Dailey, K. M., Scott, A. J., Khan, S., & Wilkinson, J. C. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00306 · Cited by 37

Atypical Protein Phosphatases: Emerging Players in Cellular Signaling

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Succinylation of a KEAP1 sensor lysine promotes NRF2 activation

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Mitochondrial proteolysis: Its emerging roles in stress responses

Sekine, S., & Ichijo, H. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.10.012 · Cited by 35

Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1

Ngo, V., Karunatilleke, N. C., Brickenden, A. M., Choy, W., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11020243 · Cited by 36

Impact of cigarette-smoking on sperm DNA methylation and its effect on sperm parameters

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A Conserved Motif Mediates both Multimer Formation and Allosteric Activation of Phosphoglycerate Mutase 5

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Radiotherapy-induced heart disease: a review of the literature

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Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases

Liang, M.-Z., Ke, T.-L., & Chen, L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.730604 · Cited by 33

Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway

Tabolacci, E., Tringali, G., Nobile, V., Duca, S., Pizzoferrato, M., Bottoni, P., & Clementi, M. E. (2023) · Antioxidants · doi:10.3390/antiox12040820 · Cited by 33

Early Stage Functions of Mitochondrial Autophagy and Oxidative Stress in Acetaminophen‐Induced Liver Injury

Gao, Y., Chu, S., Zhang, Z., Zuo, W., Xia, C., Ai, Q., Luo, P., Cao, P., & Chen, N. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25788 · Cited by 32

The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress

Sekine, S., Akari, Y., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K., & Ichijo, H. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.01.031 · Cited by 31

Strategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help?

Visioli, F., Ingram, A., Beckman, J. S., Magnusson, K. R., & Hagen, T. M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.008 · Cited by 31

The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2

Plafker, K. S., & Plafker, S. M. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1057 · Cited by 30

ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3

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Nrf2 signaling pathway in trace metal carcinogenesis: A cross-talk between oxidative stress and angiogenesis

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The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

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Characterization of a new phosphatase from Plasmodium.

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Morin offsets PTZ-induced neuronal degeneration and cognitive decrements in rats: The modulation of TNF-α/TNFR-1/RIPK1,3/MLKL/PGAM5/Drp-1, IL-6/JAK2/STAT3/GFAP and Keap-1/Nrf-2/HO-1 trajectories

El‐Aal, S. A. A., El-Abhar, H. S., & Abulfadl, Y. S. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175213 · Cited by 28

Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

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Histidine Phosphorylation: Protein Kinases and Phosphatases

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