Cited by 114Developmental Biology and Gene RegulationCraniofacial Disorders and TreatmentsNeurogenesis and neuroplasticity mechanisms

Neural crest cell signaling pathways critical to cranial bone development and pathology

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Mishina, Yuji, Snider, Taylor Nicholas·2014·Experimental Cell Research

Abstract

Neural crest cells appear early during embryogenesis and give rise to many structures in the mature adult. In particular, a specific population of neural crest cells migrates to and populates developing cranial tissues. The ensuing differentiation of these cells via individual complex and often intersecting signaling pathways is indispensible to growth and development of the craniofacial complex. Much research has been devoted to this area of development with particular emphasis on cell signaling events required for physiologic development. Understanding such mechanisms will allow researchers to investigate ways in which they can be exploited in order to treat a multitude of diseases affecting the craniofacial complex. Knowing how these multipotent cells are driven towards distinct fates could, in due course, allow patients to receive regenerative therapies for tissues lost to a variety of pathologies. In order to realize this goal, nucleotide sequencing advances allowing snapshots of entire genomes and exomes are being utilized to identify molecular entities associated with disease states. Once identified, these entities can be validated for biological significance with other methods. A crucial next step is the integration of knowledge gleaned from observations in disease states with normal physiology to generate an explanatory model for craniofacial development. This review seeks to provide a current view of the landscape on cell signaling and fate determination of the neural crest and to provide possible avenues of approach for future research.

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Authors
Mishina, Y., & Snider, T. N.
Affiliations
University of Michigan (US)
Corresponding author
Mishina, Yuji
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2014-07
Volume
325
Issue
2
Pages
138-147
ISSN
0014-4827 (ISSN-L)
OpenAlex
W2037680071
Cited by
114
References
141
Citations by year
2026: 12 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 3
FWCI
0.97
Type
journal article
Language
en
Open access
Locations
  • Experimental Cell Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Dental and Craniofacial Research (R01DE020843, T32DE007057)
  • Core Research for Evolutional Science and Technology
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
neural crest cells, cranial bone development, craniofacial development, signaling pathways, cell fate determination, regenerative therapy, craniofacial diseases, craniofacial embryology
MeSH terms
Animals, Bone Development, Humans, Neural Crest, Skull, Signal Transduction, Embryonic Development

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