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Cited by 211Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchBlood disorders and treatments

Pro-inflammatory cytokines: Emerging players regulating HSC function in normal and diseased hematopoiesis

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Mirantes, Cristina, Passegué, Emmanuelle, Pietras, Eric M.·2014·Experimental Cell Research
DOI 10.1016/j.yexcr.2014.08.017PMC PMC4250307
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Abstract

Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the regulatory factors that maintain proper HSC function and lineage output under normal conditions are well understood, significantly less is known about how HSC fate is regulated in response to inflammation or disease. As many blood disorders are associated with overproduction of pro-inflammatory cytokines, significant interest has emerged in understanding the impact of these factors on HSC function. In this review we highlight key advances demonstrating the impact of pro-inflammatory cytokines on the biology of HSCs and the BM niche, and address ongoing questions regarding their role in normal and pathogenic hematopoiesis.

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  • IL-1 signaling is closely linked to chronic inflammatory diseases and plays a critical role in the activation of inflammatory myelopoiesis.

    “IL-1β is produced in response to a wide range of physiological insults, and IL-1 signaling is closely linked to a wide variety of chronic inflammatory diseases, where it plays a critical role in the activation of inflammatory myelopoiesis (Ueda et al., 2009; Dinarello, 2011; Mirantes et al., 2014; Pietras, 2017).”

    From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Mirantes et al., 2014

    The IL-6 section says IL-1 activates myelopoiesis in response to infection and inflammatory disease. It does not establish that IL-1 signaling is linked to a wide variety of chronic inflammatory diseases or that its role is critical; the passage specifically describing a critical activator in chronic inflammatory disorders concerns IL-6, not IL-1. (LLM, conf=0.84)

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Cited by

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Authors
Mirantes, C., Passegué, E., & Pietras, E. M.
Affiliations
University of California, San Francisco (US)
Corresponding author
Pietras, Eric M.
ORCID
Pietras, Eric M.
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2014-12
Volume
329
Issue
2
Pages
248-254
ISSN
0014-4827 (ISSN-L)
DOI
10.1016/j.yexcr.2014.08.017
PMC
PMC4250307
OpenAlex
W2087990669
Cited by
211
References
3
Citations by year
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FWCI
2.77
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Cell Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (T32AI007334)
  • National Institute of Diabetes and Digestive and Kidney Diseases (K01DK098315)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
Keywords
inflammatory cytokines, hematopoietic stem cells, hematopoiesis, bone marrow microenvironment, inflammation, self-renewal, hematologic disorders
MeSH terms
Animals, Cell Differentiation, Hematologic Diseases, Hematopoiesis, Hematopoietic Stem Cells, Humans, Cytokines, Inflammation Mediators

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