The DOI matches its Crossref record; 209 of the 211 references it cites were found in a registry or an index.
Mechanical regulation of myofibroblast phenoconversion and collagen contraction
Abstract
Activated fibroblasts promote physiological wound repair following tissue injury. However, dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced production and contraction of collagen-rich extracellular matrix. At the peak of their activities, fibroblasts undergo phenotypic conversion into highly contractile myofibroblasts by developing muscle-like features, including formation of contractile actin-myosin bundles. The phenotype and function of fibroblasts and myofibroblasts are mechanically regulated by matrix stiffness using a feedback control system that is integrated with the progress of tissue remodelling. The actomyosin contraction machinery and cell-matrix adhesion receptors are critical elements that are needed for mechanosensing by fibroblasts and the translation of mechanical signals into biological responses. Here, we focus on mechanical and chemical regulation of collagen contraction by fibroblasts and the involvement of these factors in their phenotypic conversion to myofibroblasts.
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“During fibroblast-to-myofibroblast transition, a complex mechanochemical signaling is activated involving profibrotic secreted factors such as TGFβ and Wnt and ECM-degrading enzymes and intracellular effectors required for stress fiber contractility [127,131].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [131]
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Items 201–209 of 209
The Role of the MRTF-A/SRF Pathway in Ocular Fibrosis
Yu‐Wai‐Man, C., Treisman, R., Bailly, M., & Khaw, P. T. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14692 · Cited by 34
Extracellular matrix in cardiovascular pathophysiology
Bloksgaard, M., Lindsey, M. L., & Martinez‐Lemus, L. A. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00631.2018 · Cited by 34
Kerroch, M., Alfieri, C., Dorison, A., Boffa, J., Chatziantoniou, C., & Dussaule, J. (2016) · Scientific Reports · doi:10.1038/srep21262 · Cited by 32
Arora, P. D., Wang, Y., Bresnick, A. R., Janmey, P. A., & McCulloch, C. A. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-11-1536 · Cited by 24
Self-citationProtease Activated Receptor-1 Deficiency Diminishes Bleomycin-Induced Skin Fibrosis
Duitman, J., Ruela-de-Sousa, R. R., Shi, K., de Boer, O. J., Borensztajn, K., Florquin, S., Peppelenbosch, M. P., & Spek, C. A. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00027 · Cited by 19
Gelsolin and Non-muscle Myosin IIA Interact to Mediate Calcium-regulated Collagen Phagocytosis
Arora, P. D., Wang, Y., Janmey, P. A., Bresnick, A. R., Yin, H. L., & McCulloch, C. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.247783 · Cited by 17
Self-citationChaponnier, C., & Gabbiani, G. (2016) · F1000Research · doi:10.12688/f1000research.8154.1 · Cited by 13
Leask, A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6430-7_34 · Cited by 13
Targeting the myofibroblast to improve wound healing
Hinz, B. (2016) · Elsevier eBooks · doi:10.1016/b978-1-78242-455-0.00003-3 · Cited by 12
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2 of the 211 references couldn’t be matched to a known paper.
Research works printed but not linked: 7
- Martinez, 2017, Idiopathic pulmonary fibrosis, Nature reviews, Dis. Prim., 3, 17074
- Ampe, 2017, vol. 235, 1
- Coelho, 2016, Contribution of collagen adhesion receptors to tissue fibrosis, Cell Tissue Res., 365, 521, 10.1007/s00441-016-2440-8 · DOI
- Coelho, 2018, Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosis, Cell Adhes. Migrat., 12, 348
- Leitinger, 2014, 310, 39
- Froese, 2016, Stretch induced activation of TGF-beta1 in pulmonary fibrosis, Am. J. Respir. Crit. Care Med., 194, 84, 10.1164/rccm.201508-1638OC · DOI · Paper page
- Piersma, 2015, YAP1 is a driver of myofibroblast differentiation in normal and diseased fibroblasts, Am. J. Pathol., 185, 3326, 10.1016/j.ajpath.2015.08.011 · DOI · Paper page
Cited by
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Transforming growth factor–β in tissue fibrosis
Frangogiannis, N. G. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190103 · Cited by 1,354
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Younesi, F. S., Miller, A. E., Barker, T. H., Rossi, F. M. V., & Hinz, B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00716-0 · Cited by 755
“anti-fibrotic therapies to break this loop, which has evolved multiple redundancies to promote rapid healing of injured tissues at the expense of functionality 72 .”
InfluentialSelf-citationEvasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
Hinz, B., & Lagares, D. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0324-5 · Cited by 642
Self-citationRole of fibroblasts in wound healing and tissue remodeling on Earth and in space
Cialdai, F., Risaliti, C., & Monici, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.958381 · Cited by 390
Pakshir, P., Noskovicova, N., Lodyga, M., Son, D. O., Schuster, R., Goodwin, A., Karvonen, H., & Hinz, B. (2020) · Journal of Cell Science · doi:10.1242/jcs.227900 · Cited by 293
“…recent strategies tackle different components of the TGF-β1 activation machinery, which provide cell- and context-specificity (Akhurst, 2017; de Gramont et al., 2017; Friedman et al., 2013; Ganesh and Massague, 2018; Hinz, 2016c; Huynh et al., 2019; Lodyga and Hinz, 2019; Varga and Pasche, 2009).”
BackgroundSelf-citation
Metadata
- Authors
- Hinz, B., McCulloch, C. A., & Coelho, N. M.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Coelho, Nuno M.
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 379
- Issue
- 1
- Pages
- 119-128
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W2934133090
- Semantic Scholar
- 6f2d57f6aad8ed5a88713504974535d1eb19f620
- Cited by
- 182
- References
- 211
- Citations by year
- 2026: 23 · 2025: 19 · 2024: 28 · 2023: 27 · 2022: 20 · 2021: 38 · 2020: 14 · 2019: 13
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research CIHR (#375597)
- Canada Foundation for Innovation and Ontario Research Fund (#36050)
- E-Rare Joint Transnational Program ‘Development of Innovative Therapeutic Approaches for Rare Diseases’ (# ERL-138395)
- CMC is supported by a CIHR Operating grant (MOP416228)
- Canada Research Chair in Matrix Dynamics
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- collagen contraction, fibroblast activation, extracellular matrix stiffness, mechanotransduction, actomyosin contractility, fibrosis, tissue remodeling, wound healing
- MeSH terms
- Animals, Collagen, Extracellular Matrix, Fibrosis, Humans, Phenotype, Wound Healing, Myofibroblasts
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