Mechanical regulation of myofibroblast phenoconversion and collagen contraction

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290

TGF-β: the master regulator of fibrosis

Meng, X.-M., Nikolic-Paterson, D. J., & Lan, H. Y. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.48 · Cited by 3,528

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

Wang, N., Butler, J. P., & Ingber, D. E. (1993) · Science · doi:10.1126/science.7684161 · Cited by 3,007

Non-muscle myosin II takes centre stage in cell adhesion and migration

Vicente‐Manzanares, M., Ma, X., Adelstein, R. S., & Horwitz, A. R. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2786 · Cited by 2,137

Mechanotransduction and extracellular matrix homeostasis

Humphrey, J. D., Dufresne, E. R., & Schwartz, M. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3896 · Cited by 2,124

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

Parsons, J. T., Horwitz, A. R., & Schwartz, M. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2957 · Cited by 2,081

The Myofibroblast

Hinz, B., Phan, S. H., Thannickal, V. J., Galli, A., Bochaton-Piallat, M.-L., & Gabbiani, G. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070112 · Cited by 2,068

ROCKs: multifunctional kinases in cell behaviour

Riento, K., & Ridley, A. J. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1128 · Cited by 1,941

Cardiac Fibrosis: The Fibroblast Awakens

Travers, J. G., Kamal, F. A., Robbins, J., Yutzey, K. E., & Blaxall, B. C. (2016) · Circulation Research · doi:10.1161/circresaha.115.306565 · Cited by 1,596

Stretching Single Talin Rod Molecules Activates Vinculin Binding

Hernández, A. E. D. R., Pérez‐Jiménez, R., Liu, R., Roca‐Cusachs, P., Fernández, J. M., & Sheetz, M. P. (2009) · Science · doi:10.1126/science.1162912 · Cited by 1,492

Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

Wynn, T. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31487 · Cited by 1,487

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

Gabbiani, G., Ryan, G. B., & Majno, G. (1971) · Experientia · doi:10.1007/bf02147594 · Cited by 1,485

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478

Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity

Hinz, B., Celetta, G., Tomasek, J. J., Gabbiani, G., & Chaponnier, C. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.9.2730 · Cited by 1,288

TGF-β signaling in fibrosis

Biernacka, A., Dobaczewski, M. P., & Frangogiannis, N. G. (2011) · Growth Factors · doi:10.3109/08977194.2011.595714 · Cited by 1,205

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

Desmoulière, A., Redard, M., Darby, I. A., & Gabbiani, G. (1995) · Europe PMC (PubMed Central) · Cited by 1,185

Integrin-mediated mechanotransduction

Sun, Z., Guo, S., & Fässler, R. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201609037 · Cited by 1,128

YAP/TAZ upstream signals and downstream responses

Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086

Type 2 immunity in tissue repair and fibrosis

Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells

Link, A., Vogt, T. K., Favre, S., Britschgi, M. R., Acha‐Orbea, H., Hinz, B., Cyster, J. G., & Luther, S. A. (2007) · Nature Immunology · doi:10.1038/ni1513 · Cited by 949

Actin stress fibers – assembly, dynamics and biological roles

Tojkander, S., Gateva, G., & Lappalainen, P. (2012) · Journal of Cell Science · doi:10.1242/jcs.098087 · Cited by 900

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00300.2014 · Cited by 874

Mechanisms of Mechanotransduction

Orr, A. W., Helmke, B. P., Blackman, B. R., & Schwartz, M. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.006 · Cited by 838

The myofibroblast matrix: implications for tissue repair and fibrosis

Klingberg, F., Hinz, B., & White, E. S. (2013) · The Journal of Pathology · doi:10.1002/path.4104 · Cited by 776

The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer

Affo, S., Yu, L.-X., & Schwabe, R. F. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100322 · Cited by 757

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells

Zaidel-Bar, R., Ballestrem, C., Kam, Z., & Geiger, B. (2003) · Journal of Cell Science · doi:10.1242/jcs.00792 · Cited by 719

The myofibroblast: Paradigm for a mechanically active cell

Hinz, B. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.020 · Cited by 717

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., & Keely, P. J. (2009) · Oncogene · doi:10.1038/onc.2009.299 · Cited by 694

Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

Totsukawa, G., Yamakita, Y., Yamashiro, S., Hartshorne, D. J., Sasaki, Y., & Matsumura, F. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.4.797 · Cited by 689

YAP regulates cell mechanics by controlling focal adhesion assembly

Nardone, G., Cruz, J. O. L., Vrbský, J., Martini, C., Přibyl, J., Skládal, P., Pešl, M., Caluori, G., Pagliari, S., Martino, F. D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15321 · Cited by 685

Forcing cells into shape: the mechanics of actomyosin contractility

Murrell, M. P., Oakes, P. W., Lenz, M., & Gardel, M. L. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4012 · Cited by 675

Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL

Vartiainen, M., Guettler, S., Larijani, B., & Treisman, R. (2007) · Science · doi:10.1126/science.1141084 · Cited by 672

Integrins and Extracellular Matrix in Mechanotransduction

Schwartz, M. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005066 · Cited by 662

Therapy for Fibrotic Diseases: Nearing the Starting Line

Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655

Extracellular matrix as a driver of progressive fibrosis

Herrera, J., Henke, C. A., & Bitterman, P. B. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93557 · Cited by 639

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 637

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

Fu, X., Khalil, H., Kanisicak, O., Boyer, J. G., Vagnozzi, R. J., Maliken, B. D., Sargent, M. A., Prasad, V., Valiente-Alandi, I., Blaxall, B. C., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98215 · Cited by 636

Preparing the ground for tissue regeneration: from mechanism to therapy

Forbes, S. J., & Rosenthal, N. A. (2014) · Nature Medicine · doi:10.1038/nm.3653 · Cited by 607

Myofibroblast Differentiation by Transforming Growth Factor-1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase

Thannickal, V. J., Lee, D. Y., White, E. S., Cui, Z., Larios, J. M., Chacon, R., Horowitz, J. C., Day, R. M., & Thomas, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208544200 · Cited by 606

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

Pasapera, A. M., Schneider, I. C., Rericha, E. C., Schlaepfer, D. D., & Waterman, C. M. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200906012 · Cited by 593

Regeneration of fat cells from myofibroblasts during wound healing

Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., et al. (2017) · Science · doi:10.1126/science.aai8792 · Cited by 584

Targeting extracellular matrix stiffness to attenuate disease: from molecular mechanisms to clinical trials

Lampi, M. C., & Reinhart-King, C. A. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0475 · Cited by 551

Fibroblasts in myocardial infarction: A role in inflammation and repair

Shinde, A. V., & Frangogiannis, N. G. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.11.015 · Cited by 535

Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction

Huang, X., Yang, N., Fiore, V. F., Barker, T. H., Sun, Y., Morris, S. W., Ding, Q., Thannickal, V. J., & Zhou, Y. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0050oc · Cited by 530

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

Wong, V. W., Rustad, K. C., Akaishi, S., Sorkin, M., Glotzbach, J. P., Januszyk, M., Nelson, E. R., Levi, K., Paterno, J., Vial, I. N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2574 · Cited by 515

The good and the bad collagens of fibrosis – Their role in signaling and organ function

Karsdal, M. A., Nielsen, S. H., Leeming, D. J., Langholm, L. L., Nielsen, M. J., Manon-Jensen, T., Siebuhr, A., Gudmann, N. S., Rønnow, S., Sand, J. M., et al. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.014 · Cited by 509

YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis

Szeto, S. G., Narimatsu, M., Lu, M., He, X., Sidiqi, A. M., Tolosa, M. F., Chan, L., Freitas, K. D., Bialik, J. F., Majumder, S., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050499 · Cited by 478

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

Zhou, Y., Huang, X., Hecker, L., Kurundkar, D., Kurundkar, A., Liu, H., Jin, T. H., Desai, L. P., Bernard, K. F., & Thannickal, V. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66700 · Cited by 466

Extracellular matrix remodeling and cardiac fibrosis

Li, L., Zhao, Q., & Kong, W. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.013 · Cited by 458

Liver fibrosis: Direct antifibrotic agents and targeted therapies

Schuppan, D., Ashfaq–Khan, M., Yang, A. T., & Kim, Y. O. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.04.006 · Cited by 451

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

Dupont, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.034 · Cited by 449

Myofibroblasts

Hinz, B. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.009 · Cited by 424

Focal adhesions, stress fibers and mechanical tension

Burridge, K., & Guilluy, C. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.029 · Cited by 409

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

Small, E. M., Thatcher, J. E., Sutherland, L. B., Kinoshita, H., Gerard, R. D., Richardson, J. A., DiMaio, J. M., Sadek, H. A., Kuwahara, K., & Olson, E. N. (2010) · Circulation Research · doi:10.1161/circresaha.110.223172 · Cited by 376

Sensing extracellular matrix: An update on discoidin domain receptor function

Vogel, W. F., Abdulhussein, R., & Ford, C. E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.02.012 · Cited by 368

Mechanosensing and fibrosis

Tschumperlin, D. J., Ligresti, G., Hilscher, M. B., & Shah, V. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93561 · Cited by 359

Resolution of organ fibrosis

Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 358

Signaling Networks that Regulate Cell MigrationPreprint

Devreotes, P. N., & Horwitz, A. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005959 · Cited by 355

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

Austen, K., Ringer, P., Mehlich, A., Chrostek‐Grashoff, A., Kluger, C., Klingner, C., Sabass, B., Zent, R., Rief, M., & Grashoff, C. (2015) · Nature Cell Biology · doi:10.1038/ncb3268 · Cited by 348

The precursor form of IL-1α is an intracrine proinflammatory activator of transcription

Werman, A., Werman-Venkert, R., White, R. M., Lee, J.-K., Werman, B., Krelin, Y., Voronov, E., Dinarello, C. A., & Apte, R. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308705101 · Cited by 346

"CONTRACTILE INTERSTITIAL CELLS" IN PULMONARY ALVEOLAR SEPTA: A POSSIBLE REGULATOR OF VENTILATION/PERFUSION RATIO?

Kapançi, Y., Assimacopoulos, A., Irlé, C., Zwahlen, A., & Gabbiani, G. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.60.2.375 · Cited by 346

Force activates smooth muscle α-actin promoter activity through the Rho signaling pathway

Zhao, X.-H., Laschinger, C. A., Arora, P. D., Szászi, K., Kapùs, A., & McCulloch, C. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.001586 · Cited by 325

Ligation of protease-activated receptor 1 enhances v 6 integrin-dependent TGF- activation and promotes acute lung injury

Jenkins, G. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27183 · Cited by 322

Control of Mechanotransduction by Molecular Clutch Dynamics

Elósegui-Artola, A., Trepat, X., & Roca‐Cusachs, P. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.01.008 · Cited by 314

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

Reed, N. I., Jo, H., Chen, C., Tsujino, K., Arnold, T. D., DeGrado, W. F., & Sheppard, D. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa5094 · Cited by 311

Diverse origins of the myofibroblast—implications for kidney fibrosis

Falke, L. L., Gholizadeh, S., Goldschmeding, R., Kok, R. J., & Nguyen, T. Q. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.246 · Cited by 303

Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1

Shintani, Y., Fukumoto, Y., Chaika, N. V., Svoboda, R. A., Wheelock, M. J., & Johnson, K. R. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708137 · Cited by 284

Second harmonic imaging and scoring of collagen in fibrotic tissues

Strupler, M., Pena, A., Hernest, M., Tharaux, P., Martin, J. L., Beaurepaire, E., & Schanne‐Klein, M. (2007) · Optics Express · doi:10.1364/oe.15.004054 · Cited by 274

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

Kumar, A., Ouyang, M., van den Dries, K., McGhee, E. J., Tanaka, K., Anderson, M. D., Groisman, A., Goult, B. T., Anderson, K. I., & Schwartz, M. A. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201510012 · Cited by 265

Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics

Schöber, M., Raghavan, S., Nikolova, M., Polak, L., Pasolli, H. A., Beggs, H. E., Reichardt, L. F., & Fuchs, E. V. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608010 · Cited by 253

The integrin–collagen connection – a glue for tissue repair?

Zeltz, C., & Gullberg, D. (2016) · Journal of Cell Science · doi:10.1242/jcs.180992 · Cited by 250

Combinatorial activation of FAK and AKT by transforming growth factor-β1 confers an anoikis-resistant phenotype to myofibroblasts

Horowitz, J. C., Rogers, D. S., Sharma, V., Vittal, R., White, E. S., Cui, Z., & Thannickal, V. J. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.10.001 · Cited by 248

Extracellular matrix: The driving force of mammalian diseases

Iozzo, R. V., & Gubbiotti, M. A. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.023 · Cited by 236

A comparison of the rates of synthesis and turnover of collagen and non-collagen proteins in adult rat periodontal tissues and skin using a microassay

Sodek, J. (1977) · Archives of Oral Biology · doi:10.1016/0003-9969(77)90095-4 · Cited by 233

Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution

von der Ecken, J., Heissler, S. M., Pathan-Chhatbar, S., Manstein, D. J., & Raunser, S. (2016) · Nature · doi:10.1038/nature18295 · Cited by 231

β- and γ-cytoplasmic actins display distinct distribution and functional diversity

Dugina, V. B., Zwaenepoel, I., Gabbiani, G., Clément, S., & Chaponnier, C. (2009) · Journal of Cell Science · doi:10.1242/jcs.041970 · Cited by 227

The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

Hinz, B., Gabbiani, G., & Chaponnier, C. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201049 · Cited by 226

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

Klingberg, F., Chow, M. L., Koehler, A., Boo, S., Buscemi, L., Quinn, T. M., Costell, M., Alman, B. A., Genot, E. M., & Hinz, B. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201402006 · Cited by 226

The origin of fibrogenic myofibroblasts in fibrotic liver

Kisseleva, T. (2017) · Hepatology · doi:10.1002/hep.28948 · Cited by 224

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

Martin, K., Pritchett, J. P., Llewellyn, J., Mullan, A. F., Athwal, V. S., Dobie, R., Harvey, E., Zeef, L. A. H., Farrow, S. N., Streuli, C. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12502 · Cited by 223

Lysophosphatidic acid as a lipid mediator with multiple biological actions

Aikawa, S., Hashimoto, T., Kano, K., & Aoki, J. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu077 · Cited by 219

Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

Talele, N. P., Fradette, J., Davies, J. E., Kapùs, A., & Hinz, B. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.05.004 · Cited by 218

Integrin-mediated regulation of TGFβ in fibrosis

Henderson, N. C., & Sheppard, D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.10.005 · Cited by 216

Lysophosphatidic Acid Induces αvβ6 Integrin-Mediated TGF-β Activation via the LPA2 Receptor and the Small G Protein Gαq

Xu, M. Y., Porte, J., Knox, A. J., Weinreb, P. H., Maher, T. M., Violette, S. M., McAnulty, R. J., Sheppard, D., & Jenkins, G. R. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080160 · Cited by 215

Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis

Froese, A. R., Shimbori, C., Bellaye, P.-S., Inman, M., Obex, S., Fatima, S., Jenkins, G., Gauldie, J., Ask, K., & Kolb, M. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201508-1638oc · Cited by 214

Vinculin controls talin engagement with the actomyosin machinery

Atherton, P., Stutchbury, B., Wang, D.-Y., Jethwa, D., Tsang, R., Meiler-Rodriguez, E., Wang, P., Bate, N., Zent, R., Barsukov, I., et al. (2015) · Nature Communications · doi:10.1038/ncomms10038 · Cited by 210

Discoidin domain receptors in disease

Borza, C. M., & Pozzi, A. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.12.002 · Cited by 205

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

Johnson, L. A., Rodansky, E. S., Haak, A. J., Larsen, S. D., Neubig, R. R., & Higgins, P. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000437615.98881.31 · Cited by 203

Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

Walraven, M., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.020 · Cited by 199

Tension, contraction and tissue morphogenesis

Heer, N. C., & Martin, A. C. (2017) · Development · doi:10.1242/dev.151282 · Cited by 193

Cell–collagen interactions: the use of peptide Toolkits to investigate collagen–receptor interactions

Farndale, R. W., Lisman, T., Bihan, D. G., Hamaia, S. W., Smerling, C., Pugh, N., Konitsiotis, A. D., Leitinger, B., de Groot, P. G., Jarvis, G. E., et al. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360241 · Cited by 193

Distinct focal adhesion protein modules control different aspects of mechanotransduction

Stutchbury, B., Atherton, P., Tsang, R., Wang, D., & Ballestrem, C. (2017) · Journal of Cell Science · doi:10.1242/jcs.195362 · Cited by 190

The inner workings of stress fibers − from contractile machinery to focal adhesions and back

Livne, A., & Geiger, B. (2016) · Journal of Cell Science · doi:10.1242/jcs.180927 · Cited by 188

Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

Jiang, D., Correa‐Gallegos, D., Christ, S., Stefańska, A., Liu, J., Ramesh, P., Rajendran, V., Santis, M. M. D., Wagner, D. E., & Rinkevich, Y. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0073-8 · Cited by 187

Long-range self-organization of cytoskeletal myosin II filament stacks

Hu, S., Dasbiswas, K., Guo, Z., Tee, Y.-H., Thiagarajan, V., Hersen, P., Chew, T., Safran, S. A., Zaidel‐Bar, R., & Bershadsky, A. D. (2017) · Nature Cell Biology · doi:10.1038/ncb3466 · Cited by 183

Matrix Stiffness: the Conductor of Organ Fibrosis

Santos, A., & Lagares, D. (2018) · Current Rheumatology Reports · doi:10.1007/s11926-018-0710-z · Cited by 183

α11β1 Integrin Recognizes the GFOGER Sequence in Interstitial Collagens

Zhang, W., Käpylä, J., Puranen, J. S., Knight, C. G., Tiger, C., Pentikäinen, O. T., Johnson, M. S., Farndale, R. W., Heino, J., & Gullberg, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210313200 · Cited by 180

Molecular and tissue alterations of collagens in fibrosis

Ricard‐Blum, S., Baffet, G., & Théret, N. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.004 · Cited by 179

The collagen receptor subfamily of the integrins

White, D. J., Puranen, S., Johnson, M. S., & Heino, J. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.08.016 · Cited by 176

Myofibroblast Differentiation Is Induced in Keratinocyte-Fibroblast Co-Cultures and Is Antagonistically Regulated by Endogenous Transforming Growth Factor-β and Interleukin-1

Shephard, P., Martin, G. E. M., Smola, S., Brunner, G., Krieg, T. M., & Smola, H. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63764-9 · Cited by 176

Architecture shapes contractility in actomyosin networks

Koenderink, G. H., & Paluch, E. K. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.01.015 · Cited by 175

Increased Expression of Integrin αvβ5 Induces the Myofibroblastic Differentiation of Dermal Fibroblasts

Asano, Y., Ihn, H., Yamane, K., Jinnin, M., & Tamaki, K. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.041306 · Cited by 175

Expression of integrin β1 by fibroblasts is required for tissue repair in vivo

Liu, S., Shiwen, X., Blumbach, K., Eastwood, M., Denton, C. P., Eckes, B., Krieg, T., Abraham, D., & Leask, A. (2010) · Journal of Cell Science · doi:10.1242/jcs.070672 · Cited by 174

The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix

Klingberg, F., Chau, G., Walraven, M., Boo, S., Koehler, A., Chow, M. L., Olsen, A. L., Im, M., Lodyga, M., Wells, R. G., et al. (2018) · Journal of Cell Science · doi:10.1242/jcs.201293 · Cited by 173

Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro

Gateva, G., Kremneva, E., Reindl, T., Kotila, T., Kogan, K., Gressin, L., Gunning, P. W., Manstein, D. J., Michelot, A., & Lappalainen, P. (2017) · Current Biology · doi:10.1016/j.cub.2017.01.018 · Cited by 168

Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

Sisson, T. H., Ajayi, I. O., Subbotina, N., Dodi, A. E., Rodansky, E. S., Chibucos, L. N., Kim, K. K., Keshamouni, V. G., White, E. S., Zhou, Y., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.12.005 · Cited by 164

The perivascular origin of pathological fibroblasts

Di Carlo, S. E., & Peduto, L. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93558 · Cited by 164

Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis

Chen, H., Qu, J., Huang, X., Kurundkar, A., Zhu, L., Yang, N., Venado, A. E., Ding, Q., Liu, G., Antony, V. B., et al. (2016) · Nature Communications · doi:10.1038/ncomms12564 · Cited by 159

Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly

Tojkander, S., Gateva, G., Husain, A., Krishnan, R., & Lappalainen, P. (2015) · eLife · doi:10.7554/elife.06126 · Cited by 157

CCN2 is required for bleomycin‐induced skin fibrosis in mice

Liu, S., Shiwen, X., Abraham, D., & Leask, A. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30074 · Cited by 156

Mechanisms of Lung Fibrosis Resolution

Glasser, S. W., Hagood, J. S., Wong, S. S., Taype, C. A., Madala, S. K., & Hardie, W. D. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.01.018 · Cited by 151

Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation

Xu, H., Bihan, D. G., Chang, F., Huang, P. H., Farndale, R. W., & Leitinger, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052209 · Cited by 150

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

Speight, P., Kofler, M., Szászi, K., & Kapus, A. (2016) · Nature Communications · doi:10.1038/ncomms11642 · Cited by 144

Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

Velasquez, L. S., Sutherland, L. B., Liu, Z., Grinnell, F., Kamm, K. E., Schneider, J. W., Olson, E. N., & Small, E. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316764110 · Cited by 142

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts

Piersma, B., de Rond, S., Werker, P. M. N., Boo, S., Hinz, B., van Beuge, M. M., & Bank, R. A. (2015) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.08.011 · Cited by 135

Modulation of Prosurvival Signaling in Fibroblasts by a Protein Kinase Inhibitor Protects against Fibrotic Tissue Injury

Vittal, R., Horowitz, J. C., Moore, B. B., Zhang, H., Martínez, F. J., Toews, G. B., Standiford, T. J., & Thannickal, V. J. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62260-2 · Cited by 129

The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis

Knipe, R. S., Probst, C. K., Lagares, D., Franklin, A., Spinney, J. J., Brazee, P. L., Grasberger, P. E., Zhang, L., Black, K. E., Sakai, N., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0075oc · Cited by 129

Discoidin Domain Receptor 1 Null Mice Are Protected against Hypertension-Induced Renal Disease

Flamant, M., Placier, S., Rodenas, A., Curat, C. A., Vogel, W. F., Chatziantoniou, C., & Dussaule, J. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006060677 · Cited by 128

Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts

Luchsinger, L. L., Patenaude, C. A., Smith, B. D., & Layne, M. D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276931 · Cited by 127

Mechanical Stress Is Required for High-Level Expression of Connective Tissue Growth Factor

Schild, C., & Trüeb, B. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5458 · Cited by 126

Myocardin-Related Transcription Factors A and B Are Key Regulators of TGF-β1-Induced Fibroblast to Myofibroblast Differentiation

Crider, B. J., Risinger, G. M., Haaksma, C. J., Howard, E. W., & Tomasek, J. J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.219 · Cited by 124

Regulation of myofibroblast activities: Calcium pulls some strings behind the scene

Castella, L. F., Gabbiani, G., McCulloch, C. A., & Hinz, B. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.033 · Cited by 124

Discoidin Domain Receptor 1 Is a Major Mediator of Inflammation and Fibrosis in Obstructive Nephropathy

Guerrot, D., Kerroch, M., Placier, S., Vandermeersch, S., Avillach, C., Mael-Ainin, M., Chatziantoniou, C., & Dussaule, J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.023 · Cited by 122

Actomyosin contractility and collective migration: may the force be with you

Pandya, P., Orgaz, J. L., & Sanz‐Moreno, V. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.06.006 · Cited by 121

β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin

Sabra, H., Brunner, M., Mandati, V., Wehrle‐Haller, B., Lallemand, D., Ribba, A., Chevalier, G., Guardiola, P., Block, M. R., & Bouvard, D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.808063 · Cited by 121

Myosin II in mechanotransduction: master and commander of cell migration, morphogenesis, and cancer

Aguilar-Cuenca, R., Juanes-García, A., & Vicente‐Manzanares, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1439-5 · Cited by 119

Disruption of Interleukin-1 Signaling Improves the Quality of Wound Healing

Thomay, A. A., Daley, J. M., Sabo, E., Worth, P. J., Shelton, L. J., Harty, M. W., Reichner, J. S., & Albina, J. E. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080765 · Cited by 119

Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies

Lemos, D. R., & Duffield, J. S. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5174 · Cited by 115

A biomechanical perspective on stress fiber structure and function

Kassianidou, E., & Kumar, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.04.006 · Cited by 114

LTBPs in biology and medicine: LTBP diseases

Rifkin, D. B., Rifkin, W. J., & Zilberberg, L. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.11.014 · Cited by 112

Mapping of DDR1 Distribution and Oligomerization on the Cell Surface by FRET Microscopy

Mihai, C., Chotani, M. A., Elton, T. S., & Agarwal, G. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.10.067 · Cited by 112

Structural basis of the collagen‐binding mode of discoidin domain receptor 2

Ichikawa, O., Osawa, M., Nishida, N., Goshima, N., Nomura, N., & Shimada, I. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601833 · Cited by 109

Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction

Coelho, N. M., Arora, P. D., van Putten, S., Boo, S., Petrovic, P., Lin, A. X., Hinz, B., & McCulloch, C. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.061 · Cited by 109

The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA

Huang, Y., Arora, P. D., McCulloch, C. A., & Vogel, W. F. (2009) · Journal of Cell Science · doi:10.1242/jcs.046219 · Cited by 108

Matrix-fibrinogen enhances wound closure by increasing both cell proliferation and migration

Rybarczyk, B. J., Lawrence, S. O., & Simpson‐Haidaris, P. J. (2003) · Blood · doi:10.1182/blood-2003-03-0822 · Cited by 106

Mediated nuclear import and export of TAZ and the underlying molecular requirements

Kofler, M., Speight, P., Little, D., Ciano‐Oliveira, C. D., Szászi, K., & Kapùs, A. (2018) · Nature Communications · doi:10.1038/s41467-018-07450-0 · Cited by 105

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer

Unbekandt, M., & Olson, M. F. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1133-6 · Cited by 103

TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism

Miranda, M. Z., Bialik, J. F., Speight, P., Dan, Q., Yeung, T., Szászi, K., Pedersen, S. F., & Kapus, A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.780502 · Cited by 103

Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes

Fenix, A. M., Neininger, A. C., Taneja, N., Hyde, K., Visetsouk, M. R., Garde, R. J., Liu, B., Nixon, B. R., Manalo, A. E., Becker, J. R., et al. (2018) · eLife · doi:10.7554/elife.42144 · Cited by 101

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis

Shiwen, X., Stratton, R. J., Nikitorowicz-Buniak, J., Abdi, B. A., Ponticos, M., Denton, C. P., Abraham, D., Takahashi, A., Suki, B., Layne, M. D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126015 · Cited by 99

Pathology of collagen degradation. A review.

Pérez-Tamayo, R. (1978) · PubMed Central · Cited by 97

Interleukin-1beta stimulates human renal fibroblast proliferation and matrix protein production by means of a transforming growth factor-beta-dependent mechanism.

Vesey, D. A., Cheung, C. W. Y., Cuttle, L., Endre, Z. H., Gobe, G. C., & Johnson, D. W. (2002) · PubMed · doi:10.1067/mlc.2002.128468 · Cited by 97

The molecular clutch model for mechanotransduction evolves

Swaminathan, V., & Waterman, C. M. (2016) · Nature Cell Biology · doi:10.1038/ncb3350 · Cited by 96

Mechanosensing in cell–matrix adhesions – Converting tension into chemical signals

Hytönen, V. P., & Wehrle‐Haller, B. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.027 · Cited by 96

Matrix mechanics and regulation of the fibroblast phenotype

Hinz, B. (2013) · Periodontology 2000 · doi:10.1111/prd.12030 · Cited by 95

Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases

Fu, H.-L., Sohail, A., Valiathan, R. R., Wasinski, B. D., Kumarasiri, M., Mahasenan, K. V., Bernardo, M. M., Tokmina‐Roszyk, D., Fields, G. B., Mobashery, S., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.409599 · Cited by 94

TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms

Scharenberg, M. A., Pippenger, B. E., Sack, R., Zingg, D., Ferralli, J., Schenk, S., Martín, I., & Chiquet‐Ehrismann, R. (2014) · Journal of Cell Science · doi:10.1242/jcs.142075 · Cited by 93

Role of the Lysophospholipid Mediators Lysophosphatidic Acid and Sphingosine 1-Phosphate in Lung Fibrosis

Shea, B. S., & Tager, A. M. (2012) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201201-005aw · Cited by 91

Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery

Kothiwale, S., Borza, C. M., Lowe, E. W., Pozzi, A., & Meiler, J. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.09.025 · Cited by 91

New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts

Schulz, J.-N., Plomann, M., Sengle, G., Gullberg, D., Krieg, T. M., & Eckes, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.025 · Cited by 88

Prostaglandin E2 Inhibits α-Smooth Muscle Actin Transcription during Myofibroblast Differentiation via Distinct Mechanisms of Modulation of Serum Response Factor and Myocardin-related Transcription Factor-A

Penke, L. R. K., Huang, S. K., White, E. S., & Peters-Golden, M. L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.558130 · Cited by 87

Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype

Southern, B. D., Grove, L. M., Rahaman, S. O., Abraham, S., Scheraga, R. G., Niese, K. A., Sun, H., Herzog, E. L., Liu, F., Tschumperlin, D. J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.712380 · Cited by 86

Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis

Makino, K., Makino, T., Stawski, L., Lipson, K. E., Leask, A., & Trojanowska, M. E. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1356-3 · Cited by 84

Targeting of Discoidin Domain Receptor 2 (DDR2) Prevents Myofibroblast Activation and Neovessel Formation During Pulmonary Fibrosis

Zhao, H., Bian, H., Bu, X., Zhang, S., Zhang, P., Yu, J., Lai, X., Li, D., Zhu, C., Yao, L., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.109 · Cited by 84

In the beginning there were soft collagen-cell gels: towards better 3D connective tissue models?

Brown, R. A. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.07.001 · Cited by 83

Cellular Signaling by Collagen-Binding Integrins

Heino, J. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-9153-3_10 · Cited by 83

Impaired dermal wound healing in discoidin domain receptor 2-deficient mice associated with defective extracellular matrix remodeling

Olaso, E., Lin, H., Wang, L., & Friedman, S. L. (2011) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-4-5 · Cited by 83

Mesenchymal stromal cells and liver fibrosis: a complicated relationship

Haldar, D., Henderson, N. C., Hirschfield, G. M., & Newsome, P. N. (2016) · The FASEB Journal · doi:10.1096/fj.201600433r · Cited by 83

Colonic pericryptal fibroblasts

Sappino, A. P., Dietrich, P. Y., Skalli, O., Widgren, S., & Gabbiani, G. (1989) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00718649 · Cited by 83

Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor

Sakai, N., Chun, J. J. M., Duffield, J. S., Lagares, D., Wada, T., Luster, A. D., & Tager, A. M. (2016) · Kidney International · doi:10.1016/j.kint.2016.09.030 · Cited by 82

The specific NH2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo.

Chaponnier, C., Goethals, M., Janmey, P. A., Gabbiani, F., Gabbiani, G., & Vandekerckhove, J. S. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.4.887 · Cited by 81

Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

Juskaite, V., Corcoran, D., & Leitinger, B. (2017) · eLife · doi:10.7554/elife.25716 · Cited by 78

Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator

Chen, A., Arora, P. D., McCulloch, C. A., & Wilde, A. (2017) · Nature Communications · doi:10.1038/s41467-017-01231-x · Cited by 78

Contribution of collagen adhesion receptors to tissue fibrosis

Coelho, N. M., & McCulloch, C. A. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2440-8 · Cited by 74

Intestinal fibrosis

Latella, G., & Rieder, F. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000363 · Cited by 72

A novel mechanism of TGFβ‐induced actin reorganization mediated by Smad proteins and Rho GTPases

Vardouli, L., Vasilaki, E., Papadimitriou, E., Kardassis, D., & Stournaras, C. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06549.x · Cited by 71

Actomyosin stress fiber mechanosensing in 2D and 3D

Lee, S., & Kumar, S. (2016) · F1000Research · doi:10.12688/f1000research.8800.1 · Cited by 69

The Recruitment of the Interleukin-1 (IL-1) Receptor-associated Kinase (IRAK) into Focal Adhesion Complexes Is Required for IL-1β-induced ERK Activation

MacGillivray, M. K., Cruz, T. F., & McCulloch, C. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003186200 · Cited by 67

Mammalian nonmuscle myosin II comes in three flavors

Shutova, M. S., & Svitkina, T. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.103 · Cited by 67

Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts

Sonin, D. L., Wakatsuki, T., Routhu, K. V., Harmann, L. M., Petersen, M., Meyer, J., & Strande, J. L. (2013) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248413485434 · Cited by 66

Calcium Homeostasis and Ionic Mechanisms in Pulmonary Fibroblasts

Janssen, L. J., Mukherjee, S., & Ask, K. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0269tr · Cited by 65

ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)

Shitomi, Y., Thøgersen, I. B., Ito, N., Leitinger, B., Enghild, J. J., & Itoh, Y. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-10-1463 · Cited by 65

Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen

Staudinger, L. A., Spano, S. J., Lee, W., Coelho, N. M., Rajshankar, D., Bendeck, M. P., Moriarty, T. J., & McCulloch, C. A. (2013) · Biology Open · doi:10.1242/bio.20135090 · Cited by 64

Matrix Rigidity Mediates TGFβ1-induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization

O’Connor, J. W., Riley, P. N., Nalluri, S. M., Ashar, P. K., & Gomez, E. W. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24895 · Cited by 61

Targeting coagulation factor receptors – protease‐activated receptors in idiopathic pulmonary fibrosis

Lin, C., Borensztajn, K., & Spek, C. A. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13623 · Cited by 59

Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosis

Coelho, N. M., & McCulloch, C. A. (2018) · Cell Adhesion & Migration · doi:10.1080/19336918.2018.1448353 · Cited by 59

Myosin II isoform co-assembly and differential regulation in mammalian systems

Beach, J. R., & Hammer, J. A. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.01.012 · Cited by 58

Requirements of Focal Adhesions and Calcium Fluxes for Interleukin-1-induced ERK Kinase Activation and c-fos Expression in Fibroblasts

Lo, Y. Y. C., Luo, L., McCulloch, C. A., & Cruz, T. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.7059 · Cited by 58

Hic-5 is required for myofibroblast differentiation by regulating mechanically dependent MRTF-A nuclear accumulation

Varney, S. D., Betts, C. B., Zheng, R., Wu, L., Hinz, B., Zhou, J., & Water, L. V. D. (2016) · Journal of Cell Science · doi:10.1242/jcs.170589 · Cited by 58

RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation

Oh, R. S., Haak, A. J., Smith, K. M. J., Ligresti, G., Choi, K. M., Xie, T., Wang, S., Walters, P., Thompson, M. A., Freeman, M., et al. (2018) · Journal of Cell Science · doi:10.1242/jcs.209932 · Cited by 57

Mechanical stability of talin rod controls cell migration and substrate sensing

Rahikainen, R., von Essen, M., Schaefer, M., Qi, L., Azizi, L., Kelly, C., Ihalainen, T. O., Wehrle‐Haller, B., Bastmeyer, M., Huang, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03335-2 · Cited by 57

Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer

Ungefroren, H., Gieseler, F., Kaufmann, R., Settmacher, U., Lehnert, H., & Rauch, B. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061568 · Cited by 57

Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis

Htwe, S. S., Cha, B. H., Yue, K., Khademhosseini, A., Knox, A. J., & Ghaemmaghami, A. M. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0306oc · Cited by 56

Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition

Speight, P., Nakano, H., Kelley, T. J., Hinz, B., & Kapùs, A. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-04-0220 · Cited by 54

Effects of interleukin-1 on cardiac fibroblast function: Relevance to post-myocardial infarction remodelling

Turner, N. A. (2013) · Vascular Pharmacology · doi:10.1016/j.vph.2013.06.002 · Cited by 53

Whole animal knockout of smooth muscle alpha‐actin does not alter excisional wound healing or the fibroblast‐to‐myofibroblast transition

Tomasek, J. J., Haaksma, C. J., Schwartz, R. J., & Howard, E. W. (2012) · Wound Repair and Regeneration · doi:10.1111/wrr.12001 · Cited by 50

The Role of Discoidin Domain Receptor 1 in Inflammation, Fibrosis and Renal Disease

Dorison, A., Dussaule, J., & Chatziantoniou, C. (2017) · The Nephron journals/Nephron journals · doi:10.1159/000479119 · Cited by 49

Smooth muscle actin isoforms: A tug of war between contraction and compliance

Arnoldi, R., Hiltbrunner, A., Dugina, V. B., Tille, J., & Chaponnier, C. (2013) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2013.06.002 · Cited by 48

The N-terminal Ac-EEED sequence plays a role in α-smooth-muscle actin incorporation into stress fibers

Clément, S., Hinz, B., Dugina, V. B., Gabbiani, G., & Chaponnier, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.01732 · Cited by 46

The relative roles of collagen adhesive receptor DDR2 activation and matrix stiffness on the downregulation of focal adhesion kinase in vascular smooth muscle cells

Bhadriraju, K., Chung, K., Spurlin, T. A., Haynes, R. J., Elliott, J. T., & Plant, A. L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.08.036 · Cited by 45

Stable incorporation of α‐smooth muscle actin into stress fibers is dependent on specific tropomyosin isoforms

Prunotto, M., Bruschi, M., Gunning, P. W., Gabbiani, G., Weibel, F., Ghiggeri, G. M., Petretto, A., Scaloni, A., Bonello, T., Schevzov, G., et al. (2015) · Cytoskeleton · doi:10.1002/cm.21230 · Cited by 45

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Ramage, L. (2011) · Cell Health and Cytoskeleton · doi:10.2147/chc.s21829 · Cited by 44

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Ghosh, S., Ashcraft, K. A., Jahid, M. J., April, C., Ghajar, C. M., Ruan, J., Wang, H., Foster, M., Hughes, D. C., Ramírez, A. G., et al. (2013) · Nature Communications · doi:10.1038/ncomms2794 · Cited by 42

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Song, S., Shackel, N. A., Wang, X. M., Ajami, K., McCaughan, G. W., & Gorrell, M. D. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.068 · Cited by 40

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Yamashiro, S., Gokhin, D. S., Sui, Z., Bergeron, S. E., Rubenstein, P. A., & Fowler, V. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.555128 · Cited by 39

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