Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis

Making sense of latent TGFβ activation

Annes, J. P., Munger, J. S., & Rifkin, D. B. (2002) · Journal of Cell Science · doi:10.1242/jcs.00229 · Cited by 1,624 · see citing works

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346 · see citing works

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

Sime, P. J., Xing, Z., Graham, F. L., Csaky, K. G., & Gauldie, J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119590 · Cited by 1,050 · see citing works

Latent TGF-β structure and activation

Shi, M., Zhu, J., Wang, R., Chen, X., Mi, L., Walz, T., & Springer, T. A. (2011) · Nature · doi:10.1038/nature10152 · Cited by 1,013 · see citing works

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

Barry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870 · see citing works

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3282 · Cited by 866 · see citing works

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

Liu, F., Mih, J. D., Shea, B. S., Kho, A. T., Sharif, A. S., Tager, A. M., & Tschumperlin, D. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004082 · Cited by 799 · see citing works

Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis

Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577 · see citing works

Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction

Huang, X., Yang, N., Fiore, V. F., Barker, T. H., Sun, Y., Morris, S. W., Ding, Q., Thannickal, V. J., & Zhou, Y. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0050oc · Cited by 530 · see citing works

TGF-β – an excellent servant but a bad master

Kubiczkova, L., Sedlarikova, L., Hajek, R., & Sevcikova, S. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-183 · Cited by 511 · see citing works

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

Zhou, Y., Huang, X., Hecker, L., Kurundkar, D., Kurundkar, A., Liu, H., Jin, T. H., Desai, L. P., Bernard, K. F., & Thannickal, V. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66700 · Cited by 452 · see citing works

Latent Transforming Growth Factor-β (TGF-β) Binding Proteins: Orchestrators of TGF-β Availability

Rifkin, D. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400029200 · Cited by 422 · see citing works

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

Zhao, J., Shi, W., Wang, Y., Chen, H., Bringas, P., Datto, M., Frederick, J. P., Wang, X., & Warburton, D. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00151.2001 · Cited by 411 · see citing works

Smad3 Null Mice Develop Airspace Enlargement and Are Resistant to TGF-β-Mediated Pulmonary Fibrosis

Bonniaud, P., Kolb, M. R. J., Galt, T., Robertson, J. V., Robbins, C. S., Stämpfli, M. R., Lavery, C., Margetts, P. J., Roberts, A. B., & Gauldie, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.2099 · Cited by 383 · see citing works

Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals

Maeda, T., Sakabe, T., Sunaga, A., Sakai, K., Rivera, A. L., Keene, D. R., Sasaki, T., Stavnezer, E., Iannotti, J. P., Schweitzer, R., et al. (2011) · Current Biology · doi:10.1016/j.cub.2011.04.007 · Cited by 363 · see citing works

The role of proteases in transforming growth factor-β activation

Jenkins, G. R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.11.026 · Cited by 358 · see citing works

TGF-β: From latent to active

Khalil, N. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)00259-2 · Cited by 341 · see citing works

TGF-β1, but Not TGF-β2 or TGF-β3, is Differentially Present in Epithelial Cells of Advanced Pulmonary Fibrosis: An Immunohistochemical Study

Khalil, N., O'Connor, R. N., Flanders, K. C., & Unruh, H. W. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.14.2.8630262 · Cited by 328 · see citing works

Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice

Yang, Z., Mu, Z., Dabovic, B., Jurukovski, V., Yu, D., Sung, J. J., Xiong, X., & Munger, J. S. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611044 · Cited by 321 · see citing works

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study

Jenkins, R. G., Simpson, J. K., Saini, G., Bentley, J. H., Russell, A.-M., Braybrooke, R., Molyneaux, P. L., McKeever, T. M., Wells, A. U., Flynn, A., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00048-x · Cited by 314 · see citing works

Ligation of protease-activated receptor 1 enhances v 6 integrin-dependent TGF- activation and promotes acute lung injury

Jenkins, G. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27183 · Cited by 314 · see citing works

The α _v β ₁ integrin plays a critical in vivo role in tissue fibrosis

Reed, N. I., Jo, H., Chen, C., Tsujino, K., Arnold, T. D., DeGrado, W. F., & Sheppard, D. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa5094 · Cited by 311 · see citing works

Pulmonary Fibrosis Correlates With Outcome in Adult Respiratory Distress Syndrome

Martin, C., Papazian, L., Payan, M.-J., SAUX, P., & Gouin, F. (1995) · CHEST Journal · doi:10.1378/chest.107.1.196 · Cited by 272 · see citing works

Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor

Bonniaud, P., Margetts, P. J., Kolb, M. R. J., SCHROEDER, J., Kapoun, A. M., Damm, D., Murphy, A., Chakravarty, S., Dugar, S., Higgins, L. S., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200405-612oc · Cited by 258 · see citing works

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

Buscemi, L., Ramonet, D., Klingberg, F., Formey, A., Smith-Clerc, J., Meister, J.-J., & Hinz, B. (2011) · Current Biology · doi:10.1016/j.cub.2011.11.037 · Cited by 257 · see citing works

Matrix control of transforming growth factor- function

Horiguchi, M., Ota, M., & Rifkin, D. B. (2012) · The Journal of Biochemistry · doi:10.1093/jb/mvs089 · Cited by 256 · see citing works

TGF-β and Smad3 Signaling Link Inflammation to Chronic Fibrogenesis

Bonniaud, P., Margetts, P. J., Ask, K., Flanders, K., Gauldie, J., & Kolb, M. R. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5390 · Cited by 252 · see citing works

Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3

Eickelberg, O., Köhler, E. S., Reichenberger, F., Bertschin, S., Woodtli, T., Erné, P., Perruchoud, A. P., & Roth, M. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.276.5.l814 · Cited by 225 · see citing works

Mice that lack activity of αvβ6- and αvβ8-integrins reproduce the abnormalities of Tgfb1 - and Tgfb3 -null mice

Aluwihare, P., Mu, Z., Zhao, Z., Yu, D., Weinreb, P. H., Horan, G. S. B., Violette, S. M., & Munger, J. S. (2008) · Journal of Cell Science · doi:10.1242/jcs.035246 · Cited by 224 · see citing works

Lysophosphatidic Acid Induces αvβ6 Integrin-Mediated TGF-β Activation via the LPA2 Receptor and the Small G Protein Gαq

Xu, M. Y., Porte, J., Knox, A. J., Weinreb, P. H., Maher, T. M., Violette, S. M., McAnulty, R. J., Sheppard, D., & Jenkins, G. R. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080160 · Cited by 212 · see citing works

Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction

Sarrazy, V., Koehler, A., Chow, M. L., Zimina, E., Li, C. X., Kato, H., Caldarone, C. A., & Hinz, B. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu053 · Cited by 209 · see citing works

Transglutaminase 2 and Its Role in Pulmonary Fibrosis

Olsen, K. C., Sapinoro, R., Kottmann, R. M., Kulkarni, A. A., Iismaa, S. E., Johnson, G. V. W., Thatcher, T. H., Phipps, R. P., & Sime, P. J. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201101-0013oc · Cited by 186 · see citing works

Mechanical stress induces lung fibrosis by epithelial–mesenchymal transition*

Cabrera-Benítez, N. E., Parotto, M., Post, M., Han, B., Spieth, P. M., Cheng, W.-E., Valladares, F., Villar, J., Liu, M., Sato, M., et al. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31822f09d7 · Cited by 166 · see citing works

Pulmonary Function Testing in Idiopathic Interstitial Pneumonias

Martínez, F. J., & Flaherty, K. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200602-022tk · Cited by 166 · see citing works

Matrices of Physiologic Stiffness Potently Inactivate Idiopathic Pulmonary Fibrosis Fibroblasts

Marinković, A., Liu, F., & Tschumperlin, D. J. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0335oc · Cited by 162 · see citing works

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-β1

Ahamed, J., Burg, N. D., Yoshinaga, K., Janczak, C. A., Rifkin, D. B., & Coller, B. S. (2008) · Blood · doi:10.1182/blood-2008-04-151753 · Cited by 154 · see citing works

Integrin αvβ5-Mediated TGF-β Activation by Airway Smooth Muscle Cells in Asthma

Tatler, A. L., John, A. E., Jolly, L., Habgood, A., Porte, J., Brightling, C. E., Knox, A. J., Pang, L., Sheppard, D., Huang, X., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003507 · Cited by 149 · see citing works

Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness

Marinković, А., Mih, J. D., Park, J., Liu, F., & Tschumperlin, D. J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00108.2012 · Cited by 143 · see citing works

Thy-1-Integrin αvβ5 Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation

Zhou, Y., Hagood, J. S., Lu, B., Merryman, W. D., & Murphy-Ullrich, J. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126227 · Cited by 118 · see citing works

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αvβ6-dependent physical force

Giacomini, M. M., Travis, M. A., Kudo, M., & Sheppard, D. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.01.020 · Cited by 107 · see citing works

Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

Jiang, C., Huang, H. F., Liu, J., Wang, Y., Lu, Z., & Xu, Z. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078293 · Cited by 96 · see citing works

Acute Exacerbation of Idiopathic Interstitial Pneumonia Following Lung Surgery in 3 of 68 Consecutive Patients: A Retrospective Study

Sakamoto, S., Homma, S. A., Mun, M., Fujii, T., Kurosaki, A., & Yoshimura, K. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.3390 · Cited by 75 · see citing works

Activation of the Wnt/β-Catenin Signaling Pathway by Mechanical Ventilation Is Associated with Ventilator-Induced Pulmonary Fibrosis in Healthy Lungs

Villar, J., Cabrera-Benítez, N. E., Valladares, F., Casula, M., Flores, C., Blanch, L. L., Quílez, M. E., Santana-Rodríguez, N., Kacmarek, R. M., & Slutsky, A. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023914 · Cited by 73 · see citing works

Regulation of TGF-β storage and activation in the human idiopathic pulmonary fibrosis lung

Leppäranta, O., Sens, C., Salmenkivi, K., Kinnula, V. L., Keski‐Oja, J., Myllärniemi, M., & Koli, K. M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1385-9 · Cited by 73 · see citing works

Comparison between conventional and "clinical" assessment of experimental lung fibrosis

Ask, K., Labiris, R., Farkas, L., Moeller, A., Froese, A., Farncombe, T. H., McClelland, G. B., Inman, M. D., Gauldie, J., & Kolb, M. R. J. (2008) · Journal of Translational Medicine · doi:10.1186/1479-5876-6-16 · Cited by 73 · see citing works

The Impact of Smoking on Mechanical Properties of the Lungs in Idiopathic Pulmonary Fibrosis and Sarcoidosis

Hanley, M. E., King, T. E., Schwarz, M. I., Watters, L. C., Shen, A. S., & Cherniack, R. M. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.5.1102 · Cited by 64 · see citing works

Influenza Promotes Collagen Deposition via αvβ6 Integrin-mediated Transforming Growth Factor β Activation

Jolly, L., Stavrou, A., Vanderstocken, G., Meliopoulos, V., Habgood, A., Tatler, A. L., Porte, J., Knox, A. J., Weinreb, P. H., Violette, S. M., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.582262 · Cited by 55 · see citing works

Extracellular matrix microenvironment contributes actively to pulmonary fibrosis

Shimbori, C., Gauldie, J., & Kolb, M. R. J. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328363f4de · Cited by 54 · see citing works

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis

Madala, S. K., Korfhagen, T. R., Schmidt, S., Davidson, C. R., Edukulla, R., Ikegami, M., Violette, S. M., Weinreb, P. H., Sheppard, D., & Hardie, W. D. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00357.2013 · Cited by 52 · see citing works

Postoperative Acute Exacerbation of IPF after Lung Resection for Primary Lung Cancer

Watanabe, A., Kawaharada, N., & Higami, T. (2011) · Pulmonary Medicine · doi:10.1155/2011/960316 · Cited by 50 · see citing works

Integrins as Modulators of Transforming Growth Factor Beta Signaling in Dermal Fibroblasts During Skin Regeneration After Injury

Boo, S., & Dagnino, L. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0394 · Cited by 30 · see citing works

Fibrosis: from mechanisms to medicines

Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works

Transforming growth factor–β in tissue fibrosis

Frangogiannis, N. G. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190103 · Cited by 1,310 · see citing works

Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis

Moss, B. J., Ryter, S. W., & Rosas, I. O. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042320-030240 · Cited by 839 · see citing works

Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomised, placebo-controlled, phase 2b trial

Behr, J., Prasse, A., Kreuter, M., Johow, J., Rabe, K. F., Bonella, F., Bonnet, R., Grohe, C., Held, M., Wilkens, H., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30554-3 · Cited by 522 · see citing works

The extracellular matrix as a multitasking player in disease

Theocharis, A., Manou, D., & Karamanos, N. (2019) · The FEBS Journal · doi:10.1111/febs.14818 · Cited by 403 · see citing works

TGF-β1 – A truly transforming growth factor in fibrosis and immunity

Lodyga, M., & Hinz, B. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.010 · Cited by 462 · see citing works

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396 · see citing works

The myofibroblast in wound healing and fibrosis: answered and unanswered questions

Bochaton‐Piallat, M., Gabbiani, G., & Hinz, B. (2016) · F1000Research · doi:10.12688/f1000research.8190.1 · Cited by 295 · see citing works

Matrix abnormalities in pulmonary fibrosis

Upagupta, C., Shimbori, C., Alsilmi, R. A., & Kolb, M. R. J. (2018) · European Respiratory Review · doi:10.1183/16000617.0033-2018 · Cited by 287 · see citing works

The natural history of progressive fibrosing interstitial lung diseases

Kolb, M. R. J., & Vašáková, M. (2019) · Respiratory Research · doi:10.1186/s12931-019-1022-1 · Cited by 275 · see citing works

Imperfect wound healing sets the stage for chronic diseases

Martin, P. B., Pardo-Pastor, C., Jenkins, G. R., & Rosenblatt, J. (2024) · Science · doi:10.1126/science.adp2974 · Cited by 259 · see citing works

Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis

Tai, Y., Woods, E. L., Dally, J., Kong, D., Steadman, R., Moseley, R., & Midgley, A. C. (2021) · Biomolecules · doi:10.3390/biom11081095 · Cited by 244 · see citing works

RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field

Ludwig, B. S., Kessler, H., Kossatz, S., & Reuning, U. (2021) · Cancers · doi:10.3390/cancers13071711 · Cited by 239 · see citing works

Mechanical regulation of chromatin and transcription

Dupont, S., & Wickström, S. A. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00493-6 · Cited by 240 · see citing works

The Role of Myofibroblasts in Physiological and Pathological Tissue Repair

Schuster, R., Younesi, F., Ezzo, M., & Hinz, B. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041231 · Cited by 232 · see citing works

Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis

Meyer, K. C. (2017) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2017.1312346 · Cited by 226 · see citing works

MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program

Wang, Y., Zhang, L., Wu, G.-R., Zhou, Q., Yue, H., Rao, L.-Z., Yuan, T., Mo, B., Wang, F.-X., Chen, L.-M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abb6075 · Cited by 227 · see citing works

Healing after COVID-19: are survivors at risk for pulmonary fibrosis?

McDonald, L. T. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00238.2020 · Cited by 223 · see citing works

Skin Changes During Ageing

Bonté, F., Girard, D., Archambault, J.-C., & Desmoulière, A. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_10 · Cited by 215 · see citing works

Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic?

Wolters, P. J., Blackwell, T. S., Eickelberg, O., Loyd, J. E., Kaminski, N., Jenkins, G., Maher, T. M., Molina-Molina, M., Noble, P. W., Raghu, G., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30007-9 · Cited by 196 · see citing works

TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts

Vallée, A., & Lecarpentier, Y. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0362-3 · Cited by 200 · see citing works

Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

Walraven, M., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.020 · Cited by 194 · see citing works

Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology

Selman, M., & Pardo, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101393 · Cited by 190 · see citing works

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

Hinz, B., McCulloch, C. A., & Coelho, N. M. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.03.027 · Cited by 182 · see citing works

Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models

Désogère, P. A., Tapias, L. F., Hariri, L. P., Rotile, N. J., Rietz, T. A., Probst, C. K., Blasi, F., Day, H., Mino-Kenudson, M. A., Weinreb, P., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf4696 · Cited by 175 · see citing works

Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices. Disease Modeling and Drug Discovery

Alsafadi, H. N., Uhl, F. E., Pineda, R., Bailey, K. E., Rojas, M. M., Wagner, D. E., & Königshoff, M. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0276tr · Cited by 145 · see citing works

Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice

Goh, K. Y., He, L., Song, J., Jinno, M., Rogers, A. J., Sethu, P., Halade, G. V., Rajasekaran, N. S., Liu, X., Prabhu, S. D., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101100 · Cited by 142 · see citing works

Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis

Lehmann, M., Buhl, L., Alsafadi, H. N., Klee, S., Hermann, S., Mutze, K., Ota, C., Lindner, M., Behr, J., Hilgendorff, A., et al. (2018) · Respiratory Research · doi:10.1186/s12931-018-0876-y · Cited by 136 · see citing works

Biomaterial-induced pathway modulation for bone regeneration

Vermeulen, S., Birgani, Z. N. T., & Habibović, P. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121431 · Cited by 137 · see citing works

Therapeutic targets in idiopathic pulmonary fibrosis

Kolb, M. R. J., Bonella, F., & Wollin, L. (2017) · Respiratory Medicine · doi:10.1016/j.rmed.2017.07.062 · Cited by 132 · see citing works

The extracellular matrix and mechanotransduction in pulmonary fibrosis

Deng, Z., Fear, M. W., Choi, Y. S., Wood, F. M., Allahham, A., Mutsaers, S. E., & Prêle, C. M. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105802 · Cited by 122 · see citing works

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Liao, J., Li, X., & Fan, Y. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.02.026 · Cited by 124 · see citing works

Tissue remodelling in pulmonary fibrosis

Knudsen, L., Ruppert, C., & Ochs, M. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2543-2 · Cited by 117 · see citing works

The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-β and Pulmonary Fibrosis

Savary, G., Dewaeles, E., Diazzi, S., Buscot, M., Nottet, N., Fassy, J., Courcot, E., Hénaoui, I. S., Lemaire, J., Martis, N., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201807-1237oc · Cited by 115 · see citing works

Role of Fibroblasts and Myofibroblasts on the Pathogenesis and Treatment of Pelvic Organ Prolapse

Güler, Z., & Roovers, J. (2022) · Biomolecules · doi:10.3390/biom12010094 · Cited by 111 · see citing works

TGF beta −1, −2 and −3 in the modulation of fibrosis in the cornea and other organs

Wilson, S. E. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108594 · Cited by 108 · see citing works

Effect of pirfenidone on cough in patients with idiopathic pulmonary fibrosis

van Manen, M. J. G., Birring, S. S., Vancheri, C., Vindigni, V., Renzoni, E. A., Russell, A., Wapenaar, M., Cottin, V., & Wijsenbeek, M. S. (2017) · European Respiratory Journal · doi:10.1183/13993003.01157-2017 · Cited by 99 · see citing works

Incorporating mechanical strain in organs-on-a-chip: Lung and skin

Guenat, O. T., & Francois Berthiaume, B. (2018) · Biomicrofluidics · doi:10.1063/1.5024895 · Cited by 95 · see citing works

Matrix biomechanics and dynamics in pulmonary fibrosis

Haak, A. J., Tan, Q., & Tschumperlin, D. J. (2018) · Matrix Biology · doi:10.1016/j.matbio.2017.12.004 · Cited by 95 · see citing works

Mechanical stress-induced mast cell degranulation activates TGF-β1 signalling pathway in pulmonary fibrosis

Shimbori, C., Upagupta, C., Bellaye, P., Ayaub, E. A., Sato, S., Yanagihara, T., Zhou, Q., Ognjanovic, A., Ask, K., Gauldie, J., et al. (2019) · Thorax · doi:10.1136/thoraxjnl-2018-211516 · Cited by 93 · see citing works

When things go wrong: exploring possible mechanisms driving the progressive fibrosis phenotype in interstitial lung diseases

Selman, M., & Pardo, A. (2021) · European Respiratory Journal · doi:10.1183/13993003.04507-2020 · Cited by 91 · see citing works

Synovial Fibrosis Involvement in Osteoarthritis

Zhang, L., Xing, R., Huang, Z., Ding, L., Zhang, L., Li, M., Li, X., Wang, P., & Mao, J. J. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.684389 · Cited by 88 · see citing works

CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype

Zeng, W., Xiong, L., Wu, W., Li, S., Liu, J., Yang, L., Lao, L., Huang, P., Zhang, M., Chen, H., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02540-2 · Cited by 87 · see citing works

Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung

Marchioni, A., Tonelli, R., Cerri, S., Castaniere, I., Andrisani, D., Gozzi, F., Bruzzi, G., Manicardi, L., Moretti, A., Demurtas, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126443 · Cited by 75 · see citing works

Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury?

Albert, R. K., Smith, B. J., Perlman, C. E., & Schwartz, D. A. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201903-0497pp · Cited by 72 · see citing works

Role of pirfenidone in the management of pulmonary fibrosis

Meyer, K. C., & Decker, C. (2017) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s81141 · Cited by 70 · see citing works

Alveolar Micromechanics in Bleomycin-induced Lung Injury

Knudsen, L., López-Rodríguez, E., Berndt, L., Steffen, L., Ruppert, C., Bates, J. H. T., Ochs, M., & Smith, B. J. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0044oc · Cited by 68 · see citing works

HSP47: a potential target for fibrotic diseases and implications for therapy

Bellaye, P., Burgy, O., Bonniaud, P., & Kolb, M. R. J. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1861249 · Cited by 64 · see citing works

The role of LTBPs in TGF beta signaling

Rifkin, D. B., Sachan, N., Singh, K., Sauber, E., Tellides, G., & Ramirez, F. (2021) · Developmental Dynamics · doi:10.1002/dvdy.331 · Cited by 68 · see citing works

Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis

Dolivo, D., Larson, S. A., & Dominko, T. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2880-2 · Cited by 68 · see citing works

New insights into the Hippo/YAP pathway in idiopathic pulmonary fibrosis

Sun, M., Sun, Y., Feng, Z., Kang, X., Yang, W., Wang, Y., & Luo, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105635 · Cited by 64 · see citing works

Pulmonary fibrosis: a disease of alveolar collapse and collagen deposition

Snijder, J., Peraza, J., Padilla, M. L., Capaccione, K. M., & Salvatore, M. M. (2019) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1623028 · Cited by 64 · see citing works

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

Doryab, A., Taş, S., Taskin, M. B., Yang, L., Hilgendorff, A., Gröll, J., Wagner, D. E., & Schmid, O. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201903114 · Cited by 63 · see citing works

Targeting Alveolar Repair in Idiopathic Pulmonary Fibrosis

Ptasinski, V., Stegmayr, J., Belvisi, M. G., Wagner, D. E., & Murray, L. A. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0476tr · Cited by 59 · see citing works

Mechanotransduction Regulates the Interplays Between Alveolar Epithelial and Vascular Endothelial Cells in Lung

Lin, C., Zheng, X., Lin, S., Zhang, Y., Wu, J., & Li, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.818394 · Cited by 59 · see citing works

Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis

Bellaye, P., Shimbori, C., Yanagihara, T., Carlson, D. A., Hughes, P. F., Upagupta, C., Sato, S., Wheildon, N., Haystead, T., Ask, K., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.00386-2017 · Cited by 57 · see citing works

Lysyl Oxidase–Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-β1–induced Pulmonary Fibrosis

Bellaye, P., Shimbori, C., Upagupta, C., Sato, S., Shi, W., Gauldie, J., Ask, K., & Kolb, M. R. J. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0252oc · Cited by 57 · see citing works

Extracellular matrix remodeling in idiopathic pulmonary fibrosis. It is the ‘bed’ that counts and not ‘the sleepers’

Tomos, I. P., Tzouvelekis, A., Aidinis, V., Manali, E. D., Bouros, E., Bouros, D. E., & Papiris, S. A. (2017) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2017.1300533 · Cited by 51 · see citing works

What have we learned from basic science studies on idiopathic pulmonary fibrosis?

Yanagihara, T., Sato, S., Upagupta, C., & Kolb, M. R. J. (2019) · European Respiratory Review · doi:10.1183/16000617.0029-2019 · Cited by 54 · see citing works

New insights into the roles of myofibroblasts and innervation during skin healing and innovative therapies to improve scar innervation

Lebonvallet, N., Laverdet, B., Misery, L., Desmoulière, A., & Girard, D. (2018) · Experimental Dermatology · doi:10.1111/exd.13681 · Cited by 54 · see citing works

Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model

Steffen, L., Ruppert, C., Hoymann, H.-G., Funke, M., Ebener, S., Kloth, C., Mühlfeld, C., Ochs, M., Knudsen, L., & López-Rodríguez, E. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00033.2017 · Cited by 50 · see citing works

Berberine inhibits proliferation and apoptosis of vascular smooth muscle cells induced by mechanical stretch via the PDI/ERS and MAPK pathways

Wang, L., Lie, D., Lin, N., Shi, Y., Chen, J., Zhou, Y., Chen, D., Liu, S., & Li, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118253 · Cited by 48 · see citing works

Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues

Dooling, L. J., Saini, K., Anlaş, A. A., & Discher, D. E. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.06.006 · Cited by 46 · see citing works

Surfactant dysfunction and alveolar collapse are linked with fibrotic septal wall remodeling in the TGF-β1-induced mouse model of pulmonary fibrosis

Beike, L., Wrede, C., Hegermann, J., López-Rodríguez, E., Kloth, C., Gauldie, J., Kolb, M. R. J., Maus, U. A., Ochs, M., & Knudsen, L. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0189-x · Cited by 47 · see citing works

Alveolar Dynamics and Beyond – The Importance of Surfactant Protein C and Cholesterol in Lung Homeostasis and Fibrosis

Sehlmeyer, K., Ruwisch, J., Roldán, N., & López-Rodríguez, E. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00386 · Cited by 46 · see citing works

Amelioration of bleomycin-induced lung fibrosis in rats by valproic acid and butyrate: Role of nuclear factor kappa-B, proinflammatory cytokines and oxidative stress

Kabel, A. M., Omar, M. S., & Elmaaboud, M. A. A. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.08.008 · Cited by 45 · see citing works

Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia

Calthorpe, R. J., Poulter, C., Smyth, A. R., Sharkey, D., Bhatt, J., Jenkins, G. R., & Tatler, A. L. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00106.2021 · Cited by 46 · see citing works

Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts

Wang, A., Cao, S., Stowe, J. C., & Valdez‐Jasso, D. (2021) · Cells · doi:10.3390/cells10051000 · Cited by 43 · see citing works

Tacrolimus ameliorates bleomycin-induced pulmonary fibrosis by inhibiting M2 macrophage polarization via JAK2/STAT3 signaling

Liu, B., Jiang, Q., Chen, R., Gao, S., Xia, Q., Zhu, J., Zhang, F., Shao, C., Liu, X., Li, X., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109424 · Cited by 41 · see citing works

Comparison of oral ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants.

Fakhraee, S. H., Badiee, Z., Mojtahedzadeh, S., Kazemian, M., & Kelishadi, R. (2007) · PubMed · Cited by 41 · see citing works

Excess mechanical stress and hydrogen peroxide remodel extracellular matrix of cultured human uterosacral ligament fibroblasts by disturbing the balance of MMPs/TIMPs via the regulation of TGF-β1 signaling pathway

Zhang, Q., Liu, C., Hong, S., Min, J., Yang, Q. K., Hu, M., Zhao, Y., & Hong, L. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5994 · Cited by 40 · see citing works

Engineering Biomaterials and Approaches for Mechanical Stretching of Cells in Three Dimensions

Zhang, W., Huang, G., & Xu, F. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.589590 · Cited by 42 · see citing works

Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches

Sumi, M. P., & Ghosh, A. (2022) · Cells · doi:10.3390/cells11060976 · Cited by 41 · see citing works

Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism

Li, X., Liu, Y., Tang, Y., & Xia, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1474688 · Cited by 41 · see citing works

Does Breathing Amplify Fibrosis?

Hinz, B., & Suki, B. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201601-0149ed · Cited by 39 · see citing works

Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases

Ezzo, M., & Hinz, B. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108528 · Cited by 38 · see citing works

Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activation

Walker, M., Godin, M., & Pelling, A. E. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa015 · Cited by 36 · see citing works

Pitx2 patterns an accelerator-brake mechanical feedback through latent TGFβ to rotate the gut

Sanketi, B. D., Zuela-Sopilniak, N., Bundschuh, E., Gopal, S., Hu, S., Long, J. T., Lammerding, J., Hopyan, S., & Kurpios, N. A. (2022) · Science · doi:10.1126/science.abl3921 · Cited by 34 · see citing works

Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis

Montesi, S. B., Rao, R., Liang, L. L., Goulart, H. E., Sharma, A., Digumarthy, S. R., Shea, B. S., Seethamraju, R. T., Caravan, P. D., & Tager, A. M. (2018) · European Respiratory Journal · doi:10.1183/13993003.00171-2018 · Cited by 35 · see citing works

Idiopathic Pulmonary Fibrosis

Shimbori, C., Bellaye, P., Kolb, P., & Kolb, M. R. J. (2017) · Milestones in drug therapy · doi:10.1007/978-3-0348-0977-1_3 · Cited by 38 · see citing works

Mechanism of Mechanical Trauma‐Induced Extracellular Matrix Remodeling of Fibroblasts in Association with Nrf2/ARE Signaling Suppression Mediating TGF‐β1/Smad3 Signaling Inhibition

Tang, J., Li, B., Liu, C., Li, Y., Li, Q., Wang, L., Min, J., Hu, M., Hong, S., & Hong, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8524353 · Cited by 35 · see citing works

Epidemiology and Prognostic Significance of Cough in Fibrotic Interstitial Lung Disease

Khor, Y. H., Johannson, K. A., Marcoux, V. S., Fisher, J. H., Assayag, D., Manganas, H., Khalil, N., Kolb, M. R. J., & Ryerson, C. J. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202311-2101oc · Cited by 34 · see citing works

Topographic distribution of idiopathic pulmonary fibrosis: a hybrid physics- and agent-based model

Wellman, T. J., Mondoñedo, J. R., Davis, G. S., Bates, J. H. T., & Suki, B. (2018) · Physiological Measurement · doi:10.1088/1361-6579/aaca86 · Cited by 34 · see citing works

Scar Formation: Cellular Mechanisms

Darby, I. A., & Desmoulière, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-44766-3_3 · Cited by 35 · see citing works

Cough in Idiopathic Pulmonary Fibrosis

Mann, J., Goh, N. S. L., Holland, A. E., & Khor, Y. H. (2021) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2021.751798 · Cited by 35 · see citing works

The Role of Cytokines and Molecular Pathways in Lung Fibrosis Following SARS-CoV-2 Infection: A Physiopathologic (Re)view

Lazăr, M., Săndulescu, M., Barbu, E. C., Chițu, C. E., Andreescu, D. I., Anton, A. N., Erculescu, T. M., Petre, A. M., Duca, G. T., Simion, V., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12030639 · Cited by 33 · see citing works

Scutellarin Suppresses Platelet Aggregation and Stalls Lesional Progression in Mouse With Induced Endometriosis

Ding, D., Cai, X., Zheng, H., Guo, S., & Liu, X. (2018) · Reproductive Sciences · doi:10.1177/1933719118817661 · Cited by 32 · see citing works

Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-β

Ard, S., Reed, E. B., Smolyaninova, L. V., Orlov, S. N., Mutlu, G. M., Guzy, R. D., & Dulin, N. O. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0252le · Cited by 31 · see citing works

The kidney matrisome in health, aging, and disease

Lausecker, F., Lennon, R., & Randles, M. J. (2022) · Kidney International · doi:10.1016/j.kint.2022.06.029 · Cited by 29 · see citing works

Inhibition of AXL ameliorates pulmonary fibrosis via attenuation of M2 macrophage polarisation

Kim, D. H., Kim, H. C., Im, K., Baek, I.-J., Choi, Y. J., Lee, H., Kim, D.-S., Lee, C. W., Jeong, J., Ban, K., et al. (2025) · European Respiratory Journal · doi:10.1183/13993003.00615-2024 · Cited by 31 · see citing works

A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling

Hill, M. R. S., Philp, C. J., Billington, C. K., Tatler, A. L., Johnson, S. R., O’Dea, R. D., & Brook, B. S. (2018) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-018-1037-4 · Cited by 28 · see citing works

Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite

Wu, K. K. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.759199 · Cited by 29 · see citing works

Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors

Jing, T., Miao, X., Jiang, F., Guo, M., Xing, L., Zhang, J., Zuo, D., Lei, H., & Zhai, X. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.02.023 · Cited by 27 · see citing works

Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling

Ramis, J., Middlewick, R., Pappalardo, F., Cairns, J. T., Stewart, I. D., John, A. E., Naveed, S.-U. N., Krishnan, R., Miller, S., Shaw, D. E., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.04361-2020 · Cited by 29 · see citing works

Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report

Auld, S. C., Sheshadri, A., Alexander‐Brett, J. M., Aschner, Y., Barczak, A. K., Basil, M. C., Cohen, K. A., Cruz, C. S. D., McGroder, C. F., Restrepo, M. I., et al. (2024) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202406-651st · Cited by 27 · see citing works

Mechanobiology and the extracellular matrix in pulmonary fibrosis

Ganzleben, I., & Medoff, B. D. (2025) · iScience · doi:10.1016/j.isci.2025.113993 · Cited by 27 · see citing works

Metformin and Glaucoma—Review of Anti-Fibrotic Processes and Bioenergetics

Hurley, D. J., Irnaten, M., & O'Brien, C. J. (2021) · Cells · doi:10.3390/cells10082131 · Cited by 24 · see citing works

Interstitial Lung Disease in Patients With Systemic Sclerosis: Toward Personalized-Medicine-Based Prediction and Drug Screening Models of Systemic Sclerosis-Related Interstitial Lung Disease (SSc-ILD)

Khedoe, P. P. S. J., Marges, E. R., Hiemstra, P. S., Ninaber, M. K., & Geelhoed, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01990 · Cited by 24 · see citing works

The Significance of Subpleural Sparing in CT Chest: A State-of-the-Art Review

Chong, W. H., Saha, B. K., Austin, A., & Chopra, A. (2021) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2021.01.008 · Cited by 24 · see citing works

Corrigendum: Alveolar Dynamics and Beyond – the Importance of Surfactant Protein C and Cholesterol in Lung Homeostasis and Fibrosis

Sehlmeyer, K., Ruwisch, J., Roldán, N., & López-Rodríguez, E. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00943 · Cited by 24 · see citing works

Title: Stretch Induced Activation of TGF-β1 in Pulmonary Fibrosis

Froese, A., Shimbori, C., Bellaye, P., Inman, M. D., Obex, S., Fatima, S., Gauldie, J., & Kolb, M. R. J. (2016)

Mechanical stress-induced mast cell degranulation activates TGFβ-1 signalling pathway in pulmonary fibrosis

Shimbori, C., Bellaye, P., Upagupta, C., Gauldie, J., & Kolb, M. R. J. (2016) · QJM · doi:10.1093/qjmed/hcw118.003 · Cited by 1 · see citing works

Mechanical activation of transforming growth factor Beta 1 in fibrotic lung tissue

Obex, S. (2014)

S75 Cyclical stretch induces gαq/11 mediated tgfβ activation in lung fibroblasts

Goodwin, A. T., Tatler, A., Offermanns, S., & Jenkins, G. R. (2017) · doi:10.1136/thoraxjnl-2017-210983.81

MECHANISMS OF TGFβ ACTIVATION IN LUNG FIBROSIS

Froese, A. (2012) · MacSphere (McMaster University) · doi:10.71548/17268