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Cited by 675Estrogen and related hormone effectsNeuroscience and Neuropharmacology ResearchNuclear Receptors and Signaling

The DOI matches its Crossref record; 324 of the 324 references it cites were found in a registry or an index.

Progesterone receptors: Form and function in brain

Open access
Brinton, Roberta Diaz, Thompson, Richard F., Foy, Michael R., Baudry, Michel, Wang, JunMing, Finch, Caleb E., Morgan, Todd E., Pike, Christian J., Mack, Wendy J., Stanczyk, Frank Z., Nilsen, Jon·2008·Frontiers in Neuroendocrinology
DOI 10.1016/j.yfrne.2008.02.001PMC PMC2398769
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Abstract

Emerging data indicate that progesterone has multiple non-reproductive functions in the central nervous system to regulate cognition, mood, inflammation, mitochondrial function, neurogenesis and regeneration, myelination and recovery from traumatic brain injury. Progesterone-regulated neural responses are mediated by an array of progesterone receptors (PR) that include the classic nuclear PRA and PRB receptors and splice variants of each, the seven transmembrane domain 7TMPRbeta and the membrane-associated 25-Dx PR (PGRMC1). These PRs induce classic regulation of gene expression while also transducing signaling cascades that originate at the cell membrane and ultimately activate transcription factors. Remarkably, PRs are broadly expressed throughout the brain and can be detected in every neural cell type. The distribution of PRs beyond hypothalamic borders, suggests a much broader role of progesterone in regulating neural function. Despite the large body of evidence regarding progesterone regulation of reproductive behaviors and estrogen-inducible responses as well as effects of progesterone metabolite neurosteroids, much remains to be discovered regarding the functional outcomes resulting from activation of the complex array of PRs in brain by gonadally and/or glial derived progesterone. Moreover, the impact of clinically used progestogens and developing selective PR modulators for targeted outcomes in brain is a critical avenue of investigation as the non-reproductive functions of PRs have far-reaching implications for hormone therapy to maintain neurological health and function throughout menopausal aging.

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Crossref · 10.1016/j.yfrne.2008.02.001

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324 of 324 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 3

  1. R.D. Brinton, J. Wang, L. Liu, Progesterone regulation of neural progenitor proliferation, Society for Neuroscience Annual Meeting, San Diego, CA, 2007, pp. 56.16.
  2. J.A.B. Wang, R.D., Allopregnanolone induces a rapid transient rise in intracellular calcium in embryonic hippocampal neurons via L-type calcium channel dependent mechanism, Curr. Alzheimer Res., in press.
  3. L. Zhao, S. Chen, J.M. Wang, R.D. Brinton, 17β-Estradiol induces Ca2+ influx, dendritic and nuclear Ca2+ rise and subsequent CREB activation in hippocampal neurons: a potential initiation mechanism for estrogen neurotrophism, Neuroscience, in press.

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Metadata

Authors
Brinton, R. D., Thompson, R. F., Foy, M. R., Baudry, M., Wang, J., Finch, C. E., Morgan, T. E., Pike, C. J., Mack, W. J., Stanczyk, F. Z., & Nilsen, J.
Affiliations
  • University of Southern California (US)
  • Loyola Marymount University (US)
ORCID
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2008-05
Volume
29
Issue
2
Pages
313-339
ISSN
0091-3022 (ISSN-L)
DOI
10.1016/j.yfrne.2008.02.001
PMC
PMC2398769
OpenAlex
W2113179569
Cited by
675
References
324
Citations by year
2026: 30 · 2025: 30 · 2024: 54 · 2023: 49 · 2022: 41 · 2021: 40 · 2020: 39 · 2019: 29 · 2018: 37 · 2017: 32 · 2016: 36 · 2015: 28 · 2014: 30 · 2013: 40 · 2012: 35
FWCI
3.87
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (P01AG026572)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords
progesterone receptor, progesterone, brain, PGRMC1, neurosteroids, cognition, mood, neuroinflammation, mitochondrial function, neurogenesis, myelination, traumatic brain injury, progestogens, selective progesterone receptor modulators, menopause, hormone therapy
MeSH terms
Alzheimer Disease, Animals, Brain, Brain Chemistry, Female, Humans, Male, Meiosis, Memory, Mitosis, Neuroglia, Neuronal Plasticity, Receptors, Progesterone, Neuroprotective Agents, Protein Isoforms, Cell Proliferation

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