Cited by 675Estrogen and related hormone effectsNeuroscience and Neuropharmacology ResearchNuclear Receptors and Signaling

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Progesterone receptors: Form and function in brain

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Brinton, Roberta Diaz, Thompson, Richard F., Foy, Michael R., Baudry, Michel, Wang, JunMing, Finch, Caleb E., Morgan, Todd E., Pike, Christian J., Mack, Wendy J., Stanczyk, Frank Z., Nilsen, Jon·2008·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2008.02.001PMC PMC2398769

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Abstract

Emerging data indicate that progesterone has multiple non-reproductive functions in the central nervous system to regulate cognition, mood, inflammation, mitochondrial function, neurogenesis and regeneration, myelination and recovery from traumatic brain injury. Progesterone-regulated neural responses are mediated by an array of progesterone receptors (PR) that include the classic nuclear PRA and PRB receptors and splice variants of each, the seven transmembrane domain 7TMPRbeta and the membrane-associated 25-Dx PR (PGRMC1). These PRs induce classic regulation of gene expression while also transducing signaling cascades that originate at the cell membrane and ultimately activate transcription factors. Remarkably, PRs are broadly expressed throughout the brain and can be detected in every neural cell type. The distribution of PRs beyond hypothalamic borders, suggests a much broader role of progesterone in regulating neural function. Despite the large body of evidence regarding progesterone regulation of reproductive behaviors and estrogen-inducible responses as well as effects of progesterone metabolite neurosteroids, much remains to be discovered regarding the functional outcomes resulting from activation of the complex array of PRs in brain by gonadally and/or glial derived progesterone. Moreover, the impact of clinically used progestogens and developing selective PR modulators for targeted outcomes in brain is a critical avenue of investigation as the non-reproductive functions of PRs have far-reaching implications for hormone therapy to maintain neurological health and function throughout menopausal aging.

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Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484
Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy: The Women's Health Initiative Randomized Controlled Trial
(2004) · JAMA · doi:10.1001/jama.291.14.1701 · Cited by 4,534
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506
Self-citation
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Multiple Sclerosis
Noseworthy, J. H., Lucchinetti, C. F., Rodriguez, M., & Weinshenker, B. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431307 · Cited by 3,016
The cerebellum and neural control
Ito, M. (1984) · Cited by 2,314
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., & Paul, S. M. (1986) · Science · doi:10.1126/science.2422758 · Cited by 2,225
Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women
Chlebowski, R. T., Hendrix, S. L., Langer, R. D., Stefanick, M. L., Gass, M. L. S., Lane, D. S., Rodabough, R. J., Gilligan, M. A., Cyr, M. G., Thomson, C. A., et al. (2003) · JAMA · doi:10.1001/jama.289.24.3243 · Cited by 1,871
Apolipoprotein E: Far More Than a Lipid Transport Protein
Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836
The cerebellum and neural control
Tindall, S. C. (1985) · Surgical Neurology · doi:10.1016/0090-3019(85)90320-9 · Cited by 1,760
Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.
Ben-Ari, Y. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90299-4 · Cited by 1,753
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., & Ashe, K. H. (2004) · Nature Neuroscience · doi:10.1038/nn1372 · Cited by 1,722
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
Dudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708
Synaptic Modification by Correlated Activity: Hebb's Postulate Revisited
Bi, G., & Poo, M. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.139 · Cited by 1,525
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., & Greenberg, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182296499 · Cited by 1,507
Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery
Pratt, W. B., & Toft, D. O. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322800201 · Cited by 1,497
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state
Pike, C., Burdick, D., Walencewicz, A., Glabe, C., & Cotman, C. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01676.1993 · Cited by 1,417
Self-citation
Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
Gould, E., Woolley, C., Frankfurt, M., & McEwen, B. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01286.1990 · Cited by 1,406
Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells
Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 1,385
Synaptic plasticity: LTP and LTD
Bear, M. F., & Malenka, R. C. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90101-5 · Cited by 1,355
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
Lorenzo, A., & Yankner, B. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.12243 · Cited by 1,324
Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain
Kuhn, H. G., Winkler, J., Kempermann, G., Thal, L. J., & Gage, F. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05820.1997 · Cited by 1,214
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A. V., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17977 · Cited by 1,201
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317977 · Cited by 1,189
Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative Randomized Controlled Trial. Writing Group for the Women's Health Initiative Investigators. JAMA 2002; 288(3): 321-333
Gebbie, A. E. (2002) · Journal of Family Planning and Reproductive Health Care · doi:10.1783/147118902101196685 · Cited by 1,176
Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons
Woolley, C., Gould, E., Frankfurt, M., & McEwen, B. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-12-04035.1990 · Cited by 1,107
Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance
Majewska, M. D. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90025-a · Cited by 1,089
Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat
Woolley, C. S., & McEwen, B. S. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903360210 · Cited by 1,073
Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses
Blalock, E. M., Geddes, J. W., Chen, K. C., Porter, N. M., Markesbery, W. R., & Landfield, P. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308512100 · Cited by 1,025
Physiological Action of Progesterone in Target Tissues
Graham, J. D., & Clarke, C. L. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.4.0308 · Cited by 1,007
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
Klein, W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01749-5 · Cited by 989
Estrogen Therapy in Postmenopausal Women
Yaffe, K. S., Sawaya, G. F., Lieberburg, I. M., & Grady, D. G. (1998) · JAMA · doi:10.1001/jama.279.9.688 · Cited by 947
Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS
Palmer, T. D., Markakis, E. A., Willhoite, A. R., Safar, F., & Gage, F. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08487.1999 · Cited by 909
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus
Åberg, M. A. I., Åberg, N. D., Hedbäcker, H., Oscarsson, J., & Eriksson, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02896.2000 · Cited by 852
Neurosteroids: biosynthesis and function of these novel neuromodulators
Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0188 · Cited by 820
Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon
Tropepe, V., Sibilia, M. C., Ciruna, B. G., Rossant, J., Wagner, E. F., & van der Kooy, D. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9192 · Cited by 819
Amyloid β-Protein and the Genetics of Alzheimer's Disease
Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18295 · Cited by 804
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
Zhu, Y., Rice, C. D., Pang, Y., Pace, M. C., & Thomas, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336132100 · Cited by 798
Neurogenesis in the Adult Brain
Gage, F. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00612.2002 · Cited by 796
Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
Zhu, Y., Bond, J. E., & Thomas, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436133100 · Cited by 710
Two components of long-term potentiation induced by different patterns of afferent activation
Grover, L. M., & Teyler, T. J. (1990) · Nature · doi:10.1038/347477a0 · Cited by 708
Estradiol Increases the Sensitivity of Hippocampal CA1 Pyramidal Cells to NMDA Receptor-Mediated Synaptic Input: Correlation with Dendritic Spine Density
Woolley, C. S., Weiland, N. G., McEwen, B. S., & Schwartzkroin, P. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01848.1997 · Cited by 695
Estradiol regulates hippocampal dendritic spine density via an N-methyl- D-aspartate receptor-dependent mechanism
Woolley, C. S., & McEwen, B. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07680.1994 · Cited by 679
Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males
Borrás, C., Sastre, J., García-Sala, D., Lloret, A., Pallardó, F. V., & Viña, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01356-4 · Cited by 654
Gender Differences in Acute CNS Trauma and Stroke: Neuroprotective Effects of Estrogen and Progesterone
Roof, R. L., & Hall, E. D. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.367 · Cited by 652
Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy
Turski, L., Ikonomidou, C., Turski, W. A., Bortolotto, Z. A., & Cavalheiro, É. A. (1989) · Synapse · doi:10.1002/syn.890030207 · Cited by 626
DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease
Yang, Y., Geldmacher, D., & Herrup, K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02661.2001 · Cited by 609
Neurogenesis in the Adult Brain: New Strategies for Central Nervous System Diseases
Lie, D. C., Song, H., Colamarino, S. A., Ming, G., & Gage, F. H. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121631 · Cited by 601
ProTECT: A Randomized Clinical Trial of Progesterone for Acute Traumatic Brain Injury
Wright, D. W., Kellermann, A. L., Hertzberg, V., Clark, P. L., Frankel, M., Goldstein, F. C., Salomone, J. P., Dent, L. L., Harris, O. A., Ander, D. S., et al. (2006) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2006.07.932 · Cited by 599
The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons
Singer, C. A., Figueroa, X. A., Batchelor, R. H., & Dorsa, D. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02455.1999 · Cited by 578
GABAergic dysfunction in mood disorders
Brambilla, P., Pérez, J., Barale, F., Schettini, G., & Soares, J. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001362 · Cited by 567
Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
Xu, H., Gouras, G. K., Greenfield, J. P., Vincent, B., Näslund, J., Mazzarelli, L., Fried, G., Jovanovic, J. N., Seeger, M., Relkin, N. R., et al. (1998) · Nature Medicine · doi:10.1038/nm0498-447 · Cited by 563
Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain
Busser, J., Geldmacher, D. S., & Herrup, K. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02801.1998 · Cited by 543
Effects of Estrogen Plus Progestin on Gynecologic Cancers and Associated Diagnostic Procedures The Women's Health Initiative Randomized Trial
Anderson, G. L. (2003) · JAMA · doi:10.1001/jama.290.13.1739 · Cited by 541
Neurosteroids: biochemistry and clinical significance
Mellon, S. H., & Griffin, L. D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00503-3 · Cited by 538
17β-Estradiol Enhances NMDA Receptor-Mediated EPSPs and Long-Term Potentiation
Foy, M. R., Xu, J., Xie, X., Brinton, R. D., Thompson, R. F., & Berger, T. W. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.925 · Cited by 519 · cited 1×
“Electrophysiological studies have shown that E2 enhances hippocampal CA1 synaptic transmission and plasticity by increasing NMDA and AMPA receptor activity, which results in neuronal excitation [268,75,293,294].”
Self-citation
β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease
Mattson, M. P., Barger, S. W., Cheng, B., Lieberburg, I. M., Smith‐Swintosky, V. L., & Rydel, R. E. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90009-b · Cited by 518
Neurogenesis in Adult Mammals: Some Progress and Problems
Gould, E., & Gross, C. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00619.2002 · Cited by 511
Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer’s disease
Yang, Y., Mufson, E. J., & Herrup, K. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02557.2003 · Cited by 483
Progesterone synthesis and myelin formation by Schwann cells
Koenig, H. L., Schumacher, M., Ferzaz, B., Thi, A. N. D., Ressouches, A., Guennoun, R., Jung-Testas, I., Robel, P., Akwa, Y., & Baulieu, E.-E. (1995) · Science · doi:10.1126/science.7770777 · Cited by 480
Extranuclear Steroid Receptors: Nature and Actions
Hammes, S. R., & Levin, E. R. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0022 · Cited by 475
Sedation and Analgesia for Procedures in Children
KRAUSS, B. S., & Green, S. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003303421306 · Cited by 469
Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons
Wong, M., & Moss, R. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-08-03217.1992 · Cited by 462
CREB Couples Neurotrophin Signals to Survival Messages
Finkbeiner, S. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)80866-1 · Cited by 455
Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors
Dubal, D. B., Shughrue, P. J., Wilson, M. E., Merchenthaler, I. J., & Wise, P. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06385.1999 · Cited by 449
The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors
Pratt, W. B. (1998) · Experimental Biology and Medicine · doi:10.3181/00379727-217-44252 · Cited by 446
Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
Lichtenwalner, R. J., Forbes, M. E., Bennett, S. A., Lynch, C. D., Sonntag, W. E., & Riddle, D. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00378-5 · Cited by 428
Fibroblast growth factors and their receptors in the central nervous system
Reuß, B., & Halbach, O. V. B. U. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0756-7 · Cited by 417
Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats☆
Gibbs, R. B. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00103-2 · Cited by 414
Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model
Yue, X., Lu, M. G. W., Lancaster, T., Cao, P., Honda, S., Staufenbiel, M., Harada, N., Zhong, Z., Shen, Y., & Li, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505203102 · Cited by 404
Epidemiology of Endocrine-Related Risk Factors for Breast Cancer
Bernstein, L. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1015714305420 · Cited by 402
Neurogenesis and aging: FGF‐2 and HB‐EGF restore neurogenesis in hippocampus and subventricular zone of aged mice
Jin, K., Sun, Y., Xie, L., Batteur, S., Mao, X. O., Smelick, C., Logvinova, A., & Greenberg, D. A. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00046.x · Cited by 396 · cited 1×
“For example, FGF2 enhances dentate neurogenesis in both neonatal and adult brain [247,209,222,273,48,49,282,85], and intracerebroventricular (ICV) infusions of FGF-2 upregulate dentate neurogenesis in the aged brain [159,85,132,141,160].”
Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone
Griffin, L. D., Gong, W., Verot, L., & Mellon, S. H. (2004) · Nature Medicine · doi:10.1038/nm1073 · Cited by 395
The Neurosteroids Progesterone and Allopregnanolone Reduce Cell Death, Gliosis, and Functional Deficits after Traumatic Brain Injury in Rats
Djebaı̈li, M., Guo, Q., Pettus, E. H., Hoffman, S. W., & Stein, D. G. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.106 · Cited by 387
Physiological Action of Progesterone in Target Tissues
Graham, J. D. (1997) · Endocrine Reviews · doi:10.1210/er.18.4.502 · Cited by 386
Reproductive Functions of Progesterone Receptors
Conneely, O. M. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.339 · Cited by 379
Stimulation of Neonatal and Adult Brain Neurogenesis by Subcutaneous Injection of Basic Fibroblast Growth Factor
Wagner, J. P., Black, I. B., & DiCicco-Bloom, E. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-06006.1999 · Cited by 374
Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.
Simmons, L. K., May, P. C., Tomaselli, K. J., Rydel, R. E., Fuson, K. S., Brigham, E. F., Wright, S., Lieberburg, I. M., Becker, G. W., & Brems, D. N. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10007-2 · Cited by 371
Progesterone and Estrogen Regulate Alzheimer-Like Neuropathology in Female 3xTg-AD Mice
Carroll, J. C., Rosario, E. R., Chang, L., Stanczyk, F. Z., Oddo, S., LaFerla, F. M., & Pike, C. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2718-07.2007 · Cited by 369
Self-citation
Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.
Jaffe, A. B., Toran‐Allerand, C. D., Greengard, P., & Gandy, S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36796-0 · Cited by 363
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
Hardy, J., Duff, K., Hardy, K. G., Pérez‐Tur, J., & Hutton, M. (1998) · Nature Neuroscience · doi:10.1038/1565 · Cited by 356
Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.
Allan, G. F., Leng, X., Tsai, S. Y., Weigel, N. L., Edwards, D. P., Tsai, M., & O’Malley, B. W. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41805-4 · Cited by 352
Minireview: Nuclear Receptor Coactivators--An Update
McKenna, N. J., & O’Malley, B. W. (2002) · Endocrinology · doi:10.1210/endo.143.7.8892 · Cited by 352
Progesterone Regulates Transcription of the p21 Cyclindependent Kinase Inhibitor Gene through Sp1 and CBP/p300
Owen, G. I., Richer, J. K., Tung, L. W., Takimoto, G. S., & Horwitz, K. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10696 · Cited by 348
Brain damage, sex hormones and recovery: a new role for progesterone and estrogen?
Stein, D. G. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01821-x · Cited by 336
Neurosteroid quantification in human brain regions: comparison between Alzheimer’s and nondemented patients
Weill-Engerer, S., David, J.-P., Sazdovitch, V., Liere, P., Eychenne, B., Pianos, A., Schumacher, M., Delacourte, A., Baulieu, E.-E., & Akwa, Y. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020878 · Cited by 333
Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury
HE, J., EVANS, C., Hoffman, S. D., Oyesiku, N. M., & Stein, D. G. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.008 · Cited by 332
Impact of Progestins on Estrogen-Induced Neuroprotection: Synergy by Progesterone and 19-Norprogesterone and Antagonism by Medroxyprogesterone Acetate
Nilsen, J., & Brinton, R. D. (2002) · Endocrinology · doi:10.1210/endo.143.1.8582 · Cited by 331
Self-citation
Gender influences outcome of brain injury: progesterone plays a protective role
Roof, R. L., Duvdevani, R., & Stein, D. G. (1993) · Brain Research · doi:10.1016/0006-8993(93)91526-x · Cited by 327
Stem/progenitor cell proliferation factors FGF‐2, IGF‐1, and VEGF exhibit early decline during the course of aging in the hippocampus: Role of astrocytes
Shetty, A. K., Hattiangady, B., & Shetty, G. A. (2005) · Glia · doi:10.1002/glia.20187 · Cited by 325
Progesterone Facilitates Cognitive Recovery and Reduces Secondary Neuronal Loss Caused by Cortical Contusion Injury in Male Rats
Roof, R. L., Duvdevani, R., Braswell, L., & Stein, D. G. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1147 · Cited by 322
Long-term potentiation: What's learning got to do with it?
Shors, T. J., & Matzel, L. D. (1997) · Behavioral and Brain Sciences · doi:10.1017/s0140525x97001593 · Cited by 320
Steroid and G Protein Binding Characteristics of the Seatrout and Human Progestin Membrane Receptor α Subtypes and Their Evolutionary Origins
Thomas, P., Pang, Y., Dong, J., Groenen, P. M. A., Kelder, J., de Vlieg, J., Zhu, Y., & Tubbs, C. W. (2006) · Endocrinology · doi:10.1210/en.2006-0974 · Cited by 318
Tracking the estrogen receptor in neurons: Implications for estrogen-induced synapse formation
McEwen, B. S., Akama, K. T., Alves, S. E., Brake, W. G., Bulloch, K., Lee, S. D., Li, C., Yuen, G. S., & Milner, T. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121146898 · Cited by 317
Progesterone protects against lipid peroxidation following traumatic brain injury in rats
Roof, R. L., Hoffman, S. W., & Stein, D. G. (1997) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815156 · Cited by 316
Gonadal Steroids: Effects on Excitability of Hippocampal Pyramidal Cells
Teyler, T. J., Vardaris, R. M., LEWIS, D. A., & Rawitch, A. B. (1980) · Science · doi:10.1126/science.7190730 · Cited by 315
Steroid hormones and neurosteroids in normal and pathological aging of the nervous system
Schumacher, M., Weill‐Engerer, S., Lière, P., Robert, F., Franklin, R. J. M., García‐Segura, L. M., Lambert, J. J., Mayo, W., Melcangi, R. C., Párducz, Á., et al. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.004 · Cited by 299
Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1
Groshong, S. D., Owen, G. I., Grimison, B., Schauer, I. E., Todd, M. C., Langan, T. A., Sclafani, R. A., Lange, C. A., & Horwitz, K. B. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.11.0006 · Cited by 298
Progesterone and Estrogen Regulate Oxidative Metabolism in Brain Mitochondria
Irwin, R. W., Yao, J., Hamilton, R. T., Cadenas, E., Brinton, R. D., & Nilsen, J. (2008) · Endocrinology · doi:10.1210/en.2007-1227 · Cited by 289
Self-citation
IGF-I has a direct proliferative effect in adult hippocampal progenitor cells
Åberg, M., Åberg, N. D., Palmer, T. D., Alborn, A., Carlsson‐Skwirut, C., Bang, P., Rosengren, L., Olsson, T., Gage, F. H., & Eriksson, P. S. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00082-4 · Cited by 285
Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain.
Zhou, Y., Watters, J. J., & Dorsa, D. M. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612562 · Cited by 284
Progesterone, 5α-pregnane-3,20-dione and 3α-hydroxy-5α-pregnane-20-one in specific regions of the human female brain in different endocrine states
Bixo, M., Andersson, A., Winblad, B. G., Purdy, R. H., & Bäckström, T. C. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00455-1 · Cited by 280
Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures
Pike, C. J., Walencewicz, A. J., Glabe, C. G., & Cotman, C. W. (1991) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(91)90014-9 · Cited by 274
Self-citation
Progesterone selectively increases amygdala reactivity in women
van Wingen, G. A., van Broekhoven, F., Verkes, R. J., Petersson, K. M., Bäckström, T., Buitelaar, J. K., & Fernández, G. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002030 · Cited by 273
Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose‐ and time‐dependent manner
Tanapat, P., Hastings, N. B., & Gould, E. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20385 · Cited by 270
Progesterone antagonism of the oestrogen receptor and oestrogen-induced uterine growth
Hsueh, A. J. W., Peck, E. J., & Clark, J. H. (1975) · Nature · doi:10.1038/254337a0 · Cited by 269
The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Progenitor Cells and Regulates Cell-Cycle Gene and Protein Expression
Wang, J. M., Johnston, P. B., Ball, B. G., & Brinton, R. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4520-04.2005 · Cited by 267
Self-citation
Steroid-induced meiotic division in Xenopus laevis oocytes: surface and calcium
Baulieu, É.-É., Godeau, F., Schorderet, M., & Schorderet‐Slatkine, S. (1978) · Nature · doi:10.1038/275593a0 · Cited by 266
Mood, Sexuality, Hormones, and the Menstrual Cycle. II. Hormone Levels and Their Relationship to the Premenstrual Syndrome
Bäckström, T. C., Sanders, D., Leask, R., Davidson, D., Warner, P., & Bancroft, J. (1983) · Psychosomatic Medicine · doi:10.1097/00006842-198312000-00004 · Cited by 266
Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date
Döbrössy, M. D., Drapeau, E., Aurousseau, C., Moal, M. L., Piazza, P. V., & Abrous, D. N. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001419 · Cited by 266
Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor
Begliuomini, S., Casarosa, E., Pluchino, N., Lenzi, E., Centofanti, M., Freschi, L., Pieri, M., Genazzani, A. D., Luisi, S. V., & Genazzani, A. R. (2007) · Human Reproduction · doi:10.1093/humrep/del479 · Cited by 257
Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex
Djebaı̈li, M., Hoffman, S. W., & Stein, D. G. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.023 · Cited by 256
Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling
Nilsen, J., & Brinton, R. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1334098100 · Cited by 252
Self-citation
17β-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: A potential initiation mechanism for estrogen-induced neuroprotection
Wu, T.-W., Wang, J.-M., Chen, S.-H., & Brinton, R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.027 · Cited by 249
Self-citation
Progesterone: Therapeutic opportunities for neuroprotection and myelin repair
Schumacher, M., Guennoun, R., Stein, D. G., & Nicola, A. F. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.001 · Cited by 247
Progesterone Rapidly Decreases Brain Edema: Treatment Delayed up to 24 Hours Is Still Effective
Roof, R. L., Duvdevani, R., Heyburn, J. W., & Stein, D. G. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0063 · Cited by 244
Gonadal Steroids Modify Dendritic Spine Density in Ventromedial Hypothalamic Neurons: A Golgi Study in the Adult Rat
Frankfurt, M., Gould, E., Woolley, C. S., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000125387 · Cited by 239
Astrocytes and Microglia Respond to Estrogen with Increased apoE mRNAin Vivoandin Vitro
Stone, D. J., Rozovsky, I., Morgan, T. E., Anderson, C. P., Hajian, H., & Finch, C. E. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6360 · Cited by 237
Self-citation
Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer’s Disease
Stone, D. J., Rozovsky, I., Morgan, T. E., Anderson, C. P., & Finch, C. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03180.1998 · Cited by 237
Self-citation
Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination
Schumacher, M., Guennoun, R., Robert, F., Carelli, C., Gago, N., Ghoumari, A. M., Deniselle, M. C. G., González, S. L., Ibanez, C., Labombarda, F., et al. (2004) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2004.03.007 · Cited by 236
Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury
Pettus, E. H., Wright, D. W., Stein, D. G., & Hoffman, S. W. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.004 · Cited by 235
Newly born cells in the ageing dentate gyrus display normal migration, survival and neuronal fate choice but endure retarded early maturation
Rao, M. S. R., Hattiangady, B., Abdel‐Rahman, A., Stanley, D. P., & Shetty, A. K. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03853.x · Cited by 233
Multipotential stem cells and progenitors in the vertebrate retina
Reh, T. A., & Levine, E. M. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199808)36:2 · Cited by 231
All progestins are not created equal
Stanczyk, F. Z. (2003) · Steroids · doi:10.1016/j.steroids.2003.08.003 · Cited by 226 · cited 2×
“anes (20 carbons) (see Tables 1 and 2) [258].”
Ovariectomy and 17β-estradiol modulate the levels of Alzheimer’s amyloid β peptides in brain
Petanceska, S. S., Nagy, V., Frail, D. E., & Gandy, S. (2000) · Neurology · doi:10.1212/wnl.54.12.2212 · Cited by 225
Long-term potentiation : from biophysics to behavior
Landfield, P. W., & Deadwyler, S. A. (1988) · Liss eBooks · Cited by 223
Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury
Garcı́a‐Estrada, J., del Rı́o, J. A., Luquı́n, S., et al. (1993) · Brain Research · doi:10.1016/0006-8993(93)90964-o · Cited by 223
Progesterone receptor transcription and non-transcription signaling mechanisms
Leonhardt, S. A., Boonyaratanakornkit, V., & Edwards, D. P. (2003) · Steroids · doi:10.1016/s0039-128x(03)00129-6 · Cited by 217
The classical progesterone receptor mediates Xenopus oocyte maturation through a nongenomic mechanism
Bayaa, M., Booth, R. A., Sheng, Y., & Liu, X. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220302597 · Cited by 215
Progesterone Membrane Receptor Component 1 Expression in the Immature Rat Ovary and Its Role in Mediating Progesterone’s Antiapoptotic Action
Peluso, J. J., Pappalardo, A., Lösel, R., & Wehling, M. (2006) · Endocrinology · doi:10.1210/en.2006-0114 · Cited by 214
Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester
Savage, M. J., Trusko, S. P., Howland, D. S., Pinsker, L. R., Mistretta, S., Reaume, A. G., Greenberg, B. D., Siman, R., & Scott, R. W. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01743.1998 · Cited by 213
Heparin-Binding Epidermal Growth Factor-Like Growth Factor: Hypoxia-Inducible ExpressionIn Vitroand Stimulation of NeurogenesisIn VitroandIn Vivo
Jin, K., Mao, X. O., Sun, Y., Xie, L., Jin, L., Nishi, E., Klagsbrun, M., & Greenberg, D. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05365.2002 · Cited by 207
Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3‐nitroproprionic acid in SK‐N‐SH human neuroblastoma cells
Wang, J., Green, P. S., & Simpkins, J. W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00271.x · Cited by 205
Self-citation
The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA
Conneely, O. M., Maxwell, B. L., Toft, D. O., Schrader, W. T., & O’Malley, B. W. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90395-0 · Cited by 203
The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents
Frye, C. A. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00119-9 · Cited by 201
VEGF is a chemoattractant for FGF-2–stimulated neural progenitors
Zhang, H., Vutskits, L., Pepper, M. S., & Kiss, J. Z. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200308040 · Cited by 200
Convergence of Progesterone and Epidermal Growth Factor Signaling in Breast Cancer
Lange, C. A., Richer, J. K., Shen, T., & Horwitz, K. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31308 · Cited by 200
Distribution of estrogen receptor beta (ERβ) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement
Gundlah, C., Kohama, S. G., Mirkes, S. J., Garyfallou, V. T., Urbanski, H. F., & Bethea, C. L. (2000) · Molecular Brain Research · doi:10.1016/s0006-8993(99)02475-0 · Cited by 199
The neurosteroid 3α,5α-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy
Frye, C. A. (1995) · Brain Research · doi:10.1016/0006-8993(95)00793-p · Cited by 197
Multiplicity of Progesterone's Actions and Receptors in the Mammalian Ovary1
Peluso, J. J. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.105.049924 · Cited by 197
A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors
Krebs, C. J., Jarvis, E. D., Chan, J. S. W., Lydon, J. P., Ogawa, S., & Pfaff, D. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12816 · Cited by 195
Progesterone Receptor Membrane Component-1 (PGRMC1) Is the Mediator of Progesterone’s Antiapoptotic Action in Spontaneously Immortalized Granulosa Cells As Revealed by PGRMC1 Small Interfering Ribonucleic Acid Treatment and Functional Analysis of PGRMC1 Mutations
Peluso, J. J., Romak, J. J., & Liu, X. (2007) · Endocrinology · doi:10.1210/en.2007-1050 · Cited by 195
Ovarian Hormones Elicit Phosphorylation of Akt and Extracellular-Signal Regulated Kinase in Explants of the Cerebral Cortex
Singh, M. (2001) · Endocrine · doi:10.1385/endo:14:3:407 · Cited by 194
Allopregnanolone inhibits learning in the Morris water maze
Johansson, I., Birzniece, V., Lindblad, C., Olsson, T., & Bäckström, T. C. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02414-9 · Cited by 193
Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: A multimodal analysis
Leonelli, E., Bianchi, R., Cavaletti, G., Caruso, D., Crippa, D., García‐Segura, L. M., Lauria, G., Magnaghi, V., Roglio, I., & Melcangi, R. C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.014 · Cited by 192
Estrogens and neuroprotection
Wise, P. M. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00611-2 · Cited by 191
From oocyte maturation to the in vitro cell cycle: the history of discoveries of Maturation-Promoting Factor (MPF) and Cytostatic Factor (CSF)
Masui, Y. (2001) · Differentiation · doi:10.1046/j.1432-0436.2001.690101.x · Cited by 189
Neuroprotective properties of 17β‐estradiol, progesterone, and raloxifene in MPTP C57Bl/6 mice
Callier, S., Morissette, M., Grandbois, M., Pélaprat, D., & Paolo, T. D. (2001) · Synapse · doi:10.1002/syn.1067 · Cited by 186
EstradiolIn VivoRegulation of Brain Mitochondrial Proteome
Nilsen, J., Irwin, R. W., Gallaher, T. K., & Brinton, R. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4391-07.2007 · Cited by 184
Self-citation
Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: recent insights and remaining challenges.Preprint
Brinton, R. (2001) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.39601 · Cited by 183
Self-citation
Patients with Premenstrual Syndrome Have a Different Sensitivity to a Neuroactive Steroid during the Menstrual Cycle Compared to Control Subjects
Sundström, I., Andersson, A., Nyberg, S., Ashbrook, D., Purdy, R. H., & Bäckström, T. (1998) · Neuroendocrinology · doi:10.1159/000054307 · Cited by 182
Convergence of Progesterone with Growth Factor and Cytokine Signaling in Breast Cancer
Richer, J. K., Lange, C. A., Manning, N. G., Owen, G. I., Powell, R. L., & Horwitz, K. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31317 · Cited by 181
Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice
Reddy, D. S., Castaneda, D. C., O’Malley, B. W., & Rogawski, M. A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.065268 · Cited by 181
The Role of Hormones and Hormonal Treatments in Premenstrual Syndrome
m, T. R. B. C., Andréen, L., Birzniece, V., rn, I. B., Johansson, I., Nordenstam-Haghjo, M., Nyberg, S., Poromaa, I. S., m, G. R. W., Wang, M., et al. (2003) · CNS Drugs · doi:10.2165/00023210-200317050-00003 · Cited by 180
Progesterone Protects against Necrotic Damage and Behavioral Abnormalities Caused by Traumatic Brain Injury
Shear, D. A., Galani, R., Hoffman, S. W., & Stein, D. G. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.8020 · Cited by 179
Hormone Replacement Therapy Regimens and Breast Cancer Risk
Weiss, L. K., Burkman, R. T., Cushing‐Haugen, K. L., Voigt, L. F., Simon, M. S., Daling, J. R., Norman, S. A., Bernstein, L., Ursin, G., Marchbanks, P. A., et al. (2002) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(02)02502-4 · Cited by 176
Modulation of Aβ peptides by estrogen in mouse models
Zheng, H., Xu, H., Uljon, S., Gross, R., Hardy, K. G., Gaynor, J., LaFrancois, J. J., Simpkins, J. W., Refolo, L. M., Petanceska, S. S., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00690.x · Cited by 175
Progesterone induces a rapid increase in [Ca2+]in of Xenopus laevis oocytes.
Wasserman, W. W., Pinto, L. H., O’Connor, C. M., et al. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1534 · Cited by 171
Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System
Schumacher, M., Guennoun, R., Ghoumari, A. M., Massaad, C., Robert, F., El‐Etr, M., Akwa, Y., Rajkowski, K. M., & Baulieu, É.-É. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0050 · Cited by 170
Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum
Geinisman, Y., Ganeshina, O., Yoshida, R., Berry, R. W., Disterhoft, J. F., & Gallagher, M. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.001 · Cited by 166
Mitochondria as Therapeutic Targets of Estrogen Action in the Central Nervous System
Nilsen, J., & Brinton, R. D. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337193 · Cited by 166
Self-citation
Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia
Gibson, C. L., Constantin, D., Prior, M. J. W., et al. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.01.009 · Cited by 164
Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice.
Kokate, T. G., Banks, M. K., Magee, T., Yamaguchi, S., & Rogawski, M. A. (1999) · PubMed · Cited by 164
Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle‐aged ovariectomized female rats
Bimonte‐Nelson, H. A., Francis, K. R., Umphlet, C. D., & Granholm, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04867.x · Cited by 163
Finasteride, a 5α-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice
Kokate, T. G., Banks, M. K., Magee, T., Yamaguchi, S., & Rogawski, M. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38006-1 · Cited by 163
Changes in Progesterone Receptor Isoforms Content in the Rat Brain During the Oestrous Cycle and After Oestradiol and Progesterone Treatments
Guerra‐Araiza, C., Cruz, O. V., González‐Arenas, A., Chavira, R., & Camacho‐Arroyo, I. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01088.x · Cited by 162
Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats
Azcoitia, Í. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00234-8 · Cited by 162
Progesterone inhibits human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors.
Dai, D. D., Wolf, D. M., Litman, E. S., White, M. J., & Leslie, K. K. (2002) · PubMed · Cited by 161
Hormonal Regulation of CREB Phosphorylation in the Anteroventral Periventricular Nucleus
Gu, G., Rojo, A. A., Zee, M. C., Yu, J., & Simerly, R. B. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03035.1996 · Cited by 156
Estrogen Activation of Cyclic Adenosine 5′-Monophosphate Response Element-Mediated Transcription Requires the Extracellularly Regulated Kinase/Mitogen-Activated Protein Kinase Pathway
Wade, C. B., & Dorsa, D. M. (2003) · Endocrinology · doi:10.1210/en.2002-220899 · Cited by 156
Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats
Robertson, C. L., Puskar, A., Hoffman, G. E., Murphy, A. Z., Saraswati, M., & Fiskum, G. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.09.014 · Cited by 152
Reduced Progesterone Metabolites Protect Rat Hippocampal Neurones From Kainic Acid Excitotoxicity In Vivo
Ciriza, I., Azcoitia, Í., & García‐Segura, L. M. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01121.x · Cited by 151
Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes
Fabian, J., Morrison, D. K., & Daar, I. O. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.3.645 · Cited by 150
Dehydroepiandrosterone, pregnenolone and sexsteroids down‐regulate reactive astroglia in the male ratbrain after a penetrating brain injury
Garcı́a‐Estrada, J., Luquı́n, S., Fernandez, A. M., & García‐Segura, L. M. (1999) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00065-3 · Cited by 150
Speedy: a novel cell cycle regulator of the G2/M transition
Lenormand, J., Dellinger, R. W., Knudsen, K. E., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1869 · Cited by 150
Gene Expression of Progesterone Receptor Isoforms in the Rat Brain
Kato, J., Hirata, S., Nozawa, A., & Yamada-Mouri, N. (1994) · Hormones and Behavior · doi:10.1006/hbeh.1994.1043 · Cited by 149
Neuroprotection by transforming growth factor-β1 involves activation of nuclear factor-κB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways
Zhu, Y., Culmsee, C., Klumpp, S., & Krieglstein, J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.037 · Cited by 149
Allopregnanolone, a progesterone metabolite, enhances behavioral recovery and decreases neuronal loss after traumatic brain injury
He, J., Hoffman, S. W., & Stein, D. G. (2004) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2004-00243 · Cited by 146
How Progesterone Impairs Memory for Biologically Salient Stimuli in Healthy Young Women
van Wingen, G. A., van Broekhoven, F., Verkes, R. J., Petersson, K. M., Bäckström, T. C., Buitelaar, J. K., & Fernández, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1715-07.2007 · Cited by 142
Estrogen Lowers Alzheimer β-Amyloid Generation by Stimulating trans-Golgi Network Vesicle Biogenesis
Greenfield, J. P., Leung, L. W., Cai, D., Kaasik, K., Gross, R. S., Rodriguez-Boulan, E. J., Greengard, P., & Xu, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110009200 · Cited by 137
Isoform/variant mRNAs for sex steroid hormone receptors in humans
Hirata, S., Shoda, T., Kato, J., & Hoshi, K. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00028-6 · Cited by 136
Distribution of cells containing progesterone receptor mRNA in the female rat di- and telencephalon: an in situ hybridization study
Hagihara, K., Hirata, S., Osada, T., Hirai, M., & Kato, J. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90179-f · Cited by 134
Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment
Hoffman, G. E. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00104-3 · Cited by 133
Bidirectional transcription regulation of glial fibrillary acidic protein by estradiol in vivo and in vitro.
Stone, D., Song, Y., Anderson, C. P., Krohn, K., Finch, C., & Rozovsky, I. (1998) · Endocrinology · doi:10.1210/endo.139.7.6084 · Cited by 133
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Baulieu, É.-É., & Schumacher, M. (2000) · Steroids · doi:10.1016/s0039-128x(00)00173-2 · Cited by 133
Dimerization of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90-kDa heat shock protein.
DeMarzo, A. M., Beck, C. A., Oñate, S. A., & Edwards, D. P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.72 · Cited by 132
Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor α knockout mouse uterus
Curtis, S. W., Clark, J. A., Myers, P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3646 · Cited by 131
Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain
Guerra‐Araiza, C., Coyoy-Salgado, A., & Camacho‐Arroyo, I. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00845-6 · Cited by 131
Free calcium changes associated with hormone action in amphibian oocytes
Moreau, M., Vilain, J., & Guerrier, P. (1980) · Developmental Biology · doi:10.1016/0012-1606(80)90329-2 · Cited by 130
17β-estradiol induces Ca2+ influx, dendritic and nuclear Ca2+ rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: A potential initiation mechanism for estrogen neurotrophism
Zhao, L.-Q., Chen, S.-H., Wang, M. J., & Brinton, R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.054 · Cited by 129
Self-citation
17α-estradiol and 17β-estradiol treatments are effective in lowering cerebral amyloid-β levels in AβPPSWE transgenic mice
Levin-Allerhand, J. A., Lominska, C. E., Wang, J. R., & Smith, J. D. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4601 · Cited by 129
Self-citation
Progesterone Neuroprotection in the Wobbler Mouse, a Genetic Model of Spinal Cord Motor Neuron Disease
Deniselle, M. C. G. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0564 · Cited by 128
Neurogenesis and brain injury: managing a renewable resource for repair
Hallbergson, A. F., Gnatenco, C., & Peterson, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20098 · Cited by 126
Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25‐Dx expression in the rat spinal cord
Labombarda, F., González, S. L., Deniselle, M. C. G., Vinson, G. P., Schumacher, M., Nicola, A. F. D., & Guennoun, R. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02055.x · Cited by 123
Specific Progesterone Binding to a Membrane Protein and Related Nongenomic Effects on Ca2+-Fluxes in Sperm
Falkenstein, E., Heck, M., Gerdes, D., Grube, D. F., Christ, M., Weigel, M., Buddhikot, M., Meizel, S., & Wehling, M. (1999) · Endocrinology · doi:10.1210/endo.140.12.7304 · Cited by 123
Electrophysiological evidence for a rapid membrane action of the gonadal steroid, 17β-estradiol, on CA1 pyramidal neurons of the rat hippocampus
Wong, M., & Moss, R. L. (1991) · Brain Research · doi:10.1016/0006-8993(91)91057-8 · Cited by 123

Research works printed but not linked: 3

R.D. Brinton, J. Wang, L. Liu, Progesterone regulation of neural progenitor proliferation, Society for Neuroscience Annual Meeting, San Diego, CA, 2007, pp. 56.16.
J.A.B. Wang, R.D., Allopregnanolone induces a rapid transient rise in intracellular calcium in embryonic hippocampal neurons via L-type calcium channel dependent mechanism, Curr. Alzheimer Res., in press.
L. Zhao, S. Chen, J.M. Wang, R.D. Brinton, 17β-Estradiol induces Ca2+ influx, dendritic and nuclear Ca2+ rise and subsequent CREB activation in hippocampal neurons: a potential initiation mechanism for estrogen neurotrophism, Neuroscience, in press.

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Authors: Brinton, R. D., Thompson, R. F., Foy, M. R., Baudry, M., Wang, J., Finch, C. E., Morgan, T. E., Pike, C. J., Mack, W. J., Stanczyk, F. Z., & Nilsen, J.
Affiliations: University of Southern California (US)
Loyola Marymount University (US)
ORCID: Baudry, Michel
Finch, Caleb E.
Morgan, Todd E.
Pike, Christian J.
Mack, Wendy J.
Stanczyk, Frank Z.
Nilsen, Jon
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2008-05
Volume: 29
Issue: 2
Pages: 313-339
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2008.02.001
PMC: PMC2398769
OpenAlex: W2113179569
Cited by: 675
References: 324
Citations by year: 2026: 30 · 2025: 30 · 2024: 54 · 2023: 49 · 2022: 41 · 2021: 40 · 2020: 39 · 2019: 29 · 2018: 37 · 2017: 32 · 2016: 36 · 2015: 28 · 2014: 30 · 2013: 40 · 2012: 35
FWCI: 3.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P01AG026572)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: progesterone receptor, progesterone, brain, PGRMC1, neurosteroids, cognition, mood, neuroinflammation, mitochondrial function, neurogenesis, myelination, traumatic brain injury, progestogens, selective progesterone receptor modulators, menopause, hormone therapy
MeSH terms: Alzheimer Disease, Animals, Brain, Brain Chemistry, Female, Humans, Male, Meiosis, Memory, Mitosis, Neuroglia, Neuronal Plasticity, Receptors, Progesterone, Neuroprotective Agents, Protein Isoforms, Cell Proliferation

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Progesterone receptors: Form and function in brain

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