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Cited by 489

The DOI matches its Crossref record; 232 of the 232 references it cites were found in a registry or an index.

Sex differences in Parkinson’s disease

Open access
Gillies, Glenda E., Pienaar, Ilse S., Vohra, Shiv, Qamhawi, Zahi·2014·Frontiers in Neuroendocrinology
DOI 10.1016/j.yfrne.2014.02.002
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Abstract

Parkinson's disease (PD) displays a greater prevalence and earlier age at onset in men. This review addresses the concept that sex differences in PD are determined, largely, by biological sex differences in the NSDA system which, in turn, arise from hormonal, genetic and environmental influences. Current therapies for PD rely on dopamine replacement strategies to treat symptoms, and there is an urgent, unmet need for disease modifying agents. As a significant degree of neuroprotection against the early stages of clinical or experimental PD is seen, respectively, in human and rodent females compared with males, a better understanding of brain sex dimorphisms in the intact and injured NSDA system will shed light on mechanisms which have the potential to delay, or even halt, the progression of PD. Available evidence suggests that sex-specific, hormone-based therapeutic agents hold particular promise for developing treatments with optimal efficacy in men and women.

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Metadata

Authors
Gillies, G. E., Pienaar, I. S., Vohra, S., & Qamhawi, Z.
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2014-08
Volume
35
Issue
3
Pages
370-384
ISSN
0091-3022 (ISSN-L)
DOI
10.1016/j.yfrne.2014.02.002
OpenAlex
W1993241967
Cited by
489
References
232
FWCI
17.07
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Sex differences in Parkinson’s disease. https://app.cochat.ai/papers/10.1016/j.yfrne.2014.02.002
The paper
Gillies, G. E., Pienaar, I. S., Vohra, S., & Qamhawi, Z. (2014). Sex differences in Parkinson’s disease. Frontiers in Neuroendocrinology. https://doi.org/10.1016/j.yfrne.2014.02.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.