Cited by 1,540Sex and Gender in HealthcareSexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Why sex matters for neuroscience

Cahill, Larry·2006·Nature Reviews Neuroscience

Abstract

A rapidly burgeoning literature documents copious sex influences on brain anatomy, chemistry and function. This article highlights some of the more intriguing recent discoveries and their implications. Consideration of the effects of sex can help to explain seemingly contradictory findings. Research into sex influences is mandatory to fully understand a host of brain disorders with sex differences in their incidence and/or nature. The striking quantity and diversity of sex-related influences on brain function indicate that the still widespread assumption that sex influences are negligible cannot be justified, and probably retards progress in our field.

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Crossref · 10.1038/nrn1909

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Authors
Cahill, L.
Affiliations
University of California, Irvine (US)
Corresponding author
Cahill, Larry
Venue
Nature Reviews Neuroscience
Published
2006-05-10
Volume
7
Issue
6
Pages
477-484
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2000567681
Cited by
1,540
References
98
Citations by year
2026: 38 · 2025: 55 · 2024: 46 · 2023: 46 · 2022: 67 · 2021: 86 · 2020: 128 · 2019: 86 · 2018: 71 · 2017: 81 · 2016: 103 · 2015: 84 · 2014: 98 · 2013: 85 · 2012: 91
FWCI
10.42
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Keywords
sex differences, sex hormones, neuroanatomy, neurochemistry, brain function, sex differences in disease incidence, sex as a biological variable
MeSH terms
Animals, Brain, Female, Humans, Male, Memory, Neurosciences, Serotonin, Sex Factors, Maze Learning

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