CoChat
Sign Up
Cited by 37Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

Dynamic transcriptome profiling in DNA damage-induced cellular senescence and transient cell-cycle arrest

Open access
Zhao, Zhen, Dong, Qiongye, Liu, Xuehui, Wei, Lei, Liu, Liyang, Li, Yanda, Wang, Xiaowo·2020·Genomics
DOI 10.1016/j.ygeno.2019.07.020
Open this paper in CoChat — free accountOpen PDF

Abstract

Cellular senescence is an irreversible cell cycle arrest process associated with aging and senescence-related diseases. DNA damage is an extensive feature of cellular senescence and aging. Different levels of DNA damage could lead to cellular senescence or transient cell-cycle arrest, but the genetic regulatory mechanisms determining cell fate are still not clear. In this work, high-resolution time course analysis of gene expression in DNA damage-induced cellular senescence and transient cell-cycle arrest was used to explore the transcriptomic differences between different cell fates after DNA damage response and to investigate the key regulatory factors affecting senescent cell fates. Pathways such as the cell cycle, DNA repair and cholesterol metabolism showed characteristic differential response. A number of key transcription factors were predicted to regulating cell cycle and DNA repair. Our study provides genome-wide insights into the molecular-level mechanisms of senescent cell fate decisions after DNA damage response.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.ygeno.2019.07.020

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

No citation lists for this paper

No citation lists for this paper yet — checked again daily.

References 66 · Cited by 37

Research works printed but not linked: 62

  1. D. Munoz-Espin, M. Serrano, Cellular senescence: from physiology to pathology, Nat. Rev. Mol. Cell Biol. 15 (7) (2014) 482-496 Epub 2014/06/24 https://doi.org/ 10.1038/nrm3823 (PubMed PMID: 24954210). · DOI · Paper page
  2. N. Bhatia-Dey, R.R. Kanherkar, S.E. Stair, E.O. Makarev, A.B. Csoka, Cellular se- nescence as the causal Nexus of aging, Front. Genet. 7 (2016) 13, https://doi.org/ 10.3389/fgene.2016.00013 (PubMed PMID: 26904101; PubMed Central PMCID: PMCPMC4751276). · DOI
  3. L. Galluzzi, J.M. Bravo-San Pedro, G. Kroemer, Autophagy mediates tumor sup- pression via cellular senescence, Trends Cell Biol. 26 (1) (2016) 1-3, https://doi. org/10.1016/j.tcb.2015.11.001 (PubMed PMID: 26612212). · DOI
  4. J. Chang, Y. Wang, L. Shao, R.M. Laberge, M. Demaria, J. Campisi, et al., Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice, Nat. Med. 22 (1) (2016) 78-83, https://doi.org/10.1038/nm.4010 (PubMed PMID: 26657143; PubMed Central PMCID: PMCPMC4762215). · DOI · Paper page
  5. O.A. Sedelnikova, I. Horikawa, D.B. Zimonjic, N.C. Popescu, W.M. Bonner, J.C. Barrett, Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks, Nat. Cell Biol. 6 (2) (2004) 168-170, https:// doi.org/10.1038/ncb1095 (PubMed PMID: 14755273). · DOI · Paper page
  6. Z. Tu, K.M. Aird, B.G. Bitler, J.P. Nicodemus, N. Beeharry, B. Xia, et al., Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence, Dev. Cell 21 (6) (2011) 1077-1091, https://doi.org/10.1016/j.devcel.2011.10.010 (PubMed PMID: 22137763; PubMed Central PMCID: PMCPMC3241855). · DOI
  7. L. Hayflick, The limited in vitro lifetime of human diploid cell strains, Exp. Cell Res. 37 (1965) 614-636 (PubMed PMID: 14315085).
  8. J. Li, M.S. Bonkowski, S. Moniot, D. Zhang, B.P. Hubbard, A.J. Ling, et al., A conserved NAD+ binding pocket that regulates protein-protein interactions during aging, Science. 355 (6331) (2017) 1312-1317, https://doi.org/10.1126/science. aad8242 (PubMed PMID: 28336669). · DOI
  9. W. Shi, M.K. Tang, Y. Yao, C. Tang, Y.L. Chui, K.K. Lee, BRE plays an essential role in preventing replicative and DNA damage-induced premature senescence, Sci. Rep. 6 (2016) 23506, , https://doi.org/10.1038/srep23506 (PubMed PMID: 27001068; PubMed Central PMCID: PMCPMC4802329). · DOI
  10. P. Cekan, K. Hasegawa, Y. Pan, E. Tubman, D. Odde, J.Q. Chen, et al., RCC1-de- pendent activation of ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence, Mol. Biol. Cell 27 (8) (2016) 1346-1357, https:// doi.org/10.1091/mbc.E16-01-0025 (PubMed PMID: 26864624; PubMed Central PMCID: PMCPMC4831887). · DOI
  11. Y.M. Kim, H.O. Byun, B.A. Jee, H. Cho, Y.H. Seo, Y.S. Kim, et al., Implications of time-series gene expression profiles of replicative senescence, Aging Cell 12 (4) (2013) 622-634, https://doi.org/10.1111/acel.12087 (PubMed PMID: 23590226). · DOI · Paper page
  12. A.R. Young, M. Narita, M. Ferreira, K. Kirschner, M. Sadaie, J.F. Darot, et al., Autophagy mediates the mitotic senescence transition, Genes Dev. 23 (7) (2009) 798-803 Epub 2009/03/13 https://doi.org/10.1101/gad.519709 (PubMed PMID: 19279323; PubMed Central PMCID: PMCPMC2666340). · DOI · Paper page
  13. A. Ciccia, S.J. Elledge, The DNA damage response: making it safe to play with knives, Mol Cell. 40 (2) (2010) 179-204 Epub 2010/10/23 https://doi.org/10. 1016/j.molcel.2010.09.019 (PubMed PMID: 20965415; PubMed Central PMCID: PMCPMC2988877). · DOI · Paper page
  14. V. Gorbunova, A. Seluanov, Z. Mao, C. Hine, Changes in DNA repair during aging, Nucleic Acids Res. 35 (22) (2007) 7466-7474, https://doi.org/10.1093/nar/ gkm756 (PubMed PMID: 17913742; PubMed Central PMCID: PMCPMC2190694). · DOI · Paper page
  15. J.E. Purvis, K.W. Karhohs, C. Mock, E. Batchelor, A. Loewer, G. Lahav, p53 dy- namics control cell fate, Science. 336 (6087) (2012) 1440-1444, https://doi.org/ 10.1126/science.1218351 (PubMed PMID: 22700930; PubMed Central PMCID: PMCPMC4162876). · DOI · Paper page
  16. A. Ocampo, P. Reddy, P. Martinez-Redondo, A. Platero-Luengo, F. Hatanaka, T. Hishida, et al., In Vivo amelioration of age-associated hallmarks by partial re- programming, Cell 167 (7) (2016) 1719-33 e12, https://doi.org/10.1016/j.cell. 2016.11.052 (PubMed PMID: 27984723). · DOI · Paper page
  17. L. Cao, W. Li, S. Kim, S.G. Brodie, C.X. Deng, Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform, Genes Dev. 17 (2) (2003) 201-213, https://doi.org/10.1101/gad.1050003 (PubMed PMID: 12533509; PubMed Central PMCID: PMCPMC195980). · DOI · Paper page
  18. J.H. Chen, C.N. Hales, S.E. Ozanne, DNA damage, cellular senescence and orga- nismal ageing: causal or correlative? Nucleic Acids Res. 35 (22) (2007) 7417-7428, https://doi.org/10.1093/nar/gkm681 (PubMed PMID: 17913751; PubMed Central PMCID: PMCPMC2190714). · DOI
  19. M. Brenner, V.J. Hearing, The protective role of melanin against UV damage in human skin, Photochem. Photobiol. 84 (3) (2008) 539-549, https://doi.org/10. 1111/j.1751-1097.2007.00226.x (PubMed PMID: 18435612; PubMed Central PMCID: PMCPMC2671032). · DOI · Paper page
  20. M. Deschenes, B. Chabot, The emerging role of alternative splicing in senescence and aging, Aging Cell (2017), https://doi.org/10.1111/acel.12646 (PubMed PMID: 28703423). · DOI
  21. A. Budovsky, T. Craig, J. Wang, R. Tacutu, A. Csordas, J. Lourenco, et al., LongevityMap: a database of human genetic variants associated with longevity, Trends Genet. 29 (10) (2013) 559-560, https://doi.org/10.1016/j.tig.2013.08.003 (PubMed PMID: 23998809). · DOI
  22. D. Kim, G. Pertea, C. Trapnell, H. Pimentel, R. Kelley, S.L. Salzberg, TopHat2: ac- curate alignment of transcriptomes in the presence of insertions, deletions and gene fusions, Genome Biol. 14 (4) (2013) R36, https://doi.org/10.1186/gb-2013-14-4- r36 (PubMed PMID: 23618408; PubMed Central PMCID: PMCPMC4053844). · DOI · Paper page
  23. S. Anders, P.T. Pyl, W. Huber, HTSeq-a Python framework to work with high- throughput sequencing data, Bioinformatics. 31 (2) (2015) 166-169, https://doi. org/10.1093/bioinformatics/btu638 (PubMed PMID: 25260700; PubMed Central PMCID: PMCPMC4287950). · DOI · Paper page
  24. S. Anders, W. Huber, Differential expression analysis for sequence count data, Genome Biol. 11 (10) (2010) R106, https://doi.org/10.1186/gb-2010-11-10-r106 (PubMed PMID: 20979621; PubMed Central PMCID: PMCPMC3218662). · DOI · Paper page
  25. L. Wang, Z. Feng, X. Wang, X. Wang, X. Zhang, DEGseq: an R package for identi- fying differentially expressed genes from RNA-seq data, Bioinformatics. 26 (1) (2010) 136-138, https://doi.org/10.1093/bioinformatics/btp612 (PubMed PMID: 19855105). · DOI · Paper page
  26. M.J. Nueda, S. Tarazona, A. Conesa, Next maSigPro: updating maSigPro bio- conductor package for RNA-seq time series, Bioinformatics. 30 (18) (2014) 2598-2602, https://doi.org/10.1093/bioinformatics/btu333 (PubMed PMID: 24894503; PubMed Central PMCID: PMCPMC4155246). · DOI
  27. M.H. Schulz, W.E. Devanny, A. Gitter, S. Zhong, J. Ernst, Z. Bar-Joseph, DREM 2.0: improved reconstruction of dynamic regulatory networks from time-series expres- sion data, BMC Syst. Biol. 6 (2012) 104, https://doi.org/10.1186/1752-0509-6-104 (PubMed PMID: 22897824; PubMed Central PMCID: PMCPMC3464930). · DOI
  28. D. Xu, H. Tahara, The role of exosomes and microRNAs in senescence and aging, Adv. Drug Deliv. Rev. 65 (3) (2013) 368-375, https://doi.org/10.1016/j.addr. 2012.07.010 (PubMed PMID: 22820533). · DOI
  29. J. Ratajczak, M. Wysoczynski, F. Hayek, A. Janowska-Wieczorek, M.Z. Ratajczak, Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication, Leukemia. 20 (9) (2006) 1487-1495, https://doi.org/ 10.1038/sj.leu.2404296 (PubMed PMID: 16791265). · DOI · Paper page
  30. D.A. Rockx, R. Mason, A. van Hoffen, M.C. Barton, E. Citterio, D.B. Bregman, et al., UV-induced inhibition of transcription involves repression of transcription initia- tion and phosphorylation of RNA polymerase II, Proc. Natl. Acad. Sci. U. S. A. 97 (19) (2000) 10503-10508, https://doi.org/10.1073/pnas.180169797 (PubMed PMID: 10973477; PubMed Central PMCID: PMCPMC27054). · DOI
  31. T. Shimi, V. Butin-Israeli, S.A. Adam, R.B. Hamanaka, A.E. Goldman, C.A. Lucas, et al., The role of nuclear Lamin B1 in cell proliferation and senescence, Genes Dev. 25 (24) (2011) 2579-2593, https://doi.org/10.1101/gad.179515.111 (PubMed PMID: 22155925; PubMed Central PMCID: PMCPMC3248680). · DOI · Paper page
  32. S.N. Mowla, E.W. Lam, P.S. Jat, Cellular senescence and aging: the role of B-MYB, Aging Cell 13 (5) (2014) 773-779 Epub 2014/07/02 https://doi.org/10.1111/acel. 12242 (PubMed PMID: 24981831). · DOI
  33. D. Bhaumik, G.K. Scott, S. Schokrpur, C.K. Patil, A.V. Orjalo, F. Rodier, et al., MicroRNAs miR-146a/b negatively modulate the senescence-associated in- flammatory mediators IL-6 and IL-8, Aging (Albany NY) 1 (4) (2009) 402-411 (Epub 2010/02/12. PubMed PMID: 20148189; PubMed Central PMCID: PMC2818025).
  34. K. Matuoka, K. Yu Chen, Nuclear factor Y (NF-Y) and cellular senescence, Exp. Cell Res. 253 (2) (1999) 365-371, https://doi.org/10.1006/excr.1999.4605 (PubMed PMID: 10585259). · DOI
  35. P. Benatti, M.L. Chiaramonte, M. Lorenzo, J.A. Hartley, D. Hochhauser, N. Gnesutta, et al., NF-Y activates genes of metabolic pathways altered in cancer cells, Oncotarget. 7 (2) (2016) 1633-1650, https://doi.org/10.18632/oncotarget.6453 (PubMed PMID: 26646448; PubMed Central PMCID: PMCPMC4811486). · DOI
  36. K. Simons, E. Ikonen, How cells handle cholesterol, Science. 290 (5497) (2000) 1721-1726 (PubMed PMID: 11099405).
  37. T. Fulop Jr., N. Douziech, A.C. Goulet, S. Desgeorges, A. Linteau, G. Lacombe, et al., Cyclodextrin modulation of T lymphocyte signal transduction with aging, Mech. Ageing Dev. 122 (13) (2001) 1413-1430 (PubMed PMID: 11470130).
  38. M. Molander-Melin, K. Blennow, N. Bogdanovic, B. Dellheden, J.E. Mansson, P. Fredman, Structural membrane alterations in Alzheimer brains found to be as- sociated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains, J. Neurochem. 92 (1) (2005) 171-182, https://doi.org/10.1111/j.1471-4159.2004. 02849.x (PubMed PMID: 15606906). · DOI
  39. B. Bang, R. Gniadecki, B. Gajkowska, Disruption of lipid rafts causes apoptotic cell death in HaCaT keratinocytes, Exp. Dermatol. 14 (4) (2005) 266-272, https://doi. org/10.1111/j.0906-6705.2005.00283.x (PubMed PMID: 15810884). · DOI
  40. S. Yamazaki, A. Iwama, Y. Morita, K. Eto, H. Ema, H. Nakauchi, Cytokine signaling, lipid raft clustering, and HSC hibernation, Ann. N. Y. Acad. Sci. 1106 (2007) 54-63, https://doi.org/10.1196/annals.1392.017 (PubMed PMID: 17442772). · DOI
  41. A. Badana, M. Chintala, G. Varikuti, N. Pudi, S. Kumari, V.R. Kappala, et al., Lipid raft integrity is required for survival of triple negative breast cancer cells, J. Breast Cancer 19 (4) (2016) 372-384, https://doi.org/10.4048/jbc.2016.19.4.372 (PubMed PMID: 28053625; PubMed Central PMCID: PMCPMC5204043). · DOI
  42. S. Suman, O.C. Rodriguez, T.A. Winters, A.J. Fornace Jr., C. Albanese, K. Datta, Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production, Aging (Albany NY) 5 (8) (2013) 607-622, https://doi.org/10.18632/aging.100587 (PubMed PMID: 23928451; PubMed Central PMCID: PMCPMC3796214). · DOI
  43. S. Macip, M. Igarashi, P. Berggren, J. Yu, S.W. Lee, S.A. Aaronson, Influence of induced reactive oxygen species in p53-mediated cell fate decisions, Mol. Cell. Biol. 23 (23) (2003) 8576-8585 (PubMed PMID: 14612402; PubMed Central PMCID: PMCPMC262651).
  44. H. Lucero, D. Gae, G.E. Taccioli, Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response, J. Biol. Chem. 278 (24) (2003) 22136-22143, https://doi.org/10.1074/ jbc.M301579200 (PubMed PMID: 12672807). · DOI
  45. S. Gaubatz, G.J. Lindeman, S. Ishida, L. Jakoi, J.R. Nevins, D.M. Livingston, et al., E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control, Mol. Cell 6 (3) (2000) 729-735 (PubMed PMID: 11030352).
  46. L. Turchi, M. Fareh, E. Aberdam, S. Kitajima, F. Simpson, C. Wicking, et al., ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress, Cell Death Differ. 16 (5) (2009) 728-737, https://doi.org/10.1038/cdd.2009.2 (PubMed PMID: 19219066). · DOI
  47. H. Fung, P. Liu, B. Demple, ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis, Mol. Cell. Biol. 27 (24) (2007) 8834-8847, https://doi.org/10.1128/ MCB.00974-07 (PubMed PMID: 17938202; PubMed Central PMCID: PMCPMC2169401). · DOI
  48. J. Zhang, Y. Zhang, H. Lv, Q. Yu, Z. Zhou, Q. Zhu, et al., Human stem cells from the apical papilla response to bacterial lipopolysaccharide exposure and anti-in- flammatory effects of nuclear factor I C, J. Endod. 39 (11) (2013) 1416-1422, https://doi.org/10.1016/j.joen.2013.07.018 (PubMed PMID: 24139265). · DOI
  49. L.J. Jensen, M. Kuhn, M. Stark, S. Chaffron, C. Creevey, J. Muller, et al., STRING 8- a global view on proteins and their functional interactions in 630 organisms, Nucleic Acids Res. 37 (Database) (2009) D412-D416, https://doi.org/10.1093/ nar/gkn760 (PubMed PMID: 18940858; PubMed Central PMCID: PMCPMC2686466). · DOI
  50. S. Han, E.A. Schroeder, C.G. Silva-Garcia, K. Hebestreit, W.B. Mair, A. Brunet, Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan, Nature. 544 (7649) (2017) 185-190, https://doi.org/10.1038/nature21686 (PubMed PMID: 28379943; PubMed Central PMCID: PMCPMC5391274). · DOI
  51. P. Khongkow, U. Karunarathna, M. Khongkow, C. Gong, A.R. Gomes, E. Yague, et al., FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance, Oncogene. 33 (32) (2014) 4144-4155, https://doi.org/10. 1038/onc.2013.457 (PubMed PMID: 24141789; PubMed Central PMCID: PMCPMC3969838). · DOI
  52. C. Pararasa, J. Ikwuobe, S. Shigdar, A. Boukouvalas, I.T. Nabney, J.E. Brown, et al., Age-associated changes in long-chain fatty acid profile during healthy aging pro- mote pro-inflammatory monocyte polarization via PPARgamma, Aging Cell 15 (1) (2016) 128-139, https://doi.org/10.1111/acel.12416 (PubMed PMID: 26522807; PubMed Central PMCID: PMCPMC4717269). · DOI
  53. L. Cao, W. Li, S. Kim, S.G. Brodie, C.X. Deng, Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform, Genes Dev. 17 (2) (2003) 201-213, https://doi.org/10.1101/gad.1050003 (PubMed PMID: 12533509; PubMed Central PMCID: PMCPMC195980). · DOI · Paper page
  54. F. Supek, M. Bosnjak, N. Skunca, T. Smuc, REVIGO summarizes and visualizes long lists of gene ontology terms, PLoS One 6 (7) (2011) e21800, , https://doi.org/10. 1371/journal.pone.0021800 (PubMed PMID: 21789182; PubMed Central PMCID: PMCPMC3138752). · DOI · Paper page
  55. M. Watanabe, S. Balazadeh, T. Tohge, A. Erban, P. Giavalisco, J. Kopka, et al., Comprehensive dissection of spatiotemporal metabolic shifts in primary, secondary, and lipid metabolism during developmental senescence in Arabidopsis, Plant Physiol. 162 (3) (2013) 1290-1310, https://doi.org/10.1104/pp.113.217380 (PubMed PMID: 23696093; PubMed Central PMCID: PMCPMC3707545). · DOI
  56. J. Ernst, H.L. Plasterer, I. Simon, Z. Bar-Joseph, Integrating multiple evidence sources to predict transcription factor binding in the human genome, Genome Res. 20 (4) (2010) 526-536, https://doi.org/10.1101/gr.096305.109 (PubMed PMID: 20219943; PubMed Central PMCID: PMCPMC2847756). · DOI
  57. Z. Lu, G. Marcelin, F. Bauzon, H. Wang, H. Fu, S.L. Dun, et al., pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location, EMBO J. 32 (6) (2013) 844-857, https://doi.org/10.1038/emboj.2013.25 (PubMed PMID: 23403926; PubMed Central PMCID: PMCPMC3604720). · DOI
  58. K.C. Kural, N. Tandon, M. Skoblov, O.V. Kel-Margoulis, A.V. Baranova, Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence, BMC Genomics 17 (Suppl. 14) (2016) 1030, , https://doi.org/10.1186/s12864-016-3352-4 (PubMed PMID: 28105936; PubMed Central PMCID: PMCPMC5249001). · DOI
  59. A. Martin-Segura, T. Ahmed, A. Casadome-Perales, I. Palomares-Perez, E. Palomer, A. Kerstens, et al., Age-associated cholesterol reduction triggers brain insulin re- sistance by facilitating ligand-independent receptor activation and pathway de- sensitization, Aging Cell (2019) e12932, , https://doi.org/10.1111/acel.12932 (PubMed PMID: 30884121). · DOI
  60. X. Ding, W. Zhang, S. Li, H. Yang, The role of cholesterol metabolism in cancer, Am. J. Cancer Res. 9 (2) (2019) 219-227 (PubMed PMID: 30906624; PubMed Central PMCID: PMCPMC6405981).
  61. J. Balraj, K. Jairaman, V. Kalieswaran, A. Jayaraman, Bioprospecting lovastatin production from a novel producer Cunninghamella blakesleeana, 3 Biotech. 8 (8) (2018) 359, https://doi.org/10.1007/s13205-018-1384-y (PubMed PMID: 30105184; PubMed Central PMCID: PMCPMC6081836). · DOI
  62. A.C. Huang, Y.D. Cheng, L.H. Huang, Y.T. Hsiao, S.F. Peng, K.W. Lu, et al., Casticin induces DNA damage and impairs DNA repair in human bladder Cancer TSGH-8301 cells, Anticancer Res. 39 (4) (2019) 1839-1847, https://doi.org/10.21873/ anticanres.13291 (PubMed PMID: 30952724). · DOI

Authors
Zhao, Z., Dong, Q., Liu, X., Wei, L., Liu, L., Li, Y., & Wang, X.
Affiliations
Beijing National Research Center for Information Science and Technology (CN)
Corresponding author
Wang, Xiaowo
ORCID
Venue
Genomics
Publisher
Elsevier BV
Published
2020-03
Volume
112
Issue
2
Pages
1309-1317
ISSN
0888-7543 (ISSN-L)
DOI
10.1016/j.ygeno.2019.07.020
OpenAlex
W2965516837
Cited by
37
References
66
Citations by year
2026: 1 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 1
FWCI
2.41
Type
journal article
Language
en
Open access
Licence
Locations
  • Genomics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords
cellular senescence, DNA damage response, temporal gene expression, cell fate determination, DNA repair, cholesterol metabolism, cell cycle, transcription factors, aging
MeSH terms
Cell Line, Cholesterol, DNA Damage, Humans, Transcription Factors, Cellular Senescence, Cell Cycle Checkpoints, Transcriptome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review