Changes in DNA repair during aging

A DNA damage checkpoint response in telomere-initiated senescence

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Gene regulation and DNA damage in the ageing human brain

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DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

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Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

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Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

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Sensing and repairing DNA double-strand breaks

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Mechanism and regulation of human non-homologous DNA end-joining

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The age of cancer

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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

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Does oxidative damage to DNA increase with age?

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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

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Increased cell-to-cell variation in gene expression in ageing mouse heart

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Aging and Genome Maintenance: Lessons from the Mouse?

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Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

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Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice.

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Subpathways of nucleotide excision repair and their regulation

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A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

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DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.

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Cancer predisposition caused by elevated mitotic recombination in Bloom mice

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The mechanics of base excision repair, and its relationship to aging and disease

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DNA damage and repair in telomeres: relation to aging

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A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair

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LOSS OF CONSTITUTIONAL HETEROZYGOSITY IN HUMAN CANCER

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Pathways for mitotic homologous recombination in mammalian cells

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Non-homologous DNA end joining in plant cells is associated with deletions and filler DNA insertions

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The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

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DNA end joining becomes less efficient and more error-prone during cellular senescence

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Repair of Site-Specific Double-Strand Breaks in a Mammalian Chromosome by Homologous and Illegitimate Recombination

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Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells

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Double-strand-break-induced homologous recombination in mammalian cells

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Rapid accumulation of genome rearrangements in liver but not in brain of old mice

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Somatic mutations and aging: a re-evaluation

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Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

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Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

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Mechanisms and implications of the age-associated decrease in DNA repair capacity

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DNA damage and rpair with age in individual human lymphocytes

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The effect of donor age on the processing of UV-damaged DNA by cultured human cells: Reduced DNA repair capacity and increased DNA mutability

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Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner

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Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

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Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53

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The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

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Cell cycle-dependent expression of the mouseRad51 gene in proliferating cells

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Large genome rearrangements as a primary cause of aging

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In vivo human somatic mutation: frequency and spectrum with age

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Age‐dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria

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Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52

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Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases

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Extensive Loss of Heterozygosity Is Suppressed during Homologous Repair of Chromosomal Breaks

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DNA end joining activity is reduced in Alzheimer's disease

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DNA repair in late-passage human cells

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Aging alters the apoptotic response to genotoxic stress

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Attenuation of DNA polymerase β-dependent base excision repair and increased DMS-induced mutagenicity in aged mice

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Overexpression of enzymes that repair endogenous damage to DNA

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Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

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Mutation Frequency and Specificity With Age in Liver, Bladder and Brain of lacI Transgenic Mice

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Determination of hprt mutant frequencies in T-lymphocytes from a healthy pediatric population: statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age

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Microsatellite instability and DNA mismatch repair in human cancer

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Age-related Base Excision Repair Activity in Mouse Brain and Liver Nuclear Extracts

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Effect of dietary restriction on in vivo somatic mutation in mice

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Nucleotide Excision Repair Disorders and the Balance Between Cancer and Aging

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Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence

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DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons

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Nucleotide Excision Repair of Actively Transcribed Versus Nontranscribed DNA in Rat Hepatocytes: Effect of Age and Dietary Restriction

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Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

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Increased chromosomal aberrations in first metaphases of cells isolated from the kidneys of aged mice.

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Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging

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Making ends meet in old age: DSB repair and aging

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Human lymphocytes resistant to 6-thioguanine increase with age

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Frequency of spontaneous chromosome aberrations in mice: effects of age

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Changes in the level and distribution of Ku proteins during cellular senescence

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Non‐homologous DNA end joining in the mature rat brain

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Effect of age on the formation and repair of UV photoproducts in human skin in situ

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Tissue-specific changes of DNA repair protein Ku and mtHSP70 in aging rats and their retardation by caloric restriction

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Aged human skin removes UVB-induced pyrimidine dimers from the epidermis more slowly than younger adult skin in vivo

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Mitotic recombination is suppressed by chromosomal divergence in hybrids of distantly related mouse strains

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DNA oligonucleotide treatment corrects the age‐associated decline in DNA repair capacity

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Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice

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Reduced DNA gap repair in aging rat neuronal extracts and its restoration by DNA polymerase β and DNA‐ligase

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Base Excision Repair Is Limited by Different Proteins in Male Germ Cell Nuclear Extracts Prepared from Young and Old Mice

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Age-dependent decline in rejoining of X-ray-induced DNA double-strand breaks in normal human lymphocytes

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Age-Dependent Usage of Double-Strand-Break Repair Pathways

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Ageing and the mismatch repair system

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Gene targeting in normal somatic cells: inactivation of the interferon–γ receptor in myoblasts

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Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution

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DNA repair and epidemiology of basal cell carcinoma

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Nucleotide Excision Repair Activity Varies Among Murine Spermatogenic Cell Types1

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Transgenic mouse models for studying mutations in vivo: applications in aging research

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Age-Related Loss of the DNA Repair Response Following Exposure to Oxidative Stress

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