The DOI matches its Crossref record; 141 of the 145 references it cites were found in a registry or an index.
An alternate pathway for androgen regulation of brain function: Activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5α-androstane-3β,17β-diol
Open accessAbstract
The complexity of gonadal steroid hormone actions is reflected in their broad and diverse effects on a host of integrated systems including reproductive physiology, sexual behavior, stress responses, immune function, cognition, and neural protection. Understanding the specific contributions of androgens and estrogens in neurons that mediate these important biological processes is central to the study of neuroendocrinology. Of particular interest in recent years has been the biological role of androgen metabolites. The goal of this review is to highlight recent data delineating the specific brain targets for the dihydrotestosterone metabolite, 5alpha-androstane, 3beta,17beta-diol (3beta-Diol). Studies using both in vitro and in vivo approaches provide compelling evidence that 3beta-Diol is an important modulator of the stress response mediated by the hypothalmo-pituitary-adrenal axis. Furthermore, the actions of 3beta-Diol are mediated by estrogen receptors, and not androgen receptors, often through a canonical estrogen response element in the promoter of a given target gene. These novel findings compel us to re-evaluate the interpretation of past studies and the design of future experiments aimed at elucidating the specific effects of androgen receptor signaling pathways.
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“or the testosterone metabolite, dihydrotestosterone, may be converted to 3beta-diol, which itself can activate ERbeta (Handa et al., 2008).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Handa et al., 2008
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Metadata
- Authors
- Handa, R. J., Pak, T. R., Kudwa, A. E., Lund, T. D., & Hinds, L.
- Affiliations
- Colorado State University (US)
- Loyola University Chicago (US)
- Corresponding author
- Handa, Robert J.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 53
- Issue
- 5
- Pages
- 741-752
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC2430080
- OpenAlex
- W2042179361
- Cited by
- 205
- References
- 145
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 9 · 2023: 2 · 2022: 6 · 2021: 18 · 2020: 18 · 2019: 4 · 2018: 8 · 2017: 11 · 2016: 12 · 2015: 11 · 2014: 14 · 2013: 12 · 2012: 10
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service
- National Institute of Neurological Disorders and Stroke (R01NS039951, NS 033917)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- 5α-androstane-3β,17β-diol, estrogen receptor beta, hypothalamic-pituitary-adrenal axis, stress response, estrogen response element, androgen receptor signaling, neuroendocrinology, sex steroids
- MeSH terms
- Androgens, Animals, Behavior, Behavior, Animal, Mental Disorders, Brain, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Promoter Regions, Genetic, Sex Characteristics, Dihydrotestosterone, Stress, Psychological, Androstane-3,17-diol, Signal Transduction, Estrogen Receptor beta
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