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Behavioral effects of chronic adolescent stress are sustained and sexually dimorphic
Open accessAbstract
Evidence suggests that women are more susceptible to stress-related disorders than men. Animal studies demonstrate a similar female sensitivity to stress and have been used to examine the underlying neurobiology of sex-specific effects of stress. Although our understanding of the sex-specific effects of chronic adolescent stress has grown in recent years, few studies have reported the effects of adolescent stress on depressive-like behavior. The purpose of this study was to determine if a chronic mixed modality stressor (consisting of isolation, restraint, and social defeat) during adolescence (PND 37-49) resulted in differential and sustained changes in depressive-like behavior in male and female Wistar rats. Female rats exposed to chronic adolescent stress displayed decreased sucrose consumption, hyperactivity in the elevated plus maze, decreased activity in the forced swim test, and a blunted corticosterone response to an acute forced swim stress compared to controls during both adolescence (PND 48-57) and adulthood (PND 96-104). Male rats exposed to chronic adolescent stress did not manifest significant behavioral changes at either the end of adolescence or in adulthood. These data support the proposition that adolescence may be a stress sensitive period for females and exposure to stress during adolescence results in behavioral effects that persist in females. Studies investigating the sex-specific effects of chronic adolescent stress may lead to a better understanding of the sexually dimorphic incidence of depressive and anxiety disorders in humans and ultimately improve prevention and treatment strategies.
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“Preclinical studies show that during puberty, stressors have stronger behavioral effects on behavior in females than males (20–22).”
From Sexual differentiation of neural mechanisms of stress sensitivity during puberty (2023) · cites this paper as [22]
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“Sex differences in stress sensitivity emerge at puberty in both humans (63, 64) and other animals (20–22), coinciding with an increased incidence of anxiety in women (10, 12, 14, 15).”
From Sexual differentiation of neural mechanisms of stress sensitivity during puberty (2023) · cites this paper as [22]
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Metadata
- Authors
- Bourke, C. H., & Neigh, G. N.
- Affiliations
- Emory University (US)
- Corresponding author
- Neigh, Gretchen N.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 60
- Issue
- 1
- Pages
- 112-120
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC3112263
- OpenAlex
- W1988474369
- Cited by
- 201
- References
- 58
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 23 · 2020: 5 · 2019: 25 · 2018: 13 · 2017: 16 · 2016: 14 · 2015: 13 · 2014: 17 · 2013: 15 · 2012: 13
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Environmental Health Sciences (T32ES012870)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sex differences, depression-like behavior, social defeat, restraint stress, isolation stress, forced swim test, sucrose intake, hyperactivity, anxiety disorders
- MeSH terms
- Adolescent, Adolescent Behavior, Animals, Corticosterone, Dominance-Subordination, Female, Humans, Male, Restraint, Physical, Sex Characteristics, Sex Factors, Social Behavior, Stress, Psychological, Swimming, Rats, Wistar, Maze Learning, Rats, Long-Evans, Rats
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