Cited by 201Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

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Behavioral effects of chronic adolescent stress are sustained and sexually dimorphic

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Bourke, Chase H., Neigh, Gretchen N.·2011·Hormones and Behavior

DOI 10.1016/j.yhbeh.2011.03.011PMC PMC3112263

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Abstract

Evidence suggests that women are more susceptible to stress-related disorders than men. Animal studies demonstrate a similar female sensitivity to stress and have been used to examine the underlying neurobiology of sex-specific effects of stress. Although our understanding of the sex-specific effects of chronic adolescent stress has grown in recent years, few studies have reported the effects of adolescent stress on depressive-like behavior. The purpose of this study was to determine if a chronic mixed modality stressor (consisting of isolation, restraint, and social defeat) during adolescence (PND 37-49) resulted in differential and sustained changes in depressive-like behavior in male and female Wistar rats. Female rats exposed to chronic adolescent stress displayed decreased sucrose consumption, hyperactivity in the elevated plus maze, decreased activity in the forced swim test, and a blunted corticosterone response to an acute forced swim stress compared to controls during both adolescence (PND 48-57) and adulthood (PND 96-104). Male rats exposed to chronic adolescent stress did not manifest significant behavioral changes at either the end of adolescence or in adulthood. These data support the proposition that adolescence may be a stress sensitive period for females and exposure to stress during adolescence results in behavioral effects that persist in females. Studies investigating the sex-specific effects of chronic adolescent stress may lead to a better understanding of the sexually dimorphic incidence of depressive and anxiety disorders in humans and ultimately improve prevention and treatment strategies.

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Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period
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Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., Meaney, M. J., & Plotsky, P. M. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62132-9 · Cited by 726
Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence
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Donner, N. C., & Lowry, C. A. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1271-7 · Cited by 379
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Prevalence of depression and its association with quality of life in clinically stable patients with COVID-19
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The effects of early life stress on reward processing
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From the stressed adolescent to the anxious and depressed adult: Investigations in rodent models
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Self-citation
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Self-citation
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Self-citation
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Authors: Bourke, C. H., & Neigh, G. N.
Affiliations: Emory University (US)
Corresponding author: Neigh, Gretchen N.
ORCID: Bourke, Chase H.
Neigh, Gretchen N.
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2011-06
Volume: 60
Issue: 1
Pages: 112-120
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2011.03.011
PMC: PMC3112263
OpenAlex: W1988474369
Cited by: 201
References: 58
Citations by year: 2026: 5 · 2025: 9 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 23 · 2020: 5 · 2019: 25 · 2018: 13 · 2017: 16 · 2016: 14 · 2015: 13 · 2014: 17 · 2013: 15 · 2012: 13
FWCI: 5.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Environmental Health Sciences (T32ES012870)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: sex differences, depression-like behavior, social defeat, restraint stress, isolation stress, forced swim test, sucrose intake, hyperactivity, anxiety disorders
MeSH terms: Adolescent, Adolescent Behavior, Animals, Corticosterone, Dominance-Subordination, Female, Humans, Male, Restraint, Physical, Sex Characteristics, Sex Factors, Social Behavior, Stress, Psychological, Swimming, Rats, Wistar, Maze Learning, Rats, Long-Evans, Rats

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Behavioral effects of chronic adolescent stress are sustained and sexually dimorphic

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