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Cited by 87Growth Hormone and Insulin-like Growth FactorsTraumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular Disturbances

Growth hormone (GH) and brain trauma

Devesa, Jesús, Reimunde, Pedro, Devesa, Pablo, Barberá, Matías, Arce, Víctor·2013·Hormones and Behavior
DOI 10.1016/j.yhbeh.2012.02.022
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Abstract

Growth hormone (GH) is a pleiotropic hormone with known neurotrophic effects. We aimed to study whether GH administration might be useful together with rehabilitation in the recovery of TBI patients. 13 TBI patients (8 M, 5 F; age: 6-53 years old) were studied. Time after TBI: 2.5 months to 11 years; 5 patients showed acquired GH-deficiency (GHD). Disabilities observed: cognitive disorders; motor plegias; neurogenic dysphagia (n=5), vegetative coma (n=2) and amaurosis (n=1). All but one TBI patient followed intense rehabilitation for years. Treatment consisted of GH administration (maximal dose 1 mg/day, 5 days/week, resting 15-days every 2-months, until a maximum of 8 months) and clinical rehabilitation according to the individual needs (3-4 h/day, 5 days/week, during 6-12 months). Informed consent was obtained before commencing GH administration. GH significantly increased plasma IGF-1 values (ng.mL(-1)) in both GHD and no GHD patients, being then similar between both groups (GHD: 275.6±35.6 [p<0.01 vs. baseline], no GHD: 270.2±64 [p<0.05 vs. baseline]). In all the cases clear significant improvements were observed during and at the end of the combined treatment. Cognitive improvements appeared earlier and were more important than motor improvements. Swallowing improved significantly in all TBI patients with neurogenic dysphagia (2 of them in a vegetative state). Visual performance was ameliorated in the patient with amaurosis. No undesirable side-effects were observed. Our data indicate that GH can be combined with rehabilitation for improving disabilities in TBI patients, regardless of whether or not they are GHD.

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  • Early recognition and intervention, including hormone replacement when appropriate, may improve neurocognitive recovery and overall rehabilitation outcomes after pediatric TBI.

    “Early recognition and intervention, including hormone replacement when appropriate, may improve neurocognitive recovery and overall rehabilitation outcomes.”

    From Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions (2025) · cites this paper as [33]

  • Devesa et al. found that GH treatment combined with rehabilitation in 13 TBI patients, 5 of whom had acquired GHD, produced substantial cognitive improvements, with cognitive function recovery occurring more rapidly and significantly than motor function recovery.

    “For instance, Devesa et al. studied the effects of GH treatment in combination with rehabilitation in 13 TBI patients, 5 of whom had acquired GHD. Their findings revealed substantial cognitive improvements, with cognitive function recovery occurring more rapidly and significantly compared to motor function recovery [33].”

    From Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions (2025) · cites this paper as [33]

  • GH may facilitate the proliferation, differentiation, and survival of new neurons in response to brain injury.

    “Based on the experimental evidence, it was hypothesized that GH may facilitate the proliferation, differentiation, and survival of new neurons in response to brain injury (191,192).”

    From Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach (2015) · cites this paper as [192]

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Authors
Devesa, J., Reimunde, P., Devesa, P., Barberá, M., & Arce, V.
Affiliations
  • Universidade de Santiago de Compostela (ES)
  • Universidade da Coruña (ES)
Corresponding author
Devesa, Jesús
ORCID
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2013-02
Volume
63
Issue
2
Pages
331-344
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2012.02.022
OpenAlex
W2007129533
Cited by
87
References
101
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 8 · 2018: 13 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 1
FWCI
3.85
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
growth hormone therapy, traumatic brain injury, rehabilitation, insulin-like growth factor I, neurotrophic effects, cognitive recovery, motor recovery, neurogenic dysphagia, visual impairment
MeSH terms
Accidents, Traffic, Adolescent, Adult, Animals, Brain Injuries, Child, Female, Humans, Male, Middle Aged, Growth Hormone, Young Adult

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