Cited by 70Growth Hormone and Insulin-like Growth FactorsNerve injury and regenerationTraumatic Brain Injury and Neurovascular Disturbances

Role of growth hormone (GH) in the treatment on neural diseases: from neuroprotection to neural repair

Open access
Arce, Víctor M., Devesa, Pablo, Devesa, Jesús·2013·Neuroscience Research

Abstract

Growth hormone (GH) is a pleiotropic hormone that exerts important functions in the control of brain development as well as in the regulation neuronal differentiation and function, together with several behavioral and psychological effects that have been linked to its modulatory actions on brain neurotransmitters. In addition, the possibility that GH may play a role on brain repair after injury has been also envisaged, and a number of reports have shown that GH administration following injury confers neuroprotection and accelerates the recovery of some neural functions. In this review we have analyzed the state of the art of GH administration in several neural diseases. Though more studies are still necessary in order to completely understand the importance of GH in these processes, the promising results obtained so far, together with the absence of untoward effects during GH therapy, encourages the development of clinical assays in order to further support the use GH treatment in neural diseases in which neuroprotection and/or neuroregeneration are involved.

Integrity signals

Registry

Crossref · 10.1016/j.neures.2013.03.014

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • GH may facilitate the proliferation, differentiation, and survival of new neurons in response to brain injury.

    “Based on the experimental evidence, it was hypothesized that GH may facilitate the proliferation, differentiation, and survival of new neurons in response to brain injury (191,192).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Arce, V. M., Devesa, P., & Devesa, J.
Affiliations
Universidade de Santiago de Compostela (ES)
Corresponding author
Devesa, Jesús
Venue
Neuroscience Research
Publisher
Elsevier BV
Published
2013-08
Volume
76
Issue
4
Pages
179-186
ISSN
0168-0102 (ISSN-L)
OpenAlex
W2086179172
Cited by
70
References
123
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 6 · 2014: 3
FWCI
0.93
Type
journal article
Language
en
Open access
Locations
  • Neuroscience Research (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
growth hormone, neuroprotection, nerve regeneration, neurological disorders, brain injury, neuronal differentiation, neurotransmitters, brain development, neurological recovery
MeSH terms
Animals, Brain Injuries, Cognition, Humans, Nerve Regeneration, Neurons, Growth Hormone, Neuroprotective Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review