Cited by 103Cardiac Fibrosis and RemodelingCell death mechanisms and regulationCardiac Ischemia and Reperfusion

The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.

Apoptosis and heart failure: clinical relevance and therapeutic target

GARG, S, NARULA, J, CHANDRASHEKHAR, Y·2005·Journal of Molecular and Cellular Cardiology

DOI 10.1016/j.yjmcc.2004.11.006

Open this paper in CoChat — free account

Abstract

Heart failure is the final common pathway of diverse etiologies that are characterized by impaired systolic and/or diastolic function with high morbidity and mortality. An integral part of pathogenesis of heart failure is myocyte loss. The traditional explanation for myocyte loss was cell necrosis but over the last decade, there has been a surge of evidence affirming the role of apoptosis in genesis of heart failure. Studies have raised apoptosis from a 'histologic curiosity' to an exciting 'clinical target' that can be modulated to attenuate the progression of heart failure. This review will focus on the clinical relevance of apoptosis in human and experimental heart failure and identify some of the progress made in myocardial anti-apoptotic intervention.

Integrity signals

Registry

Crossref · 10.1016/j.yjmcc.2004.11.006

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling
Cohn, J. N., Ferrari, R., & Sharpe, N. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00630-0 · Cited by 2,161
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673
Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
Gottlieb, R. A., Burleson, K. O., Kloner, R. A., Babior, B., & Engler, R. L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117504 · Cited by 1,442
Apoptosis in Myocytes in End-Stage Heart Failure
Narula, J., Haider, N., Virmani, R., DiSalvo, T. G., Kolodgie, F. D., Hajjar, R. J., Schmidt, U., Semigran, M. J., Dec, G. W., & Khaw, B.-A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351603 · Cited by 1,430
Self-citation
Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.
Kajstura, J., Cheng, W. N., Krzysztof Reiss, F., CLARK, W. A., Sonnenblick, E. H., Krajewski, S., Reed, J., Olivetti, G., & Anversa, P. (1996) · PubMed · Cited by 1,039
Apoptosis in human acute myocardial infarction.
Saraste, A., Pulkki, K., Kallajoki, M., Henriksen, K., Parvinen, M., & Voipio-Pulkki, L.-M. (1997) · Circulation · doi:10.1161/01.cir.95.2.320 · Cited by 825 · cited 2×
“[14] Saraste A, Pulkki K, Kallajoki M, Henriksen K, Parvinen M, VoipioPulkki M.”
Background
Apoptosis in Ischemic and Reperfused Rat Myocardium
Fliss, H., & Gattinger, D. A. (1996) · Circulation Research · doi:10.1161/01.res.79.5.949 · Cited by 803
A mechanistic role for cardiac myocyte apoptosis in heart failure
Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., & Kitsis, R. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17664 · Cited by 765
Norepinephrine Stimulates Apoptosis in Adult Rat Ventricular Myocytes by Activation of the β-Adrenergic Pathway
Communal, C., Singh, K., Pimentel, D. R., & Colucci, W. S. (1998) · Circulation · doi:10.1161/01.cir.98.13.1329 · Cited by 690

Show all 77 references

Sorted by citations

Cardiac remodeling in obesity
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Attenuation by Metallothionein of Early Cardiac Cell Death via Suppression of Mitochondrial Oxidative Stress Results in a Prevention of Diabetic Cardiomyopathy
Cai, L., Wang, Y., Zhou, G., Chen, T., Song, Y., Li, X., & Kang, Y. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.022 · Cited by 378
Obesity and subtypes of incident cardiovascular disease
Ndumele, C. E., Matsushita, K., Lazo, M., Bello, N., Blumenthal, R. S., Gerstenblith, G., Nambi, V., Ballantyne, C. M., Solomon, S. D., Selvin, E., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003921 · Cited by 259
Exercise‐induced protection against myocardial apoptosis and necrosis: MnSOD, calcium‐handling proteins, and calpain
French, J. P., Hamilton, K. L., Quindry, J. C., Lee, Y., Upchurch, P. A., & Powers, S. K. (2008) · The FASEB Journal · doi:10.1096/fj.07-102541 · Cited by 153
Mechanisms of Disease: apoptosis in heart failure—seeing hope in death
Narula, J., Haider, N., Arbustini, E., & Chandrashekhar, Y. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0710 · Cited by 141
Self-citation
Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP
Potts, M. B., Vaughn, A. E., McDonough, H., Patterson, C., & Deshmukh, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504082 · Cited by 116
Obesity, Subclinical Myocardial Injury, and Incident Heart Failure
Ndumele, C. E., Coresh, J., Lazo, M., Hoogeveen, R. C., Blumenthal, R. S., Folsom, A. R., Selvin, E., Ballantyne, C. M., & Nambi, V. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.05.017 · Cited by 113
Survivin Determines Cardiac Function by Controlling Total Cardiomyocyte Number
Levkau, B., Schäfers, M. A., Wohlschlaeger, J., Lipinski, K. V. W., Keul, P., Hermann, S., Kawaguchi, N., Kirchhof, P. F., Fabritz, L., Stypmann, J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.734160 · Cited by 111
Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin: possible role in modulating NADPH oxidase/ROS-mediated NFκB redox signaling cascade
Priya, L. B., Baskaran, R., Huang, C., & Padma, V. V. (2017) · Scientific Reports · doi:10.1038/s41598-017-12060-9 · Cited by 100
Aconitine-induced Ca2+ overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats
Sun, G., Sun, H. L., Meng, X., Hu, J., Zhang, Q., Liu, B., Wang, M., Xu, H., & Sun, X. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.05.005 · Cited by 100
Gene expression signals involved in ischemic injury, extracellular matrix composition and fibrosis defined by global mRNA profiling of the human left ventricular myocardium
Gabrielsen, A., Lawler, P. R., Yongzhong, W., Steinbrüchel, D. A., Dimo, B., Paulsson‐Berne, G., Kastrup, J., & Hansson, G. K. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.12.016 · Cited by 96
Investigation of Hypoxia-Induced Myocardial Injury Dynamics in a Tissue Interface Mimicking Microfluidic Device
Ren, L. M., Liu, W., Wang, Y., Wang, J., Tu, Q., Xu, J., Liu, R., Shen, S., & Wang, J. (2012) · Analytical Chemistry · doi:10.1021/ac3025812 · Cited by 90
Analysis of necroptotic proteins in failing human hearts
Szobi, A., Gonçalvesová, E., Varga, Z. V., Leszek, P., Kuśmierczyk, M., Hulman, M., Kyselovič, J., Ferdinandy, P., & Adameová, A. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1189-5 · Cited by 82
“How Do Cardiomyocytes Die?” Apoptosis and Autophagic Cell Death in Cardiac Myocytes
Kunapuli, S., Rosanio, S., & Schwarz, E. R. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.02.002 · Cited by 78
Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1
Liu, M., Galli, G. L. J., Wang, Y., Fan, Q., Wang, Z., Wang, X., & Xiao, W. L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00774 · Cited by 72
Apoptosis predominates in nonmyocytes in heart failure
Park, M., Shen, Y.-T., Gaussin, V., Heyndrickx, G. R., Bartúnek, J., Resuello, R. R. G., Natividad, F. F., Kitsis, R. N., Vatner, D. E., & Vatner, S. F. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00310.2009 · Cited by 72
Linoleate-Rich High-Fat Diet Decreases Mortality in Hypertensive Heart Failure Rats Compared With Lard and Low-Fat Diets
Chicco, A. J., Sparagna, G. C., McCune, S. A., Johnson, C. A., Murphy, R. C., Bolden, D. A., Rees, M. L., Gardner, R. T., & Moore, R. L. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114264 · Cited by 74
Leptin attenuates cardiac apoptosis after chronic ischaemic injury
McGaffin, K. R., Zou, B., McTiernan, C. F., & O'Donnell, C. P. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp071 · Cited by 71
Pathophysiology of Heart Failure
Mann, D. L. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00025-1 · Cited by 69
Cardioprotective effects of baicalein on heart failure via modulation of Ca2+ handling proteins in vivo and in vitro
Zhao, F., Fu, L., Yang, W. P., Dong, Y., Yang, J., Sun, S., & Hou, Y. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.12.036 · Cited by 64
Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca2+-ATPase 2a
Hu, W., Xu, T., Wu, P., Pan, D., Chen, J., Chen, J., Zhang, B., Zhu, H., & Li, D. (2017) · Scientific Reports · doi:10.1038/srep41017 · Cited by 63
Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress
Dalal, S., Zha, Q., Daniels, C. R., Steagall, R. J., Joyner, W. L., Gadeau, A., Singh, M., & Singh, K. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00954.2013 · Cited by 57
Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model
Zhang, Y., Liao, P., Zhu, M., Li, W., Hu, D., Guan, S., & Chen, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000459708 · Cited by 59
Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs
Yan, X., Wu, H., Ren, J., Liu, Y., Wang, S., Yang, J., Qin, S., & Wu, D. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.05.006 · Cited by 58
High Glucose Alters Cardiomyocyte Contacts and Inhibits Myofibrillar Formation
Dyntar, D., Sergeev, P., Klisic, J., Ambühl, P. M., SCHAUB, M. C., & Donath, M. Y. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1904 · Cited by 55
Molecular imaging of myocardial infarction
Jaffer, F. A., Sosnovik, D. E., Nahrendorf, M., & Weissleder, R. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.09.008 · Cited by 52
Autophagy and Oncosis/Necroptosis Are Enhanced in Cardiomyocytes from Heart Failure Patients
Corsetti, G., Chen-Scarabelli, C. A., Romano, C., Pasini, E., Dioguardi, F. S., Onorati, F., Knight, R. A., Patel, H., Saravolatz, L. I. I., Faggian, G. G., et al. (2019) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.913436 · Cited by 51
A molecular MRI probe to detect treatment of cardiac apoptosis in vivo
Dash, R., Chung, J., Chan, T., Yamada, M., Barral, J. K., Nishimura, D. G., Yang, P. C.-M., & Simpson, P. C. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22876 · Cited by 46
Exercise and Cardiac Preconditioning Against Ischemia Reperfusion Injury
Quindry, J. C., & Hamilton, K. L. (2013) · Current Cardiology Reviews · doi:10.2174/1573403x113099990033 · Cited by 45
Beneficial effects of physical exercise on hypertension and cardiovascular adverse remodeling of diet-induced obese rats
Pinheiro, A. R., Cunha, A. R., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.01.009 · Cited by 43
Left ventricular assist device-induced molecular changes in the failing myocardium
Soppa, G. K. R., Barton, P. J. R., Terracciano, C. M., & Yacoub, M. H. (2008) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3282fc7010 · Cited by 42
The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK
Zhang, T., Xu, L., Guo, X., Tao, H., Liu, Y., Liu, X., Zhang, Y., & Meng, X. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.09.001 · Cited by 45
Protective effect of hyperoside on heart failure rats via attenuating myocardial apoptosis and inducing autophagy
Guo, X., Zhang, Y., Lu, C., Qu, F., & Jiang, X. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2019.1685369 · Cited by 42
N-acetylglucosamine Conjugated to Nanoparticles Enhances Myocyte Uptake and Improves Delivery of a Small Molecule p38 Inhibitor for Post-infarct Healing
Gray, W. D., Che, P.-L., Brown, M. E., Ning, X., Murthy, N., & Davis, M. E. (2011) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-011-9292-0 · Cited by 42
Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction
Ravassa, S., González, A., López, B., Beaumont, J., Querejeta, R., Larman, M., & Dı́ez, J. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm370 · Cited by 41
Myocardial repair: from salvage to tissue reconstruction
Ruvinov, E., Dvir, T., Leor, J., & Cohen, S. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.5.669 · Cited by 41
Inducing Endogenous Cardiac Regeneration: Can Biomaterials Connect the Dots?
Bar, A., & Cohen, S. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00126 · Cited by 40
Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice
Chua, C. C., Gao, J., Ho, Y.-S., Xiong, Y., Xu, X., Chen, Z., Hamdy, R. C., & Chua, B. H. L. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.01.007 · Cited by 36
β -Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of β 1 Integrins
Amin, P., Singh, M., & Singh, K. (2011) · Journal of Signal Transduction · doi:10.1155/2011/179057 · Cited by 35
Exercise training delays cardiac remodeling in a mouse model of cancer cachexia
Fernandes, L. G., Tobias, G. C., da Paixão, A. O., Dourado, P. M. M., Voltarelli, V. A., & Brum, P. C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118392 · Cited by 34
Recurrent low-level Troponin I elevation is a worse prognostic indicator than occasional injury pattern in patients hospitalized with heart failure
Ather, S., Hira, R. S., Shenoy, M. H., Fatemi, O., Deswal, A. M., Aguilar, D. A., Ramasubbu, K., Bolos, M., Chan, W., & Bozkurt, B. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.10.113 · Cited by 35
Bioengineering the Infarcted Heart by Applying Bio-inspired Materials
Ruvinov, E., Harel-Adar, T., & Cohen, S. (2011) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-011-9288-9 · Cited by 34
Apoptosis: a potentially reversible, meta-stable state of the heart
Masri, C. S., & Chandrashekhar, Y. (2008) · Heart Failure Reviews · doi:10.1007/s10741-007-9069-3 · Cited by 30
Self-citation
Caspases in myocardial infarction.
Zidar, N., Jera, J., Maja, J., & Dusan, S. (2007) · Advances in Clinical Chemistry · doi:10.1016/s0065-2423(07)44001-x · Cited by 34
β-asarone inhibits gastric cancer cell proliferation
Wu, J., Zhang, X., Sun, Q., Chen, M., LIU, S.-L., Zhang, X., Zhou, J., & Zou, X. (2015) · Oncology Reports · doi:10.3892/or.2015.4316 · Cited by 29
Leptin, a mediator of cardiac damage associated with obesity
Martínez‐Martínez, E., Jurado-López, R., Cervantes-Escalera, P., Cachofeiro, V., & Miana, M. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0060 · Cited by 27
Role of caspase-independent apoptosis in cardiovascular diseases
Bae, S. (2007) · Frontiers in bioscience · doi:10.2741/2861 · Cited by 28
Apoptosis in hypertensive heart disease: a clinical approach
González, A., Ravassa, S., López, B., Loperena, I., Querejeta, R., & Dı́ez, J. (2006) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000231397.64362.70 · Cited by 28
Role of apoptosis in ventricular remodeling
Chandrashekhar, Y. (2005) · Current Heart Failure Reports · doi:10.1007/s11897-005-0003-5 · Cited by 27
Self-citation
Simultaneous regulation of apoptotic gene silencing and angiogenic gene expression for myocardial infarction therapy: Single-carrier delivery of SHP-1 siRNA and VEGF-expressing pDNA
Kim, D., Ku, S. H., Kim, H., Jeong, J. H., Lee, M., Kwon, I. C., Choi, D., & Kim, S. H. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.10.017 · Cited by 25
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2
Li, Y., Chandra, T. P., Song, X., Nie, L., Liu, M., Yi, J., Zheng, X., Chu, C., & Yang, J. (2021) · Technology and Health Care · doi:10.3233/thc-218020 · Cited by 25
Cardiac Tissue Engineering
Ruvinov, E., Sapir, Y., & Cohen, S. (2012) · Synthesis lectures on tissue engineering · doi:10.2200/s00437ed1v01y201207tis009 · Cited by 37
Intracardiac lipid accumulation, lipoatrophy of muscle cells and expansion of myocardial infarction in type 2 diabetic patients
Borisov, A. B., Ushakov, A. V., Zagorul'ko, A. K., Novikov, N. Y., Selivanova, K. F., Edwards, C. A., & Russell, M. W. W. (2007) · Micron · doi:10.1016/j.micron.2007.11.002 · Cited by 25
Cardiotoxicity and Apoptotic Activity in Subacute Endosulfan Toxicity and the Protective Effect of Vitamin C in Rabbits: A Pathological Study
Özmen, Ö. (2013) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.2013006476 · Cited by 23
Cobalt Chloride Pretreatment Attenuates Myocardial Apoptosis After Hypothermic Circulatory Arrest
Kerendi, F., Kirshbom, P. M., Halkos, M. E., Wang, N.-P., Kin, H., Jiang, R., Zhao, Z., Kanter, K. R., Guyton, R. A., & Vinten‐Johansen, J. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.01.059 · Cited by 23
Astragaloside IV attenuates chronic intermittent hypoxia‐induced myocardial injury by modulating Ca 2+ homeostasis
Jiang, S., Jiao, G., Chen, Y., Han, M., Wang, X., & Liu, W. (2020) · Cell Biochemistry and Function · doi:10.1002/cbf.3538 · Cited by 22
Over-expression of a modified bifunctional apoptosis regulator protects against cardiac injury and doxorubicin-induced cardiotoxicity in transgenic mice
Chua, C. C., Gao, J., Ho, Y., Xu, X., Kuo, I.-C., Chua, K. Y., Wang, H., Hamdy, R. C., Reed, J., & Chua, B. H. L. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn257 · Cited by 21
Effect of Curcumin on Doxorubicin-induced Cytotoxicity in H9c2 Cardiomyoblast Cells
Hosseinzadeh, L., Behravan, J., Mosaffa, F., Bahrami, G., Bahrami, A. R., & Karimi, G. (2011) · Iranian journal of basic medical sciences. · doi:10.22038/ijbms.2011.4964 · Cited by 21
Anti-apoptotic potential of gymnemic acid phospholipid complex pretreatment in Wistar rats with experimental cardiomyopathy.
Pathan, R. A., Bhandari, U., Javed, S., & Nag, T. C. (2012) · PubMed · Cited by 19
Pathophysiologie der chronischen Herzinsuffizienz
Weil, J., & Schunkert, H. (2006) · Clinical Research in Cardiology · doi:10.1007/s00392-006-2005-z · Cited by 20
Epicardial fat, left ventricular strain, and T1-relaxation times in obese individuals with a normal ejection fraction
Homsi, R., Yuecel, S., Schlesinger‐Irsch, U., Meier-Schroers, M., Kuetting, D. L. R., Luetkens, J. A., Sprinkart, A. M., Schild, H. H., & Thomas, D. K. (2019) · Acta Radiologica · doi:10.1177/0284185119826549 · Cited by 18
Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation
Afshin Samali, A., O’Mahoney, M. E., Reeve, J. L., Logue, S. E., Szegezdi, É., McMahon, J. M., & Fearnhead, H. O. (2007) · APOPTOSIS · doi:10.1007/s10495-006-0017-9 · Cited by 17
Gelsolin and Cardiac Myocyte Apoptosis
Nishio, R., & Matsumori, A. (2009) · Circulation Research · doi:10.1161/circresaha.109.196329 · Cited by 16
Heart-targeted overexpression of Nip3a in zebrafish embryos causes abnormal heart development and cardiac dysfunction
Wang, W., Huang, C., Lu, Y., Hsin, J.-P., Prabhakar, V. R., Cheng, C., & Hwang, S. L. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.06.174 · Cited by 16
Multiple organ failure of tumor-bearing rabbits in cancer cachexia is caused by apoptosis of normal organ cells
Sumi (1992) · International Journal of Oncology · doi:10.3892/ijo_00000129 · Cited by 15
Correlation between apoptosis and left ventricular remodeling in subacute phase of myocardial ischemia and reperfusion
Wakabayashi, H., Taki, J., Inaki, A., Shiba, K., Matsunari, I., & Kinuya, S. (2015) · EJNMMI Research · doi:10.1186/s13550-015-0152-9 · Cited by 14
Cardiac molecular markers of programmed cell death are activated in end-stage heart failure patients supported by left ventricular assist device
Prescimone, T., Masotti, S., D’Amico, A., Caruso, R., Cabiati, M., Caselli, C., Viglione, F., Verde, A., Ry, S. D., & Giannessi, D. (2014) · Cardiovascular Pathology · doi:10.1016/j.carpath.2014.04.003 · Cited by 14
Detection and prognostic impact of renal dysfunction in patients with chronic heart failure and normal serum creatinine
Scrutinio, D., Passantino, A., Lagioia, R., Santoro, D., & Cacciapaglia, E. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.08.042 · Cited by 12
Cardiac effects of renal ischemia
Dominguez, J. H., Xie, D., & Kelly, K. J. (2022) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00183.2022 · Cited by 13
Caspase-1 transcripts in failing human heart after mechanical unloading
Prescimone, T., D’Amico, A., Caselli, C., Cabiati, M., Viglione, F., Caruso, R., Verde, A., Ry, S. D., Trivella, M. G., & Giannessi, D. (2014) · Cardiovascular Pathology · doi:10.1016/j.carpath.2014.08.002 · Cited by 13
Current applications of nanotechnology for magnetic resonance imaging of apoptosis.
Strijkers, G., van Tilborg, G. V., Geelen, T., Reutelingsperger, C., & Nicolay, K. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-609-2_22 · Cited by 8
Cardiovascular System
Greaves, P. (2007) · Elsevier eBooks · doi:10.1016/b978-044452771-4/50008-0 · Cited by 10
La insuficiencia cardíaca en el año 2005
Jiménez-Navarro, M. F., Dı́ez, J., Delgado, J. F., & Leiro, M. G. C. (2006) · Revista Española de Cardiología · doi:10.1157/13084449 · Cited by 10
Xinfuli improves cardiac function, histopathological changes and attenuate cardiomyocyte apoptosis in rats with doxorubicin-induced cardiotoxicity.
Lu, P., Ma, J., Liang, X., Guo, C., Yang, Y.-K., Yang, K., Shen, Q., Ma, L., & Zhou, X. (2016) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2016.12.001 · Cited by 9
Cardiovascular System
Greaves, P. (2012) · Elsevier eBooks · doi:10.1016/b978-0-444-53856-7.00007-5 · Cited by 8
Sevoflurane-mediated modulation of oxidative myocardial injury
Sedghi, S., Khadra, W. Z., Pourafkari, L., Knight, P. R., Alderson, F., & Nader, N. D. (2023) · Journal of Cardiovascular and Thoracic Research · doi:10.34172/jcvtr.2023.31724 · Cited by 7
Alterations in Ventricular Structure
Anand, I. S., & Florea, V. G. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5895-3.10015-4 · Cited by 7
Molecular Mechanisms of Cardioprotection by Taurine on Ischemia-Induced Apoptosis in Cultured Cardiomyocytes
Takahashi, K., Takatani, T., Uozumi, Y., Ito, T., Matsuda, T., Fujio, Y., Schaffer, S. W., & Azuma, J. (2006) · Springer eBooks · doi:10.1007/978-0-387-33504-9_28 · Cited by 6
Exploring the Efficacy Enhancement Mechanism of Qixue Shuangbu prescription after TCM processing for treating chronic heart failure by regulating ERK/Bcl-2/Bax/Caspases-3 signaling pathway
Wang, Q., Jiang, Y., Xie, S. Y., & Chen, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30476 · Cited by 5
Avances en cardiopatía hipertensiva. Mecanismos de remodelado implicados en la transición de la hipertrofia a la insuficiencia cardiaca
Beaumont, J., Arias, T., López, B., González, A., Ravassa, S., Hermida, N., Querejeta, R., & Dı́ez, J. (2007) · Revista Española de Cardiología Suplementos · doi:10.1016/s1131-3587(07)75252-4 · Cited by 5
Screening and Monitoring for Cardiotoxicity During Cancer Treatment
Khouri, M. G., Klem, I., Shenoy, C., Sulpher, J. A., & Dent, S. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-43096-6_3 · Cited by 4
Cytotoxic and Apoptogenic Properties of 2-Phenylthiazole-4-carboxamide Derivatives in Human Carcinoma Cell Lines
Tarhan, H. N., Hosseinzadeh, L., Aliabadi, A., Gholamine, B., & Foroumadi, A. (2012) · doi:10.22110/jrps.v1i1.60 · Cited by 4
Bioinformatic analysis of microarray data reveals several key genes related to heart failure.
Zhang, Z., Cao, H., Liu, G., Fan, H.-M., & Liu, Z.-M. (2013) · PubMed · Cited by 4
METALLOTHIONEIN AND CARDIOMYOPATHY
Cai, L. (2008) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812778949_0012 · Cited by 4
Role of soluble Fas ligand in myocardial remodeling, severity and outcomes of chronic heart failure
Teplyakov, A. T., Березикова, Е. Н., Shilov, S. N., Grakova, E. V., Торим, Ю. Ю., Ефремов, А. В., Попова, А. А., Пустоветова, М. Г., Sabirova, А. Y., & Kopeva, K. V. (2016) · Terapevticheskii arkhiv · doi:10.17116/terarkh201688910-16 · Cited by 4
IQ-RKT Formulation mitigates cardiomyocytes injury by targeting AGEs-RAGE-ROS-dependent TRAF3IP2/JNK apoptotic nexus in diabetes
Jahan, H., Fatima, U., Asad, S., Zahoor, S., Tufail, P., Zainab, D., Siddiqui, N. N., Ullah, A., Pizzi, M., & Choudhary, M. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.01.004 · Cited by 3
The role of cardiomyocyte apoptosis in mechanisms of ischemic myocardial remodeling
Хлапов, А. П., Vechersky, Y. Y., Ryazantsevа, N. V., Kalyuzhin, V. V., Mustafina, L. R., Shipulin, V. V., & Novitsky, V. V. (2008) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2008-3-33-38 · Cited by 2
Principles of Cardiovascular Tissue Engineering
Ruvinov, E., Shandalov, Y., Levenberg, S., & Cohen, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-420145-3.00018-3 · Cited by 2
Hipertensión arterial, cardiopatía hipertensiva e insuficiencia cardíaca. Papel de los diuréticos de asa
Anguita, M. P., Toledano, F., León, C., & Castillo, J. C. (2008) · Medicina Clínica · doi:10.1157/13128726 · Cited by 2
Structural Remodeling in the Development of Chronic Systolic Heart Failure: Implication for Treatment
Anand, I. S., & Florea, V. G. (2017) · Springer eBooks · doi:10.1007/978-3-319-44577-9_17 · Cited by 1
Association of serum leptin and resistin levels among obese Saudi patients with acute myocardial infarction in Asir region
Dera, A. A., Algamdi, B., Ahmad, I., Shahrani, M. M. A., Alraey, Y., Hashlan, I., Alwadei, I., Zaman, G. S., Al-Faifi, M., Gahtani, R. M., et al. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.6.1 · Cited by 1
Beyond perfusion: a review of peptide radiopharmaceuticals for cardiovascular imaging
Krol, V. E., Sharma, V., Kusmirek, J. E., Zahid, M., Johnson, D. R., & Pandey, M. K. (2025) · npj Imaging · doi:10.1038/s44303-025-00124-9 · Cited by 1
Renin–Angiotensin–Aldosterone System and Cardiomyocyte Apoptosis in Hypertensive Heart Disease
González, A., Ravassa, S., López, B., Beaumonta, J., & Dı́ez, J. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0528-4_14 · Cited by 1
Instructive Biomaterials for Myocardial Regeneration and Repair
Ruvinov, E., & Cohen, S. (2011) · Studies in mechanobiology, tissue engineering and biomaterials · doi:10.1007/8415_2010_53 · Cited by 1
An Assessment of the Chances of Antiapoptotic Drug Therapy in Patients with Neurodegenerative Disorders
Waldmeier, P. C. (2007) · Elsevier eBooks · doi:10.1016/b978-044452809-4/50162-9
Exercise-Induced Cardioprotection: Overview with an Emphasis on the Role of Antioxidants
Hamilton, K. L., & Quindry, J. C. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_28
La céruloplasmine et l'oxyde nitrique dans la protection des cellules cardiaques
Gagné, J. (2008) · Archipel (Université du Québec à Montréal)
Obesity and Cardiac Dysfunction
Sweeney, G., Litwin, S. E., & Abel, E. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_14
Postmitochondrial regulation of apoptosis in neurons and cancer cells
Vaughn, A. E. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvyq-7s62
Evolving Concepts on the Basic Mechanisms of Heart Failure
Dorobanţu, M., & Onciul, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-45237-1_2

Authors: GARG, S., NARULA, J., & CHANDRASHEKHAR, Y.
Affiliations: Drexel University (US)
University of California, Irvine Medical Center (US)
University of Minnesota (US)
ORCID: GARG, S
NARULA, J
Venue: Journal of Molecular and Cellular Cardiology
Publisher: Elsevier BV
Published: 2005-01
Volume: 38
Issue: 1
Pages: 73-79
ISSN: 0022-2828 (ISSN-L)
DOI: 10.1016/j.yjmcc.2004.11.006
OpenAlex: W2110058514
Cited by: 103
References: 77
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 3 · 2012: 7
FWCI: 5.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Molecular and Cellular Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Keywords: apoptosis, heart failure, cardiomyocyte loss, myocardial necrosis, anti-apoptotic therapy, heart failure pathogenesis, systolic dysfunction, diastolic dysfunction, therapeutic target
MeSH terms: Animals, Humans, Cardiomyopathies, Myocardial Reperfusion Injury, Apoptosis, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Apoptosis and heart failure: clinical relevance and therapeutic target

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks