The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.
Apoptosis and heart failure: clinical relevance and therapeutic target
Abstract
Heart failure is the final common pathway of diverse etiologies that are characterized by impaired systolic and/or diastolic function with high morbidity and mortality. An integral part of pathogenesis of heart failure is myocyte loss. The traditional explanation for myocyte loss was cell necrosis but over the last decade, there has been a surge of evidence affirming the role of apoptosis in genesis of heart failure. Studies have raised apoptosis from a 'histologic curiosity' to an exciting 'clinical target' that can be modulated to attenuate the progression of heart failure. This review will focus on the clinical relevance of apoptosis in human and experimental heart failure and identify some of the progress made in myocardial anti-apoptotic intervention.
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“Myocyte apoptosis has been suggested to be an important etiological component of heart failure, particularly in the transition from compensatory remodeling to heart failure (112), although this concept has been somewhat contentious (95, 189, 295, 301).”
From Cardiac remodeling in obesity (2008) · cites this paper as [112]
Citations
Cites
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Cohn, J. N., Ferrari, R., & Sharpe, N. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00630-0 · Cited by 2,161
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673
Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
Gottlieb, R. A., Burleson, K. O., Kloner, R. A., Babior, B., & Engler, R. L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117504 · Cited by 1,442
Apoptosis in Myocytes in End-Stage Heart Failure
Narula, J., Haider, N., Virmani, R., DiSalvo, T. G., Kolodgie, F. D., Hajjar, R. J., Schmidt, U., Semigran, M. J., Dec, G. W., & Khaw, B.-A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351603 · Cited by 1,430
Self-citationKajstura, J., Cheng, W. N., Krzysztof Reiss, F., CLARK, W. A., Sonnenblick, E. H., Krajewski, S., Reed, J., Olivetti, G., & Anversa, P. (1996) · PubMed · Cited by 1,039
Apoptosis in human acute myocardial infarction.
Saraste, A., Pulkki, K., Kallajoki, M., Henriksen, K., Parvinen, M., & Voipio-Pulkki, L.-M. (1997) · Circulation · doi:10.1161/01.cir.95.2.320 · Cited by 825 · cited 2×
“[14] Saraste A, Pulkki K, Kallajoki M, Henriksen K, Parvinen M, VoipioPulkki M.”
BackgroundApoptosis in Ischemic and Reperfused Rat Myocardium
Fliss, H., & Gattinger, D. A. (1996) · Circulation Research · doi:10.1161/01.res.79.5.949 · Cited by 803
A mechanistic role for cardiac myocyte apoptosis in heart failure
Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., & Kitsis, R. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17664 · Cited by 765
Communal, C., Singh, K., Pimentel, D. R., & Colucci, W. S. (1998) · Circulation · doi:10.1161/01.cir.98.13.1329 · Cited by 690
Cited by
Sorted by citations
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Cai, L., Wang, Y., Zhou, G., Chen, T., Song, Y., Li, X., & Kang, Y. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.022 · Cited by 378
Obesity and subtypes of incident cardiovascular disease
Ndumele, C. E., Matsushita, K., Lazo, M., Bello, N., Blumenthal, R. S., Gerstenblith, G., Nambi, V., Ballantyne, C. M., Solomon, S. D., Selvin, E., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003921 · Cited by 259
French, J. P., Hamilton, K. L., Quindry, J. C., Lee, Y., Upchurch, P. A., & Powers, S. K. (2008) · The FASEB Journal · doi:10.1096/fj.07-102541 · Cited by 153
Mechanisms of Disease: apoptosis in heart failure—seeing hope in death
Narula, J., Haider, N., Arbustini, E., & Chandrashekhar, Y. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0710 · Cited by 141
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Metadata
- Authors
- GARG, S., NARULA, J., & CHANDRASHEKHAR, Y.
- Affiliations
- Drexel University (US)
- University of California, Irvine Medical Center (US)
- University of Minnesota (US)
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 38
- Issue
- 1
- Pages
- 73-79
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2110058514
- Cited by
- 103
- References
- 77
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 3 · 2012: 7
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- apoptosis, heart failure, cardiomyocyte loss, myocardial necrosis, anti-apoptotic therapy, heart failure pathogenesis, systolic dysfunction, diastolic dysfunction, therapeutic target
- MeSH terms
- Animals, Humans, Cardiomyopathies, Myocardial Reperfusion Injury, Apoptosis, Disease Progression
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