Cited by 103Cardiac Fibrosis and RemodelingCell death mechanisms and regulationCardiac Ischemia and Reperfusion

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Apoptosis and heart failure: clinical relevance and therapeutic target

GARG, S, NARULA, J, CHANDRASHEKHAR, Y·2005·Journal of Molecular and Cellular Cardiology

DOI 10.1016/j.yjmcc.2004.11.006

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Abstract

Heart failure is the final common pathway of diverse etiologies that are characterized by impaired systolic and/or diastolic function with high morbidity and mortality. An integral part of pathogenesis of heart failure is myocyte loss. The traditional explanation for myocyte loss was cell necrosis but over the last decade, there has been a surge of evidence affirming the role of apoptosis in genesis of heart failure. Studies have raised apoptosis from a 'histologic curiosity' to an exciting 'clinical target' that can be modulated to attenuate the progression of heart failure. This review will focus on the clinical relevance of apoptosis in human and experimental heart failure and identify some of the progress made in myocardial anti-apoptotic intervention.

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Authors: GARG, S., NARULA, J., & CHANDRASHEKHAR, Y.
Affiliations: Drexel University (US)
University of California, Irvine Medical Center (US)
University of Minnesota (US)
ORCID: GARG, S
NARULA, J
Venue: Journal of Molecular and Cellular Cardiology
Publisher: Elsevier BV
Published: 2005-01
Volume: 38
Issue: 1
Pages: 73-79
ISSN: 0022-2828 (ISSN-L)
DOI: 10.1016/j.yjmcc.2004.11.006
OpenAlex: W2110058514
Cited by: 103
References: 77
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 3 · 2012: 7
FWCI: 5.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Molecular and Cellular Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Keywords: apoptosis, heart failure, cardiomyocyte loss, myocardial necrosis, anti-apoptotic therapy, heart failure pathogenesis, systolic dysfunction, diastolic dysfunction, therapeutic target
MeSH terms: Animals, Humans, Cardiomyopathies, Myocardial Reperfusion Injury, Apoptosis, Disease Progression

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Apoptosis and heart failure: clinical relevance and therapeutic target

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