The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Monocyte and macrophage contributions to cardiac remodeling
Open accessAbstract
The mammalian heart contains a population of resident macrophages that expands in response to myocardial infarction and hemodynamic stress. This expansion occurs likely through both local macrophage proliferation and monocyte recruitment. Given the role of macrophages in tissue remodeling, their contribution to adaptive processes in the heart is conceivable but currently poorly understood. In this review, we discuss monocyte and macrophage heterogeneity associated with cardiac stress, the cell’s potential contribution to the pathogenesis of cardiac fibrosis, and describe different tools to study and characterize these innate immune cells. Finally, we highlight their potential role as therapeutic targets.
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Citations
Cites
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BackgroundInfluentialA Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
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Self-citationIdentification of splenic reservoir monocytes and their deployment to inflammatory sites
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Self-citationTranscriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation
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“These markers include CD11b, CD45, CD68, CD115, F4/80, Ly-6C and MAC-3 in addition to the core macrophage signature suggested by the Immunological Genome Project, which include FCGR1 and MerTK [75].”
Background
Cited by
Cardiac macrophages promote diastolic dysfunction
Hulsmans, M., Sager, H. B., Roh, J. D., Valero-Muñoz, M., Houstis, N. E., Iwamoto, Y., Sun, Y., Wilson, R. M., Wojtkiewicz, G., Tricot, B., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171274 · Cited by 494
Self-citationRusso, I., & Frangogiannis, N. G. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.011 · Cited by 474
Sano, S., Oshima, K., Wang, Y., Katanasaka, Y., Sano, M., & Walsh, K. (2018) · Circulation Research · doi:10.1161/circresaha.118.313225 · Cited by 417
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair
Lafuse, W. P., Wozniak, D. J., & Rajaram, M. V. S. (2020) · Cells · doi:10.3390/cells10010051 · Cited by 401
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease
Gourdie, R. G., Dimmeler, S., & Kohl, P. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.89 · Cited by 332
Metadata
- Authors
- Hulsmans, M., Sam, F., & Nahrendorf, M.
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 93
- Pages
- 149-155
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2175910351
- Cited by
- 277
- References
- 19
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
