The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair
Open accessAbstract
The immune system plays a pivotal role in the initiation, development and resolution of inflammation following insult or damage to organs. The heart is a vital organ which supplies nutrients and oxygen to all parts of the body. Heart failure (HF) has been conventionally described as a disease associated with cardiac tissue damage caused by systemic inflammation, arrhythmia and conduction defects. Cardiac inflammation and subsequent tissue damage is orchestrated by the infiltration and activation of various immune cells including neutrophils, monocytes, macrophages, eosinophils, mast cells, natural killer cells, and T and B cells into the myocardium. After tissue injury, monocytes and tissue-resident macrophages undergo marked phenotypic and functional changes, and function as key regulators of tissue repair, regeneration and fibrosis. Disturbance in resident macrophage functions such as uncontrolled production of inflammatory cytokines, growth factors and inefficient generation of an anti-inflammatory response or unsuccessful communication between macrophages and epithelial and endothelial cells and fibroblasts can lead to aberrant repair, persistent injury, and HF. Therefore, in this review, we discuss the role of cardiac macrophages on cardiac inflammation, tissue repair, regeneration and fibrosis.
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1 retracted
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Cited by
Metabolism of tissue macrophages in homeostasis and pathology
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Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
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Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired
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Human Organoids for Predictive Toxicology Research and Drug Development
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Du, J., Dong, Y., Song, J., Shui, H., Xiao, C., Hu, Y., Zhou, S., & Wang, S. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13266 · Cited by 29
Metadata
- Authors
- Lafuse, W. P., Wozniak, D. J., & Rajaram, M. V. S.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2020-12-31
- Volume
- 10
- Issue
- 1
- Pages
- 51
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W3115840934
- Cited by
- 401
- References
- 204
- FWCI
- 22.62
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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