The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Increased Microglial Exosomal miR-124-3p Alleviates Neurodegeneration and Improves Cognitive Outcome after rmTBI
Open accessAbstract
Repetitive mild traumatic brain injury (rmTBI) is considered to be an important risk factor for long-term neurodegenerative disorders such as Alzheimer's disease, which is characterized by β-amyloid abnormalities and impaired cognitive function. Microglial exosomes have been reported to be involved in the transportation, distribution, and clearance of β-amyloid in Alzheimer's disease. However, their impacts on the development of neurodegeneration after rmTBI are not yet known. The role of miRNAs in microglial exosomes on regulating post-traumatic neurodegeneration was investigated in the present study. We demonstrated that miR-124-3p level in microglial exosomes from injured brain was significantly altered in the acute, sub-acute, and chronic phases after rmTBI. In in vitro experiments, microglial exosomes with upregulated miR-124-3p (EXO-124) alleviated neurodegeneration in repetitive scratch-injured neurons. The effects were exerted by miR-124-3p targeting Rela, an inhibitory transcription factor of ApoE that promotes the β-amyloid proteolytic breakdown, thereby inhibiting β-amyloid abnormalities. In mice with rmTBI, the intravenously injected microglial exosomes were taken up by neurons in injured brain. Besides, miR-124-3p in the exosomes was transferred into hippocampal neurons and alleviated neurodegeneration by targeting the Rela/ApoE signaling pathway. Consequently, EXO-124 treatments improved the cognitive outcome after rmTBI, suggesting a promising therapeutic strategy for future clinical translation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“When administered intravenously, these exosomes were found to inhibit neuronal inflammation and autophagy, enhance neurogenesis, and consequently improve neurological outcomes in mice [169].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [169]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Ge et al. discovered that miR-124 is abundantly present in sEVs derived from M2-microglia.”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [169]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Notably, miR-124-3p within these exosomes was transferred to hippocampal neurons, where it mitigated neurodegeneration by targeting the Rela/ApoE signaling pathway.”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [169]
The cited source says what the claim attributes to it.
In the citing paper
“Specifically, in mice models of repetitive mild TBI, these microglial exosomes were observed to be internalized by neurons in the injured brain.”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [169]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30371-x · Cited by 2,609
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Benilova, I., Karran, E., & De Strooper, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3028 · Cited by 1,962
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Asai, H., Ikezu, S., Tsunoda, S., Medalla, M., Luebke, J., Haydar, T., Wolozin, B., Butovsky, O., Kügler, S., & Ikezu, T. (2015) · Nature Neuroscience · doi:10.1038/nn.4132 · Cited by 1,591
A polarizing question: do M1 and M2 microglia exist?
Ransohoff, R. M. (2016) · Nature Neuroscience · doi:10.1038/nn.4338 · Cited by 1,573
Object recognition test in mice
Leger, M., Quiedeville, A., Bouet, V., Haelewyn, B., Boulouard, M., Schumann-Bard, P., & Freret, T. (2013) · Nature Protocols · doi:10.1038/nprot.2013.155 · Cited by 1,357
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329 · cited 1×
“In addition, the expression of Ab clearance genes could be downregulated with the progression of AD in response to pro-inflammatory cytokines produced by activated microglia.(20,21) These studies suggest that the beneficial/detrimental effects of microglial exosomes are determined by the progressing stages of AD and a…”
BackgroundApoE Promotes the Proteolytic Degradation of Aβ
Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.010 · Cited by 876
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 247
Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics
Pauwels, M. J., Xie, J., Ceroi, A., Balusu, S., Castelein, J., Wonterghem, E. V., Imschoot, G. V., Ward, A., Menheniott, T. R., Gustafsson, O., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121830 · Cited by 19
Lin, K., Lin, W., Guo, Z., Chen, C., Liang, C., & Cai, X. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1545690 · Cited by 19
The role of microglial exosomes in brain injury
Chen, Y., Zhu, J., Ji, J., Liu, Z., & Ren, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1003809 · Cited by 18
Zhao, J., Zhang, W., Wang, S., Li, Z., Huang, Y., & Li, L. (2022) · Aging · doi:10.18632/aging.204398 · Cited by 18
miR ‐124‐3p improves mitochondrial function of renal tubular epithelial cells in db/db mice
Liang, L., Wo, C., Yuan, Y., Cao, H., Tan, W., Zhou, X., Wang, D., Chen, R., Shi, M., Zhang, F., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202201202rr · Cited by 17
Rajizadeh, M. A., Motamedy, S., Mir, Y., Akhgarandouz, F., Nematollahi, M. H., & Nezhadi, A. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105011 · Cited by 17
Kaurani, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052866 · Cited by 20
Yin-Yang: two sides of extracellular vesicles in inflammatory diseases
Zeng, B., Li, Y., Khan, N., Su, A., Yang, Y., Mi, P., Jiang, B., Liang, Y., & Duan, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02779-9 · Cited by 17
Self-citationGe, X., Zhu, L., Li, W., Sun, J., Chen, F., Li, Y., Lei, P., & Zhang, J. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2020.7481 · Cited by 18
Self-citationAdvances in Research on Exosomal miRNAs in Central Nervous System Diseases
Feng, G., Lan, X., Qin, S., Shi, Y., Zhao, Q., Li, Q., & Zhong, L. (2025) · ASN NEURO · doi:10.1080/17590914.2025.2465546 · Cited by 21
Chi, W., He, Y., Chen, S., Guo, L., Yuan, Y., Li, R., Liu, R., Zhou, D., Du, J., Xu, T., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.05.010 · Cited by 16
Neural Stem Cell‐Derived Extracellular Vesicles for Advanced Neural Repair
Moretti, E. H., Lin, A. L. Y., Peruzzotti‐Jametti, L., Pluchino, S., & Mozafari, S. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70170 · Cited by 16
Jin, Y., Zhang, Y., Song, M., Zhou, J., Zhang, H., & Ding, Y. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100344 · Cited by 17
Kong, E., Geng, X., Wu, F., Yue, W. W., Sun, Y., & Feng, X. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18090 · Cited by 16
Exosomal non-coding RNAs: gatekeepers of inflammation in autoimmune disease
Saadh, M. J., Allela, O. Q. B., Al-Hussainy, A. F., Baldaniya, L., Rekha, M. M., Nathiya, D., Kaur, P., Aminov, Z., Sameer, H. N., Hameed, H. G., et al. (2025) · Journal of Inflammation · doi:10.1186/s12950-025-00443-z · Cited by 20
Roles of microRNA-124 in traumatic brain injury: a comprehensive review
Wu, P., Bao, H., Li, X., & Zhang, H. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1298508 · Cited by 16
Nahvi, R. J., Tanelian, A., Nwokafor, C., Godino, A., Parise, E. M., Estill, M. S., Shen, L., Nestler, E. J., & Sabban, E. L. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114162 · Cited by 18
Wang, P., Dong, S., Liu, F., Liu, A., & Wang, Z. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114265 · Cited by 14
Huang, X., Xu, X., Wang, C., Wang, Y., Yang, Y., Yao, T., Bai, R., Pei, X., Bai, F., & Li, P. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1145307 · Cited by 14
Taheri, A. T., Golshadi, Z., Zare, H., Alinaghipour, A., Faghihi, Z., Dadgostar, E., Tamtaji, Z., Aschner, M., Mirzaei, H., Tamtaji, O. R., et al. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01461-w · Cited by 15
Therapeutic effect of extracellular vesicles from different cell sources in traumatic brain injury
Gao, Y., Wang, C., Jin, F., Han, G., & Cui, C. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101772 · Cited by 13
Ashmwe, M., Posa, K., Rührnößl, A., Heinzel, J. C., Heimel, P., Mock, M., Schädl, B., Keibl, C., Couillard‐Després, S., Redl, H. R., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10071630 · Cited by 15
Research progress on miR-124-3p in the field of kidney disease
Chen, G., Wang, Y., Zhang, L., Yang, K., Wang, X., & Chen, X. (2024) · BMC Nephrology · doi:10.1186/s12882-024-03688-7 · Cited by 13
Gong, J., Li, J., Li, J., He, A., Ren, B., Zhao, M., Li, K., Zhang, Y., He, M., Liu, Y., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04858-w · Cited by 15
Yu, M., Tian, T., Zhang, J., & Hu, T. (2022) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2022.03.010 · Cited by 14
Self-citationBukke, S. P. N., Yadav, S., Prajapati, S., Rani, S. S., Reddy, M. S., Thalluri, C., Chettupalli, A. K., Goruntla, N., Pradeepkumar, B., Eftekhari, Z., et al. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2607157 · Cited by 12
Mohamadzadeh, O., Hajinouri, M., Moammer, F., Zadeh, S. S. T., Shafiei, G. O., Jafari, A., Ostadian, A., Talaei, S. A., Hamblin, M. R., Yazdi, A. J., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03321-y · Cited by 12
Kim, K., Hong, E. P., Lee, Y., McLean, Z. L., Elezi, E., Lee, R., Kwak, S., McAllister, B., Massey, T. H., Lobanov, S. V., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322924121 · Cited by 11
Role of miRNAs in neurovascular injury and repair
Sawant, H., Sun, B., Mcgrady, E., & Bihl, J. C. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241254772 · Cited by 12
Hsi, P. T., Tandon, V., & Kaplan, D. L. (2025) · Scientific Reports · doi:10.1038/s41598-025-04835-2 · Cited by 11
Traumatic Brain Injury: Novel Experimental Approaches and Treatment Possibilities
Pilipović, K., Janković, T., Bumber, J. R., Belančić, A., & Mršić‐Pelčić, J. (2025) · Life · doi:10.3390/life15060884 · Cited by 11
MiR-214-3p Prevents the Development of Perioperative Neurocognitive Disorders in Elderly Rats
Wang, Y.-H., Chen, Y.-W., Xiao, W.-L., Li, X., Feng, L., Liu, Y.-L., & Duan, X.-X. (2022) · Current Medical Science · doi:10.1007/s11596-022-2572-x · Cited by 9
Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis
Molibeli, K. M., Hu, R. H., Liu, Y., Xiong, D., & Tang, L. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.769832 · Cited by 11
Advancing Alzheimer’s disease therapy through engineered exosomal Macromolecules
Jain, S., Murmu, A., & Chauhan, A. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149590 · Cited by 10
Tu, Y., Hsueh, Y.-H., & Huang, H.-C. (2021) · Current Neurovascular Research · doi:10.2174/1567202618666211012162111 · Cited by 10
Luo, H., Chen, J. M., Liu, J., Wang, W., Hou, C., Jiang, X., Ma, J., Xu, F., Aili, X., Zhou, Z., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2024.1479272 · Cited by 9
Exosome-based therapies and biomarkers in stroke: Current advances and future directions
Poondla, N., Babaeizad, A., Sheykhhasan, M., Barry, C. J., Manoochehri, H., Tanzadehpanah, H., Mahaki, H., & Al-Musawi, S. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115286 · Cited by 11
Romero-García, N., Ruiz-Pacheco, A., Huete-Acevedo, J., Monleón, B., Vicente, A., Mas‐Bargues, C., Sanz‐Ros, J., García‐Pérez, M. L., Gutiérrez, A., Carbonell, J., et al. (2025) · Critical Care · doi:10.1186/s13054-025-05477-6 · Cited by 10
Sanadgol, N., Mousavi, P., Sadri, F., Voelz, C., Scheld, M., Khalseh, R., Amini, J., Karimi, E., Rahi, A., Sepand, M. R., et al. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00502-8 · Cited by 10
He, Y., Zhu, H., Zhou, Z., & Qu, K.-K. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i8.108933 · Cited by 9
Engineered exosomes derived from stem cells: a new brain-targeted strategy
Waqas, A., Huang, S., & Chen, L. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2306877 · Cited by 9
Self-citationChen, Y., Huang, Y., Chen, C., Wen, Y., Tsai, R., & Chen, C. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.1.17 · Cited by 9
Negah, S. S., Moradi, H. R., Forouzanfar, F., Sahraian, M. A., & Faraji, M. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04344-8 · Cited by 8
Anjum, A., Chan, A., Hussain, H. B., & Lokanathan, Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s522028 · Cited by 8
Salim, M. W., Zhang, W., Collins‐Praino, L. E., Wang, Y., & Care, A. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202504608 · Cited by 8
Tumor Suppressor MicroRNAs in Clinical and Preclinical Trials for Neurological Disorders
Lui, A., Do, T., Alzayat, O., Yu, N., Phyu, S. M., Santuya, H. J., Liang, B., Kailash, V., Liu, D., Inslicht, S. S., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17040426 · Cited by 9
Usefi, F., Rustamzadeh, A., Ghobadi, Z., Sadigh, N., Mohebi, N., Ariaei, A., & Moradi, F. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01371-2 · Cited by 8
The role of microglia in neurological diseases with involvement of extracellular vesicles
Xie, H., Wu, F., Mao, J., Wang, Y., Zhu, J., Zhou, X., Hong, K., Li, B., Qiu, X., & Wen, C. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106700 · Cited by 9
Wang, Z., Zhang, X., Wang, Y., & Xiao, D. (2021) · Clinical and Experimental Optometry · doi:10.1080/08164622.2021.1913043 · Cited by 8
Han, Z. H., Zhang, L., Ma, M., & Keshavarzi, M. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04292-4 · Cited by 8
Exercise mimetics: molecular mechanisms, biological and therapeutic effects
Zhang, J., Shao, Q., 程腾, Lin, J., Tang, Y., Lu, H., Zhang, Y., Yu, Z., & Cao, L. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00483-8 · Cited by 8
Self-citationYang, Z., Liang, Z., Lin, Y., Lin, F., Rao, J., Xu, X., Wang, C., & Chen, C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1147194 · Cited by 7
Dong, Z., Jia, L., Han, W., Wang, Y., Sheng, M., Ren, Y., Weng, Y., Li, H., & Yu, W. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110668 · Cited by 7
Exosomes: A Cellular Communication Medium That Has Multiple Effects On Brain Diseases
Fang, X., Zhou, D., Wang, X., Ma, Y., Zhong, G., Jing, S., Huang, S., & Wang, Q. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03957-4 · Cited by 7
Self-citationFeng, S., Wu, Z., Zheng, X., Shao, Z., Lin, Q., & Sun, S. (2024) · European journal of medical research · doi:10.1186/s40001-024-01790-y · Cited by 7
An, Y., Su, G., Chen, W., Song, J., Chai, M., Zhu, L., & Zhang, Z. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.105949 · Cited by 7
Self-citationSharma, D., Srivastava, S., & Babu, M. R. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10639-4 · Cited by 8
Roles of microglial membranes in Alzheimer's disease
Shin, J., & Lee, J. C. (2020) · Current topics in membranes · doi:10.1016/bs.ctm.2020.08.007 · Cited by 7
Xiao, L., Hu, M., Yuan, W., Liu, Y., Li, J., Bai, C., & Yuan, Z. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.153903 · Cited by 7
Xie, M., Wang, T., Feng, J., Ma, D., Feng, L., & Hao, Y. (2025) · Current Neuropharmacology · doi:10.2174/1570159x23666250225091729 · Cited by 7
Pal, S., & Mandal, S. (2025) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2025.1004111 · Cited by 9
Jia, Z.-X., Guo, M., Li, M., Liao, P., Yan, B., Zhang, W., Cheng, F.-Y., Liu, Y., Zhang, Z.-H., Wei, C., et al. (2025) · Military Medical Research · doi:10.1186/s40779-025-00631-1 · Cited by 7
Self-citationMu, S. M., Xue, D., Qin, X., Du, G., & Zhou, Y. (2023) · Advanced Biology · doi:10.1002/adbi.202300084 · Cited by 6
Dwyer, M. K. R., Amelinez-Robles, N., Polsfuss, I., Herbert, K. L., Kim, C., Varghese, N. J., Parry, T. J., Buller, B., Verdoorn, T. A., Billing, C. B., et al. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114608 · Cited by 6
Exosomes in epilepsy: bridging neuroinflammation, diagnosis, and therapeutic delivery
Li, B., Zhu, Y., Chen, L., Cui, J., & Zhang, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1667122 · Cited by 7
Research progress of exosomes used in the Alzheimer's disease treatment
Gao, X., Yang, K., Yuan, X., Song, M., Wang, T., & Shen, C. (2025) · Discover Nano · doi:10.1186/s11671-025-04361-0 · Cited by 6
Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment
Tahmasebi, F., Asl, E. R., Vahidinia, Z., & Barati, S. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01478-1 · Cited by 6
Wang, M., Zhang, B., Jin, F., Li, G., Cui, C., & Feng, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32022 · Cited by 6
RetractedFunctional Roles of Mesenchymal Stem Cell-derived Exosomes in Ischemic Stroke Treatment
Farzaneh, M., & Khoshnam, S. E. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x18666221222123818 · Cited by 5
A New Paradigm in Spinal Cord Injury Therapy: from Cell-free Treatment to Engineering Modifications
Qin, B., Hu, X., Huang, Y., Yang, R.-H., & Xiong, K. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230418090857 · Cited by 5
Extracellular Vesicles: The Invisible Heroes and Villains of COVID‐19 Central Neuropathology
Chang, H., Chen, E., Hu, Y., Wu, L., Deng, L., Ye, S., Mao, X., Zhu, T., Liu, J., & Chen, C. (2023) · Advanced Science · doi:10.1002/advs.202305554 · Cited by 4
Corraliza-Gómez, M., Ianni, M., Nogueira, D. E. S., Salvador, W. O. S., Migueis, M., Garcı́a-Alloza, M., Rodrigues, C. A. V., Cabral, J. M. S., & Brites, D. M. T. O. (2026) · Journal of Biological Engineering · doi:10.1186/s13036-025-00597-7 · Cited by 4
Huang, Y., Zhong, C.-Y., Burley, G., Shi, Y., & Lin, S. (2026) · Metabolites · doi:10.3390/metabo16030148 · Cited by 4
Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles
Zhang, Y., Yin, Z., Zou, Z., Feng, S., & Xu, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1613378 · Cited by 4
Self-citationLiu, Y., Liao, P., Yan, B., Li, D., Zhang, S., Zhang, W., Jia, Z., Zhang, Z., Gao, H., Liu, Q., et al. (2025) · Aging Cell · doi:10.1111/acel.70228 · Cited by 4
Self-citationYan, X., Shen, H., Zhao, M., Nie, S., Huang, Y., & Sun, J. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00798 · Cited by 4
Chen, M., Gu, C., Lai, Y., Lin, Y., Xu, Y., Li, X., & Chen, X. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s580440 · Cited by 4
Lu, D., Sun, H., Fan, H., Li, N., Li, Y., Yin, X., Fan, Y., Sun, H., Wang, S., & Xin, T. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.011 · Cited by 4
Self-citationZheng, Y., Wang, Y., Liu, W., Mujite, A., Li, Y., Ma, X., Abulimiti, M., Maimaitiaili, N., & Qin, H. (2025) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2025.12807 · Cited by 4
Self-citationDovrolis, N., Nikou, M., Gkrouzoudi, A., Dimitriadis, N., & Maroulakou, I. G. (2022) · Biomolecules · doi:10.3390/biom12020263 · Cited by 4
Toledano‐Díaz, A., Álvarez, M. I., & Tolédano, A. (2022) · Journal of Central Nervous System Disease · doi:10.1177/11795735221123896 · Cited by 5
Small extracellular vesicles as potential theranostic tools in central nervous system disorders
Guo, M., Wang, L., Yin, Z., Chen, F., & Lei, P. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115407 · Cited by 4
Self-citationMicroRNA and Alzheimer’s disease: Diagnostic biomarkers and potential therapeutic targets
Huang, Y., Chen, Y., He, Z., Lu, W., Lai, H., Wang, Y., & Wang, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00002 · Cited by 4
Wei, H., Zhang, G., Xu, Y., Zhao, A., Zheng, Y., Shao, Y. W., Yang, L., Wang, J., & Jiang, X. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157238 · Cited by 3
Liu, Y. N., Liu, S., Yan, B., Yin, Z., Liao, P., Wang, Y., Li, D., Han, Z., Zhang, S., Ge, X., et al. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112931 · Cited by 3
Self-citationXing, L., Liu, A., Gao, W., Li, J., Yao, M., Song, J., Duan, P., & Li, H. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71330 · Cited by 3
MicroRNAs: A Novel Approach for Monitoring Treatment Response in Major Depressive Disorder?
Cătană, C.-S., Marta, M. M., Ungureanu, D., & Crișan, C. (2025) · Non-Coding RNA · doi:10.3390/ncrna11020021 · Cited by 4
Zhou, J., Pu, Y., Ren, X., Li, L., Chen, Z., Lo, E. H., & Li, W. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x251348816 · Cited by 3
Self-citationRelation between tumor micro-environment and epigenetic alterations in hematological malignancies
Torres, X., & Cómbita, A. L. (2021) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2021.100024 · Cited by 3
Zohoncon, T. M., Sawadogo, J., Ouattara, A. K., Zouré, A. A., Ouedraogo, M. N. L., Ouédraogo, P., Djigma, F. W., Nadembega, C., Kabore, R., Ouermi, D., et al. (2023) · Advances in Alzheimer s Disease · doi:10.4236/aad.2023.124005 · Cited by 3
Microglia-derived sEV: Friend or foe in the pathogenesis of cognitive impairment
Chen, L., & Wang, W. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111287 · Cited by 3
Eva, T. A., Shenoy, A., Gupta, V. B., Palanivel, V., Salkar, A., Nasab, S. N., Chitranshi, N., Mirzaei, M., You, Y., Graham, S. L., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05304-7 · Cited by 2
Wang, X., Fan, Y., Dong, X., Wu, H., & Guan, Q. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.112152 · Cited by 3
Two epigenetic markers of the fibromyalgia syndrome: A matched case-control study
DeLay, M., Macian, N., Dualé, C., Pereira, B., Aissouni, Y., Lippi, Y., & Pickering, G. P. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105630 · Cited by 2
Islam, A. W., Rao, Z. K., Wilkhoo, H. S., Singh, B., Hussain, S., & Kadam, S. (2026) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2026.1004137 · Cited by 2
Zhang, Q., Chen, T., Chen, J., Ai, Y., Chen, Z., Liu, G., Zhang, Y., Liu, B., Liu, J., Tang, Z., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04064-3 · Cited by 2
Diana, A., Gaido, G., Maxia, C., & Murtas, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249630 · Cited by 2
Biomarkers in Brain Traumatic Injury
Sabet, H. S., Sabet, F. S., Shojaei, K., Yaghoubi, F., & Jafarian, M. (2022) · The Neuroscience Journal of Shefaye Khatam · doi:10.52547/shefa.11.1.133 · Cited by 2
Applications and Developments of Gene Therapy Drug Delivery Systems for Neurological Disorders
Nguyen, N. H., Nguyen‐Thi, P., Nguyen, T. T., Bui, V. K. H., Nguyen, N. T. T., & Giau, V. V. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400269 · Cited by 2
Yang, H.-B., Lu, D.-C., Shu, M., Li, J., & Ma, Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114049 · Cited by 2
Metadata
- Authors
- Ge, X., Guo, M., Hu, T., Li, W., Huang, S., Yin, Z., Li, Y., Chen, F., Zhu, L., Kang, C., Jiang, R., Lei, P., & Zhang, J.
- Affiliations
- Tianjin Medical University General Hospital (CN)
- Corresponding author
- Jiang, Rongcai
- Lei, Ping
- Zhang, Jianning
- ORCID
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 28
- Issue
- 2
- Pages
- 503-522
- ISSN
- 1525-0016 (ISSN-L)
- PMC
- PMC7001001
- OpenAlex
- W2990551073
- Cited by
- 242
- References
- 67
- Citations by year
- 2026: 26 · 2025: 50 · 2024: 40 · 2023: 42 · 2022: 37 · 2021: 34 · 2020: 13
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Therapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81501055, 81772060, 81720108015, 81671221)
- Tianjin Municipal Science and Technology Commission Natural Fund Project (18JCQNJC81100)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- repetitive mild traumatic brain injury, miR-124-3p, neurodegeneration, cognitive impairment, amyloid-beta, Alzheimer's disease, exosome therapy, hippocampal neurons, microglia
- MeSH terms
- Animals, Apolipoproteins E, Brain Concussion, Cognition, Disease Models, Animal, Male, Models, Biological, Neurons, Severity of Illness Index, Signal Transduction, Microglia, Computational Biology, Neurodegenerative Diseases, Gene Expression Profiling, RNA Interference, MicroRNAs, Mice, Transcription Factor RelA, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
