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Cited by 281

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2

Open access
Yang, Yuhan, Guo, Zengya, Chen, Weiwei, Wang, Xiaofeng, Cao, Meng, Han, Xuan, Zhang, Kundong, Teng, Buwei, Cao, Jun, Wu, Weidong, Cao, Peng, Huang, Chen, Qiu, Zhengjun·2021·Molecular Therapy
DOI 10.1016/j.ymthe.2020.11.024
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Abstract

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive tumors all over the world, has a generally poor prognosis, and its progression is positively correlated with the density of blood vessels. Recently, tumor-associated macrophages (TAMs) were proven to be beneficial for angiogenesis, but their mechanism of action remains unclear. Our study indicated that M2 macrophages were positively correlated with the microvessel density (MVD) of PDAC tissues, and M2 macrophage-derived exosomes (MDEs) could promote the angiogenesis of mouse aortic endothelial cells (MAECs) in vitro. At the same time, the M2 MDEs could also promote the growth of subcutaneous tumors and increase the vascular density of mice. Moreover, we also found that miR-155-5p and miR-221-5p levels in the M2 MDEs were higher than those in M0 MDEs, and they could be transferred into MAECs, as demonstrated by RNA sequencing (RNA-seq) and qPCR analysis. Our data confirmed the interaction between TAMs and the angiogenesis of PDAC by exosomes. Additionally, targeting the exosomal miRNAs derived from TAMs might provide diagnostic and therapeutic strategies for PDAC.

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Metadata

Authors
Yang, Y., Guo, Z., Chen, W., Wang, X., Cao, M., Han, X., Zhang, K., Teng, B., Cao, J., Wu, W., Cao, P., Huang, C., & Qiu, Z.
Venue
Molecular Therapy
Publisher
Elsevier BV
Published
2021-03
Volume
29
Issue
3
Pages
1226-1238
ISSN
1525-0016 (ISSN-L)
DOI
10.1016/j.ymthe.2020.11.024
OpenAlex
W3103352762
Cited by
281
References
39
FWCI
8.85
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2. https://app.cochat.ai/papers/10.1016/j.ymthe.2020.11.024
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Yang, Y., Guo, Z., Chen, W., Wang, X., Cao, M., Han, X., Zhang, K., Teng, B., Cao, J., Wu, W., Cao, P., Huang, C., & Qiu, Z. (2021). M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2020.11.024

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.