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The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

The biology and function of exosomes in cancer

Open access
Kalluri, Raghu·2016·Journal of Clinical Investigation
DOI 10.1172/jci81135
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Abstract

Humans circulate quadrillions of exosomes at all times. Exosomes are a class of extracellular vesicles released by all cells, with a size range of 40-150 nm and a lipid bilayer membrane. Exosomes contain DNA, RNA, and proteins. Exosomes likely remove excess and/or unnecessary constituents from the cells, functioning like garbage bags, although their precise physiological role remains unknown. Additionally, exosomes may mediate specific cell-to-cell communication and activate signaling pathways in cells they fuse or interact with. Exosomes are detected in the tumor microenvironment, and emerging evidence suggests that they play a role in facilitating tumorigenesis by regulating angiogenesis, immunity, and metastasis. Circulating exosomes can be used as liquid biopsies and noninvasive biomarkers for early detection, diagnosis, and treatment of cancer patients.

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Metadata

Authors
Kalluri, R.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2016-04-01
Volume
126
Issue
4
Pages
1208-1215
ISSN
  • 0021-9738 (ISSN-L)
  • 1558-8238
DOI
10.1172/jci81135
OpenAlex
W2318433546
Cited by
1,849
References
13
FWCI
56.58
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The biology and function of exosomes in cancer. https://app.cochat.ai/papers/10.1172/jci81135
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Kalluri, R. (2016). The biology and function of exosomes in cancer. Journal of Clinical Investigation. https://doi.org/10.1172/jci81135

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