The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Macrophages as a therapeutic target to promote diabetic wound healing
Open accessAbstract
It is well established that macrophages are key regulators of wound healing, displaying impressive plasticity and an evolving phenotype, from an aggressive pro-inflammatory or "M1" phenotype to a pro-healing or "M2" phenotype, depending on the wound healing stage, to ensure proper healing. Because dysregulated macrophage responses have been linked to impaired healing of diabetic wounds, macrophages are being considered as a therapeutic target for improved wound healing. In this review, we first discuss the role of macrophages in a normal skin wound healing process and discuss the aberrations that occur in macrophages under diabetic conditions. Next we provide an overview of recent macrophage-based therapeutic approaches, including delivery of ex-vivo-activated macrophages and delivery of pharmacological strategies aimed at eliminating or re-educating local skin macrophages. In particular, we focus on strategies to silence key regulator genes to repolarize wound macrophages to the M2 phenotype, and we provide a discussion of their potential future clinical translation.
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1 retracted
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Origins and Mechanisms of miRNAs and siRNAs
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The M1 and M2 paradigm of macrophage activation: Time for reassessment
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Macrophages in Tissue Repair, Regeneration, and Fibrosis
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Alternative activation of macrophages: mechanism and functions
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A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Macrophage plasticity and polarization in tissue repair and remodelling
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Metadata
- Authors
- Sharifiaghdam, M., Shaabani, E., Faridi-Majidi, R., De Smedt, S. C., Braeckmans, K., & Fraire, J. C.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 30
- Issue
- 9
- Pages
- 2891-2908
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W4289527748
- Cited by
- 573
- References
- 163
- FWCI
- 34.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sharifiaghdam, M., Shaabani, E., Faridi-Majidi, R., De Smedt, S. C., Braeckmans, K., & Fraire, J. C. (2022). Macrophages as a therapeutic target to promote diabetic wound healing. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2022.07.016
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
