The DOI matches its Crossref record; 127 of the 129 references it cites were found in a registry or an index.
Nanoparticles skin absorption: New aspects for a safety profile evaluation
Abstract
Nanoparticles (NPs) skin absorption is a wide issue, which needs to be better understood. The attempt of this review is to summarize the scientific evidence concerning open questions, i.e.: the role of NPs intrinsic characteristics (size, shape, charge, surface properties), the penetration of NPs through the intact or impaired skin barrier, the penetration pathways which should be considered and the role of NPs interaction in physiological media. The outcomes suggest that one main difference should be made between metal and non-metal NPs. Both kinds have a secondary NPs size which is given after interaction in physiological media, and allows a size-dependent skin penetration: NPs⩽4nm can penetrate and permeate intact skin, NPs size between 4 and 20nm can potentially permeate intact and damaged skin, NPs size between 21 and 45nm can penetrate and permeate only damaged skin, NPs size>45nm cannot penetrate nor permeate the skin. Other aspects play an important role, mostly for metal NPs, i.e., dissolution in physiological media, which can cause local and systemic effects, the sensitizing or toxic potential and the tendency to create aggregates. This paper suggests a decision tree to evaluate the potential risk for consumers and workers exposed to NPs.
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In the citing paper
“nanoparticles 21–45 nm only able to penetrate/permeate damaged skin”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“nanoparticles 4–20 nm potentially able to penetrate/permeate intact or damaged skin”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“nanoparticles ≤4 nm being able to penetrate/permeate intact skin”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“the underestimated risk associated with the absorption of nanoparticles through the skin [86].”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“TiO2 and ZnO nanoparticles were unable to pass through skin rendering them safe to dermal exposure.”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“Au nanoparticles can penetrate the skin, but their permeability is undetermined.”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“nanoparticles ≥45 nm unable to penetrate/permeate the skin [86].”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“Ag nanoparticles can penetrate the skin but their ability to permeate is undetermined.”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“Their use in medical dressings may result in high skin absorption, potentially affecting internal organs.”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“Concern in terms of being a hazardous material is low as gold is a noble metal, and, thus, non-toxic to human health.”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“Ni, Co, and Pd are considered more hazardous due to the high release of ions in the body [86].”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
In the citing paper
“The US is regulating nanoscale materials under the Toxic Substances Control Act (TSCA) to ensure that the manufacture and use of nanoscale materials do not pose unreasonable risks to human health and the environment [86].”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [86]
Citations
Cites
Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., et al. (2005) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-2-8 · Cited by 2,134
Epidermal Lipids, Barrier Function, and Desquamation
Elias, P. M. (1983) · Journal of Investigative Dermatology · doi:10.1038/jid.1983.12 · Cited by 1,356
Wijnhoven, S., Peijnenburg, W. J. G. M., Herberts, C. A., Hagens, W. I., Oomen, A. G., Heugens, E. H. W., Roszek, B., Bisschops, J., Gosens, I., van de Meent, D., et al. (2009) · Nanotoxicology · doi:10.1080/17435390902725914 · Cited by 1,321
Percutaneous Absorption. On the Relevance of in Vitro Data
Franz, T. (1975) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12533356 · Cited by 1,136
Drug permeation through human skin: Theory and invitro experimental measurement
Michaels, A. S., Chandrasekaran, S. K., & Shaw, J. E. (1975) · AIChE Journal · doi:10.1002/aic.690210522 · Cited by 803
Three-dimensional tissue culture based on magnetic cell levitation
Souza, G. R., Molina, J. R., Raphael, R. M., Ozawa, M. G., Stark, D. J., Levin, C. S., Bronk, L. F., Ananta, J. S., Mandelin, J., Georgescu, M., et al. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.23 · Cited by 672
Skin penetration and distribution of polymeric nanoparticles
Álvarez-Román, R., Naik, A., Kalia, Y. N., Guy, R. H., & Fessi, H. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.06.015 · Cited by 625
Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face?
Leroueil, P. R., Hong, S., Mecke, A., Baker, J. R., Orr, B. G., & Holl, M. M. B. (2007) · Accounts of Chemical Research · doi:10.1021/ar600012y · Cited by 544
Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties
Ryman-Rasmussen, J. P., Riviere, J. E., & Monteiro-Riviere, N. A. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj122 · Cited by 535
Lademann, J. M., Weigmann, H.-J., Rickmeyer, C., Barthelmes, H. U., Schaefer, H. E., Mueller, G. J., & Sterry, W. (1999) · Skin Pharmacology and Physiology · doi:10.1159/000066249 · Cited by 527
Research works printed but not linked: 5
- Baroli, 2007, Penetration of metallic nanoparticles in human full-thickness skin, J. Invest. Dermatol., 127, 1701, 10.1038/sj.jid.5700733 · DOI
- Journeay, 2014, Occupational handling of nickel nanoparticles: a case report, Am. J. Ind. Med., 10.1002/ajim.22344 · DOI
- Larese Filon, F., Mauro, M., Crosera, M., Bovenzi, M., 2013. Poster: “Platinum and Rhodium nanoparticles skin absorption” Thematic workshop on Toxicology related topics eco–nano–. University of Nova Gorica, 13th–14th June 2013.
- Larese Filon, F., Crosera, M., Adami, G., Comiati, Bovenzi M, Maina, G., 2014. Skin absorption of palladium nanoparticles: a new possible risk in the nanotechnology industry. In: 6th International Conference on Occupational and Environmental Skin to Chemicals, 2nd–3rd June 2014, Amsterdam, p. 88.
- Poland, 2013, Dermal absorption of nanomaterials; part of the “better control of nano” initiative 2012–2015, Danish Environ. Prot. Agency
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Tang, Y., Cai, R., Cao, D., Kong, X., & Lu, Y. (2018) · Toxicology · doi:10.1016/j.tox.2018.05.010 · Cited by 37
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Ngo, H. V., Tran, P. H. L., Lee, B., & Tran, T. T. D. (2019) · Nanotechnology · doi:10.1088/1361-6528/ab2e29 · Cited by 36
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López-Valdez, F., Miranda‐Arámbula, M., Ríos-Cortés, A. M., Fernández-Luqueño, F., & de la Luz, V. (2018) · Springer eBooks · doi:10.1007/978-3-319-96719-6_3 · Cited by 35
Hasnain, M., Kanwal, T., Rehman, K., Rehman, S. R. U., Aslam, S. M., Roome, T., Perveen, S., Zaidi, M. B., Saifullah, S., Yasmeen, S., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126697 · Cited by 34
Horne, J., McLoughlin, L., Bury, E., Koh, A. S., & Wujcik, E. K. (2020) · Advanced Materials Interfaces · doi:10.1002/admi.201901851 · Cited by 35
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Mogensen, M., Bojesen, S., Israelsen, N. M., Maria, M., Jensen, M., Podoleanu, A. G., Bang, O., & Hædersdal, M. (2018) · Journal of Biophotonics · doi:10.1002/jbio.201700348 · Cited by 18
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Sullivan, M., Obezo, C. G., Lipsky, Z. W., Panchal, A., & Jensen, J. (2025) · Cosmetics · doi:10.3390/cosmetics12030096 · Cited by 22
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Li, K., Chen, W., Ma, L., Yan, L., & Wang, B. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117264 · Cited by 18
Kakuda, L., Campos, P. M. B. G. M., & OLIVEIRA, W. P. D. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050595 · Cited by 17
Pan, X., Zhou, H., Li, Z., Huang, W., Zhao, Y., Huang, Y., Liang, J., Wu, J., Huang, R., Wu, M., et al. (2025) · BioNanoScience · doi:10.1007/s12668-025-01884-9 · Cited by 17
Zhang, N., Said, A., Wischke, C., Kral, V., Brodwolf, R., Volz, P., Boreham, A., Gerecke, C., Li, W., Neffe, A. T., et al. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.10.019 · Cited by 17
An integrated approach for assessing the in vitro and in vivo redox-related effects of nanomaterials
Vardakas, P., Skaperda, Z., Tekos, F., Trompeta, A.-F. A., Tsatsakis, A. M., Charitidis, C. A., & Kouretas, D. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111083 · Cited by 20
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Sindrilaru, A., Filip, G. A., Scharffetter‐Kochanek, K., & Crișan, D. (2020) · Experimental Dermatology · doi:10.1111/exd.14149 · Cited by 16
Suman, T. Y., Keerthiga, R., & Kwak, I. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04233-7 · Cited by 20
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Zhao, H., Zhao, H., Tang, Y., Li, M., Cai, Y., Xiao, X., He, F., Huang, H., Zhang, Y., & Li, J. (2024) · Biomarker Research · doi:10.1186/s40364-024-00663-0 · Cited by 16
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Sarojini, S., Balasubramanian, B., Jayaram, S., Nagaraj, V., Restine, A., Priyadarshini, P., Kaur, S., Rajeev, T. K., Pappuswamy, M., Kamyab, H., et al. (2025) · Water Air & Soil Pollution · doi:10.1007/s11270-025-08267-6 · Cited by 15
Kim, S.-H., Lee, D., Lee, J. H., Jun-Young, Y., Shin, H.-S., Lee, J., Jung, K., Jeong, J., Oh, J.-H., & Lee, J. K. (2020) · Toxics · doi:10.3390/toxics8040122 · Cited by 14
Deonas, A. N., Souza, L. M. D. S., Andrade, G. J. S., Cardozo, J. G., Dahmer, D., de Oliveira, A. G., Nakazato, G., Torezan, J. M. D., & Kobayashi, R. K. T. (2024) · Antibiotics · doi:10.3390/antibiotics13080777 · Cited by 16
Arriagada, F., Ugarte, C., Günther, G., Larraín, M. A., Guarnizo-Herrero, V., Nonell, S., & Morales, J. O. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040376 · Cited by 14
Muhtadi, W. K., Novitasari, L., Danarti, R., & Martien, R. (2020) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2020.1821053 · Cited by 14
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Bosch, A., Bott, J., Warfving, N., & Nolde, J. (2023) · Toxicology Letters · doi:10.1016/j.toxlet.2023.07.016 · Cited by 13
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Yaşayan, G., Alarcin, E., Avci-Adali, M., Ipek, T. C., Nejati, O., Özcan-Bülbül, E., Karslı, S., Bal-Öztürk, A., & Mostafavi, E. (2024) · Functionalized Nanomaterials for Cancer Research · doi:10.1016/b978-0-443-15518-5.00019-7 · Cited by 8
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Mackevica, A., Olsson, M., Mines, P. D., Heggelund, L. R., & Hansen, S. F. (2018) · NanoImpact · doi:10.1016/j.impact.2018.06.001 · Cited by 13
Gautam, A., Rakshit, M., Nguyen, K., Kathawala, M. H., Nguyen, L. T. H., Tay, C. Y., Wong, E., & Ng, K. (2019) · NanoImpact · doi:10.1016/j.impact.2019.100177 · Cited by 12
Christodoulou, M. C., Stylianou, M. A., Voukkali, I., Naddeo, V., Barceló, ., Kepertis, C., & Zorpas, A. A. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.181304 · Cited by 14
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Cortesi, R., Sguizzato, M., & Ferrara, F. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2391473 · Cited by 12
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Koivisto, A. J., Burrueco-Subirà, D., Candalija, A., Vázquez‐Campos, S., Nicosia, A., Ravegnani, F., Furxhi, I., Brigliadori, A., Zanoni, I., Blosi, M., et al. (2024) · Open Research Europe · doi:10.12688/openreseurope.17254.1 · Cited by 12
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Tiwari, N., Osorio‐Blanco, E. R., Sonzogni, A. S., Esporrín‐Ubieto, D., Wang, H., & Calderón, M. (2021) · Angewandte Chemie · doi:10.1002/ange.202107960 · Cited by 13
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Self-citationScandorieiro, S., Kimura, A. H., de Camargo, L. C., Gonçalves, M. C., da Silva, J. V. H., Risso, W. E., de Andrade, F. G., Zaia, C. T. B. V., Lonni, A. A. S. G., Martinez, C. B. D. R., et al. (2023) · Microorganisms · doi:10.3390/microorganisms11071815 · Cited by 13
Metadata
- Authors
- Larese Filon, F., Mauro, M., Adami, G., Bovenzi, M., & Crosera, M.
- Affiliations
- University of Trieste (IT)
- Corresponding author
- Mauro, Marcella
- Venue
- Regulatory Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 72
- Issue
- 2
- Pages
- 310-322
- ISSN
- 0273-2300 (ISSN-L)
- OpenAlex
- W290929610
- Cited by
- 390
- References
- 129
- Citations by year
- 2026: 17 · 2025: 50 · 2024: 37 · 2023: 41 · 2022: 35 · 2021: 40 · 2020: 50 · 2019: 34 · 2018: 28 · 2017: 22 · 2016: 31 · 2015: 5
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Regulatory Toxicology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- Funders
- European Commission
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- nanoparticles, percutaneous absorption, skin penetration, skin barrier, nanoparticle size, metal nanoparticles, nanoparticle dissolution, nanoparticle aggregation, sensitization, toxicity, skin permeation, risk assessment, decision tree
- MeSH terms
- Animals, Humans, Skin, Skin Absorption, Risk Assessment, Nanoparticles
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