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Cited by 43Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorDevelopmental and Educational Neuropsychology

Behavioral effects of low-dose methylphenidate in childhood attention deficit disorder: implications for a mechanism of stimulant drug action

SOLANTO, MARY V.·1986·Journal of the American Academy of Child Psychiatry
DOI 10.1016/s0002-7138(09)60604-x
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Crossref · 10.1016/s0002-7138(09)60604-x

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  • The idea that the clinical effects of stimulants are mediated by the ability of small increases in extracellular dopamine to produce a net decrease in phasic catecholamine release by the selective activation of dopamine autoreceptors is supported by studies showing reduction in behavioural activity levels in children with ADHD following low doses of dopamine agonists and from neurocomputational.

    “The idea that the clinical effects of stimulants are mediated by the ability of small increases in extracellular dopamine to produce a net decrease in phasic catecholamine release by the selective activation of dopamine autoreceptors (following an increase in tonic dopamine levels) (Solanto, 1984, 1998; Seeman and Madras, 1998) is supported by studies showing reduction in behavioural activity”

    From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Solanto, 1986

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Authors
SOLANTO, M. V.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
SOLANTO, MARY V.
ORCID
SOLANTO, MARY V.
Venue
Journal of the American Academy of Child Psychiatry
Publisher
Elsevier BV
Published
1986-01
Volume
25
Issue
1
Pages
96-101
ISSN
0002-7138 (ISSN-L)
DOI
10.1016/s0002-7138(09)60604-x
OpenAlex
W2010086429
Cited by
43
References
50
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2015: 1 · 2014: 1 · 2013: 1
FWCI
2.11
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Child Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
Keywords
methylphenidate, attention deficit hyperactivity disorder, locomotor activity, attention, children
MeSH terms
Attention Deficit Disorder with Hyperactivity, Child, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Methylphenidate, Receptors, Dopamine, Stimulation, Chemical

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