Lipid and apolipoprotein ratios: association with coronary artery disease and effects of rosuvastatin compared with atorvastatin, pravastatin, and simvastatin
Abstract
Plasma lipid and apolipoprotein ratios that include both an atherogenic and an antiatherogenic lipid component (eg, total cholesterol/high-density lipoprotein [HDL] cholesterol ratio, low-density lipoprotein [LDL] cholesterol/HDL cholesterol ratio, non-HDL cholesterol/HDL cholesterol ratio, and apolipoprotein [apo] B/apo A-I ratio) have been found to be strong predictors of coronary artery disease (CAD) risk. Three trials that compared the effects of rosuvastatin 10 mg versus atorvastatin 10 mg and 2 trials that compared the effects of rosuvastatin 10 mg versus simvastatin 20 mg and pravastatin 20 mg on lipid ratios in patients with hypercholesterolemia were prospectively designed for pooled analysis. At 12 weeks, in the 3-trial pooled analysis, rosuvastatin 10 mg (n = 389) showed significantly greater reductions in all 4 lipid ratios compared with atorvastatin 10 mg (n = 393) (p <0.001). The mean percent reduction from baseline in the LDL cholesterol/HDL cholesterol ratio was 51% in patients treated with rosuvastatin 10 mg versus 39% in patients treated with atorvastatin 10 mg. In the 2-trial pooled analysis, treatment with rosuvastatin 10 mg (n = 226) also resulted in significantly greater reductions in all 4 lipid ratios compared with both simvastatin 20 mg (n = 249) and pravastatin 20 mg (n = 252) (p <0.001). Mean percent reductions from baseline in the LDL cholesterol/HDL cholesterol ratio were 52%, 39%, and 30% for rosuvastatin 10 mg, simvastatin 20 mg, and pravastatin 20 mg, respectively, in these 2 trials.
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Although few studies have evaluated the validity of the non-HDL/HDL-C ratio in the prediction of cardiovascular disease, it would appear to have a predictive power similar to that of the CT/HDL-C ratio, which led to the LDL/HDL-C ratio.
“Although few studies have evaluated the validity of this lipoprotein ratio in the prediction of cardiovascular disease, it would appear to have a predictive power similar to that of the CT/HDL-C ratio, which led to the LDL/HDL-C ratio [39].”
From Residual Cardiovascular Risk: Role of Remnants Cholesterol, Monocyte/HDL Ratio and Lipoprotein Ratios on Personalized Cardiovascular Prevention (2024) · cites this paper as [39]
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- Authors
- Rader, D. J., Davidson, M. H., Caplan, R. J., & Pears, J. S.
- Affiliations
- University of Pennsylvania (US)
- AstraZeneca (United States) (US)
- AstraZeneca (United Kingdom) (GB)
- Corresponding author
- Rader, Daniel J
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 91
- Issue
- 5
- Pages
- 20-23
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2058245008
- Cited by
- 84
- References
- 15
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- rosuvastatin, atorvastatin, simvastatin, pravastatin, lipid ratios, TC/HDL-C ratio, hypercholesterolemia, coronary artery disease risk, statin comparison, pooled analysis
- MeSH terms
- Rosuvastatin Calcium, Atorvastatin, Adult, Aged, Anticholesteremic Agents, Apolipoproteins, Coronary Disease, Double-Blind Method, Europe, Female, Fluorobenzenes, Heptanoic Acids, Humans, Hypercholesterolemia, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Prospective Studies, Pyrimidines, Pyrroles, Sulfonamides, Least-Squares Analysis, Randomized Controlled Trials as Topic, Treatment Outcome, Pravastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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