Evaluation of remnant cholesterol levels and Monocyte-to-HDL-cholesterol ratio in South Asian patients with acute coronary syndrome
Open accessAbstract
Background and aims In the present study, we aimed to compare the clinical and coronary angiography features between South Asian and Caucasian patients with Acute Coronary Syndrome (ACS). In particular, we focused our analysis on the evaluation of recent cardiovascular risk markers, such as remnant cholesterol, corresponding to all plasma cholesterol minus HDL-C (high-density lipoprotein cholesterol) and LDL-C (low-density lipoprotein cholesterol), and the Monocyte-to-HDL-cholesterol ratio. We also compared values of several lipoprotein ratios and the Platelet-to-lymphocyte ratio, accurate predictors of coronary events and coronary artery disease.Methods and results We recruited 40 South Asian and 40 Caucasian patients admitted for ACS. Data were collected by consulting patients' medical records. We used Chi-square test and Student's t-test to analyse qualitative and quantitative variables, respectively. South Asian patients, compared to Caucasians, showed higher mean values of the parameters analysed: remnant cholesterol (32.6 ± 17 vs 26.5 ± 9.6), Monocyte-to-HDL-cholesterol ratio (26.4 ± 48.7 vs 16.5 ± 8.3), Platelet-to-lymphocyte ratio (124.7 ± 130.7 vs 120.5 ± 58.8). Moreover, higher mean values of several lipoprotein ratios were also found in South Asian patients compared to the control group. However, statistical significance was not reached for any of these differences observed.Conclusions The evaluation of the parameters analysed in this study might provide accurate information regarding the cardio-metabolic risk in South Asian patients. However, further studies with larger samples are needed to obtain more significant results.
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This accumulation initiates an inflammatory cascade, involving the activation of macrophages and platelets, contributing to the progression of the atherosclerotic plaque.
“This accumulation initiates an inflammatory cascade, involving the activation of macrophages and platelets, contributing to the progression of the atherosclerotic plaque [20].”
From Residual Cardiovascular Risk: Role of Remnants Cholesterol, Monocyte/HDL Ratio and Lipoprotein Ratios on Personalized Cardiovascular Prevention (2024) · cites this paper as [20]
The Discussion (page unavailable) says remnant cholesterol can accumulate in the arterial intima, causing inflammation that leads to atherosclerotic plaque formation. It separately mentions macrophage accumulation and platelet aggregation, but does not say that this accumulation activates macrophages and platelets or drives progression of an existing plaque. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe smaller dimensions of remnant particles facilitate their penetration into the arterial wall, where they accumulate within the intimal layer.
“The smaller dimensions of these particles facilitate their penetration into the arterial wall, where they accumulate within the intimal layer.”
From Residual Cardiovascular Risk: Role of Remnants Cholesterol, Monocyte/HDL Ratio and Lipoprotein Ratios on Personalized Cardiovascular Prevention (2024) · cites this paper as [20]
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- Authors
- Sucato, V., Coppola, G., Testa, G., Amata, F., Martello, M., Siddique, R., Galassi, A. R., Novo, G., & Corrado, E.
- Affiliations
- Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
- University of Palermo (IT)
- Corresponding author
- Sucato, Vincenzo
- ORCID
- Venue
- Nutrition, Metabolism and Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 31
- Issue
- 7
- Pages
- 2144-2150
- ISSN
- 0939-4753 (ISSN-L)
- OpenAlex
- W3153828685
- Cited by
- 15
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 4 · 2021: 2
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- IRIS UniPA (University of Palermo) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- remnant cholesterol, monocyte-to-HDL cholesterol ratio, acute coronary syndrome, South Asian patients, platelet-to-lymphocyte ratio, lipoprotein ratios, cardiovascular risk markers, coronary artery disease, ethnic differences in cardiovascular risk
- MeSH terms
- Heart Disease Risk Factors, Adult, Cholesterol, Coronary Artery Disease, Female, Humans, Italy, Leukocyte Count, Cholesterol, HDL, Male, Middle Aged, Monocytes, Predictive Value of Tests, Retrospective Studies, Biomarkers, Prevalence, Coronary Angiography, Risk Assessment, White People, Asian People, Acute Coronary Syndrome
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