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Cited by 135Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsVenous Thromboembolism Diagnosis and Management

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Risk of thromboembolic events in patients with atrial flutter

Seidl, Karlheinz, Hauer, Bernd, Schwick, Nicola G, Zellner, Dietmar, Zahn, Ralf, Senges, Jochen·1998·The American Journal of Cardiology
DOI 10.1016/s0002-9149(98)00419-6
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Abstract

Based on multiple studies, clear, guided anticoagulation therapy is recommended for patients with atrial fibrillation. The value of anticoagulation therapy in patients with atrial flutter, however, is less well established. Little is known about the incidence of thromboembolism in patients with atrial flutter. We evaluated the risk of thromboembolism in 191 consecutive unselected patients referred for treatment of atrial flutter. A history of embolic events was noted in 11 patients. Acute embolism (<48 hours) occurred in 4 patients (3 after direct current cardioversion, 1 after catheter ablation). During follow-up of 26+/-18 months, 9 patients experienced thromboembolic events. During the follow-up, the overall embolic event rate (including acute embolism and thromboembolic events during follow-up) was 7 % in this patient population. Risk indicators for an embolic event in an univariate analysis were organic heart disease (p = 0.037), depressed left ventricular function (p = 0.02), history of systemic hypertension (p = 0.004), and diabetes mellitus (p = 0.0038). Using multivariate analysis, a history of hypertension was the only independent predictor for elevated embolic risk in this patient population (odds ratio = 6.5; 95% confidence intervals 1.5 to 45). Thus, the thromboembolic risk is higher than previously recognized for patients with atrial flutter. Anticoagulation therapy may decrease this risk.

Overview

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Crossref · 10.1016/s0002-9149(98)00419-6

Cites

19 of 19 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. Pagadala, 1994, Thromboembolic risk of chronic atrial flutter:is the risk underestimated?, Circulation, 90, I-398

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Metadata

Authors
Seidl, K., Hauer, B., Schwick, N. G., Zellner, D., Zahn, R., & Senges, J.
Affiliations
Klinikum Ludwigshafen (DE)
Corresponding author
Seidl, Karlheinz
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1998-09
Volume
82
Issue
5
Pages
580-583
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(98)00419-6
OpenAlex
W2023282715
Cited by
135
References
19
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 4 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 4 · 2012: 8
FWCI
6.32
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Keywords
atrial flutter, thromboembolism, anticoagulation, hypertension, left ventricular function, organic heart disease, diabetes mellitus, cardioversion, catheter ablation, atrial fibrillation
MeSH terms
Aged, Anticoagulants, Atrial Flutter, Intracranial Embolism and Thrombosis, Electric Countershock, Female, Follow-Up Studies, Humans, Male, Middle Aged, Recurrence, Risk, Thromboembolism, Odds Ratio, Catheter Ablation

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