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A population-based study of mortality among patients with atrial fibrillation or flutter
Open accessAbstract
PURPOSE To determine the mortality associated with atrial flutter and atrial fibrillation in the general population. SUBJECTS AND METHODS Using the Marshfield Epidemiologic Study Area, a database that captures nearly all medical care and deaths among its 58,820 residents, we identified patients diagnosed with atrial flutter or atrial fibrillation from July 1, 1991, through June 30, 1995. Patients were followed prospectively and compared with a group of controls without these arrhythmias. RESULTS A total of 4775 person-years of follow-up were completed in 577 patients and 577 controls. Compared with controls, mortality among patients with atrial fibrillation or flutter was nearly 7.8-fold higher at 6 months (95% confidence interval [CI]: 4.1 to 15) and 2.5-fold higher (95% CI: 2.0 to 3.1; P < 0.0001) at the last follow-up (mean [+/- SD] of 3.6 +/- 2.3 years; range, 1 day to 7.3 years). At 6 months, mortality among patients with atrial flutter alone was somewhat greater than in controls and less than one third that of those with atrial fibrillation (with or without atrial flutter) (P = 0.02). At the last follow-up, however, mortality was greater among patients with atrial flutter (hazard ratio [HR] = 1.7; 95% CI: 1.2 to 2.6; P = 0.007), atrial fibrillation (HR = 2.4; 95% CI: 1.9 to 3.1; P < 0.0001), or both atrial arrhythmias (HR = 2.5; 95% CI: 1.9 to 3.3; P < 0.0001) when compared with controls in models that adjusted for cardiovascular risk factors. CONCLUSION In the general population, both atrial flutter and atrial fibrillation are independent predictors of increased late mortality. The relatively benign course during the 6-month period after the initial diagnosis of atrial flutter suggests that early diagnosis and treatment of these patients may improve their long-term survival.
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Regression Models and Life-Tables
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Regression Models and Life-Tables
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Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
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Self-citationIncidence and predictors of atrial flutter in the general population
Granada, J., Uribe, W., Chyou, P.-H., Maassen, K., Vierkant, R., Smith, P. N., Hayes, J., Eaker, E., & Vidaillet, H. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00982-7 · Cited by 375
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Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., Seward, J. B., & Tsang, T. S. M. (2006) · Circulation · doi:10.1161/circulationaha.105.595140 · Cited by 2,564
Wachtell, K., Lehto, M., Gerdts, E., Olsen, M. H., Hornestam, B., Dahlöf, B., Ibsen, H., Julius, S., Kjeldsen, S. E., Lindholm, L. H., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.10.068 · Cited by 826
Inoue, H., Fujiki, A., Origasa, H., Ogawa, S., Okumura, K., Kubota, I., Aizawa, Y., Yamashita, T., Atarashi, H., Horie, M., et al. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.06.029 · Cited by 432
Mortality Trends in Patients Diagnosed With First Atrial Fibrillation
Miyasaka, Y., Barnes, M. E., Bailey, K. R., Cha, S. S., Gersh, B. J., Seward, J. B., & Tsang, T. S. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.062 · Cited by 411
Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia
Bunch, T. J., Weiss, J. P., Crandall, B. G., May, H. T., Bair, T. L., Osborn, J. S., Anderson, J. L., Muhlestein, J. B., Horne, B. D., Lappe, D. L., et al. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2009.12.004 · Cited by 405
Metadata
- Authors
- Vidaillet, H., Granada, J. F., Chyou, P. O.-H., Maassen, K., Ortiz, M., Pulido, J. N., Sharma, P., Smith, P. N., & Hayes, J.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 113
- Issue
- 5
- Pages
- 365-370
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2020346401
- Cited by
- 289
- References
- 20
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- green
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