Mortality Trends in Patients Diagnosed With First Atrial Fibrillation
Open accessAbstract
Objectives The purpose of this study was to assess the mortality trends of atrial fibrillation (AF) in a community.Background Limited data exist regarding the mortality trends of patients diagnosed with first AF.Methods A community-based cohort of adult residents of Olmsted County, Minnesota, who had electrocardiogram-confirmed first-documented AF in the years 1980 to 2000 were identified and followed to 2004 or death. The primary outcome was all-cause mortality.Results Of a total of 4,618 residents (mean age 73 +/- 14 years) diagnosed with first AF, 3,085 died during a mean follow-up of 5.3 +/- 5.0 years. Relative to the age- and gender-matched general Minnesota population, the mortality risk was increased (p < 0.0001) with a hazard ratio (HR) of 9.62 (95% confidence interval [CI] 8.93 to 10.32) within the first 4 months and 1.66 (95% CI 1.59 to 1.73) thereafter. Cox proportional hazards modeling showed no change in overall age- and gender-adjusted mortality (HR for the year 2000 vs. 1980: 0.99; 95% CI 0.86 to 1.13; p = 0.84), even after adjustment for comorbidities. In secondary analyses, no changes in mortality were seen for early (within first 4 months) or late (after 4 months) mortality for the entire group or within the subgroup of patients who did not have cardiovascular disease at baseline.Conclusions In this cohort of patients newly diagnosed with AF, mortality risk was high, especially within the first 4 months. There was no evidence for any significant changes over the 21 years in terms of overall mortality, early or late mortality, or mortality among patients without pre-existing cardiovascular disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hormone replacement therapy in postmenopausal women does not seem to be associated with the risk of incident AF.
“Hormone replacement therapy in postmenopausal women does not seem to be associated with the risk of incident AF.”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [155]
Cites
Atrial fibrillation as an independent risk factor for stroke: the Framingham study
Wolf, P. A., Abbott, R. D., & Kannel, W. B. (1991) · Stroke · doi:10.1161/01.str.22.8.983 · Cited by 7,388 · see citing works
Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
Benjamin, E. J., Wolf, P. A., D’Agostino, R. B., Silbershatz, H., Kannel, W. B., & Levy, D. (1998) · Circulation · doi:10.1161/01.cir.98.10.946 · Cited by 4,575 · see citing works
Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., Seward, J. B., & Tsang, T. S. M. (2006) · Circulation · doi:10.1161/circulationaha.105.595140 · Cited by 2,564 · see citing works
Self-citationWang, T. J., Larson, M. G., Levy, D., Vasan, R. S., Leip, E. P., Wolf, P. A., D’Agostino, R. B., Murabito, J. M., Kannel, W. B., & Benjamin, E. J. (2003) · Circulation · doi:10.1161/01.cir.0000072767.89944.6e · Cited by 1,970 · see citing works
Stewart, S., Hart, C. L., Hole, D. J., & McMurray, J. J. V. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01236-6 · Cited by 1,562 · see citing works
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The fiamingham Study
Wolf, P. A., Dawber, T. R., Thomas, H. E., & Kannel, W. B. (1978) · Neurology · doi:10.1212/wnl.28.10.973 · Cited by 1,526 · see citing works
Krahn, A. D., Manfreda, J., TATE, R. B., Mathewson, F. A. L., & Cuddy, T. E. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80348-9 · Cited by 1,478 · see citing works
History of the Rochester Epidemiology Project
Melton, L. J. (1996) · Mayo Clinic Proceedings · doi:10.4065/71.3.266 · Cited by 1,443 · see citing works
Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities
D, E. B. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711063371906 · Cited by 1,428 · see citing works
Wang, T. J., Massaro, J. M., Levy, D. A., Vasan, R. S., Wolf, P. A., D’Agostino, R. B., Larson, M. G., Kannel, W. B., & Benjamin, E. J. (2003) · JAMA · doi:10.1001/jama.290.8.1049 · Cited by 779 · see citing works
Epidemiology and natural history of atrial fibrillation: clinical implications
Chugh, S. S., Blackshear, J. L., Shen, W.-K., Hammill, S. C., & Gersh, B. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01107-4 · Cited by 768 · see citing works
Self-citationA population-based study of mortality among patients with atrial fibrillation or flutter
Vidaillet, H. J., Jr., Granada, J. F., Chyou, P. O.-H., Maassen, K., Ortiz, M. A., Pulido, J. N., Sharma, P., Smith, P. N., & Hayes, J. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01253-6 · Cited by 288 · see citing works
Risk Factors for Ischemic Stroke
Simons, L. A., McCallum, J. C., Friedlander, Y., & Simons, J. (1998) · Stroke · doi:10.1161/01.str.29.7.1341 · Cited by 256 · see citing works
Tsang, T. S. M., Petty, G. W., Barnes, M. E., O’Fallon, W. M., Bailey, K. R., Wiebers, D. O., Sicks, J. D., Christianson, T. J. H., Seward, J. B., & Gersh, B. J. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00500-x · Cited by 228 · see citing works
Self-citationImproving survival for patients with atrial fibrillation and advanced heart failure
Stevenson, W. G., Stevenson, L. W., Middlekauff, H. R., Fonarow, G. C., Hamilton, M. A., Woo, M. A., Saxon, L. A., Natterson, P. D., Steimle, A. E., Walden, J. A., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00358-0 · Cited by 218 · see citing works
Nonrheumatic atrial fibrillation. Risk of stroke and role of antithrombotic therapy.
Cairns, J., & Connolly, S. J. (1991) · Circulation · doi:10.1161/01.cir.84.2.469 · Cited by 207 · see citing works
Mortality in an Insured Population With Atrial Fibrillation
Gajewski, J. B. (1981) · JAMA · doi:10.1001/jama.1981.03310400022019 · Cited by 197 · see citing works
Goldberg, R. J., Yarzebski, J., Lessard, D., Wu, J. J., & Gore, J. M. (2002) · American Heart Journal · doi:10.1067/mhj.2002.120410 · Cited by 154 · see citing works
A population-based model of risk factors for ischemic stroke
Whisnant, J. P., Wiebers, D. O., O’Fallon, W. M., Sicks, J. D., & Frye, R. L. (1996) · Neurology · doi:10.1212/wnl.47.6.1420 · Cited by 123 · see citing works
Frost, L., Vestergaard, P., Mosekilde, L., & Mortensen, L. S. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.08.024 · Cited by 62 · see citing works
Frost, L. (1999) · European Heart Journal · doi:10.1053/euhj.1999.1713 · Cited by 60 · see citing works
Atrial Fibrillation and Congestive Heart Failure
Scheinman, M. M. (1998) · Circulation · doi:10.1161/01.cir.98.10.941 · Cited by 52 · see citing works
Stewart, S., Macintyre, K., Chalmers, J. W., Boyd, J., Finlayson, A. R., Redpath, A., Pell, J. P., Capewell, S., & McMurray, J. J. V. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(01)00626-x · Cited by 39 · see citing works
Atrial fibrillation: a growth industry in the 21st century
Alpert, J. S. (2000) · European Heart Journal · doi:10.1053/euhj.2000.2140 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700 · see citing works
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292 · see citing works
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140 · see citing works
Global epidemiology of atrial fibrillation
Rahman, F., Kwan, G. F., & Benjamin, E. J. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.118 · Cited by 731 · see citing works
Piccini, J. P., Hammill, B. G., Sinner, M. F., Jensen, P. N., Hernandez, A. F., Heckbert, S. R., Benjamin, E. J., & Curtis, L. H. (2012) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.111.962688 · Cited by 565 · see citing works
Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis
Ko, D., Rahman, F., Schnabel, R. B., Yin, X., Benjamin, E. J., & Christophersen, I. E. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.45 · Cited by 353 · see citing works
Screening to identify unknown atrial fibrillation: A systematic review
Lowres, N., Neubeck, L., Redfern, J., & Freedman, S. B. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-02-0165 · Cited by 327 · see citing works
Rienstra, M., Lubitz, S. A., Mahida, S., Magnani, J. W., Fontes, J. D., Sinner, M. F., Van Gelder, I. C., Ellinor, P. T., & Benjamin, E. J. (2012) · Circulation · doi:10.1161/circulationaha.111.069450 · Cited by 237 · see citing works
Atrial fibrillation prevalence, incidence and risk of stroke and all-cause death among Chinese
Chien, K.-L., Su, T.-C., Hsu, H.-C., Chang, W.-T., Chen, P.-C., Chen, M.-F., & Lee, Y.-T. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.10.045 · Cited by 146 · see citing works
Kearley, K., Selwood, M., Van den Bruel, A., Thompson, M., Mant, D., Hobbs, F. R., Fitzmaurice, D., & Heneghan, C. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-004565 · Cited by 106 · see citing works
Nielsen, J. C., Lin, Y.-J., de Oliveira Figueiredo, M. J., Sepehri Shamloo, A., Alfie, A., Boveda, S., Dagres, N., Di Toro, D., Eckhardt, L. L., Ellenbogen, K., et al. (2020) · EP Europace · doi:10.1093/europace/euaa065 · Cited by 98 · see citing works
Olsson, L. G., Swedberg, K., Lappas, G., Stewart, S., & Rosengren, A. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.10.028 · Cited by 10 · see citing works
- Authors
- Miyasaka, Y., Barnes, M. E., Bailey, K. R., Cha, S. S., Gersh, B. J., Seward, J. B., & Tsang, T. S. M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Tsang, Teresa S.M.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 49
- Issue
- 9
- Pages
- 986-992
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W59237391
- Cited by
- 411
- References
- 24
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 23 · 2020: 23 · 2019: 16 · 2018: 24 · 2017: 32 · 2016: 38 · 2015: 28 · 2014: 34 · 2013: 36 · 2012: 31
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01 AG22070, R01AG022070)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- atrial fibrillation, all-cause mortality, mortality trends, newly diagnosed atrial fibrillation, early mortality risk, cardiovascular comorbidity, Olmsted County cohort
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Atrial Fibrillation, Cause of Death, Female, Humans, Longitudinal Studies, Male, Middle Aged, Minnesota, Cohort Studies, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Age of Onset, Age Distribution, Sex Distribution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
