Is syncope a risk factor for poor outcomes? comparison of patients with and without syncope
Abstract
Objective To determine whether syncope, independent of underlying comorbidities, is associated with increased mortality or other cardiovascular outcomes. Patients and methods A prospective cohort study of patients with syncope and a group of patients without syncope matched with respect to age, gender, site of care (inpatient/ outpatient) and a cardiac disease index at an urban university medical center. Overall mortality, cardiac mortality, cardiovascular outcomes, and occurrence of syncope within 1 year of study enrollment were compared between the groups with Kaplan-Meier rates and Mantel-Cox statistics. Results The characteristics of 470 patients with syncope and the matched patients without syncope were similar except that the patients without syncope had more cardiac diseases than those with syncope (P = 0.002). Patients with and without syncope had similar rates of 1-year overall mortality (9% versus 11%, P = 0.29) and cardiac mortality (3% versus 6%, P = 0.08). In multivariate analyses, syncope was not a significant predictor of overall or cardiac mortality, but male gender, age > 55 years, and congestive heart failure were. One-year rates for other cardiovascular outcomes (myocardial infarction, congestive heart failure, cardiac arrest with survival, and cerebrovascular events) in patients with syncope were similar to those in patients without syncope (P > or = 0.2 for all comparisons). Patients with syncope had a 20.2% recurrence rate in 1 year as compared with a 2.…
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Older patients (>75 years of age) who present with syncope tend to have poor outcomes, both fatal and nonfatal.
“Older patients (>75 years of age) who present with syncope tend to have poor outcomes, both fatal and nonfatal (109,679,680).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [680]
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- Authors
- Kapoor, W. N., & Hanusa, B. H.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Hanusa, Barbara H.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 100
- Issue
- 6
- Pages
- 646-655
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2066476623
- Cited by
- 180
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2018: 4 · 2017: 14 · 2016: 5 · 2015: 5 · 2014: 16 · 2013: 7 · 2012: 12
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (K04L 01899)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- syncope, mortality, cardiac mortality, cardiovascular outcomes, syncope recurrence, congestive heart failure, myocardial infarction, cerebrovascular events, cardiac arrest, risk factors, underlying heart disease
- MeSH terms
- Cause of Death, Female, Heart Diseases, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk, Risk Factors, Syncope, Multivariate Analysis, Survival Analysis
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