Syncope Evaluation in the Emergency Department Study (SEEDS): A Multidisciplinary Approach to Syncope Management
Open accessAbstract
Background— The primary aim and central hypothesis of the study are that a designated syncope unit in the emergency department improves diagnostic yield and reduces hospital admission for patients with syncope who are at intermediate risk for an adverse cardiovascular outcome. Methods and Results— In this prospective, randomized, single-center study, patients were randomly allocated to 2 treatment arms: syncope unit evaluation and standard care. The 2 groups were compared with χ 2 test for independence of categorical variables. Wilcoxon rank sum test was used for continuous variables. Survival was estimated with the Kaplan-Meier method. One hundred three consecutive patients (53 women; mean age 64±17 years) entered the study. Fifty-one patients were randomized to the syncope unit. For the syncope unit and standard care patients, the presumptive diagnosis was established in 34 (67%) and 5 (10%) patients ( P <0.001), respectively, hospital admission was required for 22 (43%) and 51 (98%) patients ( P <0.001), and total patient-hospital days were reduced from 140 to 64. Actuarial survival was 97% and 90% ( P =0.30), and survival free from recurrent syncope was 88% and 89% ( P =0.72) at 2 years for the syncope unit and standard care groups, respectively. Conclusions— The novel syncope unit designed for this study significantly improved diagnostic yield in the emergency department and reduced hospital admission and total length of hospital stay without affecting recurrent syncope and all-cause mortality among intermediate-risk patients. Observations from the present study provide benchmark data for improving patient care and effectively utilizing healthcare resources.
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In this setting, a structured ED protocol can be effective as an alternative to inpatient admission.
“In this setting, a structured ED protocol can be effective as an alternative to inpatient admission (107–110).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [107]
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Cites
Incidence and Prognosis of Syncope
Soteriades, E. S., Evans, J. C., Larson, M. G., Chen, M. H., Chen, L., Benjamin, E. J., & Levy, D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012407 · Cited by 1,364 · see citing works
Guidelines on management (diagnosis and treatment) of syncope
Brignole, M. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2739 · Cited by 951 · see citing works
A Prospective Evaluation and Follow-up of Patients with Syncope
Kapoor, W. N., Karpf, M., Wieand, S., Peterson, J. R., & Levey, G. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307283090401 · Cited by 779 · see citing works
Evaluation and outcome of emergency room patients with transient loss of consciousness
Day, S. C., Cook, E. F., Funkenstein, H., & Goldman, L. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90913-5 · Cited by 587 · see citing works
Tilt table testing for assessing syncope
Benditt, D. G., Ferguson, D. W., Grubb, B. P., Kapoor, W. N., Kugler, J., Lerman, B. B., Maloney, J. D., Ravielle, A., Ross, B. A., Sutton, R., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00236-7 · Cited by 566 · see citing works
Guidelines on management (diagnosis and treatment) of syncope-update 2004. Executive Summary.
Brignole, M., Alboni, P., Benditt, D. G., Bergfeldt, L., Blanc, J., Thomsen, P. E. B., van Dijk, J. G., Fitzpatrick, A. P., Hohnloser, S. H., Janoušek, J., et al. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.09.004 · Cited by 562 · see citing works
Evaluation and Outcome of Patients with Syncope
KAPOOR, W. N. (1990) · Medicine · doi:10.1097/00005792-199005000-00004 · Cited by 539 · see citing works
A Clinical Trial of a Chest-Pain Observation Unit for Patients with Unstable Angina
Farkouh, M. E., Smars, P. A., Reeder, G. S., Zinsmeister, A. R., Evans, R. W., Meloy, T. D., Kopecky, S. L., Allen, M., Allison, T. G., Gibbons, R. J., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199812243392603 · Cited by 516 · see citing works
Self-citationDiagnostic value of history in patients with syncope with or without heart disease
Alboni, P., Brignole, M., Menozzi, C., Raviele, A., Del Rosso, A., Dinelli, M., Solano, A., & Bottoni, N. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01241-4 · Cited by 444 · see citing works
Linzer, M., Yang, E. H., Estes III, N. A. M., Wang, P., Vorperian, V. R., & Kapoor, W. N. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-12-199706150-00012 · Cited by 437 · see citing works
Colivicchi, F. (2003) · European Heart Journal · doi:10.1016/s0195-668x(02)00827-8 · Cited by 359 · see citing works
CLINICAL GUIDELINE: Diagnosing Syncope: Part 2: Unexplained Syncope
Linzer, M., Yang, E. H., Estes, N. A. M., Wang, P., Vorperian, V. R., & Kapoor, W. N. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-1-199707010-00014 · Cited by 313 · see citing works
Syncope in advanced heart failure: high risk of sudden death regardless of origin of syncope
Middlekauff, H. R., Stevenson, W. G., Stevenson, L. W., & Saxon, L. A. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90724-f · Cited by 311 · see citing works
Risk stratification of patients with syncope
Martin, T. P., Hanusa, B. H., & Kapoor, W. N. (1997) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(97)70217-8 · Cited by 285 · see citing works
Calkins, H. G., Shyr, Y., Frumin, H., Schork, A. M., & Morady, F. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80315-5 · Cited by 231 · see citing works
Long-term outcome of paced and nonpaced patients with severe carotid sinus syndrome
Brignole, M., Menozzi, C., Lolli, G., Bottoni, N., & Gaggioli, G. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90860-2 · Cited by 210 · see citing works
Syncope: Current Diagnostic Evaluation and Management
Manolis, A. S., Linzer, M., Salem, D. N., & Estes, N. A. M. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-11-850 · Cited by 208 · see citing works
Ammirati, F. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1910 · Cited by 205 · see citing works
Is syncope a risk factor for poor outcomes? comparison of patients with and without syncope
Kapoor, W. N., & Hanusa, B. H. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(95)00052-6 · Cited by 180 · see citing works
Fenton, A. M., Hammill, S. C., Rea, R. F., Low, P. A., & Shen, W.-K. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-9-200011070-00014 · Cited by 158 · see citing works
Self-citationManagement of patients with syncope referred urgently to general hospitals
Disertori, M. (2003) · Europace · doi:10.1016/s1099-5129(03)00049-7 · Cited by 153 · see citing works
Current Evaluation and Management of Syncope
Kapoor, W. N. (2002) · Circulation · doi:10.1161/01.cir.0000031168.96232.ba · Cited by 135 · see citing works
Syncope: Mechanisms and Management
(2005) · Wiley eBooks · doi:10.1002/9780470994801 · Cited by 127 · see citing works
Management of syncope referred urgently to general hospitals with and without syncope units
Brignole, M. (2003) · Europace · doi:10.1016/s1099-5129(03)00047-3 · Cited by 118 · see citing works
Does the use of a syncope diagnostic protocol improve the investigation and management of syncope?
Farwell, D. J., & Sulke, A. N. (2004) · Heart · doi:10.1136/heart.90.1.52 · Cited by 109 · see citing works
Pires, L. A., Ganji, J. R., Jarandila, R., & Steele, R. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.15.1889 · Cited by 106 · see citing works
Croci, F. (2002) · Europace · doi:10.1053/eupc.2002.0267 · Cited by 105 · see citing works
RICHARDSON, D. A., BEXTON, R. S., SHAW, F. E., & KENNY, R. A. (1997) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1997.tb03912.x · Cited by 100 · see citing works
The economic burden of unrecognized vasodepressor syncope
Calkins, H. G., Byrne, M., El-Atassi, R., Kalbfleisch, S., Langberg, J. J., & Morady, F. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90329-n · Cited by 100 · see citing works
Risk stratification of patients with syncope in an accident and emergency department
Crane, S. (2002) · Emergency Medicine Journal · doi:10.1136/emj.19.1.23 · Cited by 98 · see citing works
Krahn, A. D., Klein, G. J., Yee, R., & Mandab, V. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70411-4 · Cited by 95 · see citing works
(2001) · Annals of Emergency Medicine · doi:10.1067/mem.2001.114838 · Cited by 89 · see citing works
Kenny, R. A. (2003) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.14.s9.8.x · Cited by 88 · see citing works
The impact of diagnostic tests in evaluating patients with syncope.
Eagle, K. A., & Hr, B. (1983) · PubMed · Cited by 85 · see citing works
Prevalence and clinical outcomes of patients with multiple potential causes of syncope
Chen, L. Y., Gersh, B. J., Hodge, D. O., Wieling, W., Hammill, S. C., & Shen, W.-K. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.4.414 · Cited by 81 · see citing works
Self-citationEpidemiology of syncope in hospitalized patients
Getchell, W. S., Larsen, G. C., Morris, C. D., & McAnulty, J. H. (1999) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1999.03199.x · Cited by 79 · see citing works
Elesber, A. A., Decker, W. W., Smars, P. A., Hodge, D. O., & Shen, W.-K. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.07.024 · Cited by 58 · see citing works
Self-citationKlein, G. J., Gersh, B. J., & Yee, R. K. (1995) · Circulation · doi:10.1161/01.cir.92.5.1332 · Cited by 50 · see citing works
Self-citationVasovagal syncope interrupting sleep?
Krediet, C. T. P., Jardine, D. L., Cortelli, P., Visman, A. G. R., & Wieling, W. (2004) · Heart · doi:10.1136/hrt.2003.031294 · Cited by 42 · see citing works
Distinct hemodynamic profiles in patients with vasovagal syncope: a heterogeneous population
Shen, W.-K., Low, P. A., Rea, R. F., Lohse, C. M., Hodge, D. O., & Hammill, S. C. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00567-2 · Cited by 37 · see citing works
Self-citationDel Greco, M., Cozzio, S., Scillieri, M., Caprari, F., Scivales, A., & Disertori, M. (2003) · PubMed · Cited by 36 · see citing works
Admission for syncope: evaluation, cost and prognosis.
Schillinger, M., Domanovits, H., Müllner, M., Herkner, H., & Laggner, A. N. (2000) · PubMed · Cited by 32 · see citing works
Syncope: Overview and Approach to Management
Olshansky, B. (2005) · Wiley eBooks · doi:10.1002/9780470994801.ch1 · Cited by 22 · see citing works
The clinical spectrum and diagnosis of syncope.
Manolis, A. S. (1993) · PubMed · Cited by 14 · see citing works
Cunningham, R. M., & Mikhail, M. G. (2001) · Emergency Medicine Clinics of North America · doi:10.1016/s0733-8627(05)70170-x · Cited by 13 · see citing works
Long-term survival after transient loss of consciousness
Lee, R. T., Cook, E. F., Day, S. C., & Goldman, L. (1988) · Journal of General Internal Medicine · doi:10.1007/bf02595791 · Cited by 10 · see citing works
Role of Invasive Electrophysiologic Testing in the Evaluation and Management of Syncope
Shen, W.-K. (1997) · Cardiac Electrophysiology Review · doi:10.1023/a:1009962028083 · Cited by 6 · see citing works
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Sorted by citations
Developed in collaboration with, European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), societies, E. B. T. F., European Society of Emergency Medicine (EuSEM), European Federation of Internal Medicine (EFIM), European Union Geriatric Medicine Society (EUGMS), American Geriatrics Society (AGS), European Neurological Society (ENS), et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp298 · Cited by 2,040 · see citing works
Self-citation2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951 · see citing works
Self-citation2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 484 · see citing works
Self-citation2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya‐Mitjans, À., de Lange, F. J., Deharo, J., Elliot, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martiın, A., et al. (2018) · Kardiologia Polska · doi:10.5603/kp.2018.0161 · Cited by 474 · see citing works
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000499 · Cited by 453 · see citing works
Self-citationShen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000498 · Cited by 408 · see citing works
Self-citationBrignole, M., Menozzi, C., Bartoletti, A., Giada, F., Lagi, A., Ungar, A., Ponassi, I., Mussi, C., Maggi, R., Re, G., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi647 · Cited by 332 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.003 · Cited by 327 · see citing works
Self-citationGuía de práctica clínica para el diagnóstico y manejo del síncope (versión 2009)
Moya‐Mitjans, À., Sutton, R., Ammirati, F., Blanc, J., Brignole, M., Dahm, J. B., Deharo, J., Gajek, J. J., Gjesdal, K., Krahn, A. D., et al. (2009) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(09)73541-8 · Cited by 277 · see citing works
Short- and Long-Term Prognosis of Syncope, Risk Factors, and Role of Hospital Admission
Costantino, G., Perego, F., Dipaola, F., Borella, M., Galli, A., Cantoni, G., Dell’Orto, S., Dassi, S., Filardo, N., Duca, P. G., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.08.059 · Cited by 246 · see citing works
Brignole, M., Ungar, A., Bartoletti, A., Ponassi, I., Lagi, A., Mussi, C., Ribani, M. A., Tava, G., Disertori, M., Quartieri, F., et al. (2006) · EP Europace · doi:10.1093/europace/eul071 · Cited by 193 · see citing works
Huff, J. S., Decker, W. W., Quinn, J. V., Perron, A. D., Napoli, A. M., Peeters, S., & Jagoda, A. S. (2007) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2007.02.001 · Cited by 157 · see citing works
Self-citationShen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.002 · Cited by 155 · see citing works
Self-citationCostantino, G., Sun, B. C., Barbic, F., Bossi, I., Casazza, G., Dipaola, F., McDermott, D., Quinn, J., Reed, M. J., Sheldon, R. S., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv378 · Cited by 138 · see citing works
Self-citationBrignole, M., Ungar, A., Casagranda, I., Gulizia, M., Lunati, M., Ammirati, F., Del Rosso, A., Sasdelli, M., Santini, M., Maggi, R., et al. (2010) · Europace · doi:10.1093/europace/eup370 · Cited by 133 · see citing works
Sheldon, R. S., Morillo, C. A., Krahn, A. D., O'Neill, B., Thiruganasambandamoorthy, V., Parkash, R., Talajic, M., Tu, J. V., Seifer, C., Johnstone, D., et al. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.11.002 · Cited by 126 · see citing works
National Study of Emergency Department Observation Services
Wiler, J. L., Ross, M. A., & Ginde, A. A. (2011) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2011.01151.x · Cited by 126 · see citing works
Kenny, R. A., Brignole, M., Dan, G., Deharo, J., van Dijk, J. G., Doherty, C. P., Hamdan, M. H., Moya‐Mitjans, À., Parry, S. W., Sutton, R., et al. (2015) · EP Europace · doi:10.1093/europace/euv115 · Cited by 124 · see citing works
Self-citationSyncope Predicts the Outcome of Cardiomyopathy Patients
Olshansky, B., Poole, J. E., Johnson, G., Anderson, J., Hellkamp, A. S., Packer, D., Mark, D. B., Lee, K. L., & Bardy, G. H. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.11.065 · Cited by 119 · see citing works
Ross, M. A., Compton, S. A., Medado, P., Fitzgerald, M., Kilanowski, P., & O’Neil, B. J. (2007) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2007.03.008 · Cited by 117 · see citing works
Sun, B. C., McCreath, H., Liang, L.-J., Bohan, S., Baugh, C., Ragsdale, L., Henderson, S. O., Clark, C., Bastani, A., Keeler, E., et al. (2014) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2013.10.029 · Cited by 114 · see citing works
Pathophysiology, Diagnosis, and Treatment of Orthostatic Hypotension and Vasovagal Syncope
Medow, M. S., Stewart, J. M., Sanyal, S., Mumtaz, A., Sica, D. A., & Frishman, W. H. (2007) · Cardiology in Review · doi:10.1097/crd.0b013e31815c8032 · Cited by 112 · see citing works
Incidence and Mortality Rates of Syncope in the United States
Alshekhlee, A., Shen, W.-K., Mackall, J. A., & Chelimsky, T. C. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.08.024 · Cited by 90 · see citing works
Self-citationSaklani, P., Krahn, A. D., & Klein, G. J. (2013) · Circulation · doi:10.1161/circulationaha.112.138396 · Cited by 89 · see citing works
Sorajja, D., Nesbitt, G. C., Hodge, D. O., Low, P. A., Hammill, S. C., Gersh, B. J., & Shen, W.-K. (2009) · Circulation · doi:10.1161/circulationaha.108.827626 · Cited by 86 · see citing works
Self-citationPriorities for Emergency Department Syncope Research
Sun, B. C., Costantino, G., Barbic, F., Bossi, I., Casazza, G., Dipaola, F., McDermott, D., Quinn, J., Reed, M., Sheldon, R. S., et al. (2014) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2014.04.014 · Cited by 86 · see citing works
Self-citationRoss, M. A., Aurora, T. K., Graff, L., Suri, P., O’Malley, R., Ojo, A., Bohan, S., & Clark, C. (2012) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0b013e31825def28 · Cited by 83 · see citing works
Barón‐Esquivias, G., Martínez Alday, J., Martı́n, A., Moya‐Mitjans, À., García–Civera, R., López Chicharro, M. P., Martín-Méndez, M., del Arco, C., & Laguna, P. (2010) · Hispana · Cited by 81 · see citing works
Bartoletti, A., Fabiani, P., Adriani, P., Baccetti, F., Bagnoli, L., Buffini, G., Cappelletti, C., Cecchini, P., Gianni, R., Lavacchi, A., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi474 · Cited by 77 · see citing works
New Concepts in the Assessment of Syncope
Brignole, M., & Hamdan, M. H. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.056 · Cited by 75 · see citing works
Management of syncope: clinical and economic impact of a Syncope Unit
Ammirati, F., Colaceci, R., Cesario, A., Strano, S., Della Scala, A., Colangelo, I., De Santo, T., Toscano, E., Ricci, R., & Santini, M. (2008) · Europace · doi:10.1093/europace/eun061 · Cited by 73 · see citing works
The diagnostic protocol in children and adolescents with syncope: a multi‐centre prospective study
Zhang, Q., Du, J., Wang, C., Du, Z., Wang, L., & Tang, C. (2009) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.01195.x · Cited by 74 · see citing works
Syncope: Classification and risk stratification
Puppala, V. K., Dickinson, O., & Benditt, D. G. (2014) · Journal of Cardiology · doi:10.1016/j.jjcc.2013.03.019 · Cited by 64 · see citing works
External validation of the San Francisco Syncope Rule in the Australian context
Cosgriff, T. M., Kelly, A., & Kerr, D. C. (2007) · Canadian Journal of Emergency Medicine · doi:10.1017/s1481803500014986 · Cited by 58 · see citing works
Implantable loop recorder versus conventional diagnostic workup for unexplained recurrent syncope
Solbiati, M., Costantino, G., Casazza, G., Dipaola, F., Galli, A., Furlan, R., Montano, N., & Sheldon, R. S. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011637.pub2 · Cited by 56 · see citing works
Benditt, D. G., & Nguyen, J. T. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.065 · Cited by 55 · see citing works
Fedorowski, A., Burri, P., Juul‐Möller, S., & Melander, O. (2010) · EP Europace · doi:10.1093/europace/euq168 · Cited by 55 · see citing works
The Recidivism Characteristics of an Emergency Department Observation Unit
Ross, M. A., Hemphill, R. R., Abramson, J. L., Schwab, K., & Clark, C. L. (2010) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2010.02.012 · Cited by 54 · see citing works
Cardiovascular assessment of falls in older people
Tan, M. P., & Kenny, R. A. (2006) · Clinical Interventions in Aging · doi:10.2147/ciia.2006.1.1.57 · Cited by 52 · see citing works
McCarthy, F., McMahon, C. G., Geary, Ú., Plunkett, P. K., Kenny, R. A., & Cunningham, C. J. (2008) · EP Europace · doi:10.1093/europace/eun323 · Cited by 53 · see citing works
Duplyakov, D. V., Golovina, G., Lyukshina, N., Surkova, E., Elger, C. E., & Surges, R. (2014) · Seizure · doi:10.1016/j.seizure.2014.03.004 · Cited by 51 · see citing works
Evaluation of Transient Ischemic Attack in an Emergency Department Observation Unit
Ganti, L., Bellolio, F., Suravaram, S., Brown, R. D., Bhagra, A., Gilmore, R. M., Boie, E. T., & Decker, W. W. (2008) · Neurocritical Care · doi:10.1007/s12028-008-9146-z · Cited by 50 · see citing works
Self-citationSyncope: Diagnosis and Management
Walsh, K., Hoffmayer, K. S., & Hamdan, M. H. (2014) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2014.11.001 · Cited by 49 · see citing works
How to Differentiate Syncope from Seizure
Sheldon, R. S. (2015) · Cardiology Clinics · doi:10.1016/j.ccl.2015.04.006 · Cited by 48 · see citing works
NT-pro-BNP for differential diagnosis in patients with syncope
Pfister, R., Diedrichs, H., Larbig, R. K., Erdmann, E., & Schneider, C. A. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.11.082 · Cited by 46 · see citing works
Application of San Francisco Syncope Rule in elderly ED patients
Schladenhaufen, R., Feilinger, S., Pollack, M., Benenson, R., & Kusmiesz, A. L. (2008) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2007.10.042 · Cited by 45 · see citing works
Schuur, J. D., Baugh, C. W., Hess, E. P., Hilton, J. A., Pines, J. M., & Asplin, B. R. (2011) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2011.01096.x · Cited by 45 · see citing works
Canadian Cardiovascular Society Clinical Practice Update on the Assessment and Management of Syncope
Sandhu, R. K., Raj, S. R., Thiruganasambandamoorthy, V., Kaul, P., Morillo, C. A., Krahn, A. D., Guzmán, J. C., Sheldon, R. S., Banijamali, H. S., Macintyre, C. J., et al. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.12.023 · Cited by 42 · see citing works
Thiruganasambandamoorthy, V., Taljaard, M., Stiell, I. G., Sivilotti, M. L. A., Murray, H., Vaidyanathan, A., Rowe, B. H., Calder, L. A., Lang, E., McRae, A., et al. (2015) · Internal and Emergency Medicine · doi:10.1007/s11739-015-1237-1 · Cited by 39 · see citing works
Gauer, R. L. (2011) · PubMed · Cited by 38 · see citing works
Ungar, A., Tesi, F., Chisciotti, V. M., Pepe, G., Vanni, S., Grifoni, S., Balzi, D., Rafanelli, M., Marchionni, N., & Brignole, M. (2016) · Europace · doi:10.1093/europace/euv106 · Cited by 36 · see citing works
Anderson, T. S., Thombley, R. L., Dudley, R. A., & Lin, G. A. (2018) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2018.08.430 · Cited by 36 · see citing works
NT-pro-BNP for diagnostic and prognostic evaluation in patients hospitalized for syncope
Pfister, R., Hagemeister, J., Esser, S., Hellmich, M., Erdmann, E., & Schneider, C. A. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.10.013 · Cited by 35 · see citing works
Reflex syncope: Diagnosis and treatment
Sutton, R. (2017) · Journal of Arrhythmia · doi:10.1016/j.joa.2017.03.007 · Cited by 34 · see citing works
Syncope: a review of emergency department management and disposition
Patel, P., & Quinn, J. (2015) · Clinical and Experimental Emergency Medicine · doi:10.15441/ceem.14.049 · Cited by 35 · see citing works
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.005 · Cited by 34 · see citing works
Self-citationRisk stratification of syncope: Current syncope guidelines and beyond
Sutton, R., Ricci, F., & Fedorowski, A. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102929 · Cited by 35 · see citing works
Key challenges in the current management of syncope
Sutton, R., Brignole, M., & Benditt, D. G. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.102 · Cited by 33 · see citing works
Sandhu, R. K., Tran, D. T., Sheldon, R. S., & Kaul, P. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.09.003 · Cited by 32 · see citing works
Stepwise evaluation of syncope: A prospective population-based controlled study
Sarasin, F., Pruvot, E. J., Louis‐Simonet, M., Hügli, O., Sztajzel, J. M., Schläpfer, J., Herrera, M., Graz, J., Berchier, C., Mischler, C., et al. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.04.077 · Cited by 32 · see citing works
Kayayurt, K., Akoglu, H., Limon, O., Ergene, A. O., Yavasi, O., Bayata, S., Berk, N. V., & Unluer, E. E. (2012) · International Journal of Emergency Medicine · doi:10.1186/1865-1380-5-17 · Cited by 31 · see citing works
Syncope in the Emergency Department
Sandhu, R. K., & Sheldon, R. S. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00180 · Cited by 31 · see citing works
Shin, T. G., Kim, J. S., Song, H. G., Jo, I. J., Sim, M. S., & Park, S.-J. (2013) · Yonsei Medical Journal · doi:10.3349/ymj.2013.54.5.1110 · Cited by 30 · see citing works
An evaluation of emergency physician selection of observation unit patients
Crenshaw, L. A., Lindsell, C. J., Storrow, A. B., & Lyons, M. S. (2006) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2005.11.002 · Cited by 30 · see citing works
Goyal, P., & Maurer, M. S. (2016) · PubMed Central · doi:10.11909/j.issn.1671-5411.2016.05.002 · Cited by 33 · see citing works
Management of Syncope in Adults: An Update
Chen, L. Y., Benditt, D. G., & Shen, W.-K. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.11.1280 · Cited by 29 · see citing works
Self-citationKanters, T. A., Wolff, C., Boyson, D., Kouakam, C., Dinh, T., Roijen, L. H., & Mölken, M. R. (2015) · EP Europace · doi:10.1093/europace/euv217 · Cited by 28 · see citing works
Exposito, V., Guzman, J. C., Orava, M., Armaganijan, L., & Morillo, C. A. (2013) · Europace · doi:10.1093/europace/eut042 · Cited by 27 · see citing works
Thiruganasambandamoorthy, V., Stiell, I. G., Sivilotti, M. L. A., Rowe, B. H., Mukarram, M. A., Arcot, K., Kwong, K., McRae, A. D., Wells, G. A., & Taljaard, M. (2017) · Academic Emergency Medicine · doi:10.1111/acem.13275 · Cited by 27 · see citing works
Bhangu, J. S., Hall, P., Devaney, N., Bennett, K., Carroll, L., Kenny, R. A., & McMahon, C. G. (2018) · European Journal of Emergency Medicine · doi:10.1097/mej.0000000000000548 · Cited by 26 · see citing works
Approach to syncope in the emergency department
Reed, M. J. (2018) · Emergency Medicine Journal · doi:10.1136/emermed-2018-207767 · Cited by 26 · see citing works
Utility of implantable loop recorders for diagnosing unexplained syncope in clinical practice
Entem, F. R., Enríquez, S. G., Cobo, M., Expósito, V., Llano, M., Ruiz, M., Olalla, J. J., & Fernández, M. O. (2009) · Clinical Cardiology · doi:10.1002/clc.20342 · Cited by 25 · see citing works
Sclafani, J. J., My, J., Zacher, L. L., & Eckart, R. E. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.205 · Cited by 25 · see citing works
History, Principles, and Policies of Observation Medicine
Ross, M. A., & Granovsky, M. A. (2017) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2017.03.001 · Cited by 25 · see citing works
Probst, M. A., Su, E., Weiss, R. E., Yagapen, A. N., Malveau, S. E., Adler, D. H., Bastani, A., Baugh, C. W., Caterino, J. M., Clark, C. L., et al. (2019) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2019.03.031 · Cited by 25 · see citing works
Numeroso, F., Mossini, G., Giovanelli, M., Lippi, G., & Cervellin, G. (2016) · Academic Emergency Medicine · doi:10.1111/acem.13013 · Cited by 24 · see citing works
Syncope in adults: Systematic review and proposal of a diagnostic and therapeutic algorithm
Rosanio, S., Schwarz, E. R., Ware, D. L., & Vitarelli, A. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.11.021 · Cited by 24 · see citing works
Syncope Risk Stratification in the Emergency Department
Costantino, G., & Furlan, R. (2012) · Cardiology Clinics · doi:10.1016/j.ccl.2012.10.003 · Cited by 24 · see citing works
Martens, L., Goode, G., Wold, J., Beck, L., Martin, G., Perings, C. A., Stolt, P., & Baggerman, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100208 · Cited by 24 · see citing works
Syncope in Adults: Terminology, Classification, and Diagnostic Strategy
Jhanjee, R., van Dijk, J. G., Sakaguchi, S., & Benditt, D. G. (2006) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2006.00508.x · Cited by 24 · see citing works
Li, J., Smyth, S. S., Clouser, J. M., McMullen, C. A., Gupta, V. A., & Williams, M. V. (2021) · Medicina · doi:10.3390/medicina57060570 · Cited by 22 · see citing works
Anderson, K. L., Limkakeng, A. T., Damuth, E., & Chandra, A. B. (2012) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2012.04.023 · Cited by 23 · see citing works
Syncope in the Emergency Department: A Practical Approach
Furlan, L., Jacobitti, G., Gianni, F., Solbiati, M., Mancusi, C., & Costantino, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13113231 · Cited by 22 · see citing works
Ruwald, M. H., & Zaręba, W. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.08.007 · Cited by 22 · see citing works
Validation of EGSYS Score in Prediction of Cardiogenic Syncope
Kariman, H., Harati, S., Safari, S., Baratloo, A., & Pishgahi, M. (2015) · Emergency Medicine International · doi:10.1155/2015/515370 · Cited by 23 · see citing works
Calkins, H. G., & Zipes, D. P. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00042-1 · Cited by 21 · see citing works
Hospitalisation in short-stay units for adults with internal medicine diseases and conditions
Strøm, C., Stefansson, J. S., Fabritius, M. L., Rasmussen, L. S., Schmidt, T. A., & Jakobsen, J. C. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012370.pub2 · Cited by 22 · see citing works
Syncope: Overview and Approach to Management
Olshansky, B. (2005) · Wiley eBooks · doi:10.1002/9780470994801.ch1 · Cited by 22 · see citing works
Syncope Management Unit: Evolution of the Concept and Practice Implementation
Shen, W. K., Traub, S. J., & Decker, W. W. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2012.11.001 · Cited by 21 · see citing works
Self-citationHuff, J. S., Decker, W. W., Quinn, J., Perron, A. D., Napoli, A. M., Peeters, S., & Jagoda, A. S. (2007) · Journal of Emergency Nursing · doi:10.1016/j.jen.2007.04.009 · Cited by 21 · see citing works
Self-citationSyncope evaluation in the emergency department
Smars, P. A., Decker, W. W., & Shen, W.-K. (2006) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32801173d7 · Cited by 21 · see citing works
Self-citationInitial Evaluation of “Syncope and Collapse”
Benditt, D. G., & Can, I. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.050 · Cited by 21 · see citing works
Dan, G.-A., Scherr, D., Jubele, K., Farkowski, M. M., Iliodromitis, K., Conte, G., Jędrzejczyk-Patej, E., Vitali-Serdoz, L., & Potpara, T. S. (2020) · EP Europace · doi:10.1093/europace/euaa085 · Cited by 20 · see citing works
Probst, M. A., Janke, A. T., Haimovich, A. D., Venkatesh, A. K., Lin, M., Kocher, K. E., Nemnom, M., & Thiruganasambandamoorthy, V. (2022) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2022.03.008 · Cited by 20 · see citing works
Solbiati, M., Dipaola, F., Villa, P., Seghezzi, S., Casagranda, I., Rabajoli, F., Fiorini, E., Porta, L., Casazza, G., Voza, A., et al. (2019) · Academic Emergency Medicine · doi:10.1111/acem.13842 · Cited by 20 · see citing works
The Establishment and Management of an Observation Unit
Conley, J. J., Bohan, J. S., & Baugh, C. W. (2017) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2017.03.002 · Cited by 20 · see citing works
Approach to the Patient with Syncope
Benditt, D. G., & Adkisson, W. O. (2012) · Cardiology Clinics · doi:10.1016/j.ccl.2012.09.002 · Cited by 19 · see citing works
Prohormones in the Early Diagnosis of Cardiac Syncope
Badertscher, P., Nestelberger, T., de Lavallaz, J. D. F., Than, M. P., Morawiec, B., Kawecki, D., Miró, Ò., López, B., Martín‐Sánchez, F. J., Bustamante, J., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006592 · Cited by 19 · see citing works
Diagnostic and Prognostic Value of High-sensitivity Cardiac Troponin T in Patients with Syncope
Christ, M., Geier, F., Popp, S., Singler, K., Smolarsky, A., Bertsch, T., Mueller, C. E., & Greve, Y. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.09.021 · Cited by 19 · see citing works
Rodríguez‐Entem, F., González‐Enríquez, S., Olalla-Antolín, J. J., Cobo-Belaustegui, M., Expósito-García, V., Llano-Cardenal, M., Casanova-Martín, M. A., & Villar, C. R. (2008) · Revista Española de Cardiología · doi:10.1157/13114953 · Cited by 19 · see citing works
- Authors
- Shen, W. K., Decker, W. W., Smars, P. A., Goyal, D. G., Walker, A. E., Hodge, D. O., Trusty, J. M., Brekke, K. M., Jahangir, A., Brady, P. A., Munger, T. M., Gersh, B. J., Hammill, S. C., & Frye, R. L.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Venue
- Circulation
- Published
- 2004-12-14
- Volume
- 110
- Issue
- 24
- Pages
- 3636-3645
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2116521722
- Cited by
- 318
- References
- 47
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 12 · 2019: 11 · 2018: 19 · 2017: 23 · 2016: 11 · 2015: 20 · 2014: 18 · 2013: 24 · 2012: 19
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Mayo Foundation for Medical Education and Research
- National Institutes of Health
- National Institute on Aging (R01AG021201, AG-21201)
- National Heart, Lung, and Blood Institute (R01HL070302)
- National Institute of Neurological Disorders and Stroke (P50NS032352)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Emergency Medicine › Emergency and Acute Care Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- syncope, syncope unit, emergency department, diagnostic yield, hospitalization, length of hospital stay, intermediate cardiovascular risk, recurrent syncope, all-cause mortality, healthcare resource utilization
- MeSH terms
- Aged, Ambulatory Care, Electrocardiography, Emergency Medical Services, Emergency Service, Hospital, Female, Follow-Up Studies, Hospitalization, Humans, Length of Stay, Male, Middle Aged, Prospective Studies, Recurrence, Syncope, Risk Assessment, Tilt-Table Test, Endpoint Determination
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