Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis

Ling, F

doi:10.1016/s0029-7844(98)00341-x

Cited by 225Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis

Ling, F·1999·Obstetrics & Gynecology

DOI 10.1016/s0029-7844(98)00341-x

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Abstract

OBJECTIVE: To evaluate and compare the safety and efficacy of leuprolide versus placebo in managing chronic pelvic pain in women with clinically suspected endometriosis. METHODS: Women 18-45 years of age with moderate to severe pelvic pain of at least 6 months' duration underwent extensive, noninvasive diagnostic testing and laboratory evaluation, including pelvic ultrasound, complete blood count, determination of erythrocyte sedimentation rate, and endocervical cultures. Those with clinically suspected endometriosis were randomized to double-blind treatment for 3 months with depot leuprolide (3.75 mg/mo) or placebo. The accuracy of the clinical diagnosis of endometriosis was evaluated by posttreatment laparoscopy. RESULTS: Of 100 women randomized, 95 completed the study: 49 in the leuprolide group and 46 in the placebo group. Women in the leuprolide group had clinically and statistically significant (P < or = .001) mean improvements from baseline after 12 weeks of therapy in all pain measures. These mean improvements were significantly greater (P < or = .001) than those in the placebo group. At 12 weeks, mean decreases in physician-rated scores for dysmenorrhea, pelvic pain, and pelvic tenderness were 1.7, 1.0, and 0.8 points greater, respectively, in the leuprolide group than in the placebo group (on a four-point scale). Thirty-eight (78%) of 49 and 40 (87%) of 46 patients in the leuprolide and placebo groups, respectively, had laparoscopically confirmed endometriosis after 12 weeks of treatment. No women withdrew from the study because of adverse events. CONCLUSION: Depot leuprolide was effective and safe for treating patients with chronic pelvic pain and clinically suspected endometriosis, confirming the potential of its empiric use in these patients.

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Leuprolide reduces pain in women whether or not endometriosis is present.
“yet leuprolide relieves pain in women, regardless of whether they have endometriosis (Ling, 1999, Jenkins et al., 2008).”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Ling, 1999

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Authors: Ling, F.
Affiliations: University of Tennessee Health Science Center (US)
Corresponding author: Ling, F
Venue: Obstetrics & Gynecology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-01
Volume: 93
Issue: 1
Pages: 51-58
ISSN: 0029-7844 (ISSN-L)
DOI: 10.1016/s0029-7844(98)00341-x
OpenAlex: W2145262010
Cited by: 222
References: 27
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 13
FWCI: 6.85
Type: journal article
Language: en
Open access: closed
Locations: Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords: chronic pelvic pain, endometriosis, dysmenorrhea, GnRH agonist therapy, laparoscopic confirmation
MeSH terms: Adolescent, Adult, Algorithms, Chronic Disease, Delayed-Action Preparations, Double-Blind Method, Endometriosis, Female, Humans, Middle Aged, Laparoscopy, Leuprolide, Pelvic Pain

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Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis

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