Cited by 107Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

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Depot leuprolide versus danazol in treatment of women with symptomatic endometriosis

Wheeler, James M., Knittle, Judith D., Miller, James D.·1992·American Journal of Obstetrics and Gynecology

DOI 10.1016/s0002-9378(11)91718-9

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Abstract

Objective We aimed to assess the efficacy of depot leuprolide versus danazol in the treatment of endometriosis. Study design A double-blind randomized trial of 270 patients from 22 centers compared the pretreatment and posttreatment laparoscopic extent of endometriosis. Pretreatment and posttreatment endometriosis symptoms and signs were assessed with standardized methods. Results When compared with danazol, leuprolide depot caused a more rapid and profound suppression of estradiol. Leuprolide depot and danazol were similarly efficacious in decreasing the extent of endometriosis, as well as the pain and tenderness associated with endometriosis. Conclusion Depot leuprolide is an effective alternative to danazol in decreasing the extent of endometriosis and endometriosis-related pain.

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Authors: Wheeler, J. M., Knittle, J. D., & Miller, J. D.
Affiliations: Houston Methodist (US)
Deerfield (United States) (US)
Corresponding author: Miller, James D.
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 1992-11
Volume: 167
Issue: 5
Pages: 1367-1371
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/s0002-9378(11)91718-9
OpenAlex: W16600810
Cited by: 106
References: 11
Citations by year: 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 1
FWCI: 3.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords: endometriosis, danazol, estradiol suppression, endometriosis-associated pain, GnRH agonist therapy, treatment efficacy comparison
MeSH terms: Adolescent, Adult, Danazol, Delayed-Action Preparations, Double-Blind Method, Endometriosis, Estradiol, Female, Genital Neoplasms, Female, Humans, Laparoscopy, Leuprolide

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Depot leuprolide versus danazol in treatment of women with symptomatic endometriosis

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