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Hyperuricemia and xanthine oxidase in preeclampsia, revisited
Abstract
Hyperuricemia is associated with the severity of preeclampsia and with fetal outcome. Traditionally the high uric acid concentration in preeclampsia has been attributed soley to renal dysfunction. Preeclampsia is also characterized by increased free radical formation and elevated oxidative stress. Xanthine dehydrogenase/oxidase produces uric acid. Xanthine dehydrogenase/oxidase is present as two isoforms in vivo. Uric acid production is coupled with formation of reactive oxygen species when the enzyme is in the oxidase form. Several factors can increase the holoenzyme activity and the conversion of xanthine dehydrogenase/oxidase to its oxidase form. These factors include hypoxia-reperfusion, cytokines, and increased substrate availability (xanthine and hypoxanthine). Preeclampsia is characterized by hyperuricemia and signs of increased formation of reactive oxygen species and decreased levels of antioxidants. Preeclampsia is also characterized by shallow implantation, producing a relatively hypoxic maternal-fetal interface, and increased turnover of trophoblast tissue, which can result in higher xanthine and hypoxanthine concentrations and higher levels of circulating cytokines. These mechanisms can lead to increased production of uric acid and free radicals and contribute to the hyperuricemia and increased oxidative stress present in preeclampsia.
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“Gui et al.(75) suggested that metformin reduced the rate of gestational hypertension because of its effects on endothelial function and its decrease in the production of reactive oxygen species, the two mechanisms implicated in the pathophysiology of preeclampsia(84–94).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [89]
In the citing paper
“Torbergsen et al. suggested that these women developed preeclampsia because their dysfunctional mitochondria could not meet the increased energy demands of pregnancy, and the failure of adequate cellular energy production led to an accumulation of ADP, which is able to mediate most of the changes seen in preeclampsia(89, 197)”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [89]
In the citing paper
“ADP is a vasoconstrictor, causes platelet aggregation, and breaks down to uric acid.”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [89]
Citations
Cites
Harrison's Principles of Internal Medicine.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-499_2 · Cited by 12,528
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
The Pathology of the Human Placenta
Benirschke, K., & Driscoll, S. G. (1967) · Springer eBooks · doi:10.1007/978-1-4612-9809-0 · Cited by 2,253
Xanthine oxidase as a source of free radical damage in myocardial ischemia
CHAMBERS, D., PARKS, D., PATTERSON, G., ROY, R., MCCORD, J., YOSHIDA, S., PARMLEY, L., & DOWNEY, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80017-1 · Cited by 672
Xanthine oxidase: biochemistry, distribution and physiology.
Parks, D. A., & Granger, D. N. (1986) · PubMed · Cited by 638
Lipid peroxidation in pregnancy: New perspectives on preeclampsia
Hubel, C. A., Roberts, J. M., Taylor, R. N., Musci, T. J., Rogers, G. M., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90778-3 · Cited by 445
Self-citationLocalization of xanthine oxidase in mammary-gland epithelium and capillary endothelium
Jarasch, E.-D., Gründ, C., Bruder, G., Heid, H., Keenan, T. W., & Franke, W. W. (1981) · Cell · doi:10.1016/0092-8674(81)90232-4 · Cited by 440
Roberts, J. M., Taylor, R. N., & Goldfien, A. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.8.700 · Cited by 389
Self-citationThe Role of Oxygen Radicals in Human Disease, with Particular Reference to the Vascular System
Halliwell, B. B. (2009) · Haemostasis · doi:10.1159/000216921 · Cited by 358
EMBOLISM TO THE LUNGS BY TROPHOBLAST
Attwood, H. D., & Park, W. W. (1961) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1961.tb02778.x · Cited by 267
Research works printed but not linked: 1
- Uotila, 1992, Plasma peroxyl radical tapping capacity in severe preeclamspia is strongly related to uric acid, Clin Exp Hypertens Pregnancy, B11-71
Cited by
Sorted by citations
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Johnson, R. J., Kang, D., Feig, D. I., Kivlighn, S. D., Kanellis, J., Watanabe, S., Tuttle, K. R., Rodríguez‐Iturbe, B., Herrera-Acosta, J., & Mazzali, M. (2003) · Hypertension · doi:10.1161/01.hyp.0000069700.62727.c5 · Cited by 1,354
Etiology and pathogenesis of preeclampsia: Current concepts
Dekker, G., & Sibai, B. M. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70160-7 · Cited by 760
Oxidative Stress in the Pathogenesis of Preeclampsia
Hubel, C. A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-139.x · Cited by 681
Self-citationBurton, G. J., Yung, H.-W., Cindrova-Davies, T., & Charnock-Jones, D. S. (2009) · Placenta · doi:10.1016/j.placenta.2008.11.003 · Cited by 502
Endothelial dysfunction and preeclampsia: role of oxidative stress
Sanchez-Aranguren, L. C., Prada, C. E., Riaño-Medina, C. E., & López, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00372 · Cited by 446
Hung, T., Skepper, J. N., Jones, D. S., & Burton, G. J. (2002) · Circulation Research · doi:10.1161/01.res.0000024411.22110.aa · Cited by 397
Schwartz, R. B., Feske, S. K., Polak, J. F., Girolami, U. D., Iaia, A., Beckner, K. M., Bravo, S. M., Klufas, R. A., Chai, R. Y., & Jt, R. (2000) · Radiology · doi:10.1148/radiology.217.2.r00nv44371 · Cited by 388
A longitudinal study of biochemical variables in women at risk of preeclampsia
Chappell, L. C., Seed, P. T., Briley, A. L., Kelly, F. J., Hunt, B. J., Jones, D. S., Mallet, A. I., & Poston, L. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.122969 · Cited by 351
Preeclampsia: A renal perspective
Karumanchi, S. A., Maynard, S. E., Stillman, I. E., Epstein, F. H., & Sukhatme, V. P. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00316.x · Cited by 320
Guerby, P., Tasta, O., Swiader, A., Pont, F., Bujold, E., Parant, O., Vayssière, C., Salvayre, R., & Nègre‐Salvayre, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101861 · Cited by 324
Hypoxia and Reoxygenation: a Possible Mechanism for Placental Oxidative Stress in Preeclampsia
Hung, T., & Burton, G. J. (2006) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/s1028-4559(09)60224-2 · Cited by 296
Oxygen, the Janus gas; its effects on human placental development and function
Burton, G. J. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00978.x · Cited by 290
Invasive Cytotrophoblasts Manifest Evidence of Oxidative Stress in Preeclampsia
Many, A., Hubel, C. A., Fisher, S. J., Roberts, J. M., & Zhou, Y. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64733-5 · Cited by 278
Self-citationJohnson, R. J., Kivlighn, S. D., Kim, Y.-G., Suga, S., & Fogo, A. B. (1999) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(99)70295-7 · Cited by 263
Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253
Accuracy of serum uric acid in predicting complications of pre‐eclampsia: a systematic review
Thangaratinam, S., Ismail, K., Sharp, S., Coomarasamy, A., & Khan, K. S. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00908.x · Cited by 210
Chappell, L. C., Seed, P. T., CStat, Kelly, F. J., Briley, A. L., Hunt, B. J., Jones, D. S., Mallet, A. I., & Poston, L. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.125735 · Cited by 209
Lala, P. K., & Chakraborty, C. (2003) · Placenta · doi:10.1016/s0143-4004(03)00063-8 · Cited by 190
Review: Oxygen and trophoblast biology – A source of controversy
Tuuli, M. G., Longtine, M. S., & Nelson, D. M. (2011) · Placenta · doi:10.1016/j.placenta.2010.12.013 · Cited by 164
Powers, R. W., Bodnar, L. M., Ness, R. B., Cooper, K. M., Gallaher, M. J., Frank, M. P., Daftary, A. R., & Roberts, J. M. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.06.066 · Cited by 154
Self-citationElevated levels of serum nitrate, a stable end product of nitric oxide, in women with pre‐eclampsia
Smárason, A. K., Allman, K. G., Young, D., & Redman, C. W. G. (1997) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb11528.x · Cited by 146
Oxidative stress in pre-eclampsia
Bowen, R. S., Moodley, J., Dutton, M. F., & Theron, A. J. (2001) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2001.080008719.x · Cited by 145
The immunology of preeclampsia
Dekker, G., & Sibai, B. M. (1999) · Seminars in Perinatology · doi:10.1016/s0146-0005(99)80057-3 · Cited by 142
Vascular Endothelial Growth Factor Is Increased in Patients With Preeclampsia
Kupferminc, M. J., Daniel, Y., Englender, T., Bar‐Am, A., Many, A., Jaffa, A. J., Gull, I., & Lessing, J. B. (1997) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1997.tb00519.x · Cited by 128
Self-citationKaya, M. G., Uyarel, H., Akpek, M., Kalay, N., Ergelen, M., Ayhan, E., Işık, T., Çiçek, G., Elçik, D., Şahin, Ö., et al. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.09.042 · Cited by 120
Pregnancy-Related Hypertension
Roberts, J. M., & Funai, E. F. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4224-2.50038-7 · Cited by 121
Self-citationThe role of oxygen in prenatal growth: studies in the chick embryo
Giussani, D. A., Salinas, C. E., Villena, M., & Blanco, C. E. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.141572 · Cited by 120
The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy
Lim, K.-H., Friedman, S. A., Ecker, J. L., Kao, L., & Kilpatrick, S. J. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70549-6 · Cited by 115
Peraçoli, J. C., Rudge, M. V. C., & Peraçoli, M. T. S. (2007) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2006.00455.x · Cited by 114
Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals
Ishizaka, N., Ishizaka, Y., Toda, E.-I., Hashimoto, H., Nagai, R., & Yamakado, M. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.04.016 · Cited by 109
Mulla, M. J., Salmon, J. E., Chamley, L., Brosens, J. J., Boeras, C., Kavathas, P., & Abrahams, V. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065237 · Cited by 110
Role of reactive oxygen species in gynecologic diseases
Sharma, R. K., & Agarwal, A. K. (2004) · Reproductive Medicine and Biology · doi:10.1111/j.1447-0578.2004.00068.x · Cited by 107
Uric acid, endothelial dysfunction and pre-eclampsia
Kang, D., Finch, J., Nakagawa, T., Karumanchi, S. A., Kanellis, J., Granger, J. P., & Johnson, R. J. (2004) · Journal of Hypertension · doi:10.1097/00004872-200402000-00001 · Cited by 108
Akpek, M., Kaya, M. G., Uyarel, H., Yarlıoğlueş, M., Kalay, N., Günebakmaz, Ö., Doğdu, O., Ardıç, İ., Elçik, D., Şahin, Ö., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.07.021 · Cited by 102
Reslan, O. M., & Khalil, R. A. (2010) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152510792481234 · Cited by 95
Study of Plasma Factors Associated With Neutrophil Activation and Lipid Peroxidation in Preeclampsia
Barden, A. E., Ritchie, J., Walters, B. N. J., Michael, C., Rivera, J., Mori, T. A., Croft, K. D., & Beilin, L. J. (2001) · Hypertension · doi:10.1161/hy1101.092969 · Cited by 90
Lam, C., Lim, K.-H., Kang, D., & Karumanchi, S. A. (2005) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.09.009 · Cited by 90
The prognostic role of serum uric acid levels in preeclampsia: A meta‐analysis
Bellos, I., Pergialiotis, V., Loutradis, D., & Daskalakis, G. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.13865 · Cited by 92
The renal response to preeclampsia
Moran, P., Lindheimer, M. D., & Davison, J. M. (2004) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.07.008 · Cited by 79
Koopmans, C. M., van Pampus, M. G., Groen, H., Aarnoudse, J. G., van den Berg, P. P., & Mol, B. W. (2009) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2009.05.014 · Cited by 76
Renal Physiology and Disease in Pregnancy
Conrad, K. P., & Karumanchi, S. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381462-3.00081-1 · Cited by 74
Pregnancy-induced hypertension and insulin resistance, evidence for a connection
Innes, K. E., & Wimsatt, J. (1999) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.1999.780401.x · Cited by 67
Dietary l-arginine prevents fetal growth restriction in rats
Vosatka, R. J., Hassoun, P. M., & Harvey-Wilkes, K. B. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)80007-0 · Cited by 65
Tsukimori, K., Yoshitomi, T., Morokuma, S., Fukushima, K., & Wake, N. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.289 · Cited by 60
Cystatin C, β‐2‐microglobulin and β‐trace protein in pre‐eclampsia
Kristensen, K. H., Wide‐Swensson, D., SCHMIDT, C., Blirup-Jensen, S., Lindström, V., Strevens, H., & GRUBB, A. O. (2007) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/00016340701318133 · Cited by 58
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Harsem, N. K., Brække, K., & Staff, A. C. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.11.014 · Cited by 57
Karabulut, A. B., Kafkaslı, A., Burak, F., & Gözükara, E. M. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1152 · Cited by 56
Bretelle, F., Sabatier, F., Blann, A. D., D’Ercole, C., Boutiere, B., Mutin, M., Boubli, L., Sampol, J., & Dignat‐George, F. (2001) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2001.00259.x · Cited by 56
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Roberts, J. M., & Speer, P. D. (2004) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.07.004 · Cited by 55
Self-citationYang, Y., Wang, Y., Zeng, X., Ma, X.-J., Zhao, Y., Qiao, J., Cao, B., Li, Y.-X., Ji, L., & Wang, Y. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1150 · Cited by 53
Murata, M., Fukushima, K., Takao, T., Seki, H., Takeda, S., & Wake, N. (2013) · Journal of Reproduction and Development · doi:10.1262/jrd.2012-053 · Cited by 53
Burton, G. J., & Hung, T. (2003) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539503001049 · Cited by 52
Total free radical trapping antioxidant potential in pre‐eclampsia
Kharb, S. (2000) · International Journal of Gynecology & Obstetrics · doi:10.1016/s0020-7292(99)00198-8 · Cited by 52
Perlman, J. M., & Risser, R. C. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70016-2 · Cited by 51
Assessing the Role of Uric Acid as a Predictor of Preeclampsia
Corominas, A. I., Medina, Y., Balconi, S., Casale, R., Farina, M., Martínez, N., & Damiano, A. E. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.785219 · Cited by 49
Association of serum uric acid level and coronary blood flow
Yıldız, A., Yılmaz, R., Demirbağ, R., Gür, M., Baş, M. M., & Erel, Ö. (2007) · Coronary Artery Disease · doi:10.1097/mca.0b013e3282f0a2a7 · Cited by 49
Physical well-being in women with a history of severe preeclampsia
Roes, E. M., Raijmakers, M. T. M., Schoonenberg, M. P. G., Wanner, N., Peters, W. H. M., & Steegers, E. A. P. (2005) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050500127740 · Cited by 49
Soluble Flt‐1 as a diagnostic marker of pre‐eclampsia
Woolcock, J., Hennessy, A., Xu, B., Thornton, C. E., Tooher, J., Makris, A., & Ogle, R. F. (2008) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2007.00804.x · Cited by 45
Pre‐eclamptic toxaemia: the role of uterine artery Doppler
Chappell, L. C., & Bewley, S. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb10118.x · Cited by 45
High uric acid level associated with increased arterial stiffness in apparently healthy women
Fang, J.-I., Wu, J., Yang, Y., Wang, R.-H., Lu, F., & Chang, C. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.07.024 · Cited by 43
Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
Manjareeka, M., & Nanda, S. (2012) · International Journal of Medical Science and Public Health · doi:10.5455/ijmsph.2013.2.43-47 · Cited by 42
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Annesi, L., Tossetta, G., Borghi, C., & Piani, F. (2024) · Antioxidants · doi:10.3390/antiox13101234 · Cited by 41
Davidge, S. T., de Groot, C. J. M., & Taylor, R. N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407866-6.00009-2 · Cited by 41
Başar, N., Şen, N., Özcan, F., Erden, G., Kanat, S., Sökmen, E., İşleyen, A., Yüzgeçer, H., Özlü, M. F., Yıldırımkaya, M., et al. (2011) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e318214ebaf · Cited by 40
Uric acid and cardiovascular disease: a renal-cardiac relationship?
Culleton, B. F. (2001) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200105000-00012 · Cited by 37
Absorption spectra of xanthines in aqueous solution: a computational study
Gómez, S., Giovannini, T., & Cappelli, C. (2020) · Physical Chemistry Chemical Physics · doi:10.1039/c9cp05420k · Cited by 35
In vitro bioactivity of extracts from seeds of Cassia absus L. growing in Pakistan
Ahmad, S., Hassan, A., Rehman, T., Basit, A., Tahir, A., & Arshad, M. A. (2019) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2019.100258 · Cited by 34
Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension?
Zharikov, S. I., Swenson, E. R., Lanaspa, M. A., Block, E. R., Patel, J. M., & Johnson, R. J. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2009.12.023 · Cited by 34
Schuiling, G. A., Koiter, T. R., & Faas, M. M. (1997) · Human Reproduction · doi:10.1093/humrep/12.10.2087 · Cited by 34
XANTHINE OXIDASE ACTIVATION IN MILD GESTATIONAL HYPERTENSION
Németh, I., Tálosi, G., Papp, A., & BODA, D. (2002) · Hypertension in Pregnancy · doi:10.1081/prg-120002905 · Cited by 33
Yalamati, P., Bhongir, A. V., Betha, K., Verma, R., & Dandge, S. (2015) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20150737 · Cited by 33
Yıldırım, A., Altınkaynak, K., Aksoy, H., Sahin, Y. N., & Akçay, F. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1090 · Cited by 32
Vitamin A and causes of maternal mortality: association and biological plausibility
Faisel, H., & Pittrof, R. (2000) · Public Health Nutrition · doi:10.1017/s1368980000000367 · Cited by 32
Choi, H. Y., Kim, S., Choi, A. R., Kim, S. G., Kim, H., Lee, J. E., Kim, H. J., & Park, H. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180406 · Cited by 31
Urinary hypoxanthine and xanthine levels in acute coronary syndromes
Turgan, N., Habif, S., Gülter, C., Şenol, B., MUTAF, I., Özmen, D., Bayındır, O., Boydak, B., & Turgan, N. (1999) · International Journal of Clinical & Laboratory Research · doi:10.1007/s005990050084 · Cited by 31
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Shoji, H., Franke, C., Demmelmair, H., & Koletzko, B. V. (2009) · Early Human Development · doi:10.1016/j.earlhumdev.2009.02.003 · Cited by 28
Güllü, H., Erdoğan, D., Çalışkan, M., Tok, D., Kulaksızoğlu, S., Yı́ldı́rı́r, A., & Müderrisoğlu, H. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.10.019 · Cited by 28
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Lyell, D. J., Lambert-Messerlian, G. M., & Giudice, L. C. (2003) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(03)00027-1 · Cited by 27
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Suzuki, S., Yoneyama, Y., Sawa, R., Otsubo, Y., Takeuchi, T., & Araki, T. (2001) · Gynecologic and Obstetric Investigation · doi:10.1159/000052918 · Cited by 26
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Metadata
- Authors
- Many, A., Hubel, C. A., & Roberts, J. M.
- Affiliations
- Magee-Womens Research Institute (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 174
- Issue
- 1
- Pages
- 288-291
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2139903790
- Cited by
- 187
- References
- 63
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 16 · 2013: 6 · 2012: 8
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD030367, 1 PO1 HD 30367-01, 1 PO1 HD 30367-02)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
- Keywords
- hyperuricemia, xanthine oxidase, xanthine dehydrogenase, preeclampsia, oxidative stress, reactive oxygen species, uric acid formation, trophoblast, maternal-fetal interface, hypoxia-reperfusion, cytokines, implantation depth, fetal outcomes
- MeSH terms
- Female, Humans, Kidney, Pre-Eclampsia, Pregnancy, Uric Acid, Xanthine Dehydrogenase, Xanthine Oxidase
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