Cited by 188Pregnancy and preeclampsia studiesGout, Hyperuricemia, Uric AcidNeurological Complications and Syndromes

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Hyperuricemia and xanthine oxidase in preeclampsia, revisited

Many, A., Hubel, C.A., Roberts, J.M.·1996·American Journal of Obstetrics and Gynecology

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Abstract

Hyperuricemia is associated with the severity of preeclampsia and with fetal outcome. Traditionally the high uric acid concentration in preeclampsia has been attributed soley to renal dysfunction. Preeclampsia is also characterized by increased free radical formation and elevated oxidative stress. Xanthine dehydrogenase/oxidase produces uric acid. Xanthine dehydrogenase/oxidase is present as two isoforms in vivo. Uric acid production is coupled with formation of reactive oxygen species when the enzyme is in the oxidase form. Several factors can increase the holoenzyme activity and the conversion of xanthine dehydrogenase/oxidase to its oxidase form. These factors include hypoxia-reperfusion, cytokines, and increased substrate availability (xanthine and hypoxanthine). Preeclampsia is characterized by hyperuricemia and signs of increased formation of reactive oxygen species and decreased levels of antioxidants. Preeclampsia is also characterized by shallow implantation, producing a relatively hypoxic maternal-fetal interface, and increased turnover of trophoblast tissue, which can result in higher xanthine and hypoxanthine concentrations and higher levels of circulating cytokines. These mechanisms can lead to increased production of uric acid and free radicals and contribute to the hyperuricemia and increased oxidative stress present in preeclampsia.

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de Mendonça, E. L. S. S., Mello, C. S., OLIVEIRA, M. G. F., & de Oliveira, A. C. M. (2023) · doi:10.58871/ed.academic.00013.v1
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The Usefulness of Gestation Corrected Hyperuricemia as Predictors of the Recurrence of Preeclampsia and Obstetric Outcomes on Subsequent Pregnancy: A Single Center Retrospective Study in South Korea
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Authors: Many, A., Hubel, C. A., & Roberts, J. M.
Affiliations: Magee-Womens Research Institute (US)
ORCID: Hubel, C.A.
Roberts, J.M.
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 1996-01
Volume: 174
Issue: 1
Pages: 288-291
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/s0002-9378(96)70410-6
OpenAlex: W2139903790
Cited by: 187
References: 63
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 16 · 2013: 6 · 2012: 8
FWCI: 2.11
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD030367, 1 PO1 HD 30367-01, 1 PO1 HD 30367-02)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
Keywords: hyperuricemia, xanthine oxidase, xanthine dehydrogenase, preeclampsia, oxidative stress, reactive oxygen species, uric acid formation, trophoblast, maternal-fetal interface, hypoxia-reperfusion, cytokines, implantation depth, fetal outcomes
MeSH terms: Female, Humans, Kidney, Pre-Eclampsia, Pregnancy, Uric Acid, Xanthine Dehydrogenase, Xanthine Oxidase

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Hyperuricemia and xanthine oxidase in preeclampsia, revisited

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