The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Hyperuricemia and xanthine oxidase in preeclampsia, revisited
Abstract
Hyperuricemia is associated with the severity of preeclampsia and with fetal outcome. Traditionally the high uric acid concentration in preeclampsia has been attributed soley to renal dysfunction. Preeclampsia is also characterized by increased free radical formation and elevated oxidative stress. Xanthine dehydrogenase/oxidase produces uric acid. Xanthine dehydrogenase/oxidase is present as two isoforms in vivo. Uric acid production is coupled with formation of reactive oxygen species when the enzyme is in the oxidase form. Several factors can increase the holoenzyme activity and the conversion of xanthine dehydrogenase/oxidase to its oxidase form. These factors include hypoxia-reperfusion, cytokines, and increased substrate availability (xanthine and hypoxanthine). Preeclampsia is characterized by hyperuricemia and signs of increased formation of reactive oxygen species and decreased levels of antioxidants. Preeclampsia is also characterized by shallow implantation, producing a relatively hypoxic maternal-fetal interface, and increased turnover of trophoblast tissue, which can result in higher xanthine and hypoxanthine concentrations and higher levels of circulating cytokines. These mechanisms can lead to increased production of uric acid and free radicals and contribute to the hyperuricemia and increased oxidative stress present in preeclampsia.
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“Gui et al.(75) suggested that metformin reduced the rate of gestational hypertension because of its effects on endothelial function and its decrease in the production of reactive oxygen species, the two mechanisms implicated in the pathophysiology of preeclampsia(84–94).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [89]
In the citing paper
“Torbergsen et al. suggested that these women developed preeclampsia because their dysfunctional mitochondria could not meet the increased energy demands of pregnancy, and the failure of adequate cellular energy production led to an accumulation of ADP, which is able to mediate most of the changes seen in preeclampsia(89, 197)”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [89]
In the citing paper
“ADP is a vasoconstrictor, causes platelet aggregation, and breaks down to uric acid.”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [89]
Citations
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Self-citationThe Role of Oxygen Radicals in Human Disease, with Particular Reference to the Vascular System
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EMBOLISM TO THE LUNGS BY TROPHOBLAST
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Sorted by citations
Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?
Johnson, R. J., Kang, D., Feig, D. I., Kivlighn, S. D., Kanellis, J., Watanabe, S., Tuttle, K. R., Rodríguez‐Iturbe, B., Herrera-Acosta, J., & Mazzali, M. (2003) · Hypertension · doi:10.1161/01.hyp.0000069700.62727.c5 · Cited by 1,354
Etiology and pathogenesis of preeclampsia: Current concepts
Dekker, G., & Sibai, B. M. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70160-7 · Cited by 760
Oxidative Stress in the Pathogenesis of Preeclampsia
Hubel, C. A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-139.x · Cited by 681
Self-citationBurton, G. J., Yung, H.-W., Cindrova-Davies, T., & Charnock-Jones, D. S. (2009) · Placenta · doi:10.1016/j.placenta.2008.11.003 · Cited by 502
Endothelial dysfunction and preeclampsia: role of oxidative stress
Sanchez-Aranguren, L. C., Prada, C. E., Riaño-Medina, C. E., & López, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00372 · Cited by 446
Metadata
- Authors
- Many, A., Hubel, C. A., & Roberts, J. M.
- Affiliations
- Magee-Womens Research Institute (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 174
- Issue
- 1
- Pages
- 288-291
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2139903790
- Cited by
- 187
- References
- 63
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 16 · 2013: 6 · 2012: 8
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD030367, 1 PO1 HD 30367-01, 1 PO1 HD 30367-02)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
- Keywords
- hyperuricemia, xanthine oxidase, xanthine dehydrogenase, preeclampsia, oxidative stress, reactive oxygen species, uric acid formation, trophoblast, maternal-fetal interface, hypoxia-reperfusion, cytokines, implantation depth, fetal outcomes
- MeSH terms
- Female, Humans, Kidney, Pre-Eclampsia, Pregnancy, Uric Acid, Xanthine Dehydrogenase, Xanthine Oxidase
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