Cited by 584Neonatal and fetal brain pathologyPreterm Birth and ChorioamnionitisNeonatal and Maternal Infections

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Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia

Yoon, Bo Hyun, Romero, Roberto, Yang, Soon Ha, Jun, Jong Kwan, Kim, In-One, Choi, Jung-Hwan, Syn, Hee Chul·1996·American Journal of Obstetrics and Gynecology

DOI 10.1016/s0002-9378(96)70585-9

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Abstract

Objective Periventricular leukomalacia, a common brain white matter lesion in preterm neonates, is a major risk factor for cerebral palsy. Recently, cytokines (i.e., tumor necrosis factor and interleukin-1(beta)) have been implicated as mediators for the development of periventricular leukomalacia. The purpose of this study was to examine the relationship between umbilical cord plasma levels of tumor necrosis factor-alpha, interleukin-1(beta), interleukin-6, and interleukin-1 receptor antagonist and the occurrence of periventricular leukomalacia in preterm neonates.Study design Umbilical cord blood was collected from 172 consecutive preterm births (25 to 36 weeks). Periventricular leukomalacia-associated lesions were diagnosed by brain ultrasonography within the first 3 days of life. Tumor necrosis factor-alpha, interleukin-1(beta) interleukin-6, and interleukin-1 receptor antagonist were measured by sensitive and specific enzyme-linked immunoassay methods. Umbilical cord arterial pH was measured at birth. Statistical analysis was performed with multiple logistic regression and receiver operating characteristic curve analysis.Results Periventricular leukomalacia-associated lesions were present in 14.5% (25/172) of infants. Plasma concentrations of interleukin-6 but not of tumor necrosis factor-alpha, interleukin-1(beta), and interleukin-1 receptor antagonist were significantly higher in neonates with periventricular leukomalacia-associated lesions than in those without these lesions (median 718, range < 226 to 32,000 pg/ml vs median < 226, range < 226 to 43,670 pg/ml; p < 0.0001). An interleukin-6 value > or = 400 pg/ml had a sensitivity of 72% (18/25) and a specificity of 74% (108/147) in the identification of periventricular leukomalacia-associated lesions. Multivariate analysis showed that umbilical cord interleukin-6 was an independent risk factor for periventricular leukomalacia (odds ratio 6.2, p < 0.002) after correction for known confounding variables (i.e., gestational age at birth, umbilical artery pH, chorioamnionitis).Conclusions Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with periventricular leukomalacia-associated lesions. Our data support the hypothesis that periventricular leukomalacia may be the result of cytokine-mediated brain injury.

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Authors: Yoon, B. H., Romero, R., Yang, S. H., Jun, J. K., Kim, I.-O., Choi, J.-H., & Syn, H. C.
Affiliations: Seoul National University (KR)
ORCID: Yoon, Bo Hyun
Romero, Roberto
Jun, Jong Kwan
Choi, Jung-Hwan
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 1996-05
Volume: 174
Issue: 5
Pages: 1433-1440
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/s0002-9378(96)70585-9
OpenAlex: W1964039180
Cited by: 584
References: 31
Citations by year: 2026: 6 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 13 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 22 · 2016: 14 · 2015: 19 · 2014: 22 · 2013: 22 · 2012: 25
FWCI: 21.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Keywords: periventricular leukomalacia, interleukin-6, umbilical cord plasma, preterm infants, white matter lesions, TNF-α, IL-1β, interleukin-1 receptor antagonist, cytokines, cerebral palsy risk, umbilical artery pH, biomarkers, risk factors, brain ultrasonography, gestational age
MeSH terms: Adult, C-Reactive Protein, Female, Fetal Blood, Humans, Immunoenzyme Techniques, Infant, Newborn, Infant, Premature, Interleukin-1, Leukomalacia, Periventricular, Osmolar Concentration, Pregnancy, ROC Curve, Sensitivity and Specificity, Tumor Necrosis Factor-alpha, Interleukin-6, Receptors, Interleukin-1

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Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia

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