Cited by 584Neonatal and fetal brain pathologyPreterm Birth and ChorioamnionitisNeonatal and Maternal Infections

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia

Yoon, Bo Hyun, Romero, Roberto, Yang, Soon Ha, Jun, Jong Kwan, Kim, In-One, Choi, Jung-Hwan, Syn, Hee Chul·1996·American Journal of Obstetrics and Gynecology

DOI 10.1016/s0002-9378(96)70585-9

Open this paper in CoChat — free account

Abstract

Objective Periventricular leukomalacia, a common brain white matter lesion in preterm neonates, is a major risk factor for cerebral palsy. Recently, cytokines (i.e., tumor necrosis factor and interleukin-1(beta)) have been implicated as mediators for the development of periventricular leukomalacia. The purpose of this study was to examine the relationship between umbilical cord plasma levels of tumor necrosis factor-alpha, interleukin-1(beta), interleukin-6, and interleukin-1 receptor antagonist and the occurrence of periventricular leukomalacia in preterm neonates.Study design Umbilical cord blood was collected from 172 consecutive preterm births (25 to 36 weeks). Periventricular leukomalacia-associated lesions were diagnosed by brain ultrasonography within the first 3 days of life. Tumor necrosis factor-alpha, interleukin-1(beta) interleukin-6, and interleukin-1 receptor antagonist were measured by sensitive and specific enzyme-linked immunoassay methods. Umbilical cord arterial pH was measured at birth. Statistical analysis was performed with multiple logistic regression and receiver operating characteristic curve analysis.Results Periventricular leukomalacia-associated lesions were present in 14.5% (25/172) of infants. Plasma concentrations of interleukin-6 but not of tumor necrosis factor-alpha, interleukin-1(beta), and interleukin-1 receptor antagonist were significantly higher in neonates with periventricular leukomalacia-associated lesions than in those without these lesions (median 718, range < 226 to 32,000 pg/ml vs median < 226, range < 226 to 43,670 pg/ml; p < 0.0001). An interleukin-6 value > or = 400 pg/ml had a sensitivity of 72% (18/25) and a specificity of 74% (108/147) in the identification of periventricular leukomalacia-associated lesions. Multivariate analysis showed that umbilical cord interleukin-6 was an independent risk factor for periventricular leukomalacia (odds ratio 6.2, p < 0.002) after correction for known confounding variables (i.e., gestational age at birth, umbilical artery pH, chorioamnionitis).Conclusions Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with periventricular leukomalacia-associated lesions. Our data support the hypothesis that periventricular leukomalacia may be the result of cytokine-mediated brain injury.

Integrity signals

Registry

Crossref · 10.1016/s0002-9378(96)70585-9

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
Selmaj, K., & Raine, C. S. (1988) · Annals of Neurology · doi:10.1002/ana.410230405 · Cited by 1,417
Antecedents of Cerebral Palsy
Nelson, K. B., & Ellenberg, J. H. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607103150202 · Cited by 945
Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways
van Deventer, S. J. H., Buller, H. R., ten Cate, J. W., Aarden, L. A., Hack, C. E., & Sturk, A. (1990) · Blood · doi:10.1182/blood.v76.12.2520.bloodjournal76122520 · Cited by 850
Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects
van der Poll, T., Buller, H. R., Cate, H. T., Wortel, C. H., Bauer, K. A., van Deventer, S. J. H., Hack, C. E., Sauerwein, H. P., ROSENBERG, R. D., & ten Cate, J. W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006073222302 · Cited by 667
Quantitative Bacteriology of Amniotic Fluid from Women with Clinical Intraamniotic Infection at Term
Gibbs, R. S., Blanco, J., Clair, P. J. S., & Castañeda, Y. S. (1982) · The Journal of Infectious Diseases · doi:10.1093/infdis/145.1.1 · Cited by 552
Amniotic fluid interleukin-6: A sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity
Yoon, B. H., Romero, R. J., Kim, C. J., Jun, J. K., Gómez, R., Choi, J., & Syn, H. C. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90028-4 · Cited by 493
Self-citation
Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.
Robbins, D. S., Shirazi, Y., Drysdale, B. E., Lieberman, A. P., Shin, H. S., & Shin, M. L. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.8.2593 · Cited by 428
Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor.
Camussi, G., Bussolino, F., Salvidio, G., & Baglioni, C. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.5.1390 · Cited by 349
Antenatal origin of neurologic damage in newborn infants
Bejar, R. F., Wozniak, P. R., Allard, M., Benirschke, K., Vaucher, Y. E., Coen, R. W., Berry, C. C., Shragg, P., Villegas, I., & Resnik, R. R. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(88)80084-x · Cited by 303
White matter damage in preterm newborns —an epidemiologic perspective
Leviton, A. E., & Paneth, N. (1990) · Early Human Development · doi:10.1016/0378-3782(90)90002-z · Cited by 265

Show all 31 references

Research works printed but not linked: 1

Verma, 1994, Obstetrical antecedents of neonatal periventricular leukomalacia (PVL) [abstract], AM J OBSTET GYNECOL, 170, 264

Sorted by citations

Items 201–300 of 584

The Pattern of Cerebral Injury in a Primate Model of Preterm Birth and Neonatal Intensive Care
Dieni, S., Inder, T. E., Yoder, B. A., Briscoe, T. A., Camm, E. J., Egan, G. F., Denton, D. A., & Rees, S. M. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.12.1297 · Cited by 61
Combined in utero hypoxia-ischemia and lipopolysaccharide administration in rats induces chorioamnionitis and a fetal inflammatory response syndrome
Maxwell, J. R., Denson, J. L., Joste, N. E., Robinson, S., & Jantzie, L. L. (2015) · Placenta · doi:10.1016/j.placenta.2015.10.009 · Cited by 61
Preterm Premature Rupture of Membranes: Is There an Optimal Gestational Age for Delivery?
Lieman, J. M., Brumfield, C. G., Carlo, W. A., & Ramsey, P. S. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000147841.79428.4b · Cited by 61
The role of granulocyte colony-stimulating factor in the neutrophilia observed in the fetal inflammatory response syndrome
Chaiworapongsa, T., Romero, R. J., Berry, S. M., Hassan, S. S., Yoon, B. H., Edwin, S. S., & Mazor, M. (2011) · Journal of Perinatal Medicine · doi:10.1515/jpm.2011.072 · Cited by 60
Self-citation
Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis
Maeyama, K., Tomioka, K., Nagase, H., Yoshioka, M., Takagi, Y., Kato, T., Mizobuchi, M., Kitayama, S., Takada, S., Nagai, M., et al. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3412-x · Cited by 58
Association of Histologic Chorioamnionitis, Increased Levels of Cord Blood Cytokines, and Intracerebral Hemorrhage in Preterm Neonates
Tauscher, M. K., Berg, D., Brockmann, M., Seidenspinner, S., Speer, C. P., & Groneck, P. (2003) · Neonatology · doi:10.1159/000068924 · Cited by 60
Changing the paradigm of IFN-γ at the interface between innate and adaptive immunity: Macrophage-derived IFN-γ
Mezouar, S., & Mège, J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir0420-619rr · Cited by 59
Episodes of hypocarbia and early-onset sepsis are risk factors for cystic periventricular leukomalacia in the preterm infant
Resch, B., Neubauer, K., Hofer, N., Resch, E., Maurer, U., Haas, J. G., & Müller, W. (2011) · Early Human Development · doi:10.1016/j.earlhumdev.2011.06.011 · Cited by 59
Risk Factors for Intraventricular Hemorrhage in Preterm Infants Born at 34 Weeks of Gestation or Less Following Preterm Premature Rupture of Membranes
Lu, H., Wang, Q., Lu, J., Zhang, Q., & Kumar, P. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.12.011 · Cited by 58
Antenatal steroids may reduce adverse neurological outcome following chorioamnionitis: Neurodevelopmental outcome and chorioamnionitis in premature infants
Kent, A. L., Lomas, F. E., Hurrion, E. M., & Dahlstrom, J. E. (2005) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2005.00585.x · Cited by 58
Antibiotics for the Prevention of Preterm Birth
Lamont, R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002243420810 · Cited by 58
Prophylactic inhibition of NF-κB expression in microglia leads to attenuation of hypoxic ischemic injury of the immature brain
Zaghloul, N., Kurepa, D., Bader, M. Y., Nagy, N., & Ahmed, M. N. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02031-9 · Cited by 66
Chorioamnionitis induced by intraamniotic lipopolysaccharide resulted in an interval-dependent increase in central nervous system injury in the fetal sheep
Gavilanes, A. W. D., Strackx, E., Kramer, B. W. W., Gantert, M., van den Hove, D., Steinbusch, H. P., Garnier, Y., Cornips, E. M. J., Steinbusch, H. W. M., Zimmermann, L. J. I., et al. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.12.003 · Cited by 57
Effects of maternal and placental inflammation on retinopathy of prematurity
Woo, S. J., Park, K. H., Jung, H. J., Kim, S. N., Choe, G., Ahn, J., & Park, K. H. (2011) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-011-1648-2 · Cited by 57
Antenatal Causes of Cerebral Palsy: Associations Between Inherited Thrombophilias, Viral and Bacterial Infection, and Inherited Susceptibility to Infection
Gibson, C. S., MacLennan, A. H., Goldwater, P. N., & Dekker, G. (2003) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200303000-00024 · Cited by 57
Infection and preterm birth: Evidence of a common causal relationship with bronchopulmonary dysplasia and cerebral palsy
Vigneswaran, R. (2000) · Journal of Paediatrics and Child Health · doi:10.1046/j.1440-1754.2000.00536.x · Cited by 57
Ovine Proinflammatory Cytokines Cross the Murine Blood-Brain Barrier by a Common Saturable Transport Mechanism
Threlkeld, S. W., Lynch, J. L., Lynch, K. M., Sadowska, G. B., Banks, W. A., & Stonestreet, B. S. (2010) · NeuroImmunoModulation · doi:10.1159/000288265 · Cited by 56
Disorders of Placental Circulation and the Fetal Brain
Redline, R. W. (2009) · Clinics in Perinatology · doi:10.1016/j.clp.2009.06.003 · Cited by 55
Public health issues related to infection in pregnancy and cerebral palsy
Schendel, D., Schuchat, A., & Thorsen, P. (2002) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.10011 · Cited by 56
Lung and Brain Damage in Preterm Newborns
Dammann, O., Leviton, A., Bartels, D. B., & Dammann, C. E. L. (2004) · Neonatology · doi:10.1159/000078175 · Cited by 56
Magnesium Sulfate Increases Intracellular Magnesium Reducing Inflammatory Cytokine Release in Neonates
Suzuki‐Kakisaka, H., Sugimoto, J., Tetarbe, M., Romani, A., Ramirez, C. M., & Bernstein, H. B. (2013) · American Journal of Reproductive Immunology · doi:10.1111/aji.12118 · Cited by 55
Preterm birth and the role of neuroprotection
Chang, E. (2015) · BMJ · doi:10.1136/bmj.g6661 · Cited by 54
Maturational Effects of Lipopolysaccharide on White-Matter Injury in Fetal Sheep
Svedin, P., Kjellmer, I., Welin, A.-K., Blad, S., & Mallard, C. E. (2005) · Journal of Child Neurology · doi:10.1177/08830738050200120501 · Cited by 54
Perinatal risk factors for adverse neurodevelopmental outcome after spontaneous preterm birth
Vermeulen, G. M., Bruinse, H. W., & de Vries, L. S. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(01)00383-9 · Cited by 54
Perinatal infection, inflammation, preterm birth, and brain injury: A review with proposals for future investigations
Reiss, J. D., Peterson, L. S., Nesamoney, S. N., Chang, A. L., Pașca, A. M., Marić, I., Shaw, G. M., Gaudilliere, B. L., Wong, R. J., Sylvester, K. G., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.113988 · Cited by 54
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis
Gomez‐Lopez, N., Romero, R. J., Xu, Y., Plazyo, O., Unkel, R., Than, N. G., Chaemsaithong, P., Chaiworapongsa, T., Dong, Z., Tarca, A. L., et al. (2016) · Reproductive Sciences · doi:10.1177/1933719116675058 · Cited by 56
Self-citation
Macrophages and Pregnancy
Mor, G., & Koga, K. (2008) · Reproductive Sciences · doi:10.1177/1933719108317253 · Cited by 54
Severe umbilical cord inflammation—a predictor of periventricular leukomalacia in very low birth weight infants
Wharton, K. N., Pınar, H., Stonestreet, B. S., Tucker, R. J., McLean, K. R., Wallach, M. T., & Vohr, B. R. (2004) · Early Human Development · doi:10.1016/j.earlhumdev.2004.02.001 · Cited by 53
Neonatal outcomes after elective delivery management of preterm premature rupture of the membranes before 34 weeks’ gestation (DOMINOS study)
Pasquier, J., Picaud, J., Rabilloud, M., Claris, O., Écochard, R., Moret, S., & Mellier, G. (2009) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2008.10.017 · Cited by 52
A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammation
Nhan‐Chang, C., Romero, R. J., Kusanovic, J. P., Gotsch, F., Edwin, S. S., Erez, O., Mittal, P., Kim, C. J., Kim, M. J., Espinoza, J., et al. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050802244946 · Cited by 51
Self-citation
The diagnostic performance of the Mass Restricted (MR) score in the identification of microbial invasion of the amniotic cavity or intra-amniotic inflammation is not superior to amniotic fluid interleukin-6
Romero, R. J., Kadar, N. R., Miranda, J., Korzeniewski, S. J., Schwartz, A. G., Chaemsaithong, P., Rogers, W. T., Soto, E., Gotsch, F., Yeo, L., et al. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.844123 · Cited by 52
Self-citation
Neutrophil extracellular traps in acute chorioamnionitis: A mechanism of host defense
Gomez‐Lopez, N., Romero, R. J., Leng, Y., Garcia‐Flores, V., Xu, Y., Miller, D., & Hassan, S. S. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12617 · Cited by 52
Self-citation
Maternal plasma interleukin-6, interleukin-1β and C-reactive protein as indicators of tocolysis failure and neonatal outcome after preterm delivery
Škrablin, S., Lovrić, H., Banović, V., Kralik, S., Dijaković, A., & Kalafatić, D. (2007) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701227877 · Cited by 52
ANTECEDENTS OF CEREBRAL PALSY IN VERY LOW–BIRTH WEIGHT INFANTS
O’Shea, T. M., & Dammann, O. (2000) · Clinics in Perinatology · doi:10.1016/s0095-5108(05)70022-1 · Cited by 52
Chronic Physiologic Instability Is Associated With Neurodevelopmental Morbidity at One and Two Years in Extremely Premature Infants
Mattia, F. R., & deRegnier, R.-A. O. (1998) · PEDIATRICS · doi:10.1542/peds.102.3.e35 · Cited by 52
Histologic chorioamnionitis and severity of illness in very low birth weight newborns
Felice, C. D., Toti, P., Parrini, S., Vecchio, A. D., Bagnoli, F., Latini, G., & Kopotic, R. J. (2005) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000160658.35437.65 · Cited by 51
The Local and Systemic Immune Response to Intrauterine LPS in the Prepartum Mouse
Edey, L. F., O'Dea, K. P., Herbert, B. R., Hua, R., Waddington, S. N., MacIntyre, D. A., Bennett, P. R., Takata, M., & Johnson, M. R. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.116.143289 · Cited by 52
Antenatal Bacterial Endotoxin Sensitizes the Immature Rat Brain to Postnatal Excitotoxic Injury
Rousset, C. I., Kassem, J., Olivier, P., Chalon, S., Gressèns, P., & Saliba, É. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31818894a1 · Cited by 50
Pathogenesis of Spontaneous Preterm Labor
Romero, R. J., & Lockwood, C. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4224-2.50031-4 · Cited by 50
Self-citation
Neuronal TGF-β1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice
Mesplès, B., Fontaine, R. H., Lelièvre, V., Launay, J., & Gressèns, P. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.018 · Cited by 50
Context‐dependent IL‐6 potentiation of interferon‐ gamma‐induced IL‐12 secretion and CD40 expression in murine microglia
Lin, H.-W., & Levison, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06366.x · Cited by 48
Intra-amniotic LPS causes acute neuroinflammation in preterm rhesus macaques
Schmidt, A. F. S., Kannan, P. S., Chougnet, C. A., Danzer, S. C., Miller, L. A., Jobe, A. H., & Kallapur, S. G. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0706-4 · Cited by 51
Investigation of Cerebral Development and Injury in the Prematurely Born Primate by Magnetic Resonance Imaging and Histopathology
Inder, T., Neil, J., Kroenke, C., Dieni, S., Yoder, B., & Rees, S. (2005) · Developmental Neuroscience · doi:10.1159/000085981 · Cited by 58
Umbilical Cord Blood IL-6 as Predictor of Early-Onset Neonatal Sepsis in Women with Preterm Prelabour Rupture of Membranes
Cobo, T., Kacerovský, M., Andrýs, C., Drahošová, M., Musilova, I. K., Hornychová, H., & Jacobsson, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069341 · Cited by 48
Maternal N-acetylcysteine suppresses fetal inflammatory cytokine responses to maternal lipopolysaccharide
Beloosesky, R., Gayle, D. A., & Ross, M. G. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.06.081 · Cited by 49
The association between proinflammatory cytokine polymorphisms and cerebral palsy in very preterm infants
Vidak, H. K., Ivković, T. C., Jokić, M., Spaventi, R., & Kapitanović, S. (2012) · Cytokine · doi:10.1016/j.cyto.2011.12.018 · Cited by 47
Accurate Prediction of the Stage of Histological Chorioamnionitis before Delivery by Amniotic Fluid IL-8 Level
Yoneda, S., Shiozaki, A., Ito, M., Yoneda, N., Inada, K., Yonezawa, R., Kigawa, M., & Saito, S. (2015) · American Journal of Reproductive Immunology · doi:10.1111/aji.12360 · Cited by 47
Bacterial vaginosis: A problematic infection from both a perinatal and neonatal perspective
Denney, J. M., & Culhane, J. F. (2009) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2009.01.008 · Cited by 46
Apoptosis and proliferation in lungs of human fetuses exposed to chorioamnionitis
May, M., Marx, A., Seidenspinner, S., & Speer, C. P. (2004) · Histopathology · doi:10.1111/j.1365-2559.2004.01936.x · Cited by 47
The wealth of information conveyed by gestational age
Leviton, A., Blair, E. M., Dammann, O., & Allred, E. N. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.09.028 · Cited by 46
Variation in the Interleukin-6 Gene Is Associated with Impaired Cognitive Development in Children Born Prematurely: A Preliminary Study
Harding, D., Brull, D. J., Humphries, S. E., Whitelaw, A., Montgomery, H., & Marlow, N. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000163523.49021.53 · Cited by 46
Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndrome
Kim, S. K., Romero, R. J., Chaiworapongsa, T., Kusanovic, J. P., Mazaki‐Tovi, S., Mittal, P., Erez, O., Vaisbuch, E., Gotsch, F., Pacora, P., et al. (2009) · Journal of Perinatal Medicine · doi:10.1515/jpm.2009.106 · Cited by 45
Self-citation
The Effect of Meconium Staining of Amniotic Fluid on the Growth of Escherichia coli and Group B Streptococcus
Eidelman, A. I., Nevet, A., Rudensky, B., Rabinowitz, R., Hammerman, C., Raveh, D., & Schimmel, M. S. (2002) · Journal of Perinatology · doi:10.1038/sj.jp.7210774 · Cited by 45
What we have learned regarding antibiotic therapy for the reduction of infant morbidity after preterm premature rupture of the membranes
Mercer, B. M., Goldenberg, R. L., Das, A., Thurnau, G. R., Bendon, R. W., Miodovnik, M., Ramsey, R. D., & Rabello, Y. A. (2003) · Seminars in Perinatology · doi:10.1016/s0146-0005(03)00016-8 · Cited by 45
Meconium-Stained Amniotic Fluid and Risk for Cerebral Palsy in Preterm Infants
Spinillo, A. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00308-6 · Cited by 45
Interleukin-8 dysregulation is implicated in brain dysmaturation following preterm birth
Sullivan, G., Galdi, P., Blesa, M., Borbye‐Lorenzen, N., Stoye, D. Q., Lamb, G. J., Evans, M. J., Quigley, A. J., Thrippleton, M. J., Skogstrand, K., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.007 · Cited by 44
A History of Our Understanding of Cerebral Vascular Development and Pathogenesis of Perinatal Brain Damage Over the Past 30 Years
Takashima, S., Itoh, M., & Oka, A. (2009) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2009.09.004 · Cited by 44
Could Cord Blood Cell Therapy Reduce Preterm Brain Injury?
Li, J., McDonald, C., Fahey, M. C., Jenkin, G., & Miller, S. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00200 · Cited by 44
The role of magnesium sulfate (MgSO4) in fetal neuroprotection
Bachnas, M. A., Akbar, M. I. A., Dachlan, E. G., & Dekker, G. (2019) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2019.1619688 · Cited by 52
Magnetic resonance imaging demonstrates long-term changes in brain structure in children born preterm and exposed to chorioamnionitis
Hatfield, T. J., Wing, D. A., Buß, C., Head, K., Muftuler, L. T., & Davis, E. P. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.07.027 · Cited by 44
Does prepregnancy bacterial vaginosis increase a mother's risk of having a preterm infant with cerebral palsy?
Dammann, O., & Leviton, A. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07554.x · Cited by 44
About one-half of early spontaneous preterm deliveries can be identified by a rapid matrix metalloproteinase-8 (MMP-8) bedside test at the time of mid-trimester genetic amniocentesis*
Kim, S. M., Romero, R. J., Lee, J. H., Chaemsaithong, P., Lee, M., Chaiyasit, N., Lee, H., & Yoon, B. H. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1094049 · Cited by 43
Self-citation
Épidémiologie, facteurs de risque et pronostic de l’enfant. RPC : rupture prématurée des membranes avant terme CNGOF
Lorthe, E. (2018) · Gynécologie Obstétrique Fertilité & Sénologie · doi:10.1016/j.gofs.2018.10.019 · Cited by 43
Maternal Infections during Pregnancy and Cerebral Palsy: A Population‐based Cohort Study
Miller, J. E., Pedersen, L. H., Streja, E., Bech, B. H., Yeargin‐Allsopp, M., Braun, K. V. N., Schendel, D., Christensen, D., Uldall, P. V., & Olsen, J. (2013) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12082 · Cited by 42
Investigation of Stillbirth
Magee, J. F. (2001) · Pediatric and Developmental Pathology · doi:10.1007/s100240010121 · Cited by 41
ORACLE--antibiotics for preterm prelabour rupture of the membranes: short-term and long-term outcomes
Kenyon, S. L., Taylor, D. J. F., Tarnow-Mordi, W., & ORACLE Collaborative Group (2002) · Acta Paediatrica · doi:10.1111/j.1651-2227.2002.tb00153.x · Cited by 41
Top-cited articles in the Journal: a bibliometric analysis
Yadava, S., Patrick, H. S., Ananth, C. V., Rosen, T., & Brandt, J. S. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.11.1091 · Cited by 42
Respiratory distress syndrome-associated inflammation is related to early but not late peri/intraventricular hemorrhage in preterm infants
Krediet, T. G., Kavelaars, A., Vreman, H. J., Heijnen, C. J., & van Bel, F. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.01.037 · Cited by 40
Interleukin-1β-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by α-phenyl-n-tert-butyl-nitrone
Fan, L.-W., Tien, L., Zheng, B., Pang, Y., Rhodes, P. G., & Cai, Z. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.024 · Cited by 39
Infection and cerebral palsy
Gilstrap, L. C., & Ramin, S. M. (2000) · Seminars in Perinatology · doi:10.1053/sper.2000.7048 · Cited by 39
Neonatal encephalopathy in the term infant: Neuroimaging and inflammatory cytokines
Foster‐Barber, A., & Ferriero, D. M. (2002) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.10009 · Cited by 39
Risk Factors for Periventricular Leukomalacia in Preterm Infants: A Systematic Review, Meta-analysis, and GRADE-Based Assessment of Certainty of Evidence
Abiramalatha, T., Bandyopadhyay, T., Ramaswamy, V. V., Shaik, N. B., Thanigainathan, S., Pullattayil, A. K., & Amboiram, P. (2021) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2021.08.003 · Cited by 38
Human Amnion Epithelial Cells Modulate Ventilation-Induced White Matter Pathology in Preterm Lambs
Barton, S. K., Melville, J. M., Tolcos, M., Polglase, G. R., McDougall, A. R. A., Azhan, A., Crossley, K. J., Jenkin, G., & Moss, T. J. M. (2015) · Developmental Neuroscience · doi:10.1159/000371415 · Cited by 38
Impact of clinical and histologic correlates of maternal and fetal inflammatory response on gestational age in preterm births
Gupta, M., Mestan, K. K. L., Martin, C. R., Pearson, C., Ortiz, K., Fu, L., Stubblefield, P. G., Cerda, S. R., Kasznica, J. M., & Wang, X. (2007) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050601156861 · Cited by 38
A molecular signature of an arrest of descent in human parturition
Mittal, P., Romero, R. J., Tarca, A. L., Drăghici, S., Nhan‐Chang, C., Chaiworapongsa, T., Hotra, J. W., Gómez, R., Kusanovic, J. P., Lee, D., et al. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.09.025 · Cited by 38
Self-citation
Hypoperfusion causes increased production of interleukin 6 and tumor necrosis factor α in the isolated, dually perfused placental cotyledon
Pierce, B. T., Pierce, L. M., Wagner, R. K., Apodaca, C. C., Hume, R. F., Nielsen, P. E., & Calhoun, B. C. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.108887 · Cited by 37
Umbilical Cord Serum Interleukin-6, C-Reactive Protein, and Myeloperoxidase Concentrations at Birth and Association with Neonatal Morbidities and Long-Term Neurodevelopmental Outcomes
Romero, R. J., Mele, L., Iams, J. D., Peaceman, A. M., Leveno, K. J., Harper, M., Caritis, S. N., Mercer, B. M., Thorp, J. M., O’Sullivan, M. J., et al. (2013) · American Journal of Perinatology · doi:10.1055/s-0033-1359723 · Cited by 36
Self-citation
Acid extrusion via blood–brain barrier causes brain alkalosis and seizures after neonatal asphyxia
Helmy, M., Ruusuvuori, E., Watkins, P. V., Voipio, J., Kanold, P. O., & Kaila, K. (2012) · Brain · doi:10.1093/brain/aws257 · Cited by 36
Microorganisms in the Placenta: Links to Early-Life Inflammation and Neurodevelopment in Children
Tomlinson, M. S., Lü, K., Stewart, J. R., Marsit, C. J., O’Shea, T. M., & Fry, R. C. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00103-18 · Cited by 38
Integrated Review of Cytokines in Maternal, Cord, and Newborn Blood: Part II— Associations With Early Infection and Increased Risk of Neurologic Damage in Preterm Infants
Pickler, R. H., Brown, L., McGrath, J. M., Lyon, D., Rattican, D., Cheng, C., Howland, L. C., & Jallo, N. (2009) · Biological Research For Nursing · doi:10.1177/1099800409344619 · Cited by 36
Etiology of cerebral palsy
Lawson, R. D., & Badawi, N. A. (2003) · Hand Clinics · doi:10.1016/s0749-0712(03)00040-4 · Cited by 35
Periventricular leukomalacia following neonatal and infant cardiac surgery
Gaynor, J. W. (2004) · Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery Annual · doi:10.1053/j.pcsu.2004.02.007 · Cited by 36
Chorioamnionitis, IL‐17A, and fetal origins of neurologic disease
Lawrence, S. M., & Wynn, J. L. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12803 · Cited by 33
The combined exposure to intra-amniotic inflammation and neonatal respiratory distress syndrome increases the risk of intraventricular hemorrhage in preterm neonates
Oh, K. J., Park, J. Y., Lee, J., Hong, J., Romero, R. J., & Yoon, B. H. (2017) · Journal of Perinatal Medicine · doi:10.1515/jpm-2016-0348 · Cited by 34
Self-citation
Increased Maternal/Fetal Blood S100B Levels Following Systemic Endotoxin Administration and Periventricular White Matter Injury in Preterm Fetal Sheep
Garnier, Y., Frigiola, A., Volti, G. L., Florio, P., Frulio, R., Berger, R. E., Alm, S., von Duering, M. U., Coumans, A. B. C., dos Reis, F. M., et al. (2009) · Reproductive Sciences · doi:10.1177/1933719109335801 · Cited by 34
Early Markers of Brain Damage in Premature Low-Birth-Weight Neonates Who Suffered from Perinatal Asphyxia and/or Infection
Fotopoulos, S., Pavlou, K., Skouteli, H. N., Papassotiriou, I., Lipsou, N., & Xanthou, M. (2001) · Neonatology · doi:10.1159/000047094 · Cited by 34
White‐matter disease of prematurity, periventricular leukomalacia, and ischemic lesions
Kuban, K. (1998) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1998.tb15417.x · Cited by 34
Identification of biological/biochemical marker(s) for preterm delivery
Thorsen, P., Schendel, D., Deshpande, A. D., Vogel, I., Dudley, D. J., & Olsen, J. (2001) · Paediatric and Perinatal Epidemiology · doi:10.1046/j.1365-3016.2001.00011.x · Cited by 33
Systemic prenatal insults disrupt telencephalon development: Implications for potential interventions
Robinson, S. (2005) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2005.06.005 · Cited by 34
Reduced IL‐10 production and ‐receptor expression in neonatal T lymphocytes
Schultz, C., Strunk, T., Temming, P., Matzke, N., & Härtel, C. (2007) · Acta Paediatrica · doi:10.1111/j.1651-2227.2007.00375.x · Cited by 33
Animal Models of Periventricular Leukomalacia
Choi, E., Park, D., Kim, T. K., Lee, S. H., Bae, D., Yang, G., Yang, Y., Kyung, J., Kim, D., Lee, W. R., et al. (2011) · Laboratory Animal Research · doi:10.5625/lar.2011.27.2.77 · Cited by 33
Infectious and inflammatory mechanisms in preterm birth and cerebral palsy
Jacobsson, B. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2003.11.014 · Cited by 32
Recent advances in human perinatal white matter injury
Back, S. A. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)32071-x · Cited by 33
Shared Effects of Genetic and Intrauterine and Perinatal Environment on the Development of Metabolic Syndrome
Vuguin, P. M., Hartil, K., Kruse, M., Kaur, H., Lin, C.-L. V., Fiallo, A., Glenn, A. S., Patel, A., Williams, L., Seki, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063021 · Cited by 34
Interleukin-1 Receptor Antagonist Reduces Neonatal Lipopolysaccharide-Induced Long-Lasting Neurobehavioral Deficits and Dopaminergic Neuronal Injury in Adult Rats
Pang, Y., Tien, L., Zhu, H., Shen, J.-Y., Wright, C., Jones, T., Mamoon, S., Bhatt, A., Cai, Z., & Fan, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16048635 · Cited by 32
Infection and fetal neurologic injury
Ugwumadu, A. H. N. (2006) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/01.gco.0000192999.12416.95 · Cited by 32
The choice of amniotic fluid in metabolomics for the monitoring of fetus health
Palmas, F., Fattuoni, C., Noto, A., Barberini, L., Dessì, A., & Fanos, V. (2016) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2016.1139456 · Cited by 34
Histo‐topographic distribution of acute inflammation of the human umbilical cord
Kim, C. J., Yoon, B. H., Kim, M., Park, J. O., Cho, S. Y., & Je, G. (2001) · Pathology International · doi:10.1046/j.1440-1827.2001.01284.x · Cited by 32
Self-citation
Non-human primate models of neonatal brain injury
Inder, T. E., Neil, J. J., Yoder, B. A., & Rees, S. M. (2004) · Seminars in Perinatology · doi:10.1053/j.semperi.2004.10.002 · Cited by 32
Cytokines and Inflammatory Response in the Fetus and Neonate
Srinivasan, L., Harris, M. C., & Kilpatrick, L. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00128-1 · Cited by 31

Authors: Yoon, B. H., Romero, R., Yang, S. H., Jun, J. K., Kim, I.-O., Choi, J.-H., & Syn, H. C.
Affiliations: Seoul National University (KR)
ORCID: Yoon, Bo Hyun
Romero, Roberto
Jun, Jong Kwan
Choi, Jung-Hwan
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 1996-05
Volume: 174
Issue: 5
Pages: 1433-1440
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/s0002-9378(96)70585-9
OpenAlex: W1964039180
Cited by: 584
References: 31
Citations by year: 2026: 6 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 13 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 22 · 2016: 14 · 2015: 19 · 2014: 22 · 2013: 22 · 2012: 25
FWCI: 21.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Keywords: periventricular leukomalacia, interleukin-6, umbilical cord plasma, preterm infants, white matter lesions, TNF-α, IL-1β, interleukin-1 receptor antagonist, cytokines, cerebral palsy risk, umbilical artery pH, biomarkers, risk factors, brain ultrasonography, gestational age
MeSH terms: Adult, C-Reactive Protein, Female, Fetal Blood, Humans, Immunoenzyme Techniques, Infant, Newborn, Infant, Premature, Interleukin-1, Leukomalacia, Periventricular, Osmolar Concentration, Pregnancy, ROC Curve, Sensitivity and Specificity, Tumor Necrosis Factor-alpha, Interleukin-6, Receptors, Interleukin-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks