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Selmaj, K., & Raine, C. S. (1988) · Annals of Neurology · doi:10.1002/ana.410230405 · Cited by 1,417

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Nelson, K. B., & Ellenberg, J. H. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607103150202 · Cited by 945

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van Deventer, S. J. H., Buller, H. R., ten Cate, J. W., Aarden, L. A., Hack, C. E., & Sturk, A. (1990) · Blood · doi:10.1182/blood.v76.12.2520.bloodjournal76122520 · Cited by 850

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van der Poll, T., Buller, H. R., Cate, H. T., Wortel, C. H., Bauer, K. A., van Deventer, S. J. H., Hack, C. E., Sauerwein, H. P., ROSENBERG, R. D., & ten Cate, J. W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006073222302 · Cited by 667

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Gibbs, R. S., Blanco, J., Clair, P. J. S., & Castañeda, Y. S. (1982) · The Journal of Infectious Diseases · doi:10.1093/infdis/145.1.1 · Cited by 552

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Yoon, B. H., Romero, R. J., Kim, C. J., Jun, J. K., Gómez, R., Choi, J., & Syn, H. C. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90028-4 · Cited by 493

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Robbins, D. S., Shirazi, Y., Drysdale, B. E., Lieberman, A. P., Shin, H. S., & Shin, M. L. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.8.2593 · Cited by 428

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Camussi, G., Bussolino, F., Salvidio, G., & Baglioni, C. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.5.1390 · Cited by 349

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Leviton, A. E., & Paneth, N. (1990) · Early Human Development · doi:10.1016/0378-3782(90)90002-z · Cited by 265

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(2006) · Springer eBooks · doi:10.1007/0-387-26742-5_26

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