Cited by 413Immune cells in cancerCancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

The DOI matches its Crossref record, with a small difference in title or year; 150 of the 155 references it cites were found in a registry or an index.

Macrophage Responses to Hypoxia

Open access

Lewis, Claire, Murdoch, Craig·2005·The American Journal of Pathology

DOI 10.1016/s0002-9440(10)62038-xPMC PMC1698733

Open this paper in CoChat — free account Open PDF

Abstract

The presence of multiple areas of hypoxia (low oxygen tension) is a hallmark feature of human and experimental tumors. Monocytes are continually recruited into tumors, differentiate into tumor-associated macrophages (TAMs), and then accumulate in these hypoxic areas. A number of recent studies have shown that macrophages respond to the levels of hypoxia found in tumors by up-regulating such transcription factors as hypoxia-inducible factors 1 and 2, which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro-metastatic genes. This could explain why high numbers of TAMs correlate with poor prognosis in various forms of cancer. In this review, we assess the evidence for hypoxia activating a distinct, pro-tumor phenotype in macrophages and the possible effect of this on the growth, invasion, angiogenesis, and immune evasion of tumors. We also discuss current attempts to selectively target TAMs for destruction or to use them to deliver gene therapy specifically to hypoxic tumor sites.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0002-9440(10)62038-x

Cites

150 of 150 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300
HIF-1α is essential for myeloid cell-mediated inflammation
Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00154-5 · Cited by 2,046
The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies
Bingle, L., Brown, N. J., & Lewis, C. E. (2002) · The Journal of Pathology · doi:10.1002/path.1027 · Cited by 2,022
Self-citation
Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays
Der, S. D., Zhou, A., Williams, B. R. G., & Silverman, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15623 · Cited by 1,840
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752
Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy
Lin, E. Y., Nguyen, A. V., Russell, R. G., & Pollard, J. W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.727 · Cited by 1,594
Angiogenesis in Wound Healing
Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00014.x · Cited by 1,463
Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
Barleon, B., Sozzani, S., Zhou, D., Weich, H., Mantovani, A., & Marmé, D. (1996) · Blood · doi:10.1182/blood.v87.8.3336.bloodjournal8783336 · Cited by 1,350

Show all 155 references

Research works printed but not linked: 2

Burton, 2000, Macrophages accumulate in avascular, hypoxic areas of prostate tumors: implications for the targeted therapeutic gene delivery to such sites, J Pathol, 192, 8A
Ohno, 2004, Correlation of histological localization of tumor-associated macrophages with clinicopathological features in endometrial cancer, Anticancer Res, 24, 3335

Sorted by citations

Items 301–400 of 412

Proteins Expressed on Tumor Endothelial Cells as Potential Targets for Anti-Angiogenic Therapy
Wu, H., & Li, P. (2008) · doi:10.29685/jcm.200804.0003 · Cited by 12
The impact of hypoxia on oncolytic virotherapy
Guo, Z. S. (2011) · Virus Adaptation and Treatment · doi:10.2147/vaat.s17832 · Cited by 12
Tumor-associated macrophages, multi-tasking cells in the cancer landscape
Marelli, G., Allavena, P., & Erreni, M. (2015) · Cancer Research Frontiers · doi:10.17980/2015.149 · Cited by 13
Advances in the understanding of the clinically relevant genetic pathways and molecular aspects of canine mammary tumours. Part 2: Invasion, angiogenesis, metastasis and therapy
Santos, A. A. F., & de Matos, A. (2015) · The Veterinary Journal · doi:10.1016/j.tvjl.2015.03.029 · Cited by 11
Macrophage-mediated Bystander Effect Triggered by Tumor Cell Apoptosis
Huang, Y., Lee, C., Borgström, P., & Gjerset, R. A. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300080 · Cited by 11
Gene therapy approaches to enhance bioreductive drug treatment
Cowen, R. L., Garside, E., Fitzpatrick, B., Papadopoulou, M. V., & Williams, K. J. (2008) · British Journal of Radiology · doi:10.1259/bjr/55070206 · Cited by 11
Tissue regeneration and reprogramming
Khan, I., Neumann, C. R., & Sinha, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816413-6.00024-1 · Cited by 12
A reconfigurable microscale assay enables insights into cancer-associated fibroblast modulation of immune cell recruitment
Yu, J., Piazza, A. N., Sparks, S., Hind, L. E., Niles, D. J., Ingram, P., Huang, W. C., Ricke, W. A., Jarrard, D. F., Anna Huttenlocher, A., et al. (2021) · Integrative Biology · doi:10.1093/intbio/zyab004 · Cited by 10
A Hypoxia–Decidual Macrophage Regulatory Axis in Normal Pregnancy and Spontaneous Miscarriage
Huang, X., Lin, Z., Zheng, Z., Shi, J., Lu, K.-Y., Wang, J., Li, M., & Shao, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179710 · Cited by 9
Characterization of Macrophage and Cytokine Interactions with Biomaterials Used in Negative-Pressure Wound Therapy
Veerasubramanian, P. K., Joe, V., Liu, W. F., & Downing, T. L. (2021) · Bioengineering · doi:10.3390/bioengineering9010002 · Cited by 9
Bone Marrow-Derived Cells in GBM Neovascularization
Bergers, G. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-553-8_31 · Cited by 10
The c-Fes protein tyrosine kinase as a potential anti-angiogenic target in cancer
Kanda, S. (2010) · Frontiers in bioscience · doi:10.2741/3732 · Cited by 8
Elevated ATF4 Expression in Odontogenic Keratocysts Epithelia: Potential Involvement in Tissue Hypoxia and Stromal M2 Macrophage Infiltration
Zhong, W., Li, Z., Jiang, H., Zou, Y., Wang, H.-T., Cai, Y., Zhao, Y. F., & Zhao, J. (2019) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155419871550 · Cited by 8
Macrophage Cell Therapy in Renal Disease
Ferenbach, D. A., & Kluth, D. (2010) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2010.03.010 · Cited by 8
Molecular oxygen sensing: implications for visceral surgery
Kiss, J., Kirchberg, J., & Schneider, M. (2012) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-012-0930-z · Cited by 8
Tumor-Associated Macrophage in Breast Tumor Microenvironment
Ma, L., Jin, Y., Xu, J., & Zhang, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26135973 · Cited by 7
Angiogenesis and Apoptosis: Data Comparison of Similar Microenvironments in the Corpus Luteum and Tumors
Min, T., Lee, S.-H., & Lee, S. (2024) · Animals · doi:10.3390/ani14071118 · Cited by 8
Sleep Disorders and Cancer
Martínez‐García, M. Á., Campos‐Rodríguez, F., & Almendros, I. (2016) · Current Sleep Medicine Reports · doi:10.1007/s40675-016-0034-3 · Cited by 7
Editorial: Combinatorial Approaches to Enhance Anti-tumor Immunity: Focus on Immune Checkpoint Blockade Therapy
Andersson, P., & Ostheimer, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02083 · Cited by 7
Generation of biological hypotheses by functional imaging links tumor hypoxia to radiation induced tissue inflammation/glucose uptake in head and neck cancer
Zschaeck, S., Zöphel, K., Seidlitz, A., Zips, D., Kotzerke, J., Baumann, M. A., Troost, E. G. C., Löck, S., & Krause, M. (2020) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2020.10.030 · Cited by 6
Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor microenvironment infiltration
Liu, W., Yang, H., Zheng, S., Luo, H., Feng, Y., & Lei, Y.-Y. (2022) · BMC Bioinformatics · doi:10.1186/s12859-022-04956-9 · Cited by 6
Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay.
Shamis, S. A. K., Savioli, F., Ammar, A., Al-Badran, S. S. F., Hatthakarnkul, P., Leslie, H., Mallon, E., Jamieson, N. B., McMillan, D. C., & Edwards, J. (2024) · PubMed · doi:10.14670/hh-18-655 · Cited by 6
Immunohistochemical Characterization and Morphometric Analysis of Macrophages in Rat Mammary Tumors
Ong, C. B., Brandenberger, C., Kiupel, M., Kariagina, A., & Langohr, I. M. (2014) · Veterinary Pathology · doi:10.1177/0300985814535611 · Cited by 6
Neuroendocrine Regulation of Cancer Progression: II. Immunological Mechanisms, Clinical Relevance, and Prophylactic Measures
Avraham, R., & Ben‐Eliyahu, S. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50016-2 · Cited by 6
Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis Ex Vivo
Mathur, S., Turnbull, A., Akaev, I., Stevens, C., Agrawal, N., Chopra, M., & Mincher, D. J. (2019) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-019-09994-1 · Cited by 7
Macrophages and Tumor Development
Ostrand‐Rosenberg, S., & Sinha, P. (2007) · Springer eBooks · doi:10.1007/978-0-387-69118-3_7 · Cited by 6
Taming the immune system through transfusion in oncology patients
Kormi, S. M. A., & Seghatchian, J. (2017) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2017.05.017 · Cited by 7
The Clinical Significance of CD163+ Tumor-Associated Macrophages (TAMs) in Laryngeal Squamous Cell Carcinoma
Ouban, A., Raddaoui, E., & Bakir, M. A. (2023) · Cureus · doi:10.7759/cureus.36339 · Cited by 5
Myeloid metabolism and its role in immunotherapy of cancer
Garlatti, V., Consonni, F. M., Ballerini, G., Incerti, M., Balboni, A., Cassatella, M. A., & Sica, A. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-012127 · Cited by 5
Nano-mechanochemical synergistic approach to reprogram tumor-associated macrophages for tumor immunotherapy
Zhang, X., Yang, Z., Zhi, H., Chen, S., Yin, W., An, L., Li, R., Cai, Y., You, C., Dong, H., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114062 · Cited by 5
Morphine and Immunosuppression in the Context of Tumor Growth and Metastasis
Koodie, L., & Roy, S. (2012) · Springer eBooks · doi:10.1007/978-94-007-5678-6_3 · Cited by 5
Inflammation and Angiogenesis: Innate Immune Cells as Modulators of Tumor Vascularization
Mueller, M. M. (2007) · Springer eBooks · doi:10.1007/978-3-540-33177-3_20 · Cited by 5
Effect of Plasma Lipoproteins and Their Complexes with Polysaccharides on Interleukin-1β Concentration in Macrophages of Mice with HA-1 Ascitic Hepatoma
Polyakov, L. M., Валерьевна, С. Д., & Panin, L. E. (2009) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-009-0557-4 · Cited by 5
Angiogenesis and the Tumor Microenvironment
Murphy, J. F. (2022) · Springer eBooks · doi:10.1007/978-3-030-80962-1_87-1 · Cited by 5
Hematopoietic colony-stimulating factors in head and neck cancers: Recent advances and therapeutic challenges
Vieira, G. D. S., Kimura, T. D. C., Scarini, J. F., de Lima‐Souza, R. A., Lavareze, L., Emerick, C., Gonçalves, M. T., Damas, I. I., Maciel, T. F., de Sá, R. S., et al. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156417 · Cited by 4
Sleep, Circadian Rhythms, and Lung Cancer
Cooper, D. H., Almendros, I., & Kendzerska, T. (2025) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/a-2531-1059 · Cited by 5
DDR1 Promotes Immune Evasion in Colorectal Cancer by Orchestrating IL33-Mediated M2-like Polarization of Tumor-Associated Macrophages
Duan, X., Yeerkenbieke, G., Feng, Y., Zhou, M., Zhang, Y., Zhou, J., & Li, J. (2026) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-25-1073 · Cited by 4
Micro/Nano-Engineering of Cells for Delivery of Therapeutics
Levy, O., Han, E., Ngai, J., Anandakumaran, P. N., Tong, Z., Ng, K. S., & Karp, J. M. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-3146-6.00012-x · Cited by 4
Effects of Calorie Restriction and Fasting on Macrophage: Potential Impact on Disease Outcomes?
Wang, L., Wang, R., Yu, X., Shi, Y., Li, S., & Yuan, Y. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300380 · Cited by 4
A Perspective of Immunotherapy for Breast Cancer: Lessons Learned and Forward Directions for All Cancers
Nahas, G. R., Walker, N. D., Bryan, M., & Rameshwar, P. (2015) · Breast Cancer Basic and Clinical Research · doi:10.4137/bcbcr.s29425 · Cited by 4
Obstructive Sleep Apnea and Cancer: Insights from Intermittent Hypoxia Experimental Models
Almendros, I., Martínez‐García, M. Á., Obeso, A., & Gozal, D. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0064-5 · Cited by 3
Lipoproteins and the Tumor Microenvironment
Dossou, A. S., Sabnis, N. A., Nagarajan, B., Mathew, E., Fudala, R., & Lacko, A. G. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-48457-6_6 · Cited by 4
Prognostic and immunological role of adaptor related protein complex 3 subunit mu2 in colon cancer
Jin, Q., Feng, J., Yan, Y., & Kuang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-023-50452-2 · Cited by 4
Phosphorylation of cAMP response element binding protein (CREB) as a marker of hypoxia in pituitary adenoma
Morimoto, D., Yoshida, D., Noha, M., Suzuki, M., OSAMURA, R. Y., & Teramoto, A. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9131-3 · Cited by 4
Long-Circulating Polymeric Nanoparticles for Drug and Gene Delivery to Tumors
Amiji, M. M., Shenoy, D. B., & Kommareddy, S. (2006) · CRC Press eBooks · doi:10.1201/9781420006636.ch13 · Cited by 4
Hypoxia and Gene Expression
Bosco, M. C., & Varesio, L. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-9167-5_5 · Cited by 3
Pivotal Role of Cranial Irradiation-Induced Peripheral, Intrinsic, and Brain-Engrafting Macrophages in Malignant Glioma
Richard, S. A., Roy, S. K., & Asiamah, E. A. (2024) · Clinical Medicine Insights Oncology · doi:10.1177/11795549241282098 · Cited by 3
Modulation of Angiogenesis by Tumor Associated Macrophages in the Tumor Microenvironment
Murphy, J. F. (2014) · MOJ Immunology · doi:10.15406/moji.2014.01.00016 · Cited by 3
Could Metabolic Therapy Become a Viable Alternative to the Standard of Care for Managing Glioblastoma?
Seyfried, T. N., Marsh, J., Mukherjee, P., Zuccoli, G., D’Agostino, D. P., Biology, P. O., & Science, B. O. (2014) · touchREVIEWS in Oncology & Haematology · doi:10.17925/ohr.2014.10.1.13 · Cited by 3
Ultrastructural Characterization of Macrophage-like Mononuclear Leukocytes in Human Astrocytic Tumors
Arismendi-Morillo, G., Castellano-Ramírez, A., & Perozo, Z. M. (2010) · Ultrastructural Pathology · doi:10.3109/01913123.2010.487972 · Cited by 3
Cancer Treatment Strategies
Seyfried, T. N. (2012) · doi:10.1002/9781118310311.ch16 · Cited by 3
Myeloid neighborhood in myeloma: Cancer's underbelly?
Dhodapkar, M. V. (2009) · American Journal of Hematology · doi:10.1002/ajh.21460 · Cited by 3
The role of hemoglobin level in predicting the response to first-line chemotherapy in advanced colorectal cancer (ACC) patients
Tampellini, M., Saini, A., Alabiso, I., Bitossi, R., Brizzi, M. P., Berruti, A., Gorzegno, G., Miraglia, S., Alabiso, O., & Dogliotti, L. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.22.90140.3564 · Cited by 3
Intravenous clusterin administration reduces myocardial infarct size in rats
Dijk, A. V., Vermond, R. A., Krijnen, P. A. J., Juffermans, L. J. M., Hahn, N. E., Makker, S. P., Aarden, L. A., Hack, E., Spreeuwenberg, M. D., van Rossum, B. C., et al. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.0014-2972.2010.02345.x · Cited by 2
Immune Therapy
Lievense, L. A., Aerts, J. G. J. V., & Hegmans, J. P. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-24223-1_4 · Cited by 2
Morbid Obesity in Women Is Associated with an Altered Intestinal Expression of Genes Related to Cancer Risk and Immune, Defensive, and Antimicrobial Response
Ho‐Plagaro, A., Rodriguez, C., Santiago‐Fernández, C., Gomez, C. L., García‐Serrano, S., Martín‐Reyes, F., Rodríguez‐Pacheco, F., Rodríguez‐Cañete, A., Alcaín‐Martínez, G., Pedreño, L. V., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10051024 · Cited by 2
DEPLETION OF TUMOR-ASSOCIATED MACROPHAGES WITH CLODRONATE-LOADED PLGA NANOPARTICLES
Sharma, G., Karmali, P. P., Sugahara, K. N., Xie, H. M., Kotamraju, V. R., Ruoslahti, E. I., & Smith, J. W. (2013) · Nano LIFE · doi:10.1142/s1793984413430058 · Cited by 2
Angiopoietin-2 Antagonists for Anti-Angiogenic Therapy
Hughes, P. E., Polverino, A. J., Oliner, J. D., & Kendall, R. L. (2007) · Springer eBooks · doi:10.1007/978-3-540-33177-3_25 · Cited by 2
The Role of Inflammation in Tumor Progression: Targeting Tumor-Associated Macrophages
Varney, M. L., & Singh, R. K. (2008) · Clinical Research and Regulatory Affairs · doi:10.1080/10601330802208291 · Cited by 2
Inhibiting angiogenesis in malignant gliomas
Chi, A. S., & Wen, P. Y. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52138-5.00019-0 · Cited by 2
Tumor associated macrophages: current research and perspectives of clinical use
Gratchev, A. N., Samoilova, D. V., Рашидова, М. А., Petrenko, A. A., & Kovaleva, O. V. (2019) · Advances in molecular oncology · doi:10.17650/2313-805x-2018-5-4-20-28 · Cited by 4
The Angiogenic Switch: Role of Immune Cells
Noonan, D. M., Ventura, A., Bruno, A., Pagani, A., & Albini, A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7219-4_5 · Cited by 2
Role of Tumor‐Associated Macrophages (TAM) in Cancer Related Inflammation
Sica, A., & Porta, C. (2010) · doi:10.1002/9780470669891.ch5 · Cited by 2
Post-transcriptional control contributes to hypoxia-induced tumorigenic phenotypes in macrophagesPreprint
Courvan, E. M. C., & Parker, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.09.561558 · Cited by 2
Immunomodulatory Effects of Intermittent Fasting and Its Implication on Cancer: Ramadan Fasting Perspective
Salem, M. L., Alwasel, S. H., Faris, M. E., Aldahmash, W., Sanoh, N. E., Elkomy, H. A., Khallaf, E. M., Shaheraldin, A. A., Solaiman, T., Mostafa, N., et al. (2025) · Springer eBooks · doi:10.1007/978-981-96-6783-3_11 · Cited by 1
A Brief Review of the Role of Macrophage Hypoxia in SiO 2 ‐Induced Pulmonary Fibrosis
Fu, Y., Liu, Y., Hu, H., Zhang, Z., & Gong, W. (2025) · Journal of Applied Toxicology · doi:10.1002/jat.4906 · Cited by 1
Significance of Tumor Microenvironment on the Genesis of: Interstitial Fluid, Angiogenesis, Haemostatic/Haemorheologic Abnormalities. Pathogenesis and Therapeutic Aspects
Baronzio, G., Freitas, I., & Hau, K. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9576-4_3 · Cited by 1
Tumor Microenvironment and its Functions
Thanee, M., Yongvanit, P., & Loilome, W. (2012) · Srinagarind Medical Journal (SMJ) - ศรีนครินทร์เวชสาร · Cited by 1
Effect of Gadolinium Chloride on the Growth and Metastasizing of Lewis Pulmonary Adenocarcinoma in Mice
Zhanaeva, S. Y., Алексеенко, Т. В., & Короленко, Т. А. (2008) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-009-0346-0 · Cited by 1
Novel Prognostic Biomarkers for Personalized Cancer Treatment
Contasta, I., Berghella, A. M., Lattanzio, R., Ciccarelli, O., Gregorio, G. D., Vizioli, M., Silvino, M., Liberatore, L. L., Navarra, L., Caterino, G., et al. (2014) · Springer eBooks · doi:10.1007/978-3-662-44946-2_3 · Cited by 1
The Tumor Microenvironment as Target for New Cancer Therapies
Schwendener, R. A., & Mete, S. (2014) · Cited by 1
Updated Landscape of the Tumor Microenvironment and Targeting Strategies in an Era of Precision Medicine
Sun, Y., & Chiao, P. J. (2017) · InTech eBooks · doi:10.5772/66575 · Cited by 1
Vascular Endothelial Growth Factor Receptor Antibodies for Anti-Angiogenic Therapy
Böhlen, P., Zhu, Z., & Hicklin, D. J. (2007) · Springer eBooks · doi:10.1007/978-3-540-33177-3_24 · Cited by 1
High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleenPreprint
Yang, W.-P., Li, M.-Q., Ding, J. M., Li, J., Wu, G., Liu, B., Gao, Y., Wang, G., & Luo, Q. (2023) · eLife · doi:10.7554/elife.87496.2 · Cited by 1
Strategies for immune intervention; from bench to bedside
Dörrie, J., Birkholz, K., & Schaft, N. (2007) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-007-0311-6
The potential role of innate immunity in the pathogenesis of post-operative adhesions
White, J. U. (2011) · Human Biology
Tumors and Ly6Chigh Monocytes
Zare, F. (2015) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Vascular Endothelial Growth Factor and Tumour-Associated Macrophages
Stockmann, C., & Johnson, R. S. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0662-4_8
Novel radioimmunotherapy for lymphoma and solid tumours both as a single agent and in combination with the vascular disrupting agents
Dancey, G. J. (2011) · UCL Discovery (University College London)
Die Bedeutung von Hypoxie und Endotoxintoleranz für die Funktion von Monozyten und Makrophagen sowie für die Wechselwirkung von Monozyten und Endothel
Winning, S. (2010) · DuEPublico (University of Duisburg-Essen)
Ischemia/reperfusion and colorectal liver metastases
van der Bilt, J. D. W. (2007) · Utrecht University Repository (Utrecht University)
A New Approach to Cancer Therapy: The Tumor Microenvironment as Target
Schwendener, R. A., & Mete, S. (2014) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-102646
THE NK CELLS PHENOTYPE AND FUNCTION IN RESECTED NON SMALL CELL LUNG CANCER: DIFFERENCES BETWEEN SQUAMOUS AND ADENOCARCINOMA AND RELATION TO TUMOR ANGIOGENESIS
Noonan, D. M. (2011)
A study on crosstalk between lung carcinoma and immune cells
Mushtaq, Q. D. (2012) · Shodhganga
Tumor Associated Immune Dysfunction: Immune Cells Involved and Suggested Therapies
Talib, W. H., & Al-Yasari, I. H. (2014) · Annual Research & Review in Biology · doi:10.9734/arrb/2014/11831
A Perspective of Immunotherapy for Breast Cancer: Lessons Learned and Forward Directions for All Cancers Supplementary Issue: Targeted Therapies in Breast Cancer Treatment
Bryan, M. (2015)
Microfluidic platforms for studying cell behavior in complex microenvironments
Byrne, M. B. (2015) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
OPINION Hypoxia in atherosclerosis and inflammation
Marsch, E., Sluimer, J. C., & Daemen, M. J. A. P. (2013)
Papel do metabolismo de tumores associados ao papilomavírus humano na modulação do fenótipo de macrófagos humanos.
Stone, S. C. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2017.tde-14032017-100604
Examining the effects of macrophage populations on cancerous tumor growth.
Mahlbacher, G. E. (2017) · doi:10.18297/etd/2816
Tubular Physiology in Acute Kidney Injury: Cell Signalling, Injury and Inflammation
Ferenbach, D. A., O'Sullivan, E. D., & Bonventre, J. V. (2018) · Springer eBooks · doi:10.1007/978-1-4939-8628-6_5
Characterization of the Arterial Adventitia as a Sonic Hedgehog Responsive Niche
Hoglund, V. J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/ehzc-b587
COMPARATIVE MORPHOLOGICAL CHANGES IN SMOOTH MYOCYTES AND MACROFAGES CD16 IN PULMONARY ARTERY AND AORTA IN FETUSES AND NEWBORNERS UNDER CHRONIC INTRAUTERINE HYPOXIA INFLUENCE
Сорокина, И. В., Markovsky, V. D., Kaluzhyna, O. V., Pliten, O. M., & Hol'yeva, N. (2019) · Inter Collegas · doi:10.35339/ic.6.4.243-247
Análise dos marcadores de células tronco tumorais em linhagens tumorais resistentes ao estresse.
Ralph, A. C. L. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2020.tde-12022020-163347
Molecular Mechanisms of Action of Histidine-rich Glycoprotein in Angiogenesis Inhibition
Lee, C. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Macrophages and Tumor Development
Ostrand‐Rosenberg, S. (2014) · Springer eBooks · doi:10.1007/978-1-4899-8056-4_6
A Narrative Review of Clinical Manifestations and Pathogenetic Mechanisms of Neuropathy Induced by Radiation Therapy
Katano, A. (2022) · Journal of Radiation and Cancer Research · doi:10.4103/jrcr.jrcr_57_21
High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleenPreprint
Yang, W.-P., Li, M.-Q., Ding, J. M., Li, J., Wu, G., Liu, B., Gao, Y., Wang, G., & Luo, Q. (2023) · eLife · doi:10.7554/elife.87496.1
F-Box and Leucine-Rich Repeat Protein 7 Is a Prognostic Biomarker and Is Correlated with the Immunosuppressive Microenvironment in Colorectal Cancer
Wang, S., Zhao, X., Zhu, S., Xu, J., & Luo, T. (2023) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2023.0075
Inflammation and Macrophage Immunity in High Altitude Pulmonary Edema
李, 佳. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.142585

Authors: Lewis, C., & Murdoch, C.
Affiliations: University of Sheffield (GB)
Corresponding author: Lewis, Claire
ORCID: Lewis, Claire
Murdoch, Craig
Venue: The American Journal of Pathology
Publisher: Elsevier BV
Published: 2005-09
Volume: 167
Issue: 3
Pages: 627-635
ISSN: 0002-9440 (ISSN-L)
DOI: 10.1016/s0002-9440(10)62038-x
PMC: PMC1698733
OpenAlex: W1515730558
Cited by: 413
References: 155
Citations by year: 2026: 2 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 15 · 2021: 16 · 2020: 19 · 2019: 21 · 2018: 13 · 2017: 25 · 2016: 19 · 2015: 17 · 2014: 26 · 2013: 20 · 2012: 27
FWCI: 1.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: American Journal Of Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
School of Medicine, University of North Carolina at Chapel Hill
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: tumor-associated macrophages, hypoxia, HIF-1, HIF-2, tumor microenvironment, tumor invasion, tumor angiogenesis, metastasis, immune evasion, macrophage polarization, TAM-targeted therapy
MeSH terms: Animals, Hypoxia, Humans, Macrophages, Neoplasms, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Macrophage Responses to Hypoxia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks