The DOI matches its Crossref record, with a small difference in title or year; 150 of the 155 references it cites were found in a registry or an index.
Macrophage Responses to Hypoxia
Open accessAbstract
The presence of multiple areas of hypoxia (low oxygen tension) is a hallmark feature of human and experimental tumors. Monocytes are continually recruited into tumors, differentiate into tumor-associated macrophages (TAMs), and then accumulate in these hypoxic areas. A number of recent studies have shown that macrophages respond to the levels of hypoxia found in tumors by up-regulating such transcription factors as hypoxia-inducible factors 1 and 2, which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro-metastatic genes. This could explain why high numbers of TAMs correlate with poor prognosis in various forms of cancer. In this review, we assess the evidence for hypoxia activating a distinct, pro-tumor phenotype in macrophages and the possible effect of this on the growth, invasion, angiogenesis, and immune evasion of tumors. We also discuss current attempts to selectively target TAMs for destruction or to use them to deliver gene therapy specifically to hypoxic tumor sites.
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“Macrophages accumulate in hypoxic environments to release prohealing and pro-angiogenic factors such as vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) [63] and enzymes such as Cyclooxygenase 2 (COX2) [64].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [64]
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Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836
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HIF-1α is essential for myeloid cell-mediated inflammation
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Research works printed but not linked: 2
- Burton, 2000, Macrophages accumulate in avascular, hypoxic areas of prostate tumors: implications for the targeted therapeutic gene delivery to such sites, J Pathol, 192, 8A
- Ohno, 2004, Correlation of histological localization of tumor-associated macrophages with clinicopathological features in endometrial cancer, Anticancer Res, 24, 3335
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Items 401–412 of 412
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Murphy, J. F. (2025) · Springer eBooks · doi:10.1007/978-3-032-00761-2_87
Etude de la dynamique des phagocytes mononucléés au cours du processus inflammatoire
Hamon, P. (2017) · theses.fr (ABES) · doi:10.70675/ee1d73beza58cz4dc7z98adz671487b5acaa
Impact du microenvironnement dans la composition, la plasticité et la formation des invadosomes
Henriet, E. (2017) · theses.fr (ABES) · doi:10.70675/b6bc42f3z4b88z41c0z8c31z890b1ab044bc
The role of HIF-1α in innate immune mechanisms and autoimmunity: A double-edged sword
Chapple, M. L., Zaldumbide, A., & Fagundes, R. R. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111429
Tumor Associated Macrophages in a MaFIA Mouse Model
Clifford, A. (2006) · ScholarsArchive (Brigham Young University)
BONE MARROW-DERIVED CELLS IN ANGIOGENESIS AND CANCER
Lauttia, S. (2014) · Työväentutkimus Vuosikirja
The Effect of Hypoxia on the Production of Interleukin-10 (IL-10) In Human Mononuclear Cells
Wang, A. P.-L. (2010) · Figshare
Studies on regulation of versican gene expression by hypoxia in primary human macrophages
Sotoodehnejadnematalahi, F. (2011) · Leicester Research Archive (University of Leicester)
Metadata
- Authors
- Lewis, C., & Murdoch, C.
- Affiliations
- University of Sheffield (GB)
- Corresponding author
- Lewis, Claire
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 167
- Issue
- 3
- Pages
- 627-635
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1698733
- OpenAlex
- W1515730558
- Cited by
- 413
- References
- 155
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 15 · 2021: 16 · 2020: 19 · 2019: 21 · 2018: 13 · 2017: 25 · 2016: 19 · 2015: 17 · 2014: 26 · 2013: 20 · 2012: 27
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- School of Medicine, University of North Carolina at Chapel Hill
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- tumor-associated macrophages, hypoxia, HIF-1, HIF-2, tumor microenvironment, tumor invasion, tumor angiogenesis, metastasis, immune evasion, macrophage polarization, TAM-targeted therapy
- MeSH terms
- Animals, Hypoxia, Humans, Macrophages, Neoplasms, Disease Progression
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