Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy
Open accessAbstract
In human breast carcinomas, overexpression of the macrophage colony–stimulating factor (CSF-1) and its receptor (CSF-1R) correlates with poor prognosis. To establish if there is a causal relationship between CSF-1 and breast cancer progression, we crossed a transgenic mouse susceptible to mammary cancer with mice containing a recessive null mutation in the CSF-1 gene (Csf1op) and followed tumor progression in wild-type and null mutant mice. The absence of CSF-1 affects neither the incidence nor the growth of the primary tumors but delayed their development to invasive, metastatic carcinomas. Transgenic expression of CSF-1 in the mammary epithelium of both Csf1op/Csf1op and wild-type tumor-prone mice led to an acceleration to the late stages of carcinoma and to a significant increase in pulmonary metastasis. This was associated with an enhanced infiltration of macrophages into the primary tumor. These studies demonstrate that the growth of mammary tumors and the development to malignancy are separate processes and that CSF-1 selectively promotes the latter process. CSF-1 may promote metastatic potential by regulating the infiltration and function of tumor-associated macrophages as, at the tumor site, CSF-1R expression was restricted to macrophages. Our data suggest that agents directed at CSF-1/CSF-1R activity could have important therapeutic effects.
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In PyMT/Csf1op/Csf1op mice, absence of CSF-1 during early neoplastic development is without apparent consequence, but late-stage invasive carcinoma and pulmonary metastases are significantly attenuated.
“Whereas the absence of CSF-1 during early neoplastic development is without apparent consequence, development of late-stage invasive carcinoma and pulmonary metastases are significantly attenuated.”
From Inflammation and cancer (2002) · cites this paper as [21]
The key difference between PyMT mice and PyMT/Csf1op/Csf1op mice is not proliferative capacity of neoplastic epithelial cells but failure to recruit mature macrophages into neoplastic tissue in the absence of CSF-1.
“The key difference between PyMT mice and PyMT/Csf1op/Csf1op mice is not in the apparent proliferative capacity of neoplastic epithelial cells, but in the failure to recruit mature macrophages into neoplastic tissue in the absence of CSF-1.”
From Inflammation and cancer (2002) · cites this paper as [21]
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“The labeling of tumor-associated macrophages likely occurs because these cells also express high levels of proteases (24), and the intraoperative identification and removal of these cells may, in fact, be beneficial to patients because these cells are associated with tumor progression and metastasis (25, 26).”
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Non-genetic engineering of cells for drug delivery and cell-based therapy
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Self-citationMIF-Dependent Control of Tumor Immunity
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“immune cellderived cytokines (48, 49), growth factors (50, 51), oxygenation (52, 53), and metabolic substrate composition (54, 55) among many other factors.”
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The many microenvironments of ovarian cancer
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- Authors
- Lin, E. Y., Nguyen, A. V., Russell, R. G., & Pollard, J. W.
- Affiliations
- Albert Einstein College of Medicine (US)
- aDepartment of Developmental and Molecular Biology and the Department of Obstetrics/Gynecology and Women's Health, Center for the Study of Reproductive Biology and Women's Health,
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-03-19
- Volume
- 193
- Issue
- 6
- Pages
- 727-740
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2193412
- OpenAlex
- W2129311237
- Cited by
- 1,594
- References
- 51
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 31 · 2023: 63 · 2022: 58 · 2021: 73 · 2020: 74 · 2019: 56 · 2018: 58 · 2017: 83 · 2016: 74 · 2015: 74 · 2014: 91 · 2013: 112 · 2012: 80
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (T32AG000194, 5T32AG00194)
- National Cancer Institute (P-30-CA13330, T32CA009060, P30CA013330)
- National Institute of Allergy and Infectious Diseases (AI-CA09060)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- colony-stimulating factor 1, CSF-1 receptor, mammary tumors, breast cancer progression, tumor invasion, metastasis, lung metastasis, tumor-associated macrophages, macrophage infiltration, transgenic mouse model, CSF1R inhibitor
- MeSH terms
- Animals, Female, Lung Neoplasms, Male, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Transgenic, Mammary Neoplasms, Animal, Macrophage Colony-Stimulating Factor, Disease Progression, Mice
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